2014
Complete remission of childhood-onset epilepsy: stability and prediction over two decades
Berg AT, Rychlik K, Levy SR, Testa FM. Complete remission of childhood-onset epilepsy: stability and prediction over two decades. Brain 2014, 137: 3213-3222. PMID: 25338950, PMCID: PMC4240301, DOI: 10.1093/brain/awu294.Peer-Reviewed Original ResearchConceptsComplete remissionSeizure resolutionSeizure outcomeInitial diagnosisChildhood epilepsyLast contactCourse of epilepsyChildhood-onset epilepsySelf-limited epilepsy syndromeProportional hazards modelProspective cohortBaseline factorsRelapse rateLate remissionEpilepsy syndromesComplete resolutionRemissionHazards modelPredictive valueEpilepsyLogistic regressionConnecticut StudyDiagnosisFurther treatmentDevelopmental problems
2011
Complete remission in nonsyndromic childhood‐onset epilepsy
Berg AT, Testa FM, Levy SR. Complete remission in nonsyndromic childhood‐onset epilepsy. Annals Of Neurology 2011, 70: 566-573. PMID: 21710620, PMCID: PMC3183287, DOI: 10.1002/ana.22461.Peer-Reviewed Original ResearchConceptsComplete remissionNonsyndromic epilepsyProspective community-based cohortEarly seizure controlChildhood-onset epilepsyCommunity-based cohortProportional hazard modelingRisk of relapseKaplan-Meier approachSeizure outcomeSeizure controlSubsequent seizuresInitial diagnosisMultivariable analysisRemissionCohort membersEarly predictorBivariate analysisHazard modelingPoor chanceOlder ageRelapseEpilepsyCauseAge effects
2010
Parental report of behavioral and cognitive diagnoses in childhood-onset epilepsy: A case–sibling-controlled analysis
Benn EK, Hesdorffer DC, Levy SR, Testa FM, DiMario FJ, Berg AT. Parental report of behavioral and cognitive diagnoses in childhood-onset epilepsy: A case–sibling-controlled analysis. Epilepsy & Behavior 2010, 18: 276-279. PMID: 20494622, PMCID: PMC2902612, DOI: 10.1016/j.yebeh.2010.04.009.Peer-Reviewed Original ResearchConceptsChildhood-onset epilepsyPsychiatric disordersSelf-injurious behaviorInfluence prognosisMetabolic insultsEpilepsySuicide attemptsCase childrenSibling controlsConnecticut StudyGenetic causeParent interviewsParental reportsDisordersLanguage disordersMorbidityPrognosisInsultDiagnosisControlYoung people
2008
Residual cognitive effects of uncomplicated idiopathic and cryptogenic epilepsy
Berg AT, Langfitt JT, Testa FM, Levy SR, DiMario F, Westerveld M, Kulas J. Residual cognitive effects of uncomplicated idiopathic and cryptogenic epilepsy. Epilepsy & Behavior 2008, 13: 614-619. PMID: 18675938, DOI: 10.1016/j.yebeh.2008.07.007.Peer-Reviewed Original ResearchConceptsCryptogenic epilepsyChildhood-onset epilepsyOngoing prospective studyNormal intelligenceStandardized neuropsychological assessmentResidual cognitive deficitsProspective studyRemission statusResidual cognitive effectsCohort 8Drug useEpilepsyCognitive deficitsSibling controlsSlower processing speedNeuropsychological assessmentCognitive effectsYoung peopleFull Scale IQCases
2004
Mortality in Childhood-Onset Epilepsy
Berg AT, Shinnar S, Testa FM, Levy SR, Smith SN, Beckerman B. Mortality in Childhood-Onset Epilepsy. JAMA Pediatrics 2004, 158: 1147-1152. PMID: 15583099, DOI: 10.1001/archpedi.158.12.1147.Peer-Reviewed Original ResearchConceptsStandardized mortality ratioRisk of deathMortality ratioMultivariable analysisOverall standardized mortality ratioProspective community-based cohortCox proportional hazards modelSevere underlying conditionsPredictors of deathChildhood-onset epilepsyCommunity-based cohortOccurrence of seizuresProportional hazards modelPoint of diagnosisCrude death rateNonsymptomatic epilepsySymptomatic etiologySymptomatic epilepsyUnderlying disorderUnderlying conditionExcess mortalityMost deathsOutcome measuresHazards modelChi2 testLongitudinal Assessment of Adaptive Behavior in Infants and Young Children With Newly Diagnosed Epilepsy: Influences of Etiology, Syndrome, and Seizure Control
Berg AT, Smith SN, Frobish D, Beckerman B, Levy SR, Testa FM, Shinnar S. Longitudinal Assessment of Adaptive Behavior in Infants and Young Children With Newly Diagnosed Epilepsy: Influences of Etiology, Syndrome, and Seizure Control. Pediatrics 2004, 114: 645-650. PMID: 15342834, DOI: 10.1542/peds.2003-1151-l.Peer-Reviewed Original ResearchConceptsSeizure controlInitial diagnosisSymptomatic etiologyEpileptic encephalopathyProspective community-based studySubtle cognitive difficultiesInfluence of etiologyChildhood-onset epilepsyOnset of epilepsyCommunity-based studyIndependent effectsMajority of childrenCognitive difficultiesSeizure outcomeSecondary outcomesPrimary outcomeParents of childrenIntractable seizuresSchool-aged childrenSyndrome typeNormal rangeBaseline scoresPredictive valueEpilepsyDomain scores