2019
Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence?
de Araujo C, Swardfager W, Zugman A, Cogo-Moreira H, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, Mansur R, Hoexter M, Picon F, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence? CNS Spectrums 2019, 25: 790-796. PMID: 31845634, DOI: 10.1017/s1092852919001688.Peer-Reviewed Original ResearchConceptsSerum BDNF concentrationsBrain-derived neurotrophic factorBDNF concentrationsBDNF genotypeCortical thicknessPsychiatric disordersSerum brain-derived neurotrophic factor (BDNF) concentrationsBrain-derived neurotrophic factor concentrationSubcortical volumesMental disordersWell-Being Behavior AssessmentBrain structuresBDNF serum concentrationsNeurotrophic factor concentrationsPeripheral blood concentrationsHigh Risk Cohort StudyLate childhoodAdult psychiatric disordersLarge independent samplesCohort studyNeurotrophic factorCortical maturationSerum concentrationsBlood concentrationsMet carriers
2015
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study
Sampaio A, Hounie A, Petribú K, Cappi C, Morais I, Vallada H, do Rosário M, Stewart S, Fargeness J, Mathews C, Arnold P, Hanna G, Richter M, Kennedy J, Fontenelle L, de Bragança Pereira C, Pauls D, Miguel E. COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study. PLOS ONE 2015, 10: e0119592. PMID: 25793616, PMCID: PMC4368617, DOI: 10.1371/journal.pone.0119592.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesCatechol O-MethyltransferaseChildEpistasis, GeneticFamilyFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHaplotypesHumansLinkage DisequilibriumMaleMonoamine OxidaseObsessive-Compulsive DisorderPhenotypePolymorphism, Single NucleotideYoung AdultConceptsAssociation studiesBroad spectrum phenotypesTransmission disequilibrium analysisSingle geneSingle nucleotide polymorphismsGenetic association studiesGene-gene interactionsGenesClassical case-control designDisequilibrium analysisGenetic componentAssociation investigationsEpistatic influencesPhenotypePolymorphismSpectrum phenotypeEpistasisOCD susceptibilityAlternative strategyRoleNarrow phenotype
2011
Association study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment
Miguita K, Cordeiro Q, Shavitt R, Miguel E, Vallada H. Association study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment. Arquivos De Neuro-Psiquiatria 2011, 69: 283-287. PMID: 21625751, DOI: 10.1590/s0004-282x2011000300003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive Agents, TricyclicClomipramineDopamine Plasma Membrane Transport ProteinsFemaleGene FrequencyGenotypeHumansMaleMutationNorepinephrine Plasma Membrane Transport ProteinsObsessive-Compulsive DisorderPolymorphism, GeneticReceptors, SerotoninSerotonin Plasma Membrane Transport ProteinsYoung Adult
2008
TNF-alpha polymorphisms are associated with obsessive-compulsive disorder
Hounie A, Cappi C, Cordeiro Q, Sampaio A, Moraes I, do Rosário M, Palácios S, Goldberg A, Vallada H, Machado-Lima A, Nakano E, Kalil J, Pauls D, Pereira C, Guilherme L, Miguel E. TNF-alpha polymorphisms are associated with obsessive-compulsive disorder. Neuroscience Letters 2008, 442: 86-90. PMID: 18639610, DOI: 10.1016/j.neulet.2008.07.022.Peer-Reviewed Original Research
2007
Association analysis between a VNTR intron 8 polymorphism of the dopamine transporter gene (SLC6A3) and obsessive- compulsive disorder in a Brazilian sample
Miguita K, Cordeiro Q, Siqueira-Roberto J, Shavitt R, Castillo J, Castillo A, Miguel E, Vallada H. Association analysis between a VNTR intron 8 polymorphism of the dopamine transporter gene (SLC6A3) and obsessive- compulsive disorder in a Brazilian sample. Arquivos De Neuro-Psiquiatria 2007, 65: 936-941. PMID: 18094849, DOI: 10.1590/s0004-282x2007000600002.Peer-Reviewed Original Research
2006
Association study between the 1287 A/G exonic polymorphism of the norepinephrine transporter (NET) gene and obsessive-compulsive disorder in a Brazilian sample
Miguita K, Cordeiro Q, Shavitt R, Miguel E, Vallada H. Association study between the 1287 A/G exonic polymorphism of the norepinephrine transporter (NET) gene and obsessive-compulsive disorder in a Brazilian sample. Brazilian Journal Of Psychiatry 2006, 28: 158-159. PMID: 16810402, DOI: 10.1590/s1516-44462006000200017.Peer-Reviewed Original Research