2023
Responsive neurostimulation as a treatment for super-refractory focal status epilepticus: a systematic review and case series.
Ernst L, Raslan A, Wabulya A, Shin H, Cash S, Yang J, Sagi V, King-Stephens D, Damisah E, Ramos A, Hussain B, Toprani S, Brandman D, Shahlaie K, Kanth K, Arain A, Peters A, Rolston J, Berns M, Patel S, Uysal U. Responsive neurostimulation as a treatment for super-refractory focal status epilepticus: a systematic review and case series. Journal Of Neurosurgery 2023, 140: 201-209. PMID: 37329518, DOI: 10.3171/2023.4.jns23367.Peer-Reviewed Original ResearchMeSH KeywordsDrug Resistant EpilepsyHumansNeoplasm Recurrence, LocalRetrospective StudiesStatus EpilepticusTreatment OutcomeConceptsSuper-refractory status epilepticusStatus epilepticusCase seriesTreatment optionsCase reportCollection formFocal status epilepticusRetrospective chart reviewSignificant adverse eventsEffective treatment optionResponsive neurostimulation systemUnique clinical scenarioData collection formOptimal stimulation settingsFocal SEAdverse eventsChart reviewLead placementEligibility criteriaResponsive neurostimulationTenth caseTotal casesIRB approvalStimulation settingsClinical scenariosContribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy
Khoshkhoo S, Wang Y, Chahine Y, Erson-Omay E, Robert S, Kiziltug E, Damisah E, Nelson-Williams C, Zhu G, Kong W, Huang A, Stronge E, Phillips H, Chhouk B, Bizzotto S, Chen M, Adikari T, Ye Z, Witkowski T, Lai D, Lee N, Lokan J, Scheffer I, Berkovic S, Haider S, Hildebrand M, Yang E, Gunel M, Lifton R, Richardson R, Blümcke I, Alexandrescu S, Huttner A, Heinzen E, Zhu J, Poduri A, DeLanerolle N, Spencer D, Lee E, Walsh C, Kahle K. Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy. JAMA Neurology 2023, 80: 578-587. PMID: 37126322, PMCID: PMC10152377, DOI: 10.1001/jamaneurol.2023.0473.Peer-Reviewed Original ResearchMeSH KeywordsAdultDrug Resistant EpilepsyEpilepsyEpilepsy, Temporal LobeFemaleHippocampusHumansMaleMiddle AgedMitogen-Activated Protein KinasesNeocortexRetrospective StudiesConceptsDrug-resistant mesial temporal lobe epilepsyMesial temporal lobe epilepsyPathogenic somatic variantsTemporal lobe epilepsyMedian ageLobe epilepsyTemporal neocortexHippocampal tissueLevel 4 epilepsy centerAvailable frozen tissueSomatic variantsControl brain tissueMedial temporal lobectomyNew therapeutic targetsMolecular assaysGene panel sequencingRas/Raf/MAPK signalingAntiseizure medicationsMost patientsCommon indicationGermline genetic variantsEpilepsy centersTemporal lobectomyEpilepsy surgerySex-matched neurotypical controlsRecent advances in epilepsy surgery
Medina-Pizarro M, Spencer D, Damisah E. Recent advances in epilepsy surgery. Current Opinion In Neurology 2023, 36: 95-101. PMID: 36762633, DOI: 10.1097/wco.0000000000001134.Peer-Reviewed Original ResearchMeSH KeywordsDrug Resistant EpilepsyElectroencephalographyEpilepsyHumansPrognosisSeizuresTreatment OutcomeConceptsEpilepsy surgeryEpilepsy centersComprehensive Epilepsy CenterDrug-resistant epilepsySurgical outcome dataReasonable surgical alternativeAdequate trialAntiseizure medicationsPreoperative evaluationSurgical candidacySurgical outcomesSeizure networkSurgical alternativeEpileptogenic networksSurgical techniqueTreatment strategiesEpileptogenic regionInvasive techniquesOutcome dataSurgeryDepth electrodesHigh-resolution structural imagingSubtle abnormalitiesDiagnostic toolStructural imaging
2022
Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy
Sivaraju A, Hirsch L, Gaspard N, Farooque P, Gerrard J, Xu Y, Deng Y, Damisah E, Blumenfeld H, Spencer DD. Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy. Neurology 2022, 99: e1-e10. PMID: 35508395, PMCID: PMC9259091, DOI: 10.1212/wnl.0000000000200569.Peer-Reviewed Original ResearchMeSH KeywordsDrug Resistant EpilepsyElectrocorticographyElectroencephalographyHumansMagnetic Resonance ImagingRetrospective StudiesTreatment OutcomeConceptsTemporal lobe onsetSeizure freedomResective surgeryIndependent predictorsLesional MRIUnfavorable predictorRefractory epilepsyContinued medical treatmentEpilepsy surgical evaluationFactors Predicting OutcomeIntracranial EEG evaluationNonlesional extratemporal epilepsySubsequent seizure freedomSustained seizure freedomThorough presurgical evaluationSeizure-free outcomeClass II evidenceMedically Refractory EpilepsyRetrospective chart reviewKaplan-Meier curvesSelect clinical scenariosMultivariable regression analysisBest multivariable modelIntracranial EEGSeizure onset localization
2021
Management of patients with medically intractable epilepsy and anterior temporal lobe encephaloceles.
Sandhu MRS, Mandel M, McGrath H, Lamsam L, Farooque P, Bronen RA, Spencer DD, Damisah EC. Management of patients with medically intractable epilepsy and anterior temporal lobe encephaloceles. Journal Of Neurosurgery 2021, 136: 709-716. PMID: 34507290, DOI: 10.3171/2021.3.jns21133.Peer-Reviewed Original ResearchMeSH KeywordsDrug Resistant EpilepsyElectroencephalographyEncephaloceleEpilepsy, Temporal LobeHumansMagnetic Resonance ImagingSeizuresTemporal LobeTreatment OutcomeConceptsTemporal lobe encephaloceleIdiopathic intracranial hypertensionRefractory epilepsyEEG findingsSigns of IIHIntractable temporal lobe epilepsyResective epilepsy surgeryManagement of patientsTemporal lobe epilepsyScalp EEG findingsSignificant neuropsychological deficitsRadiological findingsIntracranial hypertensionPreoperative evaluationEpileptogenic lesionsSurgical managementEpilepsy surgeryLobe epilepsySurgical outcomesIntractable epilepsySingle institutionSurgical dataEpileptogenic focusMedical recordsWorse outcomesImaging of Neuromodulation and Surgical Interventions for Epilepsy
Adin ME, Spencer DD, Damisah E, Herlopian A, Gerrard JL, Bronen RA. Imaging of Neuromodulation and Surgical Interventions for Epilepsy. American Journal Of Neuroradiology 2021, 42: 1742-1750. PMID: 34353787, PMCID: PMC8562735, DOI: 10.3174/ajnr.a7222.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsDeep Brain StimulationDiagnostic ImagingDrug Resistant EpilepsyEpilepsyHumansVagus Nerve StimulationConceptsSurgical interventionPostoperative imaging findingsMultiple subpial transectionsComprehensive Epilepsy CenterGroup of patientsVagus nerve stimulationDeep brain stimulationInvasive treatment decisionsNew surgical interventionLobar resectionSubpial transectionMedical therapyEpilepsy centersImaging findingsNerve stimulationTreatment algorithmTherapeutic optionsTreatment modalitiesEpilepsy interventionsPotential complicationsEpilepsy casesTreatment decisionsBrain stimulationResponsive neurostimulationNeuromodulation techniquesGerstmann Syndrome Deconstructed by Cortical Stimulation
Vaddiparti A, McGrath H, Benjamin C, Sivaraju A, Spencer DD, Hirsch LJ, Damisah E, Quraishi IH. Gerstmann Syndrome Deconstructed by Cortical Stimulation. Neurology 2021, 97: 420-422. PMID: 34187861, PMCID: PMC9246017, DOI: 10.1212/wnl.0000000000012441.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain MappingDrug Resistant EpilepsyElectric StimulationFemaleGerstmann SyndromeHumansIncreased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain
Ong C, Damisah EC, Gruenbaum SE, Dhaher R, Deng Y, Sandhu MRS, Zaveri HP, Spencer DD, Eid T. Increased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain. Epilepsia 2021, 62: e88-e97. PMID: 33949690, PMCID: PMC11259155, DOI: 10.1111/epi.16920.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmino Acids, Branched-ChainBrain ChemistryChildChild, PreschoolChromatography, High Pressure LiquidDrug Resistant EpilepsyElectrocorticographyElectroencephalographyEpilepsies, PartialExtracellular SpaceFemaleGlutamic AcidHumansIsoleucineMaleMicrodialysisMiddle AgedSeizuresTandem Mass SpectrometryYoung AdultConceptsSpontaneous seizuresDrug-resistant focal epilepsyExtracellular brain glutamateHuman epileptic brainBranched-chain amino acidsBranched chain amino acids valineRefractory epilepsyBrain microdialysisGlutamatergic neurotransmissionFocal epilepsySeizure onsetBrain glutamateEpileptic brainHuman patientsSeizuresBrain regionsDialysis samplesMammalian targetEpilepsyLiquid chromatography-tandem mass spectrometryBaselineBCAAIntracranial electroencephalographyChromatography-tandem mass spectrometryPatientsDepth Electrode Guided Anterior Insulectomy: 2-Dimensional Operative Video
Mandel M, Lamsam L, Farooque P, Spencer D, Damisah E. Depth Electrode Guided Anterior Insulectomy: 2-Dimensional Operative Video. Operative Neurosurgery 2021, 21: e121-e121. PMID: 33885821, PMCID: PMC8493659, DOI: 10.1093/ons/opab112.Peer-Reviewed Original ResearchMeSH KeywordsCerebral CortexDrug Resistant EpilepsyElectrodes, ImplantedElectroencephalographyEpilepsyFemaleHumansConceptsDepth electrodesOperative VideoEntire right hemisphereRight-handed womanIntracranial EEG studiesIctal vocalizationInsular surgeryNeurological deficitsPreoperative evaluationRefractory epilepsyEpileptiform activityEpileptogenic areaEpileptic zoneInsular resectionFrontal operculumNoninvasive resultsPatientsAnterior borderOptimal outcomesRight hemisphereInsulectomyEEG studiesSurgeryIndescribable feelingNeuronavigation