2022
Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways
Axelrud L, Hoffmann M, Vosberg D, Santoro M, Pan P, Gadelha A, Belangero S, Miguel E, Shin J, Thapar A, Smoller J, Pausova Z, Rohde L, Keller M, Paus T, Salum G. Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways. Journal Of Child Psychology And Psychiatry 2022, 64: 408-416. PMID: 36162806, DOI: 10.1111/jcpp.13708.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderPolygenic scoresOffspring cognitionIntergenerational transmissionMultiple mediation modelEducational attainmentBehavioral traitsCognitive measuresExecutive functionGeneral intelligenceHyperactivity disorderMediation modelMultiple mediationCognitive AssessmentCognitionPsychopathologyGenetic influencesParental educationPsychotic symptomsDirect associationParental geneticsAttainmentDiscovery sampleGenetic riskFathers
2020
Family accommodation mediates the impact of childhood anxiety on functional impairment
Macul Ferreira de Barros P, Polga N, Szejko N, Miguel EC, Leckman JF, Silverman WK, Lebowitz ER. Family accommodation mediates the impact of childhood anxiety on functional impairment. Journal Of Anxiety Disorders 2020, 76: 102318. PMID: 33011554, PMCID: PMC7680363, DOI: 10.1016/j.janxdis.2020.102318.Peer-Reviewed Original Research
2018
Obsessive-compulsive symptoms in children with first degree relatives diagnosed with obsessive-compulsive disorder
Chacon P, Bernardes E, Faggian L, Batistuzzo M, Moriyama T, Miguel E, Polanczyk G. Obsessive-compulsive symptoms in children with first degree relatives diagnosed with obsessive-compulsive disorder. Brazilian Journal Of Psychiatry 2018, 40: 388-393. PMID: 29898190, PMCID: PMC6899383, DOI: 10.1590/1516-4446-2017-2321.Peer-Reviewed Original ResearchConceptsPresence of OCSObsessive-compulsive disorderFirst-degree relativesObsessive-compulsive symptomsSocioeconomic statusImportant risk factorLow socioeconomic statusFuture longitudinal studiesClinical correlatesAssessed childrenRisk factorsDegree relativesFamily historySymptomsContamination/Longitudinal studyOCD diagnosisDisordersChildrenHigh rateFamily membersChildhoodCorrelatesStatus
2016
Measuring child maltreatment using multi-informant survey data: a higher-order confirmatory factor analysis
Salum G, DeSousa D, Manfro G, Pan P, Gadelha A, Brietzke E, Miguel E, Mari J, do Rosário M, Grassi-Oliveira R. Measuring child maltreatment using multi-informant survey data: a higher-order confirmatory factor analysis. Trends In Psychiatry And Psychotherapy 2016, 38: 23-32. PMID: 27007940, DOI: 10.1590/2237-6089-2015-0036.Peer-Reviewed Original ResearchConceptsConfirmatory factor analysisChild maltreatmentOppositional defiant disorder/conduct disorderAttention deficit hyperactivity disorderHigher-order confirmatory factor analysisMulti-informant approachDeficit hyperactivity disorderLower-order factorsLarge community sampleMulti-informant survey dataHigher-order factorsFactor analysisMeasures of psychopathologyTeacher-reported scoresOverall child maltreatmentFear disordersProsocial measuresHyperactivity disorderBrief measureDistress disordersCommunity sampleConduct disorderEmotional abuseDivergent validitySexual abuse
2012
Genome-wide association study of obsessive-compulsive disorder
Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund C, Rauch S, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe H, Lennertz L, Wagner M, Bellodi L, Cavallini M, Richter M, Cook E, Kennedy J, Rosenberg D, Stein D, Hemmings S, Lochner C, Azzam A, Chavira D, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy D, Wendland J, Veenstra-VanderWeele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg H, Walitza S, Egberts K, Renner T, Miguel E, Cappi C, Hounie A, Conceição do Rosário M, Sampaio A, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato C, Pato M, Voyiaziakis E, Heutink P, Cath D, Posthuma D, Smit J, Samuels J, Bienvenu O, Cullen B, Fyer A, Grados M, Greenberg B, McCracken J, Riddle M, Wang Y, Coric V, Leckman J, Bloch M, Pittenger C, Eapen V, Black D, Ophoff R, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs J, Cookson M, Singleton A, Hardy J, Crenshaw A, Parkin M, Mirel D, Conti D, Purcell S, Nestadt G, Hanna G, Jenike M, Knowles J, Cox N, Pauls D. Genome-wide association study of obsessive-compulsive disorder. Molecular Psychiatry 2012, 18: 788-798. PMID: 22889921, PMCID: PMC4218751, DOI: 10.1038/mp.2012.85.Peer-Reviewed Original ResearchConceptsExpression quantitative trait lociSingle nucleotide polymorphismsGenome-wide significant levelGenome-wide significance thresholdX-chromosome single nucleotide polymorphismsGenome-wide association studiesTrio-based analysisQuantitative trait lociAncestry-matched controlsComplex genetic etiologyTrait lociCase-control association analysisMethylation QTLsGenetic variationGene expressionAssociation studiesTop signalsAssociation analysisBroader roleSignificant enrichmentSNP microarraysCase-control sampleNucleotide polymorphismsGenetic etiologySignificance threshold