2019
Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium
Kong XZ, Boedhoe PSW, Abe Y, Alonso P, Ameis SH, Arnold PD, Assogna F, Baker JT, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Brennan BP, Buitelaar J, Calvo R, Cheng Y, Cho KIK, Dallaspezia S, Denys D, Ely BA, Feusner J, Fitzgerald KD, Fouche JP, Fridgeirsson EA, Glahn DC, Gruner P, Gürsel DA, Hauser TU, Hirano Y, Hoexter MQ, Hu H, Huyser C, James A, Jaspers-Fayer F, Kathmann N, Kaufmann C, Koch K, Kuno M, Kvale G, Kwon JS, Lazaro L, Liu Y, Lochner C, Marques P, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Medland SE, Menchón JM, Minuzzi L, Moreira PS, Morer A, Morgado P, Nakagawa A, Nakamae T, Nakao T, Narayanaswamy JC, Nurmi EL, O'Neill J, Pariente JC, Perriello C, Piacentini J, Piras F, Piras F, Pittenger C, Reddy YCJ, Rus-Oswald OG, Sakai Y, Sato JR, Schmaal L, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Tolin DF, Tsuchiyagaito A, van Rooij D, van Wingen GA, Venkatasubramanian G, Wang Z, Yun JY, Group E, Kong X, Boedhoe P, Abe Y, Alonso P, Ameis S, Anticevic A, Arnold P, Assogna F, Baker J, Banaj N, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Bollettini I, Bose A, Brandeis D, Brem S, Brennan B, Buitelaar J, Busatto G, Calvo A, Calvo R, Cheng Y, Cho K, Ciullo V, Dallaspezia S, Denys D, de Vries F, de Wit S, Dickie E, Drechsler R, Ely B, Esteves M, Falini A, Fang Y, Feusner J, Figee M, Fitzgerald K, Fontaine M, Fouche J, Fridgeirsson E, Gruner P, Gürsel D, Hall G, Hamatani S, Hanna G, Hansen B, Hauser T, Hirano Y, Hoexter M, Hu H, Huyser C, Ikari K, Jahanshad N, James A, Jaspers-Fayer F, Kathmann N, Kaufmann C, Koch K, Kuno M, Kvale G, Kwon J, Lazaro L, Liu Y, Lochner C, Magalhães R, Marques P, Marsh R, Martínez-Zalacaín I, Masuda Y, Mataix-Cols D, Matsumoto K, McCracken J, Menchón J, Miguel E, Minuzzi L, Moreira P, Morer A, Morgado P, Nakagawa A, Nakamae T, Nakao T, Narayanaswamy J, Narumoto J, Nishida S, Nurmi E, O'Neill J, Pariente J, Perriello C, Piacentini J, Piras F, Piras F, Pittenger C, Poletti S, Reddy Y, Reess T, Rus-Oswald O, Sakai Y, Sato J, Schmaal L, Shimizu E, Simpson H, Soreni N, Soriano-Mas C, Sousa N, Spalletta G, Stern E, Stevens M, Stewart S, Szeszko P, Takahashi J, Tang J, Thorsen A, Tolin D, Tsuchiyagaito A, van Rooij D, van Wingen G, van der Werf Y, Veltman D, Vecchio D, Venkatasubramanian G, Walitza S, Wang Z, Watanabe A, Xu J, Xu X, Yamada K, Yoshida T, Yun J, Zarei M, Zhao Q, Zhou C, Thompson P, Stein D, van den Heuvel O, Francks C, Thompson P, Stein D, van den Heuvel O, Francks C. Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium. Biological Psychiatry 2019, 87: 1022-1034. PMID: 31178097, PMCID: PMC7094802, DOI: 10.1016/j.biopsych.2019.04.022.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingChildHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingObsessive-Compulsive DisorderThalamusConceptsObsessive-compulsive disorderCase-control differencesBrain structural asymmetryMedication statusSubcortical structuresENIGMA consortiumSignificant case-control differencesRegional cortical thicknessPediatric obsessive-compulsive disorderPediatric datasetSubcortical asymmetriesDepression comorbidityCortical thicknessPotential associationLarger studyNeurodevelopmental processesVolume asymmetryBrain asymmetryAbnormal patternsDisordersPossible alterationsPutative linkOCD severityAsymmetry patternsMagnetic resonance
2017
Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample
Pan P, Sato J, Salum G, Rohde L, Gadelha A, Zugman A, Mari J, Jackowski A, Picon F, Miguel E, Pine D, Leibenluft E, Bressan R, Stringaris A. Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample. American Journal Of Psychiatry 2017, 174: 1112-1119. PMID: 28946760, PMCID: PMC10752293, DOI: 10.1176/appi.ajp.2017.17040430.Peer-Reviewed Original ResearchConceptsResting-state functional MRIIntrinsic functional connectivityDepressive disorderFunctional connectivityFunctional MRIReward networkFuture depressive disorderAdolescent depressive disordersLeft ventral striatumOnset of depressionBrain reward networksAberrant reward processingAttention deficit hyperactivity disorderDeficit hyperactivity disorderLongitudinal communityChildren 6Ventral striatumAdolescent depressionLogistic regressionHyperactivity disorderSubstance useYouth depressionDisordersDepressionFuture risk
2015
Temporal stability of network centrality in control and default mode networks: Specific associations with externalizing psychopathology in children and adolescents
Sato J, Biazoli C, Salum G, Gadelha A, Crossley N, Satterthwaite T, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Anés M, Moura L, Del'aquilla M, Amaro E, McGuire P, Lacerda A, Rohde L, Miguel E, Jackowski A, Bressan R. Temporal stability of network centrality in control and default mode networks: Specific associations with externalizing psychopathology in children and adolescents. Human Brain Mapping 2015, 36: 4926-4937. PMID: 26350757, PMCID: PMC6868942, DOI: 10.1002/hbm.22985.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAntisocial Personality DisorderBrainBrain MappingChildCohort StudiesFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeural Networks, ComputerNeural PathwaysConceptsDefault mode networkChild Behavior ChecklistDynamic functional connectivity patternsHigh Risk Cohort StudyBehavior ChecklistAbnormal connectivity patternsFunctional connectivity patternsResting-state fMRIPathological mental statesCohort studyConnectivity patternsPsychiatric disordersFunctional network dynamicsGeneral psychopathologyTotal scoreMode networkNetwork maturationBrain networksMaturation indexEmotional problemsChildrenAge effectsOverall presenceSpecific associationAdolescents
2014
Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study
Sato J, Salum G, Gadelha A, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Anés M, Moura L, Del’Aquilla M, Crossley N, Amaro E, Mcguire P, Lacerda A, Rohde L, Miguel E, Jackowski A, Bressan R. Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study. NeuroImage 2014, 104: 44-51. PMID: 25290886, DOI: 10.1016/j.neuroimage.2014.09.063.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAgingBrain MappingCerebral CortexChildChild DevelopmentFemaleFunctional LateralityHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysSocial ClassConceptsAngular gyrusDevelopmental trajectoriesFunctional magnetic resonance imaging (fMRI) dataBrain developmental trajectoriesBrazilian community sampleBrain maturation processesFunctional connectivity studiesNetwork connectivity changesStructural imaging findingsInhibitory controlSensitive development periodCommunity sampleEmotional changesAbstract thoughtMagnetic resonance imaging dataComplex reasoningFMRI dataCerebellar regionsDevelopmental changesBrain regionsCortical regionsConnectivity changesConnectivity studiesSubcortical regionsAdolescenceAge effects on the default mode and control networks in typically developing children
Sato J, Salum G, Gadelha A, Picon F, Pan P, Vieira G, Zugman A, Hoexter M, Anés M, Moura L, Del'Aquilla M, Amaro E, McGuire P, Crossley N, Lacerda A, Rohde L, Miguel E, Bressan R, Jackowski A. Age effects on the default mode and control networks in typically developing children. Journal Of Psychiatric Research 2014, 58: 89-95. PMID: 25085608, DOI: 10.1016/j.jpsychires.2014.07.004.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAgingBrainBrain MappingChildChild DevelopmentCohort StudiesFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysRestConceptsDefault mode networkMode networkYears of ageCross-sectional community sampleRight anterior insulaDefault modePosterior temporal cortexDorsal anteriorAge effectsNeurodevelopment studiesHealthy subjectsTemporal cortexPosterior cingulateState fMRI dataAnterior insulaBrain developmentSame acquisition parametersLeft posterior temporal cortexNeuronal modulesState fMRILate childhoodDevelopmental formationBrain networksCommunity sampleField of neuroimaging
2011
Gray Matter Volumes in Obsessive-Compulsive Disorder Before and After Fluoxetine or Cognitive-Behavior Therapy: A Randomized Clinical Trial
Hoexter M, de Souza Duran F, D'Alcante C, Dougherty D, Shavitt R, Lopes A, Diniz J, Deckersbach T, Batistuzzo M, Bressan R, Miguel E, Busatto G. Gray Matter Volumes in Obsessive-Compulsive Disorder Before and After Fluoxetine or Cognitive-Behavior Therapy: A Randomized Clinical Trial. Neuropsychopharmacology 2011, 37: 734-745. PMID: 22030709, PMCID: PMC3260985, DOI: 10.1038/npp.2011.250.Peer-Reviewed Original ResearchConceptsCognitive behavior therapyObsessive-compulsive disorderGray matter volumeLeft putamenClinical trialsOCD patientsGM volumeMatter volumeSignificant GM volume changesPathophysiology of OCDFluoxetine-treated patientsGM volume abnormalitiesMatched-healthy controlsTreatment-naive patientsFirst-line treatmentStructural brain abnormalitiesGM volume changesCBT-treated patientsGroup cognitive behavior therapySmaller GM volumeRegional brain volumesRegional brain morphologyAnterior cingulate cortexStructural magnetic resonanceRegional gray matter volume
2009
Treatment of Resistant Obsessive-Compulsive Disorder With Ventral CapsularVentral Striatal Gamma Capsulotomy: A Pilot Prospective Study
Lopes A, Greenberg B, Norén G, Canteras M, Busatto G, de Mathis M, Taub A, D'Alcante C, Hoexter M, Gouvea F, Cecconi J, Gentil A, Ferrão Y, Fuentes D, de Castro C, Leite C, Salvajoli J, Duran F, Rasmussen S, Miguel E. Treatment of Resistant Obsessive-Compulsive Disorder With Ventral CapsularVentral Striatal Gamma Capsulotomy: A Pilot Prospective Study. Journal Of Neuropsychiatry 2009, 21: 381-392. PMID: 19996246, DOI: 10.1176/jnp.2009.21.4.381.Peer-Reviewed Original ResearchConceptsResistant obsessive-compulsive disorderRefractory OCD patientsAdverse effectsPilot prospective studyObsessive-compulsive disorder patientsAdverse eventsProspective studyObsessive-compulsive disorderStereotactic radiosurgeryDepressive symptomsDisorder patientsSide effectsConventional treatmentCapsulotomyTherapeutic promisePatientsOCD patientsTreatmentSurgeryRadiosurgerySymptomsMonths
2005
Regional Gray Matter Abnormalities in Obsessive-Compulsive Disorder: A Voxel-Based Morphometry Study
Valente A, Miguel E, Castro C, Amaro E, Duran F, Buchpiguel C, Chitnis X, McGuire P, Busatto G. Regional Gray Matter Abnormalities in Obsessive-Compulsive Disorder: A Voxel-Based Morphometry Study. Biological Psychiatry 2005, 58: 479-487. PMID: 15978549, DOI: 10.1016/j.biopsych.2005.04.021.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedObsessive-Compulsive DisorderStatistics as TopicConceptsVoxel-based morphometryObsessive-compulsive disorderGray matterLeft anterior cingulate cortexOCD patientsOCD subjectsParietal associative cortexMagnetic resonance imaging studyStructural magnetic resonance imaging (MRI) studiesRegional gray matter abnormalitiesGray matter reductionsGray matter abnormalitiesResonance imaging studyGray matter volumeAnterior cingulate cortexWarrants further investigationTemporolimbic regionsMedial thalamusBrain abnormalitiesObsessive-compulsive symptom severityHealthy volunteersImplicating dysfunctionMatter volumeAssociative cortexMorphometry study