2019
Cardiomyocyte-Specific STIM1 (Stromal Interaction Molecule 1) Depletion in the Adult Heart Promotes the Development of Arrhythmogenic Discordant Alternans
Cacheux M, Strauss B, Raad N, Ilkan Z, Hu J, Benard L, Feske S, Hulot JS, Akar FG. Cardiomyocyte-Specific STIM1 (Stromal Interaction Molecule 1) Depletion in the Adult Heart Promotes the Development of Arrhythmogenic Discordant Alternans. Circulation Arrhythmia And Electrophysiology 2019, 12: e007382-e007382. PMID: 31726860, PMCID: PMC6867678, DOI: 10.1161/circep.119.007382.Peer-Reviewed Original ResearchConceptsVT/VFAPD alternansStore-operated CaVentricular tachycardia/ventricular fibrillationOptical action potential mappingAdult heartVT/Adult murine modelDiscordant alternansConduction velocity slowingSarcoplasmic reticulum CaArrhythmogenic discordant alternansInitial beatsEarly mortalityFlox/Poor survivalVentricular fibrillationDiscordant APD alternansMurine modelCardiac hypertrophyConduction velocityLittermate controlsAdult miceRapid pacingElectrophysiological substrate
2014
A formidable “TASK”: Tipping the balance in favor of rhythm control for the management of atrial fibrillation
Akar FG. A formidable “TASK”: Tipping the balance in favor of rhythm control for the management of atrial fibrillation. Heart Rhythm 2014, 11: 1806-1807. PMID: 25041966, DOI: 10.1016/j.hrthm.2014.07.018.Commentaries, Editorials and LettersMeSH KeywordsAnimalsAtrial FibrillationFemaleGene Expression RegulationHeart FailureNerve Tissue ProteinsPotassium Channels, Tandem Pore DomainRNA, Messenger
2005
Molecular mechanisms underlying K+ current downregulation in canine tachycardia-induced heart failure
Akar FG, Wu RC, Juang GJ, Tian Y, Burysek M, DiSilvestre D, Xiong W, Armoundas AA, Tomaselli GF. Molecular mechanisms underlying K+ current downregulation in canine tachycardia-induced heart failure. AJP Heart And Circulatory Physiology 2005, 288: h2887-h2896. PMID: 15681701, DOI: 10.1152/ajpheart.00320.2004.Peer-Reviewed Original Research