Immunomodulatory effects of RXR rexinoids: modulation of high-affinity IL-2R expression enhances susceptibility to denileukin diftitox
Gorgun G, Foss F. Immunomodulatory effects of RXR rexinoids: modulation of high-affinity IL-2R expression enhances susceptibility to denileukin diftitox. Blood 2002, 100: 1399-1403. PMID: 12149223, DOI: 10.1182/blood-2002-01-0300.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAlitretinoinAntineoplastic AgentsBexaroteneB-LymphocytesDiphtheria ToxinGene Expression RegulationHumansInterleukin-2Leukemia, Lymphocytic, Chronic, B-CellLeukemia-Lymphoma, Adult T-CellPrecursor B-Cell Lymphoblastic Leukemia-LymphomaReceptors, Interleukin-2Receptors, Retinoic AcidRecombinant Fusion ProteinsRetinoid X ReceptorsRetinoidsTetrahydronaphthalenesT-LymphocytesTranscription FactorsTretinoinTumor Cells, CulturedConceptsRetinoic acid receptorsImmunomodulatory effectsIL-2RHigh affinity IL-2R expressionCutaneous T-cell lymphomaHigh affinity IL-2R.Interleukin-2 receptor expressionIL-2R expressionT-cell lymphomaB cell leukemia cellsB-cell leukemiaT-cell leukemiaMechanism of actionAutoimmune diseasesHematologic malignanciesClinical activityReceptor expressionLymphoid malignanciesIL-2R.Retinoid X receptor (RXR) familyP75 subunitAcid receptorsRexinoid receptorsLeukemia cellsRexinoidsInterleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines
Cosenza L, Gorgun G, Urbano A, Foss F. Interleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines. Cellular Signalling 2002, 14: 317-325. PMID: 11858939, DOI: 10.1016/s0898-6568(01)00245-5.Peer-Reviewed Original ResearchMeSH KeywordsBrain NeoplasmsCell LineEpithelial CellsHematopoietic Stem CellsHumansImmunoblottingInterleukin Receptor Common gamma SubunitJanus Kinase 3Lung NeoplasmsNeoplasmsNuclease Protection AssaysProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-fynReceptors, Interleukin-7RNA, MessengerSignal TransductionTissue DistributionTranscription, GeneticTumor Cells, CulturedConceptsIL-7R mRNABrain tumor cell linesIL-7RIL-7RalphaCell linesTumor cell linesInterleukin-7 receptor expressionReceptor-directed therapyNational Cancer Institute tumor panelBreast cancer cell linesReceptor gamma chainLung cancer cellsInterleukin-2 receptor gamma chainHeterodimeric complex consistingS1 nuclease protection assaysCellular differentiation processesEpithelial tumor cellsCancer cell linesNuclease protection assaysS1 nuclease protectionLung cancerSerine residue phosphorylationReceptor expressionNeoplastic cell linesInterleukin-7