Topiramate Rapidly Raises Brain GABA in Epilepsy Patients
Petroff O, Hyder F, Rothman D, Mattson R. Topiramate Rapidly Raises Brain GABA in Epilepsy Patients. Epilepsia 2001, 42: 543-548. PMID: 11440351, DOI: 10.1046/j.1528-1157.2001.18800.x.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnticonvulsantsBrain ChemistryCarnosineDose-Response Relationship, DrugDrug Administration ScheduleEpilepsy, Complex PartialFructoseGamma-Aminobutyric AcidHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyOccipital LobePyrrolidinonesStimulation, ChemicalTopiramateConceptsBrain GABAOral doseLong-term pharmacodynamic effectsFirst oral doseComplex partial seizuresTPM dosesTPM therapyFirst doseFurther seizuresPartial seizuresPharmacodynamic effectsEpilepsy patientsOccipital cortexPatientsGABAPartial protectionDoseFirst dayAcid metabolismDose responseHomocarnosineSeizuresVivo measurementsSurface coilTopiramate