Featured Publications
Prevalence of and risk factors for vertebral fracture and low bone mineral density among Peruvian women aging with HIV
Cabrera D, Cornejo M, Slotkin R, Pinedo Y, Yu W, Guan W, Garcia P, Hsieh E. Prevalence of and risk factors for vertebral fracture and low bone mineral density among Peruvian women aging with HIV. Archives Of Osteoporosis 2023, 18: 64. PMID: 37160770, PMCID: PMC10170032, DOI: 10.1007/s11657-023-01250-w.Peer-Reviewed Original ResearchConceptsBone mineral densityLow bone mineral densityThoracolumbar X-rayVertebral fracturesFemoral neckRisk factorsLumbar spineOsteoporosis treatmentTotal hipTreatment gapMineral densityTotal hip bone mineral densityPresence of VFsPeruvian womenTH bone mineral densityHip bone mineral densityFN bone mineral densityLower FN BMDSubset of patientsGenant semiquantitative methodLower femoral neckImportant treatment gapsKey risk factorsAntiretroviral therapyFRAX score
2023
Assessment of regional body composition, physical function and sarcopenia among peruvian women aging with HIV: A cross-sectional study.
Cabrera D, Cornejo M, Pinedo Y, Garcia P, Hsieh E. Assessment of regional body composition, physical function and sarcopenia among peruvian women aging with HIV: A cross-sectional study. PLOS Global Public Health 2023, 3: e0000814. PMID: 37594923, PMCID: PMC10437949, DOI: 10.1371/journal.pgph.0000814.Peer-Reviewed Original ResearchShort Physical Performance BatteryActive antiretroviral therapyLimb lean massTrunk fat massCross-sectional studyFat massBody compositionSPPB scorePhysical functionPeruvian womenDual X-ray absorptiometryPhysical performancePhysical Performance BatteryGrip strength testChronic disease managementMultivariable regression analysisPopulation of womenX-ray absorptiometryCare of peopleLower SPPB scoresPhysical performance scoreRegional body compositionGlobal health concernEWGSOP criteriaAntiretroviral therapyAssessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV
Womack J, Murphy T, Leo‐Summers L, Bates J, Jarad S, Gill T, Hsieh E, Rodriguez‐Barradas M, Tien P, Yin M, Brandt C, Justice A. Assessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV. Journal Of The American Geriatrics Society 2023, 71: 1891-1901. PMID: 36912153, PMCID: PMC10258163, DOI: 10.1111/jgs.18304.Peer-Reviewed Original ResearchConceptsModifiable risk factorsFragility fracturesRisk factorsAlcohol use disorderSerious fallsPhysiologic frailtyAntiretroviral therapyOlder PWHUse disordersVeterans Aging Cohort StudyMeasures of multimorbidityAging Cohort StudyBody mass indexMultivariable logistic modelAverage attributable fractionSuccessful prevention programsKey risk factorsOpioid prescriptionsCohort studyMass indexModifiable factorsSixth decadeAttributable fractionElevated riskICD9 codes
2022
Predictive Risk Model for Serious Falls Among Older Persons Living With HIV
Womack JA, Murphy TE, Leo-Summers L, Bates J, Jarad S, Smith AC, Gill TM, Hsieh E, Rodriguez-Barradas MC, Tien PC, Yin MT, Brandt CA, Justice AC. Predictive Risk Model for Serious Falls Among Older Persons Living With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2022, 91: 168-174. PMID: 36094483, PMCID: PMC9470988, DOI: 10.1097/qai.0000000000003030.Peer-Reviewed Original ResearchConceptsMiddle-aged veteransOlder PWHAntiretroviral therapySerious fallsOlder personsVeterans Aging Cohort StudyMeasures of multimorbidityAging Cohort StudyBody mass indexMultivariable logistic regressionPredictive risk modelCohort studyMass indexInjury codesElevated riskGeneral populationSix monthsPWHLogistic regressionPotential predictorsSubstance useRadiology reportsHIVExternal causesVeterans
2021
Brief Report: Are Serious Falls Associated With Subsequent Fragility Fractures Among Veterans Living With HIV?
Womack JA, Murphy TE, Ramsey C, Bathulapalli H, Leo-Summers L, Smith AC, Bates J, Jarad S, Gill TM, Hsieh E, Rodriguez-Barradas MC, Tien PC, Yin MT, Brandt C, Justice AC. Brief Report: Are Serious Falls Associated With Subsequent Fragility Fractures Among Veterans Living With HIV? JAIDS Journal Of Acquired Immune Deficiency Syndromes 2021, 88: 192-196. PMID: 34506360, PMCID: PMC8513792, DOI: 10.1097/qai.0000000000002752.Peer-Reviewed Original ResearchConceptsSubsequent fragility fracturesFragility fracturesAntiretroviral therapySerious fallsRisk factorsVeterans Aging Cohort StudyAging Cohort StudyMultivariable logistic regressionUpper arm fracturesMiddle-aged populationYears of ageAlcohol use disorderCohort studyHip fractureVertebral fracturesArm fracturesInjury codesICD9 codesGeneral populationUse disordersLogistic regressionIntegrase inhibitorsOlder adultsRadiology reportsHIVChanges in trabecular bone score and bone mineral density in Chinese HIV-Infected individuals after one year of antiretroviral therapy
Guan WM, Pan W, Yu W, Cao W, Lin Q, Zhang ZZ, Song XJ, Li YL, Tian JP, Xu Y, Li TS, Hsieh E. Changes in trabecular bone score and bone mineral density in Chinese HIV-Infected individuals after one year of antiretroviral therapy. Journal Of Orthopaedic Translation 2021, 29: 72-77. PMID: 34094860, PMCID: PMC8164002, DOI: 10.1016/j.jot.2021.04.002.Peer-Reviewed Original ResearchTrabecular bone scoreBone mineral densityDual-energy X-ray absorptiometryLPV/rAntiretroviral therapyART initiationLower BMIBone scoreRisk factorsMineral densityBone microarchitectureBaseline TBSHuman immunodeficiency virus (HIV) infectionNormal bone mineral densityBone damageDifferent antiretroviral agentsHIV treatment historyImpaired bone microarchitectureLower baseline CD4Immunodeficiency virus infectionTraditional risk factorsClinicians additional informationX-ray absorptiometryKey risk factorsBaseline CD4Long-term trabecular bone score and bone mineral density changes in Chinese antiretroviral-treated HIV-infected individuals
Guan W, Pan W, Yu W, Cao W, Lin Q, Zhang Z, Song X, Li Y, Tian J, Xu Y, Li T, Hsieh E. Long-term trabecular bone score and bone mineral density changes in Chinese antiretroviral-treated HIV-infected individuals. Archives Of Osteoporosis 2021, 16: 41. PMID: 33624129, PMCID: PMC9675940, DOI: 10.1007/s11657-021-00890-0.Peer-Reviewed Original ResearchConceptsTrabecular bone scoreBone mineral densityTH bone mineral densityNormal bone mineral densityAntiretroviral therapyBone scoreART initiationFemoral neckMineral densityBone microarchitectureTotal hip (TH) BMDLumbar spine (LS) BMDBone mineral density changesFN bone mineral densityLarge tertiary care hospitalRetrospective chart reviewTertiary care hospitalMineral density changesMean percent decreaseResultsFour hundred fiftyPercent decreaseAdult PWHChart reviewCare hospitalBMD changes
2020
Longitudinal change in bone mineral density among Chinese individuals with HIV after initiation of antiretroviral therapy
Guo F, Song X, Li Y, Guan W, Pan W, Yu W, Li T, Hsieh E. Longitudinal change in bone mineral density among Chinese individuals with HIV after initiation of antiretroviral therapy. Osteoporosis International 2020, 32: 321-332. PMID: 32803316, PMCID: PMC9509525, DOI: 10.1007/s00198-020-05584-w.Peer-Reviewed Original ResearchConceptsTenofovir disoproxil fumarateLong-term clinical managementBone mineral density lossMineral density lossAntiretroviral therapyDisoproxil fumarateClinical managementRisk factorsGreater bone mineral density lossInitiation of TDFDual-energy x-ray absorptiometry testingHIV-specific parametersNon-TDF groupUndetectable viral loadOutpatient HIV clinicRelated risk factorsLarge tertiary hospitalBone mineral densityDensity lossAntiretroviral initiationTDF groupWeek 96HIV clinicWeek 48HIV diagnosisIncidence of hypertension among persons living with HIV in China: a multicenter cohort study
Fan H, Guo F, Hsieh E, Chen WT, Lv W, Han Y, Xie J, Li Y, Song X, Li T. Incidence of hypertension among persons living with HIV in China: a multicenter cohort study. BMC Public Health 2020, 20: 834. PMID: 32487185, PMCID: PMC7268367, DOI: 10.1186/s12889-020-08586-9.Peer-Reviewed Original ResearchConceptsIncidence of hypertensionAntiretroviral therapyChinese PLWHIncident hypertensionInitiation of ARTProspective longitudinal multicenter studyReceipt of ARTCox proportional hazards modelART-naïve patientsDetectable HIV viremiaMulticenter cohort studyCox regression analysisBody mass indexRecent viral loadLongitudinal multicenter studyProportional hazards modelHIV viremiaMedian followZidovudine exposureChronic comorbiditiesHIV careViral suppressionCohort studyConclusionsThe incidenceMass indexOptimizing Treatment for Adults with HIV/AIDS in China: Successes over Two Decades and Remaining Challenges
Cao W, Hsieh E, Li T. Optimizing Treatment for Adults with HIV/AIDS in China: Successes over Two Decades and Remaining Challenges. Current HIV/AIDS Reports 2020, 17: 26-34. PMID: 31939111, PMCID: PMC6989417, DOI: 10.1007/s11904-019-00478-x.BooksConceptsNational Free Antiretroviral Therapy ProgramAntiretroviral therapyHIV/AIDSChinese patientsFree antiretroviral therapy (ART) programLong-term antiretroviral therapyHIV/AIDS patientsFree antiretroviral drugsLifelong antiretroviral therapyHIV care cascadeAIDS/STD ControlAntiretroviral therapy coverageAntiretroviral therapy programsHIV/AIDS diagnosisHIV/AIDS treatmentNumber of patientsMulti-center studyAvailable ART regimensART regimensCare cascadeChronic complicationsAntiretroviral treatmentOverall mortalityAIDS patientsChronic inflammation
2016
Exploring HIV-related stigma among HIV-infected men who have sex with men in Beijing, China: a correlation study
Li Z, Hsieh E, Morano JP, Sheng Y. Exploring HIV-related stigma among HIV-infected men who have sex with men in Beijing, China: a correlation study. AIDS Care 2016, 28: 1394-1401. PMID: 27137205, PMCID: PMC5069196, DOI: 10.1080/09540121.2016.1179713.Peer-Reviewed Original ResearchConceptsHIV transmissionHIV stigmaStigma scoresPoor self-rated health statusBerger HIV Stigma ScaleSelf-rated health statusHIV-positive MSMIncidence of HIVMultivariable linear regression modelsHuman immunodeficiency virusLevels of HIVHIV Stigma ScaleAdverse health outcomesCross-sectional survey studySocial support networksAntiretroviral therapyHIV statusOpportunistic infectionsImmunodeficiency virusPoor adherenceSocio-demographic characteristicsRisk factorsStudy populationHIVHealth outcomes
2014
Increased bone resorption during tenofovir plus lopinavir/ritonavir therapy in Chinese individuals with HIV
Hsieh E, Fraenkel L, Xia W, Hu YY, Han Y, Insogna K, Yin MT, Xie J, Zhu T, Li T. Increased bone resorption during tenofovir plus lopinavir/ritonavir therapy in Chinese individuals with HIV. Osteoporosis International 2014, 26: 1035-1044. PMID: 25224293, PMCID: PMC4334679, DOI: 10.1007/s00198-014-2874-3.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusLopinavir/ritonavirBone turnover markersBone resorption marker levelsResorption marker levelsNon-Chinese populationsAntiretroviral therapyTreatment failureImmunodeficiency virusMarker levelsSkeletal metabolismC-terminal cross-linking telopeptideLopinavir/ritonavir therapyTreatment-naïve patientsFirst-line therapyBone resorption markersProcollagen type 1Multi-center trialPlasma samplesChinese individualsN-terminal propeptideType 1 collagenRitonavir therapyTurnover markersResorption markers