2018
Fibroblast growth factor 2 is necessary for the antidepressant effects of fluoxetine
Simard S, Shail P, MacGregor J, Sayed M, Duman RS, Vaccarino FM, Salmaso N. Fibroblast growth factor 2 is necessary for the antidepressant effects of fluoxetine. PLOS ONE 2018, 13: e0204980. PMID: 30273396, PMCID: PMC6166983, DOI: 10.1371/journal.pone.0204980.Peer-Reviewed Original ResearchConceptsChronic variable stressSelective serotonin reuptake inhibitorsPost-mortem brainsGlucocorticoid receptorTherapeutic effectMood disordersAnxiety behaviorFgf2 knockout miceAnti-depressant effectsSerotonin reuptake inhibitorsEffects of fluoxetineTreatment of depressionHippocampal glucocorticoid receptorsAnti-depressant medicationWild-type miceEffect of CVSAnti-depressive agentsNovel therapeutic targetFGF2 geneFibroblast growth factor-2HPA changesAstroglial functionAntidepressant effectsAntidepressant medicationAntidepressant treatment
2016
Fibroblast Growth Factor 2 Modulates Hypothalamic Pituitary Axis Activity and Anxiety Behavior Through Glucocorticoid Receptors
Salmaso N, Stevens HE, McNeill J, ElSayed M, Ren Q, Maragnoli ME, Schwartz ML, Tomasi S, Sapolsky RM, Duman R, Vaccarino FM. Fibroblast Growth Factor 2 Modulates Hypothalamic Pituitary Axis Activity and Anxiety Behavior Through Glucocorticoid Receptors. Biological Psychiatry 2016, 80: 479-489. PMID: 27133954, PMCID: PMC8009045, DOI: 10.1016/j.biopsych.2016.02.026.Peer-Reviewed Original ResearchConceptsFibroblast growth factor-2Hippocampal glucocorticoid receptor expressionGlucocorticoid receptor expressionAdrenal axis activityKO miceAxis activityAnxiety behaviorReceptor expressionHypothalamic-pituitary axis activityReceptor KO miceFGF2 administrationWild-type miceGrowth factor 2Receptor subtypesTherapeutic effectNeuroendocrine studiesAdult miceGlucocorticoid receptorGR promoter regionsFGF2 levelsMeasures of anxietyMiceMotor behaviorFGF2 geneFactor 2
2015
Altered expression of neuropeptides in FoxG1-null heterozygous mutant mice
Frullanti E, Amabile S, Lolli MG, Bartolini A, Livide G, Landucci E, Mari F, Vaccarino FM, Ariani F, Massimino L, Renieri A, Meloni I. Altered expression of neuropeptides in FoxG1-null heterozygous mutant mice. European Journal Of Human Genetics 2015, 24: 252-257. PMID: 25966633, PMCID: PMC4717204, DOI: 10.1038/ejhg.2015.79.Peer-Reviewed Original ResearchConceptsBasal gangliaAdult brainParvalbumin-positive GABAergic interneuronsNeonatal brain developmentWild-type littermatesGroup of neuropeptidesHeterozygous mutant miceHippocampal neurogenesisImpaired social interactionCalcium-dependent signalingTotal brainGABAergic interneuronsNeuronal excitabilityControl of movementHippocampal neuronsArginine vasopressinBehavioral impairmentsWhole brainMammalian forebrainHeterozygous miceMutant miceFOXG1 geneBrain developmentBrainAltered expression
2012
Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus
Stevens HE, Jiang GY, Schwartz ML, Vaccarino FM. Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus. Biological Psychiatry 2012, 71: 1090-1098. PMID: 22541947, PMCID: PMC3371339, DOI: 10.1016/j.biopsych.2012.03.013.Peer-Reviewed Original ResearchConceptsFGF receptor 2Fibroblast growth factorDentate gyrusReceptor 2Embryonic knockoutWater maze probe trialGrowth factor receptor 2Reference memoryFactor receptor 2Spatial reference memoryNeural stem cellsFibroblast growth factor receptor 2Immature neuronsCortical neuronsHippocampal volumeInducible knockout miceParvalbumin interneuronsShort-term learningGranule cellsKnockout miceSeparate cellular componentsHippocampusLong-term reference memoryAdult spatial memoryGrowth factor
2011
Toward a Novel Endogenous Anxiolytic Factor, Fibroblast Growth Factor 2
Salmaso N, Vaccarino FM. Toward a Novel Endogenous Anxiolytic Factor, Fibroblast Growth Factor 2. Biological Psychiatry 2011, 69: 508-509. PMID: 21353835, PMCID: PMC3058122, DOI: 10.1016/j.biopsych.2011.01.017.Commentaries, Editorials and Letters
2007
Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus
Breunig JJ, Silbereis J, Vaccarino FM, Šestan N, Rakic P. Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 20558-20563. PMID: 18077357, PMCID: PMC2154470, DOI: 10.1073/pnas.0710156104.Peer-Reviewed Original ResearchConceptsAbrogation of NotchCell cycle exitNeuronal fate determinationPrecursor cellsTransit-amplifying cellsFate determinationInducible gainCell fateCycle exitNeural precursor cellsModulates SurvivalMolecular controlPostnatal progenitor cellsLifelong additionHippocampal morphogenesisDifferentiation statePostnatal dentate gyrusNewborn granule cellsMembrane receptorsNeural stemGenetic ablationExpression of Notch1Structural plasticityProgenitor cellsEnvironmental modulators
2004
Fibroblast Growth Factor Receptor 1 Is Required for the Proliferation of Hippocampal Progenitor Cells and for Hippocampal Growth in Mouse
Ohkubo Y, Uchida AO, Shin D, Partanen J, Vaccarino FM. Fibroblast Growth Factor Receptor 1 Is Required for the Proliferation of Hippocampal Progenitor Cells and for Hippocampal Growth in Mouse. Journal Of Neuroscience 2004, 24: 6057-6069. PMID: 15240797, PMCID: PMC6729672, DOI: 10.1523/jneurosci.1140-04.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, DifferentiationCell CountCell LineageCell ProliferationCells, CulturedHeredodegenerative Disorders, Nervous SystemHippocampusHumansIn Situ HybridizationLateral VentriclesMiceMice, TransgenicMutagenesis, Site-DirectedNeurogliaNeuronsPyramidal CellsReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 1Receptors, Fibroblast Growth FactorRNA, MessengerStem CellsTransgenesConceptsHippocampal ventricular zonesDentate gyrusGrowth factor receptor 1Fibroblast growth factor receptor 1Factor receptor 1Ventricular zoneNeural stem cellsPyramidal neuronsHippocampal growthProgenitor cellsGranule cellsReceptor 1Glial fibrillary acidic protein promoterHuman glial fibrillary acidic protein promoterEmbryonic dorsal telencephalonRadial glial-like cellsRadial glial progenitor cellsHippocampal dentate gyrusParvalbumin-containing interneuronsDG granule cellsHippocampal pyramidal neuronsStem cellsHippocampal progenitor cellsRole of FGFR1Glial progenitor cells
2002
Fibroblast Growth Factor 2 Is Necessary for the Growth of Glutamate Projection Neurons in the Anterior Neocortex
Korada S, Zheng W, Basilico C, Schwartz ML, Vaccarino FM. Fibroblast Growth Factor 2 Is Necessary for the Growth of Glutamate Projection Neurons in the Anterior Neocortex. Journal Of Neuroscience 2002, 22: 863-875. PMID: 11826116, PMCID: PMC6758485, DOI: 10.1523/jneurosci.22-03-00863.2002.Peer-Reviewed Original ResearchConceptsCerebral cortexParietal cortexAnterior cerebral cortexGlutamatergic pyramidal neuronsGABA receptor agonistsGlutamatergic neuronal populationsDuration of sleepAnterior cortical regionsBasic fibroblast growth factorCell numberNull mutant miceGranule cell numberFibroblast growth factor-2Fibroblast growth factorGABA interneuronsGrowth factor 2Fgf2-/- micePyramidal neuronsInhibitory neurotransmissionProjection neuronsAnterior neocortexReceptor agonistPyramidal cellsOccipital cortexNeuronal populations
1987
Subcellular Location and Neuronal Release of Diazepam Binding Inhibitor
Ferrarese C, Vaccarino F, Alho H, Mellstrom B, Costa E, Guidotti A. Subcellular Location and Neuronal Release of Diazepam Binding Inhibitor. Journal Of Neurochemistry 1987, 48: 1093-1102. PMID: 3819722, DOI: 10.1111/j.1471-4159.1987.tb05632.x.Peer-Reviewed Original ResearchConceptsDBI-like immunoreactivitySlices of hypothalamusCerebral cortical neuronsGamma-aminobutyric acid receptorsRat brain neuronsDiazepam binding inhibitorAllosteric modulatory sitesVeratridine depolarizationNeuronal releaseCerebral cortexMicroM tetrodotoxinSlices of liverPeripheral organsCNS neuronsCortical neuronsBinding of benzodiazepinesCortical astrocytesBrain neuronsNeuromodulatory substancesRat brainSynaptosomal lysatesModulatory siteMet5-enkephalinAcid receptorsNeurons