2024
GPT-based normative models of brain sMRI correlate with dimensional psychopathology
Mendes S, Pinaya W, Pan P, Gadelha A, Belangero S, Jackowski A, Rohde L, Miguel E, Sato J. GPT-based normative models of brain sMRI correlate with dimensional psychopathology. Imaging Neuroscience 2024, 2: 1-15. DOI: 10.1162/imag_a_00204.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderChild Behavior ChecklistDeficit hyperactivity disorderAutism spectrum disorderPsychiatric disordersBrain regionsStructural MRIDimensional psychopathologyHyperactivity disorderBrazilian High-Risk Cohort StudyAttention deficit hyperactivity disorder scoresAutism Brain Imaging Data Exchange IIAdolescent Brain Cognitive DevelopmentChild Behavior Checklist scalesHigh Risk Cohort StudyDetect psychiatric symptomsEmergent psychiatric disordersBrain structural MRINeurobiological substratesNeuroimaging studiesLanguage tasksPsychiatric symptomsBehavior ChecklistPsychiatric conditionsSpectrum disorderIs waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample
Bado P, Salum G, Rohde L, Gadelha A, Pan P, Miguel E, Tripp G, Furukawa E. Is waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample. JCPP Advances 2024, 4: e12231. PMID: 38827985, PMCID: PMC11143955, DOI: 10.1002/jcv2.12231.Peer-Reviewed Original ResearchDelayed rewardsPsychiatric conditionsPresence of psychiatric disordersLife outcomesBaseline task performanceImpulsive choicePositive long-term outcomesImmediate rewardsPsychiatric disordersTask performanceADHDResults ChildrenRewardChildren's preferencesStronger preferenceSchool-based cohortDisordersLongitudinal outcomesCohort sampleFunctional outcomesChildrenCohort of Brazilian childrenBrazilian childrenPsychopathologyDiverse populationsAn evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis
Ramakrishnan D, Farhat L, Vattimo E, Levine J, Johnson J, Artukoglu B, Landeros-Weisenberger A, Zangen A, Pelissolo A, de B Pereira C, Rück C, Costa D, Mataix-Cols D, Shannahoff-Khalsa D, Tolin D, Zarean E, Meyer E, Hawken E, Storch E, Andersson E, Miguel E, Maina G, Leckman J, Sarris J, March J, Diniz J, Kobak K, Mallet L, Vulink N, Amiaz R, Fernandes R, Shavitt R, Wilhelm S, Golshan S, Tezenas du Montcel S, Erzegovesi S, Baruah U, Greenberg W, Kobayashi Y, Bloch M. An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis. Journal Of Psychiatric Research 2024, 173: 387-397. PMID: 38598877, DOI: 10.1016/j.jpsychires.2024.03.044.Peer-Reviewed Original ResearchConceptsYale-Brown Obsessive-Compulsive ScaleObsessive-compulsive disorderCGI-IRandomized-controlled trialsAdult obsessive-compulsive disorderClinical Global Impression ImprovementObsessive-Compulsive ScaleTreatment responseIndividual-patient data meta-analysisPosttreatment scoresEvaluation of treatment responseMeta-analysis of randomized-controlled trialsFirst-line therapyCGIIndividual participant dataMeta-analysisNovel treatment modalitiesExpert consensusIndividual participant data meta-analysisSystematic reviewDisordersData meta-analysisPosttreatmentRemission definitionsImpressive improvementCausal Pathways Between the Acute Experience of Violence During Pregnancy and Fetal Intrauterine Growth Restriction: A Cohort Study
Blumrich L, Silva L, Barreto V, Rohde L, Polanczyk G, Miguel E, Grisi S, Fleitlich-Bilyk B, Ferraro A. Causal Pathways Between the Acute Experience of Violence During Pregnancy and Fetal Intrauterine Growth Restriction: A Cohort Study. Journal Of Women's Health 2024, 33: 765-773. PMID: 38551182, DOI: 10.1089/jwh.2023.0645.Peer-Reviewed Original ResearchIntrauterine growth restrictionAssociated with intrauterine growth restrictionGrowth restrictionProspective population-based birth cohortCausal pathwaysFetal intrauterine growth restrictionPopulation-based birth cohortExperiences of violenceNegative health consequencesAcute experimentsHealth consequences of violenceEmergency careGestational depressionGestational trimesterLow birthweightBirth cohortAlcohol consumptionCohort studyBlood pressurePregnancyConsequences of violencePath analysis modelMediation analysisCohortAdequate fitIncreases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder
Echevarria M, Batistuzzo M, Silva R, Brunoni A, Sato J, Miguel E, Hoexter M, Shavitt R. Increases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder. Journal Of Affective Disorders 2024, 355: 175-183. PMID: 38548207, DOI: 10.1016/j.jad.2024.03.141.Peer-Reviewed Original ResearchTranscranial direct current stimulationObsessive-compulsive disorderDirect current stimulationCurrent stimulationActive transcranial direct current stimulationSensorimotor networkOCD symptom dimensionsTreatment-resistant obsessive-compulsive disorderNeurobiological mechanisms of actionObsessive-compulsive disorder pathophysiologyWhole-brain connectivity analysisDaily tDCS sessionsSymptom improvementResting-state functional MRITDCS sessionsNon-invasive neuromodulation interventionsBrain stimulation interventionsFunctional connectivity changesAssociated with connectivityLeft deltoidSymptom dimensionsNeurobiological mechanismsLeft precuneusMode networkPre/postcentral gyriPerinatal and neonatal factors and mental disorders in children and adolescents: looking for the contributions of the early environment to common and dissociable aspects of psychopathology
Leusin F, Damiano R, Mendes L, Hoffmann M, Manfro A, Pan P, Gadelha A, de Jesus Mari J, Manfro G, Miguel E, Rohde L, Bressan R, Salum G. Perinatal and neonatal factors and mental disorders in children and adolescents: looking for the contributions of the early environment to common and dissociable aspects of psychopathology. European Child & Adolescent Psychiatry 2024, 1-11. PMID: 38519607, DOI: 10.1007/s00787-024-02402-0.Peer-Reviewed Original ResearchMental disordersPsychiatric disordersCo-occurrence of mental disordersPresence of mental disordersDomains of psychopathologyYears of age childrenModel psychiatric disordersPsychiatric disorder diagnosisOverall psychopathologyBifactor modelDisorder diagnosisPsychopathologyBehavioral assessmentP-factorEarly environmentLow level of maternal educationLevel of maternal educationLow socioeconomic statusDisordersNeonatal factorsPrimary caregiversAge childrenAssociated with male sexSocioeconomic statusMaternal educationPost-COVID-19 condition: systemic inflammation and low functional exercise capacity
de Castro G, Gama L, Ramos A, da Silva G, de Souza Teixeira A, Cunha-Neto E, de Souza H, Marie S, Talib L, Coelho V, Kalil J, de Araujo A, Ritto A, Belon A, Santos A, Barrére A, Sawamura M, Lamas C, Baldi B, Carvalho C, Kulikowski L, Damiano R, Imamura M, Neto J, Lira F, Otoch J, Miguel E, Battistella L, Forlenza O, Busatto G, Seelaender M. Post-COVID-19 condition: systemic inflammation and low functional exercise capacity. Frontiers In Nutrition 2024, 11: 1295026. PMID: 38549752, PMCID: PMC10973152, DOI: 10.3389/fnut.2024.1295026.Peer-Reviewed Original ResearchPost-COVID-19 conditionTimed Up and Go testUp-and-go testPhysical performance testsAcute COVID-19Low handgrip strengthFollow-up assessment 6Cross-sectional studySelf-reported symptomsFollow-up assessmentQuality of lifeDiagnosing pulmonary lesionsHandgrip strengthSerum cytokine profilesSerum cytokine levelsImpact of inflammationControl groupMCP-1 levelsIL-4 concentrationMale participantsHospital dischargeSymptom questionnaireSymptom groupsFemale participantsDebilitating symptomsFacing the Unknown: An Inductive Analysis of the Lived Experience of Medical Residents during the COVID-19 Pandemic
Guimarães-Fernandes F, Benoit L, de Oliveira L, Neto P, Feniman D, Correia A, de Oliveira Bosoni N, Macaya D, Miguel E, Ceron-Litvoc D, Castellana G. Facing the Unknown: An Inductive Analysis of the Lived Experience of Medical Residents during the COVID-19 Pandemic. Psychopathology 2024, 57: 169-181. PMID: 38467115, DOI: 10.1159/000536135.Peer-Reviewed Original ResearchMedical residentsHealthcare professionalsExperiences of medical residentsCOVID-19 pandemicHealth care providersHealthcare delivery challengesLived experienceSemi-structured interviewsFear of infectionCare providersLimit situationPsychiatric careExistential defensivenessContent themesCOVID-19Social isolationEmotional overloadHealthcarePhenomenological analysisInductive analysisPublic healthPatient deathProfessional approachResidentsOvercome adversityAge of onset of obsessive-compulsive disorder differentially affects white matter microstructure
Vriend C, de Joode N, Pouwels P, Liu F, Otaduy M, Pastorello B, Robertson F, Ipser J, Lee S, Hezel D, van Meter P, Batistuzzo M, Hoexter M, Sheshachala K, Narayanaswamy J, Venkatasubramanian G, Lochner C, Miguel E, Reddy Y, Shavitt R, Stein D, Wall M, Simpson H, van den Heuvel O. Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure. Molecular Psychiatry 2024, 29: 1033-1045. PMID: 38228890, PMCID: PMC11176057, DOI: 10.1038/s41380-023-02390-8.Peer-Reviewed Original ResearchObsessive-compulsive disorderPathophysiology of obsessive-compulsive disorderObsessive-compulsive disorder groupAge of OCD onsetOCD onsetHealthy controlsMedication-free adultsWhite matter microstructural alterationsVisual attention processesWhite matter microstructureStructural brain networksStructural connectome analysisWhite matter tractsBayesian multilevel analysisDirection of effectAttentional processesOCD individualsBrain signaturesBrain networksDiffusion MRI studiesPost hoc analysisSagittal stratumConnectome analysisMultilevel analysisStructural connectomeChapter 21 Gamma Knife for psychiatric indications
Lopes A, de Arruda I, Batistuzzo M, Gorgulho A, de Salles A, Miguel E. Chapter 21 Gamma Knife for psychiatric indications. 2024, 495-517. DOI: 10.1016/b978-0-443-18496-3.00021-5.Peer-Reviewed Original ResearchAnorexia nervosaObsessive-compulsive disorder patientsTreatment of psychiatric disordersAnterior limb of internal capsuleObsessive-compulsive disorderVentral anterior limbGamma KnifeGK radiosurgeryMajor depressionDisorder patientsPsychiatric disordersPsychiatric indicationsNervosaDepressionInternal capsuleSurgical modalitiesAdverse eventsDisordersAnorexiaRadiosurgeryWeight gainManiaPsychiatryBrain cystsComplicationsChildhood Anxiety Symptoms as a Predictor of Psychotic Experiences in Adolescence in a High-Risk Cohort for Psychiatric Disorders
Machado V, Fonseca L, Barbosa M, Bressan R, Pan P, Rohde L, Miguel E, Salum G, Ziebold C, Gadelha A. Childhood Anxiety Symptoms as a Predictor of Psychotic Experiences in Adolescence in a High-Risk Cohort for Psychiatric Disorders. Schizophrenia Bulletin Open 2024, 5: sgae003. DOI: 10.1093/schizbullopen/sgae003.Peer-Reviewed Original ResearchBrazilian High-Risk CohortCross-lagged panel modelChildhood anxiety symptomsPsychotic experiencesAnxiety symptomsSubclinical psychotic symptomsContinuum of psychosisStandardized self-report questionnairesTime-lagged associationsCross-lagged effectsIncreased levels of anxietySelf-report questionnairesLevels of anxietyPsychosis pronenessPsychotic symptomsPsychiatric disordersSymptom domainsMental illnessAnxietyHigh-risk cohortAnxiety scoresPsychosisAdolescentsPE scoresPanel modelSocial skills in patients with obsessive-compulsive disorder before and after treatment.
da Silva F, Batistuzzo M, Diniz J, D'Alcante C, Timpano K, Shavitt R, Miguel E, Hoexter M. Social skills in patients with obsessive-compulsive disorder before and after treatment. Brazilian Journal Of Psychiatry 2024 PMID: 38875529, DOI: 10.47626/1516-4446-2024-3577.Peer-Reviewed Original ResearchObsessive-compulsive disorderObsessive-compulsive disorder symptomatologySocial skillsIllness durationControl participantsSeverity of obsessive-compulsive disorderObsessive-compulsive disorder severityObsessive-compulsive disorder symptomsSS total scoreScores compared to controlsOCD symptomatologyGroup differencesIllness onsetPredictors of SSTotal scoreCourse of treatmentSymptomatologyTreatment investigationsSS performanceTreatment effectsIllnessDisordersTreatment-naive patientsSkillsFollow-up periodThe S20 Brazilian Mental Health Report for Building a Just World and a Sustainable Planet: Part II.
Mari J, Kapczinski F, Brunoni A, Gadelha A, Baldez D, Miguel E, Scorza F, Caye A, Quagliato L, De Boni R, Salum G, Nardi A. The S20 Brazilian Mental Health Report for Building a Just World and a Sustainable Planet: Part II. Brazilian Journal Of Psychiatry 2024 PMID: 38875470, DOI: 10.47626/1516-4446-2024-3707.Peer-Reviewed Original ResearchMental health reportsHealth reportsHuman rightsMental healthMental disordersMental health careMental health policyMental health systemMental health challengesHealth Working GroupMental healthcareHealth policyHealth systemMental illnessHealth careDigital healthPhysical needsHealth challengesGeneral HospitalPsychiatric patientsInterventional psychiatryRightsTreatment settingsHealthPost-pandemic world
2023
Clinical characteristics of probands with obsessive-compulsive disorder from simplex and multiplex families
Lima M, Saraiva L, Ramos V, Oliveira M, Costa D, Disorders B, Fernandez T, Crowley J, Storch E, Shavitt R, Miguel E, Cappi C. Clinical characteristics of probands with obsessive-compulsive disorder from simplex and multiplex families. Psychiatry Research 2023, 331: 115627. PMID: 38113811, PMCID: PMC11129832, DOI: 10.1016/j.psychres.2023.115627.Peer-Reviewed Original ResearchComparing mental health semi-structured diagnostic interviews and symptom checklists to predict poor life outcomes: an 8-year cohort study from childhood to young adulthood in Brazil
Hoffmann M, Pine D, Georgiades K, Szatmari P, Miguel E, Pan P, Gadelha A, Rohde L, Merikangas K, Milham M, Satterthwaite T, Salum G. Comparing mental health semi-structured diagnostic interviews and symptom checklists to predict poor life outcomes: an 8-year cohort study from childhood to young adulthood in Brazil. The Lancet Global Health 2023, 12: e79-e89. PMID: 37980914, PMCID: PMC10716620, DOI: 10.1016/s2214-109x(23)00462-x.Peer-Reviewed Original ResearchLatin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol
Crowley J, Cappi C, Ochoa‐Panaifo M, Frederick R, Kook M, Wiese A, Rancourt D, Atkinson E, Giusti‐Rodriguez P, Anderberg J, genomics L, Group B, Abramowitz J, Adorno V, Aguirre C, Alves G, Alves G, Ancalade N, Espinosa A, Arnold P, Ayton D, Barbosa I, Castano L, Barrera C, Berardo M, Berrones D, Best J, Bigdeli T, Burton C, Buxbaum J, Callahan J, Carneiro M, Cepeda S, Chazelle E, Chire J, Munoz M, Quiroz P, Cobite J, Comer J, Costa D, Crosbie J, Cruz V, Dager G, Daza L, de la Rosa‐Gómez A, del Río D, Delage F, Dreher C, Fay L, Fazio T, Ferrão Y, Ferreira G, Figueroa E, Fontenelle L, Forero D, Fragoso D, Gadad B, Garrison S, González A, Gonzalez L, González M, Gonzalez‐Barrios P, Goodman W, Grice D, Guintivano J, Guttfreund D, Guzick A, Halvorsen M, Hovey J, Huang H, Irreño‐Sotomonte J, Janssen‐Aguilar R, Jensen M, Reynolds A, Lujambio J, Khalfe N, Knutsen M, Lack C, Lanzagorta N, Lima M, Longhurst M, Martinez D, Luna E, Marques A, Martinez M, de Los Angeles Matos M, Maye C, McGuire J, Menezes G, Minaya C, Miño T, Mithani S, de C, Morales‐Rivero A, Moreira‐de‐Oliveira M, Morris O, Muñoz S, Naqqash Z, Bracho A, Bracho B, Rojas M, Castaman L, Balmaceda T, Ortega I, Patel D, Patrick A, Paz y Mino M, Orellana J, Stumpf B, Peregrina T, Duarte T, Piacsek K, Placencia M, Prieto M, Quarantini L, Quarantini‐Alvim Y, Ramos R, Ramos I, Ramos V, Ramsey K, Ray E, Richter M, Riemann B, Rivas J, Rosario M, Ruggero C, Ruiz‐Chow A, Ruiz‐Velasco A, Sagarnaga M, Sampaio A, Saraiva L, Schachar R, Schneider S, Schweissing E, Seligman L, Shavitt R, Soileau K, Stewart S, Storch S, Strouphauer E, Cuevas V, Timpano K, la Garza B, Vallejo‐Silva A, Vargas‐Medrano J, Vásquez M, Martinez G, Weinzimmer S, Yanez M, Zai G, Zapata‐Restrepo L, Zappa L, Zepeda‐Burgos R, Zoghbi A, Miguel E, Rodriguez C, Mallen M, Moya P, Borda T, Moyano M, Mattheisen M, Pereira S, Lázaro‐Muñoz G, Martinez‐Gonzalez K, Pato M, Nicolini H, Storch E. Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2023, 195: e32962. PMID: 37946624, PMCID: PMC11076176, DOI: 10.1002/ajmg.b.32962.Peer-Reviewed Original ResearchCognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers
Damiano R, de Almeida Rocca C, de Pádua Serafim A, Loftis J, Talib L, Pan P, Cunha-Neto E, Kalil J, de Castro G, Seelaender M, Guedes B, Marie S, de Souza H, Nitrini R, Miguel E, Busatto G, Forlenza O, Group H, Utiyama E, Segurado A, Perondi B, Miethke-Morais A, Montal A, Harima L, Fusco S, Silva M, Rocha M, Marcilio I, Rios I, Kawano F, de Jesus M, Kallas É, Carmo C, Tanaka C, Marchini J, Carvalho C, Ferreira J, Levin A, Oliveira M, Guimarães T, dos Santos Lázari C, da Silva Duarte A, Sabino E, Magri M, Barros-Filho T, Francisco M. Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers. Frontiers In Immunology 2023, 14: 1174020. PMID: 37287969, PMCID: PMC10242059, DOI: 10.3389/fimmu.2023.1174020.Peer-Reviewed Original ResearchConceptsCognitive impairmentInflammatory markersSARS-CoV-2 infectionLong-term cognitive impairmentLong-term cognitive outcomesC-reactive proteinDisease severity markersCOVID-19 infectionCognitive performanceHospital dischargeInflammatory backgroundClinical statusD-dimerSeverity markersGeneral cognitionOverall cognitive performanceTNF-betaPhysical activityParticipants 6Severe formG-CSFPersistent dysregulationMultivariate analysisSociodemographic characteristicsCognitive deficits19. Spatial Normalization Discrepancies Between Native and MNI152 Brain Template Scans in Gamma Ventral Capsulotomy Patients
Giff A, Noren G, Magnotti J, Lopes A, Batistuzzo M, Hoexter M, Greenberg B, Marsland R, Miguel E, Rasmussen S, McLaughlin N. 19. Spatial Normalization Discrepancies Between Native and MNI152 Brain Template Scans in Gamma Ventral Capsulotomy Patients. Biological Psychiatry 2023, 93: s101-s102. DOI: 10.1016/j.biopsych.2023.02.259.Peer-Reviewed Original ResearchGamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response
McLaughlin N, Magnotti J, Banks G, Nanda P, Hoexter M, Lopes A, Batistuzzo M, Asaad W, Stewart C, Paulo D, Noren G, Greenberg B, Malloy P, Salloway S, Correia S, Pathak Y, Sheehan J, Marsland R, Gorgulho A, De Salles A, Miguel E, Rasmussen S, Sheth S. Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response. Translational Psychiatry 2023, 13: 134. PMID: 37185805, PMCID: PMC10130137, DOI: 10.1038/s41398-023-02425-2.Peer-Reviewed Original ResearchConceptsY-BOCS reductionObsessive-compulsive disorderGamma knife capsulotomyLesion sizeRefractory obsessive-compulsive disorderOverall lesion volumeIntractable obsessive-compulsive disorderLesion-symptom mappingVoxel-wise lesion-symptom mappingClinical improvementClinical responseWhite matter pathwaysClinical outcomesFull respondersConventional therapyInternal capsuleLesion characteristicsLesion volumeAnterior limbEffective treatmentLesion locationLesion occurrenceCoronal planeSize/locationPatientsAn Evaluation of Item Harmonization Strategies Between Assessment Tools of Psychopathology in Children and Adolescents
Hoffmann M, Moore T, Axelrud L, Tottenham N, Pan P, Miguel E, Rohde L, Milham M, Satterthwaite T, Salum G. An Evaluation of Item Harmonization Strategies Between Assessment Tools of Psychopathology in Children and Adolescents. Assessment 2023, 31: 502-517. PMID: 37042304, DOI: 10.1177/10731911231163136.Peer-Reviewed Original Research