2023
Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents
Honorato-Mauer J, Xavier G, Ota V, Chehimi S, Mafra F, Cuóco C, Ito L, Ormond R, Asprino P, Oliveira A, Bugiga A, Torrecilhas A, Bressan R, Manfro G, Miguel E, Rohde L, Pan P, Salum G, Pellegrino R, Belangero S, Santoro M. Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents. Translational Psychiatry 2023, 13: 47. PMID: 36746925, PMCID: PMC9902559, DOI: 10.1038/s41398-023-02326-4.Peer-Reviewed Original ResearchConceptsMental health disordersCross-sectional analysisMajor depressive disorderAttention-deficit/hyperactivity disorderHealth disordersAnxiety disordersExtracellular vesiclesLarge ongoing cohort studiesMiR-432-5pPeripheral extracellular vesiclesTime pointsOngoing cohort studyMiR-328-3pSerum extracellular vesiclesLongitudinal analysisWave 2Deficit/hyperactivity disorderAdolescent participantsTotal extracellular vesiclesAttention-deficit/hyperactivityMiRNA expressionCohort studyDepressive disorderMajor depressionMiR-584-5p
2022
World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part I: Anxiety disorders
Bandelow B, Allgulander C, Baldwin D, da Conceição Costa D, Denys D, Dilbaz N, Domschke K, Eriksson E, Fineberg N, Hättenschwiler J, Hollander E, Kaiya H, Karavaeva T, Kasper S, Katzman M, Kim Y, Inoue T, Lim L, Masdrakis V, Menchón J, Miguel E, Möller H, Nardi A, Pallanti S, Perna G, Rujescu D, Starcevic V, Stein D, Tsai S, Van Ameringen M, Vasileva A, Wang Z, Zohar J. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part I: Anxiety disorders. The World Journal Of Biological Psychiatry 2022, 24: 79-117. PMID: 35900161, DOI: 10.1080/15622975.2022.2086295.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderCognitive behavioral therapyAnxiety disordersPanic disorder/agoraphobiaMixed anxiety disordersPosttraumatic stress disorderSerotonin-norepinephrine reuptake inhibitorsSelective serotonin reuptake inhibitorsTreatment of anxietyFirst-line psychotherapySelective mutismBehavioral therapySeparation anxietyStress disorderSpecific phobiaObsessive-CompulsiveReuptake inhibitorsAnxietyNon-pharmacological interventionsBiological Psychiatry (WFSBP) GuidelinesFirst-line medicationSerotonin reuptake inhibitorsAdolescentsAssessment of medicationsPsychotherapyWorld Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part II: OCD and PTSD
Bandelow B, Allgulander C, Baldwin D, da Conceição Costa D, Denys D, Dilbaz N, Domschke K, Hollander E, Kasper S, Möller H, Eriksson E, Fineberg N, Hättenschwiler J, Kaiya H, Karavaeva T, Katzman M, Kim Y, Inoue T, Lim L, Masdrakis V, Menchón J, Miguel E, Nardi A, Pallanti S, Perna G, Rujescu D, Starcevic V, Stein D, Tsai S, Van Ameringen M, Vasileva A, Wang Z, Zohar J. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part II: OCD and PTSD. The World Journal Of Biological Psychiatry 2022, 24: 118-134. PMID: 35900217, DOI: 10.1080/15622975.2022.2086296.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsRepetitive transcranial magnetic stimulationCognitive behavioral therapyFirst-line treatmentDeep brain stimulationSSRI treatmentBiological Psychiatry (WFSBP) GuidelinesSecond-line medicationsNon-pharmacological treatmentSerotonin reuptake inhibitorsNon-pharmacological interventionsTreatment-resistant casesTranscranial magnetic stimulationWorld FederationTreatment of anxietyPosttraumatic stress disorderTreatment of OCDReuptake inhibitorsMedication treatmentPharmacological treatmentSNRI venlafaxineInternet-CBTConsensus panelMagnetic stimulationBrain stimulation
2021
The impact of child psychiatric conditions on future educational outcomes among a community cohort in Brazil
Hoffmann M, McDaid D, Salum G, Silva-Ribeiro W, Ziebold C, King D, Gadelha A, Miguel E, de Jesus Mari J, Rohde L, Pan P, Bressan R, Mojtabai R, Evans-Lacko S. The impact of child psychiatric conditions on future educational outcomes among a community cohort in Brazil. Epidemiology And Psychiatric Sciences 2021, 30: e69. PMID: 36178130, PMCID: PMC8581950, DOI: 10.1017/s2045796021000561.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxiety DisordersBrazilChildDepressive Disorder, MajorEducational StatusFemaleHumansMalePhobic DisordersConceptsBullying perpetrationAdverse educational outcomesPsychiatric conditionsEducational outcomesWell-Being Behavior AssessmentImpact of fearHigh family riskMental health problemsFamily riskLiteracy performanceGrade repetitionChild psychiatric conditionsFuture educational outcomesCommunity cohortPopulation attributable risk percentageSchool dropoutPerpetrationNegative long-term effectsSample attritionAttributable risk percentageLarge Brazilian cohortBehavior assessmentNegative impactRobust negative impactBrazilian childrenThe impact of generalized anxiety disorder in obsessive-compulsive disorder patients.
Sharma P, Rosário M, Ferrão Y, Albertella L, Miguel E, Fontenelle L. The impact of generalized anxiety disorder in obsessive-compulsive disorder patients. Psychiatry Research 2021, 300: 113898. PMID: 33812219, DOI: 10.1016/j.psychres.2021.113898.Peer-Reviewed Original ResearchMeSH KeywordsAnxiety DisordersComorbidityFemaleHumansObsessive-Compulsive DisorderPanic DisorderPhobic DisordersConceptsGeneralized anxiety disorderObsessive-compulsive disorderComorbid generalized anxiety disorderAnxiety disordersOnset of OCDType II bipolar disorderDiagnosis of GADTreatment of OCDObsessive-compulsive disorder patientsSevere anxiety symptomsMann-Whitney U testChi-square testPrevalent comorbiditiesClinical profileClinical severityMood disordersDisorder patientsComorbid anxietyPanic disorderBipolar disorderAvoidant behaviorComorbiditiesGreater suicidalityLogistic regressionU test
2020
Family accommodation mediates the impact of childhood anxiety on functional impairment
Macul Ferreira de Barros P, Polga N, Szejko N, Miguel EC, Leckman JF, Silverman WK, Lebowitz ER. Family accommodation mediates the impact of childhood anxiety on functional impairment. Journal Of Anxiety Disorders 2020, 76: 102318. PMID: 33011554, PMCID: PMC7680363, DOI: 10.1016/j.janxdis.2020.102318.Peer-Reviewed Original Research
2019
The speed of progression towards obsessive-compulsive disorder
Thompson E, Torres A, Albertella L, Ferrão Y, Tiego J, Shavitt R, Conceição do Rosario M, Miguel E, Fontenelle L. The speed of progression towards obsessive-compulsive disorder. Journal Of Affective Disorders 2019, 264: 181-186. PMID: 32056748, DOI: 10.1016/j.jad.2019.12.016.Peer-Reviewed Original ResearchEffects of Maternal Psychopathology and Education Level on Neurocognitive Development in Infants of Adolescent Mothers Living in Poverty in Brazil
Shephard E, Fatori D, Mauro L, de Medeiros Filho M, Hoexter M, Chiesa A, Fracolli L, Brentani H, Ferraro A, Nelson C, Miguel E, Polanczyk G. Effects of Maternal Psychopathology and Education Level on Neurocognitive Development in Infants of Adolescent Mothers Living in Poverty in Brazil. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 4: 925-934. PMID: 31345780, PMCID: PMC6863387, DOI: 10.1016/j.bpsc.2019.05.009.Peer-Reviewed Original ResearchConceptsLow maternal educationMaternal psychopathologyAttention-deficit/hyperactivity disorderMaternal anxietyNeurocognitive developmentInfant neurodevelopmentAdolescent mothersMaternal educationHyperactivity disorderInfant neurocognitive developmentMonths of ageResting-state electroencephalographyCluster-based permutation testingEducation levelOscillatory powerEarly brain developmentMaternal symptomsRisk factorsConnectivity alterationsEarly neurocognitive developmentOscillatory connectivityRelative theta powerFunctional connectivityBrain developmentPilot studyNo evidence of attentional bias toward angry faces in patients with obsessive-compulsive disorder
Skinazi M, de Mathis M, Cohab T, de Marco e Souza M, Shavitt R, Miguel E, Hoexter M, Batistuzzo M. No evidence of attentional bias toward angry faces in patients with obsessive-compulsive disorder. Brazilian Journal Of Psychiatry 2019, 41: 257-260. PMID: 30540026, PMCID: PMC6794136, DOI: 10.1590/1516-4446-2018-0130.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAttentional biasAngry facesAnxiety disorder patientsOCD patientsDifferent brain activation patternsFunctional neuroimaging protocolsSpecific OCD symptom dimensionsBrain activation patternsSymptom severityOCD symptom dimensionsDisorder patientsAB taskAB paradigmTransdiagnostic approachAB scoresIntelligence testingAnxiety disordersSymptom dimensionsActivation patternsNeuroimaging protocolPsychiatric comorbidityOne-sample t-testFaceDisorders
2017
Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder.
Costa DLC, Diniz JB, Requena G, Joaquim MA, Pittenger C, Bloch MH, Miguel EC, Shavitt RG. Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder. The Journal Of Clinical Psychiatry 2017, 78: e766-e773. PMID: 28617566, DOI: 10.4088/jcp.16m11101.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAdolescentAdultAgedAnxiety DisordersComorbidityDepressive DisorderDouble-Blind MethodDrug ResistanceDrug Therapy, CombinationFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesPsychometricsSelective Serotonin Reuptake InhibitorsYoung AdultConceptsTreatment-resistant obsessive-compulsive disorderObsessive-compulsive disorderY-BOCS scoresN-acetylcysteineNAC groupYale-Brown Obsessive Compulsive Scale scoresTreatment-resistant OCD patientsBaseline Y-BOCS scoresTreatment-Resistant ObsessivePrimary outcome measureAnxiety symptomsDSM-IV criteriaSymptom dimensionsCompulsive Scale scoresSpecific OCD symptom dimensionsOCD symptom dimensionsAntioxidant medicationsAbdominal painPlacebo groupGlutamate modulatorsSecondary outcomesTertiary hospitalOutpatient clinicSeverity scoreWeek 16Prevalence, clinical correlates and maternal psychopathology of deliberate self-harm in children and early adolescents: results from a large community study
Simioni A, Pan P, Gadelha A, Manfro G, Mari J, Miguel E, Rohde L, Salum G. Prevalence, clinical correlates and maternal psychopathology of deliberate self-harm in children and early adolescents: results from a large community study. Brazilian Journal Of Psychiatry 2017, 40: 48-55. PMID: 28832748, PMCID: PMC6899416, DOI: 10.1590/1516-4446-2016-2124.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderOppositional defiant disorderMaternal psychopathologyPsychiatric disordersClinical diagnosisCo-occurring psychiatric disordersAnxiety disordersHigh Risk Cohort StudyCommunity-based studyDiagnosis of depressionMaternal mood disordersMaternal anxiety disordersPotential confounding factorsLarge community studyChildhood psychiatric disordersChild's clinical diagnosisPrevalence of DSHCohort studyMiddle-income countriesClinical correlatesMood disordersPrevalence estimatesConfounding factorsAge groupsLogistic regressionThe Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children
Saad LO, do Rosario MC, Cesar RC, Batistuzzo MC, Hoexter MQ, Manfro GG, Shavitt RG, Leckman JF, Miguel EC, Alvarenga PG. The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 342-348. PMID: 28151703, PMCID: PMC5439443, DOI: 10.1089/cap.2016.0125.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsPsychiatric comorbidityPredictive valueBehavioral problemsDSM-IV psychiatric diagnosesPresence of OCSGroup of patientsHigh-risk cohortSignificant obsessive-compulsive symptomsNegative predictive valuePositive predictive valueHigh rateSeverity of OCSRisk cohortSchool-Aged ChildrenDepressive disorderFunctional impairmentPsychiatric diagnosisChild Behavior ChecklistComorbiditiesSevere psychopathologyBeing AssessmentScreening toolPediatric OCDAnxiety disorders
2016
Measuring child maltreatment using multi-informant survey data: a higher-order confirmatory factor analysis
Salum G, DeSousa D, Manfro G, Pan P, Gadelha A, Brietzke E, Miguel E, Mari J, do Rosário M, Grassi-Oliveira R. Measuring child maltreatment using multi-informant survey data: a higher-order confirmatory factor analysis. Trends In Psychiatry And Psychotherapy 2016, 38: 23-32. PMID: 27007940, DOI: 10.1590/2237-6089-2015-0036.Peer-Reviewed Original ResearchConceptsConfirmatory factor analysisChild maltreatmentOppositional defiant disorder/conduct disorderAttention deficit hyperactivity disorderHigher-order confirmatory factor analysisMulti-informant approachDeficit hyperactivity disorderLower-order factorsLarge community sampleMulti-informant survey dataHigher-order factorsFactor analysisMeasures of psychopathologyTeacher-reported scoresOverall child maltreatmentFear disordersProsocial measuresHyperactivity disorderBrief measureDistress disordersCommunity sampleConduct disorderEmotional abuseDivergent validitySexual abuse
2015
Attentional bias to threat in children at-risk for emotional disorders: role of gender and type of maternal emotional disorder
Montagner R, Mogg K, Bradley B, Pine D, Czykiel M, Miguel E, Rohde L, Manfro G, Salum G. Attentional bias to threat in children at-risk for emotional disorders: role of gender and type of maternal emotional disorder. European Child & Adolescent Psychiatry 2015, 25: 735-742. PMID: 26547923, DOI: 10.1007/s00787-015-0792-3.Peer-Reviewed Original ResearchConceptsMaternal emotional disordersEmotional disordersAttention biasHappy face cuesThreat attention biasDot-probe paradigmMood disordersAttention biasesAttentional biasThreat biasThreat biasesNeutral facesEmotion disordersRole of genderLongitudinal researchDepression symptomsGroup differencesDisorder interactionFamilial riskSignificant genderHigh Risk Cohort StudyLarge sampleBiasesAnxietyPsychiatric disorders
2012
Social phobia in obsessive-compulsive disorder: Prevalence and correlates
Assunção M, da Conceição Costa D, de Mathis M, Shavitt R, Ferrão Y, do Rosário M, Miguel E, Torres A. Social phobia in obsessive-compulsive disorder: Prevalence and correlates. Journal Of Affective Disorders 2012, 143: 138-147. PMID: 22858214, DOI: 10.1016/j.jad.2012.05.044.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAnxiety DisordersBody Dysmorphic DisordersBrazilComorbidityCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPhobic DisordersPrevalenceRetrospective StudiesSex FactorsSocial ClassTourette SyndromeConceptsObsessive-compulsive disorderDSM-IV Axis I DisordersLogistic regressionSocial phobiaAnxiety disordersOCD patientsCross-sectional studyStructured Clinical InterviewAxis I DisordersLow socioeconomic statusBrazilian Research ConsortiumLarge multicenter sampleBroader treatment approachesGeneralized anxiety disorderBody dysmorphic disorderYale-Brown ObsessiveClinical factorsCross-sectional designSpecific comorbiditiesMale sexObsessive-compulsive spectrum disordersUnivariate analysisLifetime prevalenceI disordersTourette syndromeBODY DYSMORPHIC DISORDER IN PATIENTS WITH OBSESSIVE–COMPULSIVE DISORDER: PREVALENCE AND CLINICAL CORRELATES
Costa D, Assunção M, Ferrão Y, Conrado L, Gonzalez C, Fontenelle L, Fossaluza V, Miguel E, Torres A, Shavitt R. BODY DYSMORPHIC DISORDER IN PATIENTS WITH OBSESSIVE–COMPULSIVE DISORDER: PREVALENCE AND CLINICAL CORRELATES. Depression And Anxiety 2012, 29: 966-975. PMID: 22815241, DOI: 10.1002/da.21980.Peer-Reviewed Original ResearchConceptsBody dysmorphic disorderObsessive-compulsive disorderSkin pickingYale-Brown ObsessiveDSM-IV Axis I DisordersClinical Global Impression ScaleEarly onsetCompulsive ScaleOCD patientsDysmorphic disorderGroup of patientsSymptoms of BDDGlobal Impression ScaleAxis I DisordersStructured Clinical InterviewComorbid body dysmorphic disorderBrazilian Research ConsortiumYounger patientsUnemployed patientsClinical featuresObsessive-compulsive spectrum disordersClinical correlatesImpression ScaleChronic depressionClinical assessmentDoes anti-obsessional pharmacotherapy treat so-called comorbid depressive and anxiety states?
Valerio C, Diniz J, Fossaluza V, de Mathis M, Belotto-Silva C, Joaquim M, Filho E, Shavitt R. Does anti-obsessional pharmacotherapy treat so-called comorbid depressive and anxiety states? Journal Of Affective Disorders 2012, 139: 187-192. PMID: 22455835, DOI: 10.1016/j.jad.2012.02.002.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPsychiatric comorbidityTreatment responseOCD treatment responseTic disordersOCD treatmentAnxiety disordersOCD patientsNon-blinded studyAdditional psychiatric disordersCertain comorbid disordersPrimary obsessive-compulsive disorderCommon comorbiditiesAdult patientsComorbid conditionsComorbid depressiveChronic conditionsMajor depressionTreatment protocolComorbiditiesComorbid disordersPsychiatric disordersDisorders ProgramConventional treatmentPossible association
2008
Anxiety Disorders and Rheumatic Fever: Is There an Association?
Seixas A, Hounie A, Fossaluza V, Curi M, Alvarenga P, De Mathis M, De Mathis M, Vallada H, Pauls D, de Bragança Pereira C, Miguel E. Anxiety Disorders and Rheumatic Fever: Is There an Association? CNS Spectrums 2008, 13: 1039-1046. PMID: 19179939, DOI: 10.1017/s1092852900017090.Peer-Reviewed Original ResearchConceptsFirst-degree relativesRheumatic feverObsessive-compulsive spectrum disordersObsessive-compulsive disorderAnxiety disordersFamily membersCase-control family studyRates of disorderRelatives of individualsPoisson regression modelsRF patientsSydenham's choreaSeparation anxiety disorderPsychiatric interviewPossible familial relationshipControl probandsRelated disordersDisordersFamilial aggregationFurther studiesPatientsChoreaFeverOCD spectrumFamily studiesObsessive–compulsive disorder: Influence of age at onset on comorbidity patterns
de Mathis M, do Rosario M, Diniz J, Torres A, Shavitt R, Ferrão Y, Fossaluza V, de Bragança Pereira C, Miguel E. Obsessive–compulsive disorder: Influence of age at onset on comorbidity patterns. European Psychiatry 2008, 23: 187-194. PMID: 18329252, DOI: 10.1016/j.eurpsy.2008.01.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAnxiety DisordersAttention Deficit Disorder with HyperactivityBrazilComorbidityCross-Sectional StudiesDisruptive, Impulse Control, and Conduct DisordersFeeding and Eating DisordersFemaleHumansMaleMental DisordersMiddle AgedObsessive-Compulsive DisorderPersonality AssessmentSex FactorsSomatoform DisordersTic DisordersConceptsImpulse control disordersInfluence of ageComorbidity patternsYale Global Tic Severity ScaleOCD patientsStructured Clinical InterviewTic Severity ScaleYale-Brown Obsessive Compulsive ScaleAttention-deficit/hyperactivity disorderObsessive Compulsive ScalePsychiatric comorbidityIllness durationTic disordersFemale genderSeverity ScaleClinical InterviewDSM-IVLower ageAnxiety disordersCompulsive ScaleHyperactivity disorderDisordersLower chanceAgeComorbiditiesWorld Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision
Bandelow B, Zohar J, Hollander E, Kasper S, Möller H, Zohar J, Hollander E, Kasper S, Möller H, Bandelow B, Allgulander C, Ayuso-Gutierrez J, Baldwin D, Buenvicius R, Cassano G, Fineberg N, Gabriels L, Hindmarch I, Kaiya H, Klein D, Lader M, Lecrubier Y, Lépine J, Liebowitz M, Lopez-Ibor J, Marazziti D, Miguel E, Oh K, Preter M, Rupprecht R, Sato M, Starcevic V, Stein D, van Ameringen M, Vega J. World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision. The World Journal Of Biological Psychiatry 2008, 9: 248-312. PMID: 18949648, DOI: 10.1080/15622970802465807.Peer-Reviewed Original ResearchMeSH KeywordsAnxiety DisordersBiological PsychiatryDrug TherapyGlobal HealthHumansObsessive-Compulsive DisorderStress Disorders, Post-TraumaticConceptsSerotonin-noradrenaline reuptake inhibitorsPost-traumatic stress disorderSelective serotonin reuptake inhibitorsObsessive-compulsive disorderPharmacological treatmentCognitive behavioral therapyReuptake inhibitorsStress disorderTricyclic antidepressantsSSRI/SNRIAnxiety disordersBiological Psychiatry (WFSBP) GuidelinesFirst-line treatmentRelapse prevention studySerotonin reuptake inhibitorsTreatment-resistant casesPotential treatment optionSubstance abuse disordersWorld FederationObsessive-CompulsiveStudy of anxiolyticsOpen studySustained efficacyStandard treatmentTreatment options