2020
Hemodynamic impairments within individual watershed areas in asymptomatic carotid artery stenosis by multimodal MRI
Kaczmarz S, Göttler J, Petr J, Hansen M, Mouridsen K, Zimmer C, Hyder F, Preibisch C. Hemodynamic impairments within individual watershed areas in asymptomatic carotid artery stenosis by multimodal MRI. Cerebrovascular And Brain Metabolism Reviews 2020, 41: 380-396. PMID: 32237952, PMCID: PMC7812517, DOI: 10.1177/0271678x20912364.Peer-Reviewed Original ResearchConceptsInternal carotid artery stenosisRelative oxygen extraction fractionRelative cerebral blood volumeCerebral blood flowCapillary transit time heterogeneityOxygen extraction capacityCarotid artery stenosisHemodynamic impairmentCerebrovascular reactivityArtery stenosisUnilateral internal carotid artery stenosisAsymptomatic internal carotid artery stenosisAsymptomatic carotid artery stenosisAge-matched healthy controlsMultimodal MRICerebral blood volumeOxygen extraction fractionTransit time heterogeneityMicrovascular impairmentStroke riskOxygenation parametersWidespread dysfunctionHealthy controlsHemodynamic parametersIndividual patients
2016
Metabolic demands of neural-hemodynamic associated and disassociated areas in brain
Sanganahalli BG, Herman P, Rothman DL, Blumenfeld H, Hyder F. Metabolic demands of neural-hemodynamic associated and disassociated areas in brain. Cerebrovascular And Brain Metabolism Reviews 2016, 36: 1695-1707. PMID: 27562867, PMCID: PMC5076793, DOI: 10.1177/0271678x16664531.Peer-Reviewed Original ResearchConceptsVentral posterolateral thalamic nucleusFunctional magnetic resonance imagingMulti-unit activityLocal field potentialsMetabolic demandsPosterolateral thalamic nucleusBlood oxygenation level-dependent (BOLD) responseSensory-evoked responsesCortical local field potentialsThalamic local field potentialsMagnetic resonance imagingLevel-dependent responsesSimilar metabolic demandThalamic nucleiForelimb cortexBlood flowBlood volumeCBV responseResonance imagingLatency differenceHemodynamicsBOLD signalOxidative metabolismDifferent metabolic demandsField potentials
2012
S Phase Entry of Neural Progenitor Cells Correlates with Increased Blood Flow in the Young Subventricular Zone
Lacar B, Herman P, Hartman NW, Hyder F, Bordey A. S Phase Entry of Neural Progenitor Cells Correlates with Increased Blood Flow in the Young Subventricular Zone. PLOS ONE 2012, 7: e31960. PMID: 22359646, PMCID: PMC3281100, DOI: 10.1371/journal.pone.0031960.Peer-Reviewed Original ResearchConceptsSubventricular zoneBlood flowNeural progenitor cellsAcute brain slice preparationGrowth factor injectionsProgenitor cellsReceptor agonist UIncreased blood flowBrain slice preparationSVZ cell proliferationCell proliferationLaser Doppler flowmetryLocal blood flowLocal hemodynamic responsesBasic fibroblast growth factorPostnatal subventricular zoneFibroblast growth factorAgonist UFactor injectionsVentricular injectionNeurovascular couplingAcute increaseSlice preparationDoppler flowmetryHemodynamic response