2022
Does presence of diabetes mellitus impact patient oncological outcomes in renal cell carcinoma: A multicenter analysis.
Saidian A, Walia A, Patil D, Saito K, Patel D, Nguyen M, Chakoumakos M, Ghali F, Narasimhan R, Perry J, Meagher M, Yasuda Y, Fujii Y, Master V. Does presence of diabetes mellitus impact patient oncological outcomes in renal cell carcinoma: A multicenter analysis. Journal Of Clinical Oncology 2022, 40: 325-325. DOI: 10.1200/jco.2022.40.6_suppl.325.Peer-Reviewed Original ResearchRenal cell carcinomaProgression-free survivalKaplan-Meier analysisCancer-specific survivalIndependent risk factorMultivariable analysisDiabetes mellitusRisk factorsOverall survivalCell carcinomaStage ICox regression multivariable analysisImpact of DMPatients' oncological outcomesNon-diabetic patientsRegression multivariable analysisOncologic effectCause mortalityOncological outcomesDiabetic patientsMulticenter analysisMeier analysisMale sexRCC patientsStage subgroupsDisparities in Cancer Specific and Overall Survival Outcomes in African Americans With Renal Cell Carcinoma: Analysis From the International Marker Consortium for Renal Cancer (INMARC)
Meagher M, Patil D, Saito K, Javier-Desloges J, Bradshaw A, Patel S, Cotta B, Yasuda Y, Eldefrawy A, Ghali F, Nasseri R, Wan F, Fujii Y, Master V, Derweesh I. Disparities in Cancer Specific and Overall Survival Outcomes in African Americans With Renal Cell Carcinoma: Analysis From the International Marker Consortium for Renal Cancer (INMARC). Urology 2022, 163: 164-176. PMID: 34995562, DOI: 10.1016/j.urology.2021.12.022.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaCancer-specific mortalityCancer-specific survivalKaplan-Meier analysisCause mortalityOverall survivalMultivariable analysisSurvival outcomesCell carcinomaStage IIIStage IFive-year cancer-specific survivalAfrican AmericansNon-African American patientsRenal cancer databasePapillary renal cell carcinomaOverall survival outcomesAfrican American raceStage III/IV RCCHigher stageIndolent histologiesSecondary outcomesPrimary outcomeRadical nephrectomyPositive marginsDisparities in Telemedicine Utilization for Urology Patients During the COVID-19 Pandemic
Javier-DesLoges J, Meagher M, Soliman S, Yuan J, Hakimi K, Ghali F, Nalawade V, Patel DN, Monga M, Murphy JD, Derweesh I. Disparities in Telemedicine Utilization for Urology Patients During the COVID-19 Pandemic. Urology 2022, 163: 76-80. PMID: 34979219, PMCID: PMC8719918, DOI: 10.1016/j.urology.2021.11.037.Peer-Reviewed Original ResearchConceptsTelemedicine utilizationMultivariable logistic regression analysisLogistic regression multivariable analysisRegression multivariable analysisSingle academic institutionLogistic regression analysisUse of telemedicineCOVID-19 pandemicNon-Hispanic whitesUrology patientsPatient characteristicsPrimary outcomeMedicaid insuranceMultivariable analysisRetrospective studyTelemedicine appointmentsUrologic conditionsProvider ageProvider trainingClinic locationProvider sexPatientsBackward model selectionZip codesVisits
2021
The association between the Affordable Care Act on insurance status, cancer stage, and overall survival in patients with renal cell carcinoma.
Javier-Desloges J, Yuan J, Soliman S, Hakimi K, Meagher M, Ghali F, Hsiang W, Patel D, Murphy J, Kim S, Derweesh I. The association between the Affordable Care Act on insurance status, cancer stage, and overall survival in patients with renal cell carcinoma. Journal Of Clinical Oncology 2021, 39: 281-281. DOI: 10.1200/jco.2021.39.6_suppl.281.Peer-Reviewed Original ResearchRenal cell carcinomaMiddle-income patientsNon-expansion statesAffordable Care ActAbsolute percentage changeIncome patientsInsurance statusExpansion statesCox regression multivariable analysisNational Cancer DatabaseRegression multivariable analysisHigh-income patientsLow-income patientsInsurance coverage statusImplementation of ACALow incomeCause mortalityPatients 40Overall survivalStage diseaseAdvanced cancerMultivariable analysisCancer groupStage migrationCell carcinoma
2020
Utilization of renal mass biopsy in patients with localized renal cell carcinoma: A population-based study utilizing the National Cancer Database
Patel DN, Ghali F, Meagher MF, Javier-Desloges J, Patel SH, Soliman S, Hakimi K, Yuan J, Murphy J, Derweesh IH. Utilization of renal mass biopsy in patients with localized renal cell carcinoma: A population-based study utilizing the National Cancer Database. Urologic Oncology Seminars And Original Investigations 2020, 39: 79.e1-79.e8. PMID: 33160847, DOI: 10.1016/j.urolonc.2020.10.015.Peer-Reviewed Original ResearchConceptsUse of RMBRenal mass biopsyRenal cell carcinomaNational Cancer DatabaseCell carcinomaMultivariable analysisCancer DatabaseMass biopsyCharlson Comorbidity IndexCurrent guideline recommendationsYear of diagnosisPopulation-based studySmall renal massesComorbidity indexSurgical treatmentGuideline recommendationsTumor sizeRenal massesPersistent underutilizationPatientsCarcinomaStudy periodTumorsBiopsyHigh rateImpact of positive surgical margins on survival after partial nephrectomy in localized kidney cancer: analysis of the National Cancer Database
Ryan S, Patel D, Ghali F, Patel S, Sarkar R, Yim K, Eldefrawy A, Cotta B, Bradshaw A, Meagher M, Hamilton Z, Murphy J, Derweesh I. Impact of positive surgical margins on survival after partial nephrectomy in localized kidney cancer: analysis of the National Cancer Database. Minerva Urologica E Nefrologica 2020, 73: 233-244. PMID: 32748614, DOI: 10.23736/s2724-6051.20.03728-5.Peer-Reviewed Original ResearchConceptsPositive surgical marginsKaplan-Meier analysisRenal cell carcinomaNational Cancer DatabaseOverall survivalPartial nephrectomyMultivariable analysisSurgical marginsPathological stageCancer DatabaseCox regression multivariable analysisN0M0 renal cell carcinomaUS National Cancer DatabaseImpact of PSMRegression multivariable analysisPT3a diseaseCause mortalityMargin statusNegative marginsResection strategyCell carcinomaAggressive surveillanceRetrospective analysisKidney cancerPatientsComparison of renal functional outcomes of active surveillance and partial nephrectomy in the management of oncocytoma
Meagher M, Lane B, Capitanio U, Mehrazin R, Bradshaw A, Noyes S, Larcher A, Eldefrawy A, Ghali F, Patel D, Bruinius J, Dutt R, Keiner C, Miller N, Wan F, Montorsi F, Derweesh I. Comparison of renal functional outcomes of active surveillance and partial nephrectomy in the management of oncocytoma. World Journal Of Urology 2020, 39: 1195-1201. PMID: 32556559, DOI: 10.1007/s00345-020-03299-5.Peer-Reviewed Original ResearchConceptsDe novo chronic kidney diseaseChronic kidney diseaseKaplan-Meier analysisPartial nephrectomyActive surveillanceMultivariable analysisBaseline eGFRTumor sizeFunctional outcomeFunctional declineCKD-free survivalGreater functional declineHigher RENAL scoreLower baseline eGFRRenal functional preservationRegression multivariable analysisClinical tumor sizeRenal functional outcomesTumor diameterKidney diseaseRENAL scoreFunctional preservationMedian changeRetrospective analysisSelect circumstancesRates and Predictors of Perioperative Complications in Cytoreductive Nephrectomy: Analysis of the Registry for Metastatic Renal Cell Carcinoma
Roussel E, Campi R, Larcher A, Verbiest A, Antonelli A, Palumbo C, Derweesh I, Ghali F, Bradshaw A, Meagher M, Heck M, Amiel T, Kriegmair M, Rubio J, Musquera M, D’Anna M, Autorino R, Guruli G, Veccia A, Linares-Espinos E, Van Bruwaene S, Hevia V, Porpiglia F, Checcucci E, Minervini A, Mari A, Pavan N, Claps F, Marchioni M, Capitanio U, Beuselinck B, Mir M, Albersen M, Group O. Rates and Predictors of Perioperative Complications in Cytoreductive Nephrectomy: Analysis of the Registry for Metastatic Renal Cell Carcinoma. European Urology Oncology 2020, 3: 523-529. PMID: 32414697, DOI: 10.1016/j.euo.2020.04.006.Peer-Reviewed Original ResearchConceptsCytoreductive nephrectomyPostoperative complicationsMultivariable analysisMRCC patientsIntraoperative complicationsBlood lossSignificant predictorsComplex surgeryMetastatic renal cell carcinoma patientsHigher intraoperative blood lossHigh-grade postoperative complicationsMetastatic renal cell carcinomaRenal cell carcinoma patientsCase loadHigh-grade morbidityMultiple postoperative complicationsIntraoperative blood lossMetastatic renal cancerCell carcinoma patientsPrimary kidney tumorsRenal cell carcinomaLogistic regression analysisTherapy eraPerioperative complicationsPostoperative morbidityOncologic and Functional Outcomes of Radical and Partial Nephrectomy in pT3a Pathologically Upstaged Renal Cell Carcinoma: A Multi-institutional Analysis
Patel S, Uzzo R, Larcher A, Peyronnet B, Lane B, Pruthi D, Reddy M, Capitanio U, Joshi S, Noyes S, Eldefrawy A, Ghali F, Meagher M, Hamilton Z, Yim K, Nasseri R, Bradshaw A, Dey S, Kirmiz S, Wan F, Liss M, Bensalah K, Montorsi F, Derweesh I. Oncologic and Functional Outcomes of Radical and Partial Nephrectomy in pT3a Pathologically Upstaged Renal Cell Carcinoma: A Multi-institutional Analysis. Clinical Genitourinary Cancer 2020, 18: e723-e729. PMID: 32600941, DOI: 10.1016/j.clgc.2020.05.002.Peer-Reviewed Original ResearchConceptsKaplan-Meier analysisRenal cell carcinomaPT3a renal cell carcinomaRecurrence-free survivalRadical nephrectomyPartial nephrectomyOverall survivalMultivariable analysisCell carcinomaFunctional outcomeDe novo eGFRGlomular filtration rateClinical T stageMulticenter retrospective analysisRisk of recurrenceMulti-institutional analysisPT3a upstagingOncologic outcomesSecondary outcomesPrimary outcomeIndependent predictorsSurvival outcomesT stagePositive marginsPredictive factorsImpact of diabetes mellitus on functional and survival outcomes in renal cell carcinoma: An international multicenter study.
Dutt R, Meagher M, Patil D, Saito K, Patel D, Ghali F, Keiner C, Miller N, Bradshaw A, Wan F, Yasuda Y, Fujii Y, Master V, Derweesh I. Impact of diabetes mellitus on functional and survival outcomes in renal cell carcinoma: An international multicenter study. Journal Of Clinical Oncology 2020, 38: 666-666. DOI: 10.1200/jco.2020.38.6_suppl.666.Peer-Reviewed Original ResearchRenal cell carcinomaIndependent risk factorChronic kidney diseaseKaplan-Meier analysisRadical nephrectomyMultivariable analysisPartial nephrectomyRisk factorsPresence of DMFunctional declineDM statusOverall survivalKidney functionRCC patientsTumor sizeCell carcinomaRenal functional declineAfrican American raceInternational multicenter studyEffects of DMNDM patientsRN patientsCause mortalityWorse OSDiabetes mellitusAssociation of robotic partial nephrectomy for clinical T2a renal mass with improved trifecta outcome compared to open partial nephrectomy: A single surgeon comparative analysis.
Ghali F, Elbakry A, Hamilton Z, Nasseri R, Eldefrawy A, Ryan S, Yim K, Patel S, Bradshaw A, Meagher M, Reddy M, Lee H, Derweesh I. Association of robotic partial nephrectomy for clinical T2a renal mass with improved trifecta outcome compared to open partial nephrectomy: A single surgeon comparative analysis. Journal Of Clinical Oncology 2020, 38: 653-653. DOI: 10.1200/jco.2020.38.6_suppl.653.Peer-Reviewed Original ResearchRobotic partial nephrectomyOpen PNPartial nephrectomyMultivariable analysisRENAL scoreRenal massesLower blood lossFirst-line optionMedian RENAL scoreAchievement of trifectaEGFR recoveryHospital staySelect patientsBlood lossConsecutive patientsMajor complicationsPositive marginsTumor sizeFunctional outcomeTrifecta achievementTrifecta outcomesRetrospective analysisMAIN OUTCOMESurgical qualityTrifecta ratesImproving detection of higher-risk or locally advanced disease features in stage I and II renal cell carcinoma.
Miller N, Derweesh I, Liu M, Bradshaw A, Dutt R, Keiner C, Meagher M, Ghali F, Patel D, Wan F, Shiehmorteza M. Improving detection of higher-risk or locally advanced disease features in stage I and II renal cell carcinoma. Journal Of Clinical Oncology 2020, 38: 625-625. DOI: 10.1200/jco.2020.38.6_suppl.625.Peer-Reviewed Original ResearchRenal cell carcinomaT3a renal cell carcinomaPerinephric fat invasionSinus fat invasionTumor edgeFat invasionVenous invasionCell carcinomaTumor necrosisPerirenal fasciaSingle-institution retrospective analysisT2 renal cell carcinomaAdvanced disease featuresPreoperative clinical stageAccuracy of CTPreoperative CT imagesPathological upstagingPerinephric strandingT3a diseaseUpstaged patientsUpstaged tumorsClinical suspicionMultivariable analysisOncologic riskAggressive diseaseAssociation of De Ritis Ratio and Neutrophil Lymphocyte Ratio with renal functional decline and all-cause mortality in renal cell carcinoma.
Keiner C, Meagher M, Patil D, Saito K, Patel D, Ghali F, Dutt R, Miller N, Bradshaw A, Wan F, Yasuda Y, Fuji Y, Master V, Derweesh I. Association of De Ritis Ratio and Neutrophil Lymphocyte Ratio with renal functional decline and all-cause mortality in renal cell carcinoma. Journal Of Clinical Oncology 2020, 38: 741-741. DOI: 10.1200/jco.2020.38.6_suppl.741.Peer-Reviewed Original ResearchNeutrophil-lymphocyte ratioPlatelet-lymphocyte ratioDe Ritis ratioKaplan-Meier analysisIndependent risk factorMultivariable analysisRenal cell carcinomaRisk factorsCause mortalityCell carcinomaFunctional declinePre-operative neutrophil-lymphocyte ratioElevated neutrophil-lymphocyte ratioMulti-institutional retrospective analysisDe novo CKDRenal functional declineHigh-risk patientsGlomerular filtration rateDe novoWorse OSLymphocyte ratioMale sexTumor sizeBlack raceFiltration rateMulticenter comparison of outcomes for clinical and pathologic T3a renal cell carcinoma.
Bradshaw A, Ghali F, Miller N, Keiner C, Dutt R, Meagher M, Yim K, Patel D, Uzzo R, Lane B, Capitanio U, Derweesh I. Multicenter comparison of outcomes for clinical and pathologic T3a renal cell carcinoma. Journal Of Clinical Oncology 2020, 38: 758-758. DOI: 10.1200/jco.2020.38.6_suppl.758.Peer-Reviewed Original ResearchRecurrence-free survivalCancer-specific survivalKaplan-Meier analysisRenal cell carcinomaPT3a renal cell carcinomaOverall survivalMultivariable analysisSecondary outcomesPrimary outcomeCell carcinomaT3a renal cell carcinomaPathologic tumor sizePoor oncologic outcomesRegression multivariable analysisClear cell histologyLog-rank testPre-operative imagingPositive margin rateHigh recurrence rateAdvanced diseaseCell histologyOncologic outcomesVenous involvementMulticenter analysisOS rates
2019
Risk Factors for Upstaging, Recurrence, and Mortality in Clinical T1-2 Renal Cell Carcinoma Patients Upstaged to pT3a Disease: An International Analysis Utilizing the 8th Edition of the Tumor-Node-Metastasis Staging Criteria
Hamilton Z, Capitanio U, Pruthi D, Ghali F, Larcher A, Patel D, Eldefrawy A, Patel S, Cotta B, Bradshaw A, Meagher M, Miller N, Carenzi C, Wan F, Liss M, McGregor T, Montorsi F, Derweesh I. Risk Factors for Upstaging, Recurrence, and Mortality in Clinical T1-2 Renal Cell Carcinoma Patients Upstaged to pT3a Disease: An International Analysis Utilizing the 8th Edition of the Tumor-Node-Metastasis Staging Criteria. Urology 2019, 138: 60-68. PMID: 31836465, DOI: 10.1016/j.urology.2019.11.036.Peer-Reviewed Original ResearchConceptsRecurrence-free survivalRisk of recurrenceRenal cell carcinomaKaplan-Meier analysisHigher clinical stageClinical stageOverall survivalMultivariable analysisPT3a upstagingRisk factorsTumor-NodeT3a renal cell carcinomaRenal cell carcinoma patientsRisk of upstagingCell carcinoma patientsMulticenter retrospective analysisPerinephric fat invasionInitial clinical stageRenal vein invasionType of surgeryPT3a diseaseCarcinoma patientsPrimary outcomeFat invasionRenal veinRobotic partial nephrectomy for clinical T2a renal mass is associated with improved trifecta outcome compared to open partial nephrectomy: a single surgeon comparative analysis
Ghali F, Elbakry A, Hamilton Z, Yim K, Nasseri R, Patel S, Eldefrawy A, Ryan S, Bradshaw A, Meagher M, Bree K, Reddy M, Lee H, Derweesh I. Robotic partial nephrectomy for clinical T2a renal mass is associated with improved trifecta outcome compared to open partial nephrectomy: a single surgeon comparative analysis. World Journal Of Urology 2019, 38: 1113-1122. PMID: 31701211, DOI: 10.1007/s00345-019-02994-2.Peer-Reviewed Original ResearchConceptsPartial nephrectomyOpen PNRenal massesMultivariable analysisRENAL scoreResultsMean tumor sizeLower blood lossBurden of morbidityFirst-line optionT2 renal massesOpen partial nephrectomyRobotic partial nephrectomyMedian RENAL scoreAchievement of trifectaEGFR recoveryHospital staySelect patientsBlood lossConsecutive patientsMajor complicationsMethodsRetrospective analysisPositive marginsTumor sizeFunctional outcomeTrifecta achievement
2016
Does Travel Time to a Radiation Facility Impact Patient Decision‐Making Regarding Treatment for Prostate Cancer? A Study of the New Hampshire State Cancer Registry
Ghali F, Celaya M, Laviolette M, Ingimarsson J, Carlos H, Rees J, Hyams E. Does Travel Time to a Radiation Facility Impact Patient Decision‐Making Regarding Treatment for Prostate Cancer? A Study of the New Hampshire State Cancer Registry. The Journal Of Rural Health 2016, 34: s84-s90. PMID: 27862285, DOI: 10.1111/jrh.12224.Peer-Reviewed Original ResearchConceptsNew Hampshire State Cancer RegistrySeason of diagnosisState Cancer RegistryNearest radiation facilityCancer RegistryProstate cancerTreatment decisionsRisk categoriesExternal beam radiation therapyD'Amico risk categoryLocalized prostate cancerYears of treatmentMultivariable regression analysisBeam radiation therapyHigh-risk categoryWinter diagnosisMultivariable analysisRadiation therapyNew diagnosisSignificant interactionMarried statusRural residenceOlder agePatientsUrban residenceWhat factors are associated with unplanned return following transurethral resection of bladder tumor? An analysis of a large single institution’s experience
Ghali F, Moses R, Raffin E, Hyams E. What factors are associated with unplanned return following transurethral resection of bladder tumor? An analysis of a large single institution’s experience. Scandinavian Journal Of Urology 2016, 50: 370-373. PMID: 27438524, DOI: 10.1080/21681805.2016.1201856.Peer-Reviewed Original ResearchConceptsAspirin therapyPreoperative antibioticsGross hematuriaMultivariable analysisTransurethral resectionTumor sizeBladder tumorsOperating roomFemale genderLargest single-institution experienceSingle institution experienceDay of surgeryFoley catheter placementLength of staySingle academic institutionHospital dischargeRetrospective reviewUnplanned returnCatheter placementFoley catheterizationInstitution experienceMean ageFoley placementDistance of residenceCommon cause