2021
NAD Repletion Therapy
Akar FG, Young LH. NAD Repletion Therapy. Circulation Research 2021, 128: 1642-1645. PMID: 34043421, PMCID: PMC8513806, DOI: 10.1161/circresaha.121.319308.Commentaries, Editorials and Letters
2018
Acute Left Ventricular Unloading Reduces Atrial Stretch and Inhibits Atrial Arrhythmias
Ishikawa K, Watanabe S, Lee P, Akar FG, Lee A, Bikou O, Fish K, Kho C, Hajjar RJ. Acute Left Ventricular Unloading Reduces Atrial Stretch and Inhibits Atrial Arrhythmias. Journal Of The American College Of Cardiology 2018, 72: 738-750. PMID: 30092950, PMCID: PMC6160394, DOI: 10.1016/j.jacc.2018.05.059.Peer-Reviewed Original ResearchConceptsLV end-diastolic pressureEnd-diastolic pressureLV unloadingMyocardial infarctionSubacute myocardial infarctionPressure-volume loopsLA pressureAortic regurgitationRyanodine receptor phosphorylationLA tissuesLV loadingReduced LV ejection fractionAtrial arrhythmia inducibilityLV assist deviceLV ejection fractionMean LA pressureLeft ventricular performancePressure-volume catheterMaximum LA volumeLV loading conditionsReceptor phosphorylationMedian 55NOX2 levelsArrhythmia inducibilityAtrial stretch
2014
Cardiac I-1c Overexpression With Reengineered AAV Improves Cardiac Function in Swine Ischemic Heart Failure
Ishikawa K, Fish KM, Tilemann L, Rapti K, Aguero J, Santos-Gallego CG, Lee A, Karakikes I, Xie C, Akar FG, Shimada YJ, Gwathmey JK, Asokan A, McPhee S, Samulski J, Samulski RJ, Sigg DC, Weber T, Kranias EG, Hajjar RJ. Cardiac I-1c Overexpression With Reengineered AAV Improves Cardiac Function in Swine Ischemic Heart Failure. Molecular Therapy 2014, 22: 2038-2045. PMID: 25023328, PMCID: PMC4429688, DOI: 10.1038/mt.2014.127.Peer-Reviewed Original ResearchConceptsIschemic heart failureHigh-dose groupHeart failureCardiac functionLarge anterior myocardial infarctionLeft ventricular ejection fractionPreload recruitable stroke workChronic heart failureAdvanced heart failureLow-dose groupVentricular ejection fractionAnterior myocardial infarctionActive inhibitor-1Ejection fractionIntracoronary injectionSaline groupContractility indexMyocardial infarctionPressure-volume analysisStroke volumeStroke workCardiac performanceHemodynamic parametersCardiovascular systemCardiac gene therapy