2018
Evolution and course of early life developmental encephalopathic epilepsies: Focus on Lennox‐Gastaut syndrome
Berg AT, Levy SR, Testa FM. Evolution and course of early life developmental encephalopathic epilepsies: Focus on Lennox‐Gastaut syndrome. Epilepsia 2018, 59: 2096-2105. PMID: 30255934, PMCID: PMC6215498, DOI: 10.1111/epi.14569.Peer-Reviewed Original ResearchConceptsLennox-Gastaut syndromeInitial presentationMedian onset ageChi-square testRefractory seizuresCentral reviewEpilepsy syndromesInfantile spasmsEncephalopathic epilepsyMedical recordsOnset ageEarly deathEpilepsySyndromeCognitive outcomesConnecticut StudyLongitudinal studyT-testSeizuresChildrenPresentationSpasmStatistical analysisYearsMortality
2017
Surgical outcome in adolescents with mesial temporal sclerosis: Is it different?
Farooque P, Hirsch L, Levy S, Testa F, Mattson R, Spencer D. Surgical outcome in adolescents with mesial temporal sclerosis: Is it different? Epilepsy & Behavior 2017, 69: 24-27. PMID: 28235653, DOI: 10.1016/j.yebeh.2016.10.028.Peer-Reviewed Original ResearchConceptsMesial temporal sclerosisTemporal sclerosisStatus epilepticusTemporal lobectomySurgical outcomesAdolescent patientsIctal onsetMore lobesEpilepsy surgery databaseScalp EEGSeizure freedomPatient populationSurgery DatabaseRisk factorsPatientsElectrographic dataLobectomyEpilepticusTwo yearsSclerosisHypometabolismNovel findingsAdolescentsMRIOutcomes
2016
Determinants of Social Outcomes in Adults With Childhood-onset Epilepsy
Berg AT, Baca CB, Rychlik K, Vickrey BG, Caplan R, Testa FM, Levy SR. Determinants of Social Outcomes in Adults With Childhood-onset Epilepsy. Pediatrics 2016, 137: e20153944. PMID: 26983470, PMCID: PMC4811319, DOI: 10.1542/peds.2015-3944.Peer-Reviewed Original Research
2014
Complete remission of childhood-onset epilepsy: stability and prediction over two decades
Berg AT, Rychlik K, Levy SR, Testa FM. Complete remission of childhood-onset epilepsy: stability and prediction over two decades. Brain 2014, 137: 3213-3222. PMID: 25338950, PMCID: PMC4240301, DOI: 10.1093/brain/awu294.Peer-Reviewed Original ResearchConceptsComplete remissionSeizure resolutionSeizure outcomeInitial diagnosisChildhood epilepsyLast contactCourse of epilepsyChildhood-onset epilepsySelf-limited epilepsy syndromeProportional hazards modelProspective cohortBaseline factorsRelapse rateLate remissionEpilepsy syndromesComplete resolutionRemissionHazards modelPredictive valueEpilepsyLogistic regressionConnecticut StudyDiagnosisFurther treatmentDevelopmental problemsLong‐term seizure remission in childhood absence epilepsy: Might initial treatment matter?
Berg AT, Levy SR, Testa FM, Blumenfeld H. Long‐term seizure remission in childhood absence epilepsy: Might initial treatment matter? Epilepsia 2014, 55: 551-557. PMID: 24512528, PMCID: PMC3999182, DOI: 10.1111/epi.12551.Peer-Reviewed Original ResearchConceptsChildhood absence epilepsyComplete remissionAtypical EEG featuresValproic acidEarly remissionAbsence epilepsyLong-term seizure outcomeLong-term seizure remissionPotential disease-modifying effectsPrimary long-term outcomeCommunity-based cohort studySignificant imaging abnormalitiesDisease-modifying effectsInitial treatment choiceLong-term outcomesInitial success rateGenetic absence modelSupporting Information sectionSeizure outcomeCohort studyFirst medicationSeizure remissionConvulsive seizuresImaging abnormalitiesInitial medication
2012
Age at onset of epilepsy, pharmacoresistance, and cognitive outcomes
Berg AT, Zelko FA, Levy SR, Testa FM. Age at onset of epilepsy, pharmacoresistance, and cognitive outcomes. Neurology 2012, 79: 1384-1391. PMID: 22972641, PMCID: PMC3448745, DOI: 10.1212/wnl.0b013e31826c1b55.Peer-Reviewed Original Research
2011
Complete remission in nonsyndromic childhood‐onset epilepsy
Berg AT, Testa FM, Levy SR. Complete remission in nonsyndromic childhood‐onset epilepsy. Annals Of Neurology 2011, 70: 566-573. PMID: 21710620, PMCID: PMC3183287, DOI: 10.1002/ana.22461.Peer-Reviewed Original ResearchConceptsComplete remissionNonsyndromic epilepsyProspective community-based cohortEarly seizure controlChildhood-onset epilepsyCommunity-based cohortProportional hazard modelingRisk of relapseKaplan-Meier approachSeizure outcomeSeizure controlSubsequent seizuresInitial diagnosisMultivariable analysisRemissionCohort membersEarly predictorBivariate analysisHazard modelingPoor chanceOlder ageRelapseEpilepsyCauseAge effects
2010
Parental report of behavioral and cognitive diagnoses in childhood-onset epilepsy: A case–sibling-controlled analysis
Benn EK, Hesdorffer DC, Levy SR, Testa FM, DiMario FJ, Berg AT. Parental report of behavioral and cognitive diagnoses in childhood-onset epilepsy: A case–sibling-controlled analysis. Epilepsy & Behavior 2010, 18: 276-279. PMID: 20494622, PMCID: PMC2902612, DOI: 10.1016/j.yebeh.2010.04.009.Peer-Reviewed Original ResearchConceptsChildhood-onset epilepsyPsychiatric disordersSelf-injurious behaviorInfluence prognosisMetabolic insultsEpilepsySuicide attemptsCase childrenSibling controlsConnecticut StudyGenetic causeParent interviewsParental reportsDisordersLanguage disordersMorbidityPrognosisInsultDiagnosisControlYoung people
2009
Frequency, prognosis and surgical treatment of structural abnormalities seen with magnetic resonance imaging in childhood epilepsy
Berg AT, Mathern GW, Bronen RA, Fulbright RK, DiMario F, Testa FM, Levy SR. Frequency, prognosis and surgical treatment of structural abnormalities seen with magnetic resonance imaging in childhood epilepsy. Brain 2009, 132: 2785-2797. PMID: 19638447, PMCID: PMC2759335, DOI: 10.1093/brain/awp187.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetAnticonvulsantsBrainChildChild, PreschoolCognitionCohort StudiesDrug ResistanceEpilepsyFemaleFunctional LateralityHumansImage Processing, Computer-AssistedInfantLogistic ModelsMagnetic Resonance ImagingMaleNeurologic ExaminationNeuropsychological TestsNeurosurgical ProceduresPrognosisSclerosisTomography, X-Ray ComputedConceptsMagnetic resonance imagingPositive MRI scansEpilepsy patientsMRI scansEpilepsy syndromesEpilepsy evaluationSurgical proceduresMultiple logistic regression analysisUse of MRIComprehensive epilepsy evaluationNon-idiopathic patientsPediatric epilepsy patientsComprehensive Epilepsy CenterPositive MRI findingsCommunity-based cohortNormal neurological examPre-surgical evaluationLogistic regression analysisIdiopathic epilepsy syndromesFrequency of lesionsClinical factorsMRI abnormalitiesMRI findingsNeurological examSurgical treatmentRemission of epilepsy after two drug failures in children: A prospective study
Berg AT, Levy SR, Testa FM, D'Souza R. Remission of epilepsy after two drug failures in children: A prospective study. Annals Of Neurology 2009, 65: 510-519. PMID: 19475671, PMCID: PMC2818062, DOI: 10.1002/ana.21642.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnticonvulsantsChildChild, PreschoolChi-Square DistributionDrug Therapy, CombinationEpilepsyFemaleFollow-Up StudiesHumansInfantInfant, NewbornMalePredictive Value of TestsProbabilityProportional Hazards ModelsProspective StudiesRecurrenceRetrospective StudiesTime FactorsTreatment FailureConceptsDrug failureRemission of epilepsyAggressive treatmentSeizure frequencyPrognostic factorsThird drugInitial diagnosisSymptomatic causesProspective studyProportional hazards techniquesIdiopathic epilepsyAppropriate drugsRemissionSecond drugLast contactOnly correlateEpilepsyDrugsChildrenFailurePredictorsRobust predictorPatientsRelapseTherapy
2008
Residual cognitive effects of uncomplicated idiopathic and cryptogenic epilepsy
Berg AT, Langfitt JT, Testa FM, Levy SR, DiMario F, Westerveld M, Kulas J. Residual cognitive effects of uncomplicated idiopathic and cryptogenic epilepsy. Epilepsy & Behavior 2008, 13: 614-619. PMID: 18675938, DOI: 10.1016/j.yebeh.2008.07.007.Peer-Reviewed Original ResearchConceptsCryptogenic epilepsyChildhood-onset epilepsyOngoing prospective studyNormal intelligenceStandardized neuropsychological assessmentResidual cognitive deficitsProspective studyRemission statusResidual cognitive effectsCohort 8Drug useEpilepsyCognitive deficitsSibling controlsSlower processing speedNeuropsychological assessmentCognitive effectsYoung peopleFull Scale IQCases
2007
Global cognitive function in children with epilepsy: A community‐based study
Berg AT, Langfitt JT, Testa FM, Levy SR, DiMario F, Westerveld M, Kulas J. Global cognitive function in children with epilepsy: A community‐based study. Epilepsia 2007, 49: 608-614. PMID: 18070088, DOI: 10.1111/j.1528-1167.2007.01461.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAge of OnsetChildChild, PreschoolCognitionCognition DisordersComorbidityConnecticutData CollectionEpilepsies, PartialEpilepsyEpilepsy, GeneralizedFollow-Up StudiesHumansInfantNeuropsychological TestsOutcome Assessment, Health CarePrognosisProspective StudiesRiskSyndromeWechsler ScalesBehavior and social competency in idiopathic and cryptogenic childhood epilepsy
Berg AT, Vickrey BG, Testa FM, Levy SR, Shinnar S, DiMario F. Behavior and social competency in idiopathic and cryptogenic childhood epilepsy. Developmental Medicine & Child Neurology 2007, 49: 487-492. PMID: 17593118, DOI: 10.1111/j.1469-8749.2007.00487.x.Peer-Reviewed Original ResearchConceptsLack of remissionWorse behavioral problemsChildhood epilepsyMedication useMedication statusBehavioral problemsImpact of remissionCurrent medication useCommunity-based studyCompetency scoresCryptogenic epilepsyInitial diagnosisAntiepileptic drugsRemissionEpilepsyWorse scoresRelated disordersChildren 8Behavioral assessmentIndependent effectsChildrenDeleterious effectsScoresAttention problems
2006
How long does it take for epilepsy to become intractable? A prospective investigation
Berg AT, Vickrey BG, Testa FM, Levy SR, Shinnar S, DiMario F, Smith S. How long does it take for epilepsy to become intractable? A prospective investigation. Annals Of Neurology 2006, 60: 73-79. PMID: 16685695, DOI: 10.1002/ana.20852.Peer-Reviewed Original ResearchConceptsEarly remission periodSeizures/monthCatastrophic epilepsyFurther remissionTreatable epilepsyProspective cohortRemission periodEpilepsy syndromesIntractable epilepsyProspective InvestigationFocal epilepsyLast contactEpilepsyEpilepsy diagnosisRemissionSyndromeMore yearsChildrenMonthsDrugsYearsSurgerySeizuresReferralCohort
2005
Special education needs of children with newly diagnosed epilepsy
Berg AT, Smith SN, Frobish D, Levy SR, Testa FM, Beckerman B, Shinnar S. Special education needs of children with newly diagnosed epilepsy. Developmental Medicine & Child Neurology 2005, 47: 749-753. DOI: 10.1111/j.1469-8749.2005.tb01072.x.Peer-Reviewed Original ResearchConceptsOnset of seizuresFirst seizureMean ageIntact childrenProspective community-based studyRemote symptomatic etiologyOnset of epilepsyCommunity-based studyTime of interviewYears 10 monthsChildren's mean ageYears 11 monthsInitiation of servicesSymptomatic etiologyChildhood epilepsyEpileptic encephalopathyService useEpilepsyTiming of servicesSeizuresCognitive abnormalitiesFormer groupChildrenAgeEtiology
2004
Mortality in Childhood-Onset Epilepsy
Berg AT, Shinnar S, Testa FM, Levy SR, Smith SN, Beckerman B. Mortality in Childhood-Onset Epilepsy. JAMA Pediatrics 2004, 158: 1147-1152. PMID: 15583099, DOI: 10.1001/archpedi.158.12.1147.Peer-Reviewed Original ResearchConceptsStandardized mortality ratioRisk of deathMortality ratioMultivariable analysisOverall standardized mortality ratioProspective community-based cohortCox proportional hazards modelSevere underlying conditionsPredictors of deathChildhood-onset epilepsyCommunity-based cohortOccurrence of seizuresProportional hazards modelPoint of diagnosisCrude death rateNonsymptomatic epilepsySymptomatic etiologySymptomatic epilepsyUnderlying disorderUnderlying conditionExcess mortalityMost deathsOutcome measuresHazards modelChi2 testModeling remission and relapse in pediatric epilepsy: application of a Markov process
Berg AT, Lin J, Ebrahimi N, Testa FM, Levy SR, Shinnar S. Modeling remission and relapse in pediatric epilepsy: application of a Markov process. Epilepsy Research 2004, 60: 31-40. PMID: 15279868, DOI: 10.1016/j.eplepsyres.2004.05.002.Peer-Reviewed Original ResearchConceptsPartial epilepsyStandard survival techniquesEpilepsy syndromesProspective community-based studyCryptogenic partial epilepsySymptomatic partial epilepsyCommunity-based studyIdiopathic partial epilepsyTerms of patientTerminal remissionThird remissionSecond remissionSubsequent remissionSecond relapseSeizure outcomeInitial diagnosisPediatric epilepsyEpileptic encephalopathySurvival techniquesRelapse outcomesRemissionSyndrome groupRelapseEpilepsyRemission episodes