2020
Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents
Manfro A, Pine D, Polanczyk G, Santoro M, Smoller J, Koenen K, Mari J, Pan P, Zugman A, Schäfer J, Belangero S, Gosmann N, Simioni A, Hoexter M, Miguel E, Gadelha A, Rohde L, Salum G. Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 60: 1501-1512. PMID: 33346031, PMCID: PMC10259767, DOI: 10.1016/j.jaac.2020.11.016.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresPsychiatric diagnosisExecutive functionHigher schizophrenia polygenic risk scoresExecutive dysfunctionHigh Risk Cohort StudySmaller intracranial volumeHigher attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderSchizophrenia polygenic risk scoresCortical surface areaDichotomized ageCohort studyFunctional impairmentRisk scoreDomains of psychopathologyBrain regionsIntracranial volumeRelevant outcomesBrain structuresHyperactivity disorderCognitive tasksLatent class analysisLower chanceDiagnosisUsing supervised machine learning on neuropsychological data to distinguish OCD patients with and without sensory phenomena from healthy controls
Stamatis C, Batistuzzo M, Tanamatis T, Miguel E, Hoexter M, Timpano K. Using supervised machine learning on neuropsychological data to distinguish OCD patients with and without sensory phenomena from healthy controls. British Journal Of Clinical Psychology 2020, 60: 77-98. PMID: 33300635, DOI: 10.1111/bjc.12272.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesFemaleHumansMachine LearningMaleNeuropsychological TestsObsessive-Compulsive DisorderSupervised Machine LearningConceptsObsessive-compulsive disorderNeuropsychological literatureNeuropsychological processesSensory phenomenaOCD patientsDistinct cognitive processesDifferent cognitive profilesExecutive function deficitsDistinct neuropsychological featuresCognitive processesNeuropsychological paradigmsCognitive profileNeuropsychological dataFunction deficitsNeuropsychological featuresHealthy controlsMultiple analytic approachesPatient subsampleSymptom presentationCommon experienceSymptom-based approachEmpirical findingsDistinct drivesRisk sensitivityMotivationCognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder
Bernardes E, Saraiva L, e Souza M, Hoexter M, Chacon P, Requena G, Miguel E, Shavitt R, Polanczyk G, Cappi C, Batistuzzo M. Cognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder. BMC Psychiatry 2020, 20: 380. PMID: 32690046, PMCID: PMC7370498, DOI: 10.1186/s12888-020-02751-5.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildCognitionExecutive FunctionHumansMemory, Short-TermNeuropsychological TestsObsessive-Compulsive DisorderConceptsObsessive-compulsive disorderObsessive-compulsive symptomsNeurocognitive domainsPediatric obsessive-compulsive disorderNon-verbal memoryProcessing speed domainCognitive domain analysisComprehensive neuropsychological batteryNon-clinical sampleYale-Brown ObsessiveSubdomain analysisVisuospatial memoryCognitive domainsExecutive functionVisuoconstructive abilitiesVisuoconstructive tasksCognitive performanceNeuropsychological variablesNeuropsychological batteryStructured Clinical InterviewProcessing speedNeurocognitive assessmentSpeed domainOCS severityCompulsive Scale
2018
Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life
Axelrud L, Santoro M, Pine D, Talarico F, Gadelha A, Manfro G, Pan P, Jackowski A, Picon F, Brietzke E, Grassi-Oliveira R, Bressan R, Miguel E, Rohde L, Hakonarson H, Pausova Z, Belangero S, Paus T, Salum G. Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life. American Journal Of Psychiatry 2018, 175: 555-563. PMID: 29495896, PMCID: PMC6372950, DOI: 10.1176/appi.ajp.2017.17050529.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlzheimer DiseaseBrazilCanadaChildCognitionFemaleHippocampusHumansMaleMemoryMultifactorial InheritanceNeuropsychological TestsOrgan SizeRisk FactorsConceptsHippocampal volumeEarly-life cognitionCanadian sampleMemory taskCognitive abilitiesExecutive functionImmediate recallMemory performanceCognitive testsGenetic riskReplication sampleBrain algorithmPolygenic risk scoresStandardized testsLower hippocampal volumeDistinct tasksBrain structuresAlzheimer's diseaseCognitionIndependent samplesLate-life dementiaDevelopmental conditionsRecallPrevious evidenceTask
2016
NEUROPSYCHOLOGICAL PREDICTORS OF TREATMENT RESPONSE TO COGNITIVE BEHAVIORAL GROUP THERAPY IN OBSESSIVE–COMPULSIVE DISORDER
Braga D, Abramovitch A, Fontenelle L, Ferrão Y, Gomes J, Vivan A, Ecker K, Bortoncello C, Mittelman A, Miguel E, Trentini C, Cordioli A. NEUROPSYCHOLOGICAL PREDICTORS OF TREATMENT RESPONSE TO COGNITIVE BEHAVIORAL GROUP THERAPY IN OBSESSIVE–COMPULSIVE DISORDER. Depression And Anxiety 2016, 33: 848-861. PMID: 27100799, DOI: 10.1002/da.22509.Peer-Reviewed Original ResearchConceptsCognitive-behavioral group therapyObsessive-compulsive disorderBehavioral group therapyNeuropsychological test performanceTest performanceNeuropsychological domainsCBGT groupGroup therapyOCD patientsNeuropsychological outcome measuresNeuropsychological predictorsNeuropsychological functioningNeuropsychological measuresOCD symptomsNeurocognitive functionDepression symptomsTreatment respondersTreatment responseParticipantsAvailable researchInconsistent resultsDisordersPredictorsAnxietyMeasures
2015
Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive–Compulsive Disorder Patients
Batistuzzo M, Hoexter M, Taub A, Gentil A, Cesar R, Joaquim M, D'Alcante C, McLaughlin N, Canteras M, Shavitt R, Savage C, Greenberg B, Norén G, Miguel E, Lopes A. Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive–Compulsive Disorder Patients. Neuropsychopharmacology 2015, 40: 1837-1845. PMID: 25645373, PMCID: PMC4839507, DOI: 10.1038/npp.2015.33.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRefractory OCD patientsOCD patientsVisuospatial memory performanceComprehensive neuropsychological evaluationObsessive-compulsive disorder patientsTreatment-refractory obsessive-compulsive disorder patientsCognitive flexibilityNeuropsychological domainsMemory performanceVisuospatial learningNeuropsychological functioningVisuospatial perceptionIntellectual functioningInhibitory controlRefractory obsessive-compulsive disorderTreatment-refractory OCD patientsMemory improvementGamma ventral capsulotomyMotor functioningNeuropsychological evaluationNeuropsychological outcomesEffects of GVCMotor performanceFunctioning
2014
High risk cohort study for psychiatric disorders in childhood: rationale, design, methods and preliminary results
Salum G, Gadelha A, Pan P, Moriyama T, Graeff‐Martins A, Tamanaha A, Alvarenga P, Krieger F, Fleitlich‐Bilyk B, Jackowski A, Sato J, Brietzke E, Polanczyk G, Brentani H, de Jesus Mari J, Do Rosário M, Manfro G, Bressan R, Mercadante M, Miguel E, Rohde L. High risk cohort study for psychiatric disorders in childhood: rationale, design, methods and preliminary results. International Journal Of Methods In Psychiatric Research 2014, 24: 58-73. PMID: 25469819, PMCID: PMC6878239, DOI: 10.1002/mpr.1459.Peer-Reviewed Original ResearchConceptsHigh Risk Cohort StudyMental disordersCohort studyPsychiatric disordersHigh-risk stratumChild mental disordersChildhood psychiatric disordersUseful clinical informationDiagnostic instrumentHigh riskClinical informationScreening instrumentFamily psychopathologyDisordersBaseline phaseScreening procedureChild psychiatryChildrenParticipation ratesPreliminary resultsPrevalenceStudyFamily rates
2012
Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive–compulsive disorder
Hoexter M, Dougherty D, Shavitt R, D'Alcante C, Duran F, Lopes A, Diniz J, Batistuzzo M, Evans K, Bressan R, Busatto G, Miguel E. Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive–compulsive disorder. European Neuropsychopharmacology 2012, 23: 569-580. PMID: 22841131, DOI: 10.1016/j.euroneuro.2012.06.014.Peer-Reviewed Original ResearchConceptsGray matter volumeMedial prefrontal cortexCognitive behavioral therapyObsessive-compulsive disorderTreatment responseTreatment-naïve OCD patientsTreatment groupsMagnetic resonance imagingMatter volumeOrbitofrontal cortexLateral orbitofrontal cortexSymptom improvementOCD patientsFluoxetine treatment groupTrial of fluoxetineSerotonin reuptake inhibitorsAdequate therapeutic approachStructural magnetic resonance imagingCBT treatment groupRight medial prefrontal cortexGroup-based cognitive behavioral therapyRegional gray matter volumeStructural MRI scansDistinct brain regionsYale-Brown ObsessiveNeuropsychological predictors of response to randomized treatment in obsessive–compulsive disorder
D'Alcante C, Diniz J, Fossaluza V, Batistuzzo M, Lopes A, Shavitt R, Deckersbach T, Malloy-Diniz L, Miguel E, Hoexter M. Neuropsychological predictors of response to randomized treatment in obsessive–compulsive disorder. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2012, 39: 310-317. PMID: 22789662, DOI: 10.1016/j.pnpbp.2012.07.002.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyObsessive-compulsive disorderCalifornia Verbal Learning TestVictoria Stroop TestVerbal Learning TestNeuropsychological measuresOCD patientsMental flexibilityVerbal memoryNeuropsychological predictorsLearning TestHigher verbal IQDifferent neuropsychological profilesUnderwent neuropsychological assessmentExecutive functioningExecutive abilitiesVerbal IQStroop testNeuropsychological profileNeuropsychological assessmentIntellectual functionHeuristic valueLarge sampleMemoryTreatment response
2011
Cognitive Dysfunction in Post-Traumatic Obsessive–Compulsive Disorder
Borges M, Braga D, Iêgo S, D'Alcante C, Sidrim I, Machado M, Pinto P, Cordioli A, do Rosário M, Petribú K, Mendlowicz M, Mari J, Miguel E, Fontenelle L. Cognitive Dysfunction in Post-Traumatic Obsessive–Compulsive Disorder. Australian & New Zealand Journal Of Psychiatry 2011, 45: 76-85. PMID: 21174503, DOI: 10.3109/00048674.2010.527822.Peer-Reviewed Original ResearchConceptsSet-shifting abilityObsessive-compulsive disorderPoor set-shifting abilitiesWechsler Memory Scale-Logical MemoryBrief Visual Memory TestWisconsin Card Sorting TestVisual memory testsIowa Gambling TaskCard Sorting TestFollowing neuropsychological testsWechsler Abbreviated ScaleTypes of OCDPosttraumatic stress disorderObsessive-compulsive symptomsMemory testVisuospatial memoryGambling TaskLogical memorySorting TestAbbreviated ScaleNeurocognitive patternsNeuropsychological testsStress disorderVisuospatial recognitionCompulsive disorder
2010
Response to Sham and Active Gamma Ventral Capsulotomy in Otherwise Intractable Obsessive-Compulsive Disorder
Gouvea F, Lopes A, Greenberg B, Canteras M, Taub A, Mathis M, Miguel E. Response to Sham and Active Gamma Ventral Capsulotomy in Otherwise Intractable Obsessive-Compulsive Disorder. Stereotactic And Functional Neurosurgery 2010, 88: 177-182. PMID: 20431329, DOI: 10.1159/000313870.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHumansInternal CapsuleNeuropsychological TestsObsessive-Compulsive DisorderPlacebosRadiosurgeryTreatment OutcomeConceptsRefractory obsessive-compulsive disorderGamma ventral capsulotomyClinical responseSham surgeryObsessive-compulsive disorderSurgical techniquePsychopathological changesRadiosurgical proceduresRemarkable ameliorationActive interventionCompulsive disorderDisordersActive procedureCapsulotomySurgeryShamRadiosurgeryObsessive–compulsive disorder: a review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM‐V
Leckman JF, Denys D, Simpson HB, Mataix‐Cols D, Hollander E, Saxena S, Miguel EC, Rauch SL, Goodman WK, Phillips KA, Stein DJ. Obsessive–compulsive disorder: a review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM‐V. Depression And Anxiety 2010, 27: 507-527. PMID: 20217853, PMCID: PMC3974619, DOI: 10.1002/da.20669.Peer-Reviewed Original ResearchMeSH KeywordsBrainDiagnostic and Statistical Manual of Mental DisordersHumansNeuropsychological TestsObsessive-Compulsive DisorderSelective Serotonin Reuptake Inhibitors
2009
Neuropsychological Outcome of Ventral CapsularVentral Striatal Gamma Capsulotomy for Refractory Obsessive-Compulsive Disorder: A Pilot Study
Taub A, Lopes A, Fuentes D, D'Alcante C, de Mathis M, Canteras M, Siviero M, Greenberg B, Norén G, Batistuzzo M, Hoexter M, Cecílio S, Savage C, Rasmussen S, Miguel E. Neuropsychological Outcome of Ventral CapsularVentral Striatal Gamma Capsulotomy for Refractory Obsessive-Compulsive Disorder: A Pilot Study. Journal Of Neuropsychiatry 2009, 21: 393-397. PMID: 19996247, DOI: 10.1176/jnp.2009.21.4.393.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderObsessive-compulsive patientsProfound cognitive deficitsAbstract reasoningNeuropsychological batteryRefractory obsessive-compulsive disorderCognitive deficitsNeuropsychological outcomesGamma knife capsulotomyMemoryVocabularyPilot studyDeficitsReasoningLearningDisordersAttentionBatteries
1996
Recall and recognition memory in obsessive-compulsive disorder
Savage C, Keuthen N, Jenike M, Brown H, Baer L, Kendrick A, Miguel E, Rauch S, Albert M. Recall and recognition memory in obsessive-compulsive disorder. Journal Of Neuropsychiatry 1996, 8: 99-103. PMID: 8845711, DOI: 10.1176/jnp.8.1.99.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitionFemaleHumansMaleMental RecallNeuropsychological TestsObsessive-Compulsive DisorderPsychiatric Status Rating ScalesVerbal Behavior