The Classically Cardioprotective Agent Diazoxide Elicits Arrhythmias in Type 2 Diabetes Mellitus
Xie C, Hu J, Motloch LJ, Karam BS, Akar FG. The Classically Cardioprotective Agent Diazoxide Elicits Arrhythmias in Type 2 Diabetes Mellitus. Journal Of The American College Of Cardiology 2015, 66: 1144-1156. PMID: 26337994, PMCID: PMC4560843, DOI: 10.1016/j.jacc.2015.06.1329.Peer-Reviewed Original ResearchConceptsAction potential durationVentricular tachyarrhythmiasT2DM heartsIschemia-induced ventricular tachyarrhythmiasOptical action potential mappingType 2 diabetes mellitusAdenosine triphosphate-sensitive potassium channelsMitochondrial adenosine triphosphate-sensitive potassium channelsTriphosphate-sensitive potassium channelsLow-dose diazoxideFree fatty acid levelsIncidence of arrhythmiasNormal Sprague-Dawley ratsSprague-Dawley ratsOnset of arrhythmiasMessenger ribonucleic acid expressionFatty acid levelsRibonucleic acid expressionAPD adaptationElicit arrhythmiasUntreated T2DMIschemic eventsDiabetes mellitusDiabetic patientsIschemic challenge