2022
A novel exosome-based therapy for post-MI arrhythmias
Cacheux M, Akar FG. A novel exosome-based therapy for post-MI arrhythmias. European Heart Journal 2022, 43: 2157-2159. PMID: 35325140, DOI: 10.1093/eurheartj/ehac155.Peer-Reviewed Original ResearchAnimalsArrhythmias, CardiacCardiomyopathiesExosomesHumansMyocardial InfarctionMyocardial IschemiaSwine
2018
Primary Effect of SERCA2a Gene Transfer on Conduction Reserve in Chronic Myocardial Infarction
Motloch LJ, Cacheux M, Ishikawa K, Xie C, Hu J, Aguero J, Fish KM, Hajjar RJ, Akar FG. Primary Effect of SERCA2a Gene Transfer on Conduction Reserve in Chronic Myocardial Infarction. Journal Of The American Heart Association 2018, 7: e009598. PMID: 30371209, PMCID: PMC6222964, DOI: 10.1161/jaha.118.009598.Peer-Reviewed Original ResearchConceptsMyocardial infarctionVentricular tachycardiaSERCA 2aVirus serotype 1Heart failureOptical action potential mappingPacing-induced ventricular tachycardiaIschemic heart failureNonischemic heart failureSerotype 1SERCA2a gene transferChronic myocardial infarctionExpression of Cx43Contractile reserveVelocity reserveHemodynamic functionDobutamine stressAnterior MIElectrophysiological effectsQRS durationConduction reserveConduction velocityNaive pigsAnimal modelsElectrophysiological substrateAcute Left Ventricular Unloading Reduces Atrial Stretch and Inhibits Atrial Arrhythmias
Ishikawa K, Watanabe S, Lee P, Akar FG, Lee A, Bikou O, Fish K, Kho C, Hajjar RJ. Acute Left Ventricular Unloading Reduces Atrial Stretch and Inhibits Atrial Arrhythmias. Journal Of The American College Of Cardiology 2018, 72: 738-750. PMID: 30092950, PMCID: PMC6160394, DOI: 10.1016/j.jacc.2018.05.059.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArrhythmias, CardiacAtrial FibrillationFemaleMaleMyocardial InfarctionStroke VolumeSwineVentricular Function, LeftConceptsLV end-diastolic pressureEnd-diastolic pressureLV unloadingMyocardial infarctionSubacute myocardial infarctionPressure-volume loopsLA pressureAortic regurgitationRyanodine receptor phosphorylationLA tissuesLV loadingReduced LV ejection fractionAtrial arrhythmia inducibilityLV assist deviceLV ejection fractionMean LA pressureLeft ventricular performancePressure-volume catheterMaximum LA volumeLV loading conditionsReceptor phosphorylationMedian 55NOX2 levelsArrhythmia inducibilityAtrial stretch
2014
Cardiac I-1c Overexpression With Reengineered AAV Improves Cardiac Function in Swine Ischemic Heart Failure
Ishikawa K, Fish KM, Tilemann L, Rapti K, Aguero J, Santos-Gallego CG, Lee A, Karakikes I, Xie C, Akar FG, Shimada YJ, Gwathmey JK, Asokan A, McPhee S, Samulski J, Samulski RJ, Sigg DC, Weber T, Kranias EG, Hajjar RJ. Cardiac I-1c Overexpression With Reengineered AAV Improves Cardiac Function in Swine Ischemic Heart Failure. Molecular Therapy 2014, 22: 2038-2045. PMID: 25023328, PMCID: PMC4429688, DOI: 10.1038/mt.2014.127.Peer-Reviewed Original ResearchConceptsIschemic heart failureHigh-dose groupHeart failureCardiac functionLarge anterior myocardial infarctionLeft ventricular ejection fractionPreload recruitable stroke workChronic heart failureAdvanced heart failureLow-dose groupVentricular ejection fractionAnterior myocardial infarctionActive inhibitor-1Ejection fractionIntracoronary injectionSaline groupContractility indexMyocardial infarctionPressure-volume analysisStroke volumeStroke workCardiac performanceHemodynamic parametersCardiovascular systemCardiac gene therapy