2022
Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder
Bertolín S, Alonso P, Martínez-Zalacaín I, Menchón J, Jimenez-Murcia S, Baker J, Bargalló N, Batistuzzo M, Boedhoe P, Brennan B, Feusner J, Fitzgerald K, Fontaine M, Hansen B, Hirano Y, Hoexter M, Huyser C, Jahanshad N, Jaspers-Fayer F, Kuno M, Kvale G, Lazaro L, Machado-Sousa M, Marsh R, Morgado P, Nakagawa A, Norman L, Nurmi E, O’Neill J, Ortiz A, Perriello C, Piacentini J, Picó-Pérez M, Shavitt R, Shimizu E, Simpson H, Stewart S, Thomopoulos S, Thorsen A, Walitza S, Wolters L, Group E, Real E, Segalas C, Morer A, Brem S, Ferreira S, Moreira P, Hagen K, Hamatani S, Takahashi J, Yoshida T, de Mathis M, Miguel E, Pariente J, Tang J, Thompson P, van den Heuvel O, Stein D, Soriano-Mas C. Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 62: 403-414. PMID: 36526161, PMCID: PMC10065927, DOI: 10.1016/j.jaac.2022.07.865.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyObsessive-compulsive disorderCBT responseCortical thicknessMagnetic Resonance Imaging PredictorsBaseline cortical thicknessPrefrontal cortex thicknessFirst-line treatmentRostral middle frontal gyrusPrefrontal cortical thicknessIdentification of predictorsHigher cortical thicknessMiddle frontal gyrusRight prefrontal cortexCortical surface areaMechanism of actionAdult patientsImaging predictorsPrefrontal cortex regionsClinical managementLarge seriesSubcortical volumesAdult populationFrontal polePrefrontal cortex
2020
Delayed Brain Cyst Formation After Gamma Knife Anterior Capsulotomy
Kasabkojian S, Dwan A, Maziero M, de Salles A, Gorgulho A, Miguel E, Fillipo de Queiroz Vattimo E, Lopes A. Delayed Brain Cyst Formation After Gamma Knife Anterior Capsulotomy. World Neurosurgery 2020, 145: 298-300. PMID: 33022431, DOI: 10.1016/j.wneu.2020.07.199.Peer-Reviewed Original ResearchConceptsRefractory obsessive-compulsive disorderAnterior capsulotomyObsessive-compulsive disorderBrain cyst formationFrontal lobe symptomsMagnetic resonance imagingAnterior frontal regionsPostoperative monthBrain cystsBrain edemaManic episodesVisual hallucinationsRadiosurgical proceduresAbnormal complicationsHigh dosesCapsulotomyResonance imagingObsessive-compulsive symptomsCyst formationEffective optionLeft hemisphereRight hemisphereFrontal regionsComplicationsSymptoms
2017
Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group
Boedhoe PSW, Schmaal L, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Calvo R, Cheng Y, Cho KIK, Ciullo V, Dallaspezia S, Denys D, Feusner JD, Fitzgerald KD, Fouche JP, Fridgeirsson EA, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Jahanshad N, James A, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Morer A, Nakamae T, Nakao T, Narayanaswamy JC, Nishida S, Nurmi E, O’Neill J, Piacentini J, Piras F, Piras F, Reddy YCJ, Reess TJ, Sakai Y, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, van Wingen GA, Venkatasubramanian G, Walitza S, Wang Z, Yun JY, Thompson P, Stein D, van den Heuvel O, Boedhoe P, Schmaal L, Abe Y, Alonso P, Ameis S, Anticevic A, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Bollettini I, Bose A, Brandeis D, Brem S, Buimer E, Busatto G, Calvo A, Calvo R, Cheng Y, Cho K, Ciullo V, Dallaspezia S, de Vries F, de Wit S, Denys D, Drechsler R, Falini A, Fang Y, Feusner J, Figee M, Fitzgerald K, Fontaine M, Fouche J, Fridgeirsson E, Gruner P, Hanna G, Hauser T, Hibar D, Hoexter M, Hu H, Huyser C, Iorio M, Jahanshad N, James A, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, McCracken J, Menchón J, Miguel E, Minuzzi L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Narumoto J, Nishida S, Nurmi E, O’Neill J, Pariente J, Piacentini J, Pittenger C, Piras F, Piras F, Poletti S, Reddy Y, Reess T, Rus O, Sakai Y, Sato J, Simpson H, Soreni N, Soriano-Mas C, Spalletta G, Stevens M, Szeszko P, Tang J, Tolin D, van der Werf Y, van Wingen G, Vecchio D, Veltman D, Venkatasubramanian G, Walitza S, Wang Z, Watanabe A, Xu J, Xu X, Yamada K, Yun J, Zarei M, Zhao Q, Thompson P, Stein D, van den Heuvel O. Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group. American Journal Of Psychiatry 2017, 175: 453-462. PMID: 29377733, PMCID: PMC7106947, DOI: 10.1176/appi.ajp.2017.17050485.Peer-Reviewed Original ResearchConceptsPediatric OCD patientsAdult OCD patientsOCD patientsParietal cortexAdult obsessive-compulsive disorderCortical thickness abnormalitiesD effectsInferior parietal cortexSuperior parietal cortexLimited statistical powerTransverse temporal cortexCohen's d effectClinical characteristicsCortical abnormalitiesObsessive-compulsive disorderThickness abnormalitiesHealthy controlsCortical thicknessPatientsTemporal cortexThinner cortexMRI scansClinical heterogeneityStructural abnormalitiesDisease profile
2012
Genome-wide association study of obsessive-compulsive disorder
Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund C, Rauch S, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe H, Lennertz L, Wagner M, Bellodi L, Cavallini M, Richter M, Cook E, Kennedy J, Rosenberg D, Stein D, Hemmings S, Lochner C, Azzam A, Chavira D, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy D, Wendland J, Veenstra-VanderWeele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg H, Walitza S, Egberts K, Renner T, Miguel E, Cappi C, Hounie A, Conceição do Rosário M, Sampaio A, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato C, Pato M, Voyiaziakis E, Heutink P, Cath D, Posthuma D, Smit J, Samuels J, Bienvenu O, Cullen B, Fyer A, Grados M, Greenberg B, McCracken J, Riddle M, Wang Y, Coric V, Leckman J, Bloch M, Pittenger C, Eapen V, Black D, Ophoff R, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs J, Cookson M, Singleton A, Hardy J, Crenshaw A, Parkin M, Mirel D, Conti D, Purcell S, Nestadt G, Hanna G, Jenike M, Knowles J, Cox N, Pauls D. Genome-wide association study of obsessive-compulsive disorder. Molecular Psychiatry 2012, 18: 788-798. PMID: 22889921, PMCID: PMC4218751, DOI: 10.1038/mp.2012.85.Peer-Reviewed Original ResearchConceptsExpression quantitative trait lociSingle nucleotide polymorphismsGenome-wide significant levelGenome-wide significance thresholdX-chromosome single nucleotide polymorphismsGenome-wide association studiesTrio-based analysisQuantitative trait lociAncestry-matched controlsComplex genetic etiologyTrait lociCase-control association analysisMethylation QTLsGenetic variationGene expressionAssociation studiesTop signalsAssociation analysisBroader roleSignificant enrichmentSNP microarraysCase-control sampleNucleotide polymorphismsGenetic etiologySignificance threshold