2014
A Review of Osteocyte Function and the Emerging Importance of Sclerostin
Compton JT, Lee FY. A Review of Osteocyte Function and the Emerging Importance of Sclerostin. Journal Of Bone And Joint Surgery 2014, 96: 1659-1668. PMID: 25274791, PMCID: PMC4179450, DOI: 10.2106/jbjs.m.01096.Peer-Reviewed Original ResearchConceptsBone massPhase III clinical trialsMetastatic bone diseaseOsteoporosis-related fracturesBone mineral densityBone cellsExtensive dendritic networkNormal physiologic stateSclerostin actsParathyroid hormoneInflammatory moleculesBone metabolismClinical trialsMineral densityProstaglandin E2Bone diseaseSystemic circulationOrthopedic conditionsProtein sclerostinOsseous integrationSclerostinBone cell populationsPhysiologic stateCell populationsOsteocyte function
2007
ERK Signaling Regulates Macrophage Colony‐Stimulating Factor Expression Induced by Titanium Particles in MC3T3.E1 Murine Calvarial Preosteoblastic Cells
SEO SW, LEE D, CHO SK, KIM AD, MINEMATSU H, AYDEMIR A, GELLER JA, MACAULAY W, YANG J, LEE F. ERK Signaling Regulates Macrophage Colony‐Stimulating Factor Expression Induced by Titanium Particles in MC3T3.E1 Murine Calvarial Preosteoblastic Cells. Annals Of The New York Academy Of Sciences 2007, 1117: 151-158. PMID: 18056041, DOI: 10.1196/annals.1402.027.Peer-Reviewed Original ResearchConceptsM-CSF expressionExtracellular signal-regulated kinase (ERK) pathwaySignal-regulated kinase pathwayPreosteoblastic cellsSignal transduction pathwaysSpecific ERK inhibitorReverse transcriptase-polymerase chain reactionEnzyme-linked immunosorbent assayPreosteoclast proliferationTransduction pathwaysKinase pathwayMolecular mechanismsMacrophage colony-stimulating factorCellular environmentERK inhibitorPeriprosthetic osteolysisM-CSF productionNuclear factor kappa beta ligandCell populationsBeta ligandSignificant clinical problemTranscriptase-polymerase chain reactionExpressionDose-dependent mannerColony-stimulating factor