2023
Responsive neurostimulation as a treatment for super-refractory focal status epilepticus: a systematic review and case series.
Ernst L, Raslan A, Wabulya A, Shin H, Cash S, Yang J, Sagi V, King-Stephens D, Damisah E, Ramos A, Hussain B, Toprani S, Brandman D, Shahlaie K, Kanth K, Arain A, Peters A, Rolston J, Berns M, Patel S, Uysal U. Responsive neurostimulation as a treatment for super-refractory focal status epilepticus: a systematic review and case series. Journal Of Neurosurgery 2023, 140: 201-209. PMID: 37329518, DOI: 10.3171/2023.4.jns23367.Peer-Reviewed Original ResearchMeSH KeywordsDrug Resistant EpilepsyHumansNeoplasm Recurrence, LocalRetrospective StudiesStatus EpilepticusTreatment OutcomeConceptsSuper-refractory status epilepticusStatus epilepticusCase seriesTreatment optionsCase reportCollection formFocal status epilepticusRetrospective chart reviewSignificant adverse eventsEffective treatment optionResponsive neurostimulation systemUnique clinical scenarioData collection formOptimal stimulation settingsFocal SEAdverse eventsChart reviewLead placementEligibility criteriaResponsive neurostimulationTenth caseTotal casesIRB approvalStimulation settingsClinical scenariosContribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy
Khoshkhoo S, Wang Y, Chahine Y, Erson-Omay E, Robert S, Kiziltug E, Damisah E, Nelson-Williams C, Zhu G, Kong W, Huang A, Stronge E, Phillips H, Chhouk B, Bizzotto S, Chen M, Adikari T, Ye Z, Witkowski T, Lai D, Lee N, Lokan J, Scheffer I, Berkovic S, Haider S, Hildebrand M, Yang E, Gunel M, Lifton R, Richardson R, Blümcke I, Alexandrescu S, Huttner A, Heinzen E, Zhu J, Poduri A, DeLanerolle N, Spencer D, Lee E, Walsh C, Kahle K. Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy. JAMA Neurology 2023, 80: 578-587. PMID: 37126322, PMCID: PMC10152377, DOI: 10.1001/jamaneurol.2023.0473.Peer-Reviewed Original ResearchConceptsDrug-resistant mesial temporal lobe epilepsyMesial temporal lobe epilepsyPathogenic somatic variantsTemporal lobe epilepsyMedian ageLobe epilepsyTemporal neocortexHippocampal tissueLevel 4 epilepsy centerAvailable frozen tissueSomatic variantsControl brain tissueMedial temporal lobectomyNew therapeutic targetsMolecular assaysGene panel sequencingRas/Raf/MAPK signalingAntiseizure medicationsMost patientsCommon indicationGermline genetic variantsEpilepsy centersTemporal lobectomyEpilepsy surgerySex-matched neurotypical controls
2022
Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy
Sivaraju A, Hirsch L, Gaspard N, Farooque P, Gerrard J, Xu Y, Deng Y, Damisah E, Blumenfeld H, Spencer DD. Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy. Neurology 2022, 99: e1-e10. PMID: 35508395, PMCID: PMC9259091, DOI: 10.1212/wnl.0000000000200569.Peer-Reviewed Original ResearchMeSH KeywordsDrug Resistant EpilepsyElectrocorticographyElectroencephalographyHumansMagnetic Resonance ImagingRetrospective StudiesTreatment OutcomeConceptsTemporal lobe onsetSeizure freedomResective surgeryIndependent predictorsLesional MRIUnfavorable predictorRefractory epilepsyContinued medical treatmentEpilepsy surgical evaluationFactors Predicting OutcomeIntracranial EEG evaluationNonlesional extratemporal epilepsySubsequent seizure freedomSustained seizure freedomThorough presurgical evaluationSeizure-free outcomeClass II evidenceMedically Refractory EpilepsyRetrospective chart reviewKaplan-Meier curvesSelect clinical scenariosMultivariable regression analysisBest multivariable modelIntracranial EEGSeizure onset localizationOptimizing the surgical management of MRI‐negative epilepsy in the neuromodulation era
McGrath H, Mandel M, Sandhu MRS, Lamsam L, Adenu‐Mensah N, Farooque P, Spencer DD, Damisah EC. Optimizing the surgical management of MRI‐negative epilepsy in the neuromodulation era. Epilepsia Open 2022, 7: 151-159. PMID: 35038792, PMCID: PMC8886105, DOI: 10.1002/epi4.12578.Peer-Reviewed Original ResearchMeSH KeywordsElectrocorticographyEpilepsies, PartialEpilepsyHumansMagnetic Resonance ImagingRetrospective StudiesConceptsDeep brain stimulationMRI-negative epilepsyInvasive monitoringResponsive neurostimulationBrain stimulationSeizure outcomeNerve stimulationMRI-negative focal epilepsyGood seizure outcomeLaser interstitial thermal therapyRetrospective chart reviewVagal nerve stimulationVagus nerve stimulationIntracranial electroencephalography monitoringClass 1Interstitial thermal therapyUnderwent resectionChart reviewMore patientsSurgical treatmentAppropriate therapySurgical managementPoor outcomeSurgical interventionSurgical outcomes