2024
The human claustrum tracks slow waves during sleep
Lamsam L, Gu B, Liang M, Sun G, Khan K, Sheth K, Hirsch L, Pittenger C, Kaye A, Krystal J, Damisah E. The human claustrum tracks slow waves during sleep. Nature Communications 2024, 15: 8964. PMID: 39419999, PMCID: PMC11487173, DOI: 10.1038/s41467-024-53477-x.Peer-Reviewed Original ResearchSeizing Control: Primary Visual Cortex Epilepsy Treated With Resection and Responsive Neurostimulation: 2-Dimensional Operative Video
Merenzon M, Lamsam L, McGrath H, Sivaraju A, Hirsch L, Cukiert A, Zibly Z, Spencer D, Damisah E. Seizing Control: Primary Visual Cortex Epilepsy Treated With Resection and Responsive Neurostimulation: 2-Dimensional Operative Video. Operative Neurosurgery 2024, 27: 262-263. PMID: 39007609, DOI: 10.1227/ons.0000000000001109.Peer-Reviewed Original Research
2023
Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy
Khoshkhoo S, Wang Y, Chahine Y, Erson-Omay E, Robert S, Kiziltug E, Damisah E, Nelson-Williams C, Zhu G, Kong W, Huang A, Stronge E, Phillips H, Chhouk B, Bizzotto S, Chen M, Adikari T, Ye Z, Witkowski T, Lai D, Lee N, Lokan J, Scheffer I, Berkovic S, Haider S, Hildebrand M, Yang E, Gunel M, Lifton R, Richardson R, Blümcke I, Alexandrescu S, Huttner A, Heinzen E, Zhu J, Poduri A, DeLanerolle N, Spencer D, Lee E, Walsh C, Kahle K. Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy. JAMA Neurology 2023, 80: 578-587. PMID: 37126322, PMCID: PMC10152377, DOI: 10.1001/jamaneurol.2023.0473.Peer-Reviewed Original ResearchConceptsDrug-resistant mesial temporal lobe epilepsyMesial temporal lobe epilepsyPathogenic somatic variantsTemporal lobe epilepsyMedian ageLobe epilepsyTemporal neocortexHippocampal tissueLevel 4 epilepsy centerAvailable frozen tissueSomatic variantsControl brain tissueMedial temporal lobectomyNew therapeutic targetsMolecular assaysGene panel sequencingRas/Raf/MAPK signalingAntiseizure medicationsMost patientsCommon indicationGermline genetic variantsEpilepsy centersTemporal lobectomyEpilepsy surgerySex-matched neurotypical controlsTransfrontal Approach to the Amygdala for Ablation With Laser Interstitial Thermal Therapy: An Epilepsy Case Report
Lamsam L, Brigido M, Sivaraju A, Hirsch L, Spencer D, Chiang V, Damisah E. Transfrontal Approach to the Amygdala for Ablation With Laser Interstitial Thermal Therapy: An Epilepsy Case Report. Operative Neurosurgery 2023, 24: e381-e384. PMID: 36715982, PMCID: PMC10158899, DOI: 10.1227/ons.0000000000000576.Peer-Reviewed Original ResearchConceptsStereotactic laser amygdalohippocampotomyLaser interstitial thermal therapyEntorhinal cortexInterstitial thermal therapyComplete ablationMesial temporal lobe epilepsyTemporal arteriovenous malformationTemporal lobe epilepsyLeft temporal arteriovenous malformationMiddle frontal gyrusPrior craniotomyOpen resectionLobe epilepsyCase reportMedial amygdalaArteriovenous malformationsAnterior entorhinal cortexTransfrontal approachAmygdalaInvasive surgeryFrontal gyrusThermal therapyIntracranial electroencephalographyResection
2022
Temporal Dynamics of Competition between Statistical Learning and Episodic Memory in Intracranial Recordings of Human Visual Cortex
Sherman B, Graves K, Huberdeau D, Quraishi I, Damisah E, Turk-Browne N. Temporal Dynamics of Competition between Statistical Learning and Episodic Memory in Intracranial Recordings of Human Visual Cortex. Journal Of Neuroscience 2022, 42: 9053-9068. PMID: 36344264, PMCID: PMC9732826, DOI: 10.1523/jneurosci.0708-22.2022.Peer-Reviewed Original ResearchConceptsVisual cortexStatistical learningIntracranial recordingsStatistical learning taskBehavioural Memory TestMultivariate pattern analysisLong-term memoryExpense of memoryEncoding of informationHuman visual cortexStorage of experienceNew experiencesEpisodic memoryMemory researchMemory testFrequency taggingRapid streamGuide behaviorLearning taskNew predictive relationshipNeural predictionHuman intracranial EEGWeak expectationsNeural activityMemory formation
2021
Gerstmann Syndrome Deconstructed by Cortical Stimulation
Vaddiparti A, McGrath H, Benjamin C, Sivaraju A, Spencer DD, Hirsch LJ, Damisah E, Quraishi IH. Gerstmann Syndrome Deconstructed by Cortical Stimulation. Neurology 2021, 97: 420-422. PMID: 34187861, PMCID: PMC9246017, DOI: 10.1212/wnl.0000000000012441.Peer-Reviewed Original ResearchIncreased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain
Ong C, Damisah EC, Gruenbaum SE, Dhaher R, Deng Y, Sandhu MRS, Zaveri HP, Spencer DD, Eid T. Increased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain. Epilepsia 2021, 62: e88-e97. PMID: 33949690, PMCID: PMC11259155, DOI: 10.1111/epi.16920.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmino Acids, Branched-ChainBrain ChemistryChildChild, PreschoolChromatography, High Pressure LiquidDrug Resistant EpilepsyElectrocorticographyElectroencephalographyEpilepsies, PartialExtracellular SpaceFemaleGlutamic AcidHumansIsoleucineMaleMicrodialysisMiddle AgedSeizuresTandem Mass SpectrometryYoung AdultConceptsSpontaneous seizuresDrug-resistant focal epilepsyExtracellular brain glutamateHuman epileptic brainBranched-chain amino acidsBranched chain amino acids valineRefractory epilepsyBrain microdialysisGlutamatergic neurotransmissionFocal epilepsySeizure onsetBrain glutamateEpileptic brainHuman patientsSeizuresBrain regionsDialysis samplesMammalian targetEpilepsyLiquid chromatography-tandem mass spectrometryBaselineBCAAIntracranial electroencephalographyChromatography-tandem mass spectrometryPatientsDepth Electrode Guided Anterior Insulectomy: 2-Dimensional Operative Video
Mandel M, Lamsam L, Farooque P, Spencer D, Damisah E. Depth Electrode Guided Anterior Insulectomy: 2-Dimensional Operative Video. Operative Neurosurgery 2021, 21: e121-e121. PMID: 33885821, PMCID: PMC8493659, DOI: 10.1093/ons/opab112.Peer-Reviewed Original ResearchConceptsDepth electrodesOperative VideoEntire right hemisphereRight-handed womanIntracranial EEG studiesIctal vocalizationInsular surgeryNeurological deficitsPreoperative evaluationRefractory epilepsyEpileptiform activityEpileptogenic areaEpileptic zoneInsular resectionFrontal operculumNoninvasive resultsPatientsAnterior borderOptimal outcomesRight hemisphereInsulectomyEEG studiesSurgeryIndescribable feelingNeuronavigation
2020
Imaging and optogenetic modulation of vascular mural cells in the live brain
Tong L, Hill RA, Damisah EC, Murray KN, Yuan P, Bordey A, Grutzendler J. Imaging and optogenetic modulation of vascular mural cells in the live brain. Nature Protocols 2020, 16: 472-496. PMID: 33299155, DOI: 10.1038/s41596-020-00425-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRegional cerebral blood flowMural cellsBlood-brain barrier maintenanceCerebral ischemia mouse modelAge-related neurodegenerative diseasesCerebral blood flowSmooth muscle cell physiologyBrain blood vesselsIschemia mouse modelVascular mural cellsBrain microvesselsHigh-resolution intravital imagingVascular disordersMouse modelBlood flowMuscle cell physiologyTransgenic miceCalcium transientsAlzheimer's diseaseCalcium imagingCell subtypesBarrier maintenanceNeurodegenerative diseasesTwo-photon optogeneticsBlood vessels
2018
Cerebrospinal fluid untargeted metabolomic profiling of aneurysmal subarachnoid hemorrhage: an exploratory study
Lu AY, Damisah EC, Winkler EA, Grant RA, Eid T, Bulsara KR. Cerebrospinal fluid untargeted metabolomic profiling of aneurysmal subarachnoid hemorrhage: an exploratory study. British Journal Of Neurosurgery 2018, 32: 637-641. PMID: 30585503, DOI: 10.1080/02688697.2018.1519107.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageGlasgow Outcome ScaleLong-term outcomesASAH patientsSubarachnoid hemorrhageTime pointsCSF samplesHigh-grade aSAH patientsFisher grade 4Cerebrospinal fluid samplesFalse discovery rate correctionSpecific metabolite changesLow disabilitySurgical therapyClinical outcomesCSF metabolitesUntargeted metabolomic profilingOutcome ScaleTissue hypoxiaGrade 3Year postPatientsClinical settingMetabolite predictorsMetabolic changes
2017
Targeted two-photon chemical apoptotic ablation of defined cell types in vivo
Hill RA, Damisah EC, Chen F, Kwan AC, Grutzendler J. Targeted two-photon chemical apoptotic ablation of defined cell types in vivo. Nature Communications 2017, 8: 15837. PMID: 28621306, PMCID: PMC5501159, DOI: 10.1038/ncomms15837.Peer-Reviewed Original ResearchConceptsCell deathNucleic acid-binding dyeVivo functional consequencesCell type differencesPattern of apoptosisDose-dependent apoptosisComplex organismsMitochondrial fissionFluorescent proteinUnderstanding of mechanismsCell typesCell clearanceFunctional consequencesIndividual cellsDiverse organsDistinct populationsApoptosisMouse brainZebrafishMajor bottleneckNeural plasticityOrganismsSpeciesProteinApoptoticA fluoro-Nissl dye identifies pericytes as distinct vascular mural cells during in vivo brain imaging
Damisah EC, Hill RA, Tong L, Murray KN, Grutzendler J. A fluoro-Nissl dye identifies pericytes as distinct vascular mural cells during in vivo brain imaging. Nature Neuroscience 2017, 20: 1023-1032. PMID: 28504673, PMCID: PMC5550770, DOI: 10.1038/nn.4564.Peer-Reviewed Original Research