2021
Efficacy and safety of transcranial direct current stimulation as an add-on treatment for obsessive-compulsive disorder: a randomized, sham-controlled trial
Silva R, Brunoni A, Goerigk S, Batistuzzo M, Costa D, Diniz J, Padberg F, D’Urso G, Miguel E, Shavitt R. Efficacy and safety of transcranial direct current stimulation as an add-on treatment for obsessive-compulsive disorder: a randomized, sham-controlled trial. Neuropsychopharmacology 2021, 46: 1028-1034. PMID: 33452434, PMCID: PMC8115679, DOI: 10.1038/s41386-020-00928-w.Peer-Reviewed Original ResearchConceptsTreatment-resistant obsessive-compulsive disorderTranscranial direct current stimulationSupplementary motor areaBaseline Y-BOCS scoresActive transcranial direct current stimulationObsessive-compulsive disorderY-BOCS scoresDirect current stimulationAdverse eventsWeek 12Efficacy of tDCSCurrent stimulationCathodal transcranial direct current stimulationSham-controlled trialMild adverse eventsClinical Global ImpressionSham-controlled studyBetween-group differencesSymptoms of depressionSecondary outcomesPrimary outcomeImprovement subscaleGlobal ImpressionNeuromodulation therapiesTreatment resistance
2015
Transcranial direct current stimulation in obsessive–compulsive disorder: emerging clinical evidence and considerations for optimal montage of electrodes
Senço N, Huang Y, D’Urso G, Parra L, Bikson M, Mantovani A, Shavitt R, Hoexter M, Miguel E, Brunoni A. Transcranial direct current stimulation in obsessive–compulsive disorder: emerging clinical evidence and considerations for optimal montage of electrodes. Expert Review Of Medical Devices 2015, 12: 381-391. PMID: 25982412, PMCID: PMC5777161, DOI: 10.1586/17434440.2015.1037832.Peer-Reviewed Original ResearchConceptsTranscranial direct current stimulationDirect current stimulationSystematic reviewCurrent stimulationPotential new treatmentPre-supplementary motor areaPubMed/MEDLINEObsessive-compulsive disorder (OCD) treatmentDeep brain stimulation trialsClinical evidenceObsessive-compulsive disorderStimulation trialsDBS trialsMotor areaRTMS targetsMagnetic stimulationEligibility criteriaNeuromodulation techniquesStimulation targetsDisorder treatmentNew treatmentsBrain circuitsDifferent electrode montagesTDCS montageTrials