2015
Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones
Vorys GC, Bai H, Chandhanayingyong C, Lee CH, Compton JT, Caldwell JM, Gardner TR, Mao JJ, Lee FY. Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones. Clinical Biomechanics 2015, 30: 1114-1118. PMID: 26386637, PMCID: PMC9004608, DOI: 10.1016/j.clinbiomech.2015.08.016.Peer-Reviewed Original ResearchConceptsTorsional stiffnessHydroxyapatite composite scaffoldsCyclic torsional testsNon-locking fixationMassive segmental defectsTissue engineering strategiesLarge segmental bone defectsComposite scaffoldsLoading cyclesTorque controlSynthetic bone graftAxial stiffnessAngular rotationAxial compressionTorsional testsNon-destructive mannerGeometry representativeOptimal screw fixationSegmental bone defectsSuch scaffoldsTorque levelsStiffnessBiomechanical testingHuman tibiaEngineering strategies
2013
Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study
Amorosa L, Lee C, Aydemir, Nizami S, Hsu A, Patel N, Gardner T, Navalgund A, Kim DG, Park S, Mao J, Lee F. Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study. International Journal Of Nanomedicine 2013, Volume 8: 1637-1643. PMID: 23637532, PMCID: PMC3639117, DOI: 10.2147/ijn.s42855.Peer-Reviewed Original ResearchConceptsAddition of hMSCsPolymer-based scaffoldsLoad-bearing characteristicsPhysiologic cyclic loadingPhase angleCritical-sized segmental defectsScaffold alone groupViscous stiffnessCyclic loadingMechanical propertiesFemoral defect modelSized segmental defectsRat femoral defect modelHuman mesenchymal stem cellsMechanical simulationsScaffold groupDifferent biomechanical characteristicsEnhanced bone formationHigh phase anglesDefect modelBiomechanical characteristicsExperimental studyHost boneStiffnessDefect repair