2018
Adaptive treatment strategies for children and adolescents with Obsessive-Compulsive Disorder: A sequential multiple assignment randomized trial
Fatori D, de Bragança Pereira CA, Asbahr FR, Requena G, Alvarenga PG, de Mathis MA, Rohde LA, Leckman JF, March JS, Polanczyk GV, Miguel EC, Shavitt RG. Adaptive treatment strategies for children and adolescents with Obsessive-Compulsive Disorder: A sequential multiple assignment randomized trial. Journal Of Anxiety Disorders 2018, 58: 42-50. PMID: 30025255, DOI: 10.1016/j.janxdis.2018.07.002.Peer-Reviewed Original ResearchConceptsGroup cognitive behavioral therapySequential multiple assignmentTreatment failureInitial treatmentBaseline Yale-Brown ObsessiveChildhood OCDEffective initial treatmentProvision of treatmentCompulsive Scale scoresCognitive behavioral therapyAdaptive treatment strategiesYale-Brown ObsessiveSame regimenObsessive-compulsive disorderTreatment strategiesSymptom reductionPrimary analysisScale scoreFluoxetineTime pointsWeeksTreatmentChildrenEffect sizeTrials
2013
The impact of comorbid body dysmorphic disorder on the response to sequential pharmacological trials for obsessive-compulsive disorder
Diniz J, Costa D, Cassab R, Pereira C, Miguel E, Shavitt R. The impact of comorbid body dysmorphic disorder on the response to sequential pharmacological trials for obsessive-compulsive disorder. Journal Of Psychopharmacology 2013, 28: 603-611. PMID: 24288238, DOI: 10.1177/0269881113512042.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive Agents, Second-GenerationAntidepressive Agents, TricyclicAntipsychotic AgentsBody Dysmorphic DisordersBrazilClomipramineComorbidityDrug Therapy, CombinationFemaleFluoxetineHumansMaleObsessive-Compulsive DisorderProspective StudiesQuetiapine FumarateRisk FactorsTreatment OutcomeConceptsBody dysmorphic disorderComorbid body dysmorphic disorderPharmacological trialsDysmorphic disorderAdult obsessive-compulsive disorder (OCD) patientsSequential treatment strategyObsessive-compulsive disorder patientsSequential treatmentFluoxetine monotherapyClinical characteristicsObsessive-compulsive disorderInitial severityTreatment strategiesDisorder patientsTreatment groupsPatientsWorse responseBDD patientsEffects of sexGEE modelTrialsDisordersSequential trialsWeeksType of augmentationCan early improvement be an indicator of treatment response in obsessive-compulsive disorder? Implications for early-treatment decision-making
da Conceição Costa D, Shavitt R, Cesar R, Joaquim M, Borcato S, Valério C, Miguel E, Diniz J. Can early improvement be an indicator of treatment response in obsessive-compulsive disorder? Implications for early-treatment decision-making. Journal Of Psychiatric Research 2013, 47: 1700-1707. PMID: 23948637, DOI: 10.1016/j.jpsychires.2013.07.006.Peer-Reviewed Original ResearchConceptsBaseline Y-BOCS scoresSerotonin reuptake inhibitorsEarly improvementTreatment responseY-BOCS scoresBaseline Yale-Brown ObsessiveLogistic regressionAdequate pharmacological treatmentPotential predictive factorsWeeks of treatmentGreater reductionObsessive-compulsive disorder patientsStepwise logistic regressionWarrants further investigationYale-Brown ObsessiveClinical featuresReuptake inhibitorsObsessive-compulsive disorderPharmacological treatmentPredictive factorsMajor depressionDisorder patientsOCD treatment responseCompulsive ScaleWeeks
2012
CLINICAL PREDICTORS OF LONG‐TERM OUTCOME IN OBSESSIVE‐COMPULSIVE DISORDER
Jakubovski E, Diniz J, Valerio C, Fossaluza V, Belotto‐Silva C, Gorenstein C, Miguel E, Shavitt R. CLINICAL PREDICTORS OF LONG‐TERM OUTCOME IN OBSESSIVE‐COMPULSIVE DISORDER. Depression And Anxiety 2012, 30: 763-772. PMID: 23109056, DOI: 10.1002/da.22013.Peer-Reviewed Original ResearchConceptsLong-term outcomesObsessive-compulsive disorderPositive family historyGroup cognitive behavioral therapyDepressive disorderFamily historyOCD patientsOnset of OCDInitial treatment modalityComorbid psychiatric disordersPercent of subjectsBeck depression scoresDuration of OCDCognitive behavioral therapyYale-Brown ObsessiveUntreated patientsClinical factorsClinical predictorsInitial treatmentOpen trialWorse prognosisClinical variablesPharmacological treatmentPsychiatric comorbidityTreatment modalitiesDifferential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive–compulsive disorder
Hoexter M, Dougherty D, Shavitt R, D'Alcante C, Duran F, Lopes A, Diniz J, Batistuzzo M, Evans K, Bressan R, Busatto G, Miguel E. Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive–compulsive disorder. European Neuropsychopharmacology 2012, 23: 569-580. PMID: 22841131, DOI: 10.1016/j.euroneuro.2012.06.014.Peer-Reviewed Original ResearchConceptsGray matter volumeMedial prefrontal cortexCognitive behavioral therapyObsessive-compulsive disorderTreatment responseTreatment-naïve OCD patientsTreatment groupsMagnetic resonance imagingMatter volumeOrbitofrontal cortexLateral orbitofrontal cortexSymptom improvementOCD patientsFluoxetine treatment groupTrial of fluoxetineSerotonin reuptake inhibitorsAdequate therapeutic approachStructural magnetic resonance imagingCBT treatment groupRight medial prefrontal cortexGroup-based cognitive behavioral therapyRegional gray matter volumeStructural MRI scansDistinct brain regionsYale-Brown ObsessiveNeuropsychological predictors of response to randomized treatment in obsessive–compulsive disorder
D'Alcante C, Diniz J, Fossaluza V, Batistuzzo M, Lopes A, Shavitt R, Deckersbach T, Malloy-Diniz L, Miguel E, Hoexter M. Neuropsychological predictors of response to randomized treatment in obsessive–compulsive disorder. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2012, 39: 310-317. PMID: 22789662, DOI: 10.1016/j.pnpbp.2012.07.002.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyObsessive-compulsive disorderCalifornia Verbal Learning TestVictoria Stroop TestVerbal Learning TestNeuropsychological measuresOCD patientsMental flexibilityVerbal memoryNeuropsychological predictorsLearning TestHigher verbal IQDifferent neuropsychological profilesUnderwent neuropsychological assessmentExecutive functioningExecutive abilitiesVerbal IQStroop testNeuropsychological profileNeuropsychological assessmentIntellectual functionHeuristic valueLarge sampleMemoryTreatment response
2011
A Double-Blind, Randomized, Controlled Trial of Fluoxetine Plus Quetiapine or Clomipramine Versus Fluoxetine Plus Placebo for Obsessive-Compulsive Disorder
Diniz J, Shavitt R, Fossaluza V, Koran L, de Bragança Pereira C, Miguel E. A Double-Blind, Randomized, Controlled Trial of Fluoxetine Plus Quetiapine or Clomipramine Versus Fluoxetine Plus Placebo for Obsessive-Compulsive Disorder. Journal Of Clinical Psychopharmacology 2011, 31: 763-768. PMID: 22020357, DOI: 10.1097/jcp.0b013e3182367aee.Peer-Reviewed Original ResearchConceptsY-BOCS scoresFluoxetine groupTreatment regimenSelective serotonin reuptake inhibitorsPlacebo-controlled trialSevere adverse eventsSerotonin reuptake inhibitorsMain outcome measuresObsessive-compulsive disorder patientsCompulsive Scale scoresYale-Brown ObsessiveFluoxetine monotherapyAdverse eventsReuptake inhibitorsObsessive-compulsive disorderPrimary diagnosisOutcome measuresDisorder patientsScale scoreFluoxetineMental disordersQuetiapinePatientsStatistical ManualClomipramineGray Matter Volumes in Obsessive-Compulsive Disorder Before and After Fluoxetine or Cognitive-Behavior Therapy: A Randomized Clinical Trial
Hoexter M, de Souza Duran F, D'Alcante C, Dougherty D, Shavitt R, Lopes A, Diniz J, Deckersbach T, Batistuzzo M, Bressan R, Miguel E, Busatto G. Gray Matter Volumes in Obsessive-Compulsive Disorder Before and After Fluoxetine or Cognitive-Behavior Therapy: A Randomized Clinical Trial. Neuropsychopharmacology 2011, 37: 734-745. PMID: 22030709, PMCID: PMC3260985, DOI: 10.1038/npp.2011.250.Peer-Reviewed Original ResearchConceptsCognitive behavior therapyObsessive-compulsive disorderGray matter volumeLeft putamenClinical trialsOCD patientsGM volumeMatter volumeSignificant GM volume changesPathophysiology of OCDFluoxetine-treated patientsGM volume abnormalitiesMatched-healthy controlsTreatment-naive patientsFirst-line treatmentStructural brain abnormalitiesGM volume changesCBT-treated patientsGroup cognitive behavior therapySmaller GM volumeRegional brain volumesRegional brain morphologyAnterior cingulate cortexStructural magnetic resonanceRegional gray matter volumeGroup cognitive-behavioral therapy versus selective serotonin reuptake inhibitors for obsessive-compulsive disorder: A practical clinical trial
Belotto-Silva C, Diniz J, Malavazzi D, Valério C, Fossaluza V, Borcato S, Seixas A, Morelli D, Miguel E, Shavitt R. Group cognitive-behavioral therapy versus selective serotonin reuptake inhibitors for obsessive-compulsive disorder: A practical clinical trial. Journal Of Anxiety Disorders 2011, 26: 25-31. PMID: 21907540, DOI: 10.1016/j.janxdis.2011.08.008.Peer-Reviewed Original ResearchConceptsGroup cognitive behavioral therapyY-BOCS scoresPsychiatric comorbidityCognitive behavioral therapySSRI groupMean Y-BOCS scoreSelective serotonin reuptake inhibitorsBaseline Y-BOCS scoresY-BOCS reductionSerotonin reuptake inhibitorsMore psychiatric comorbiditiesPractical clinical trialsReal-world populationObsessive-compulsive disorder outpatientsBroad inclusion criteriaAdditional psychiatric comorbidityReuptake inhibitorsObsessive-compulsive disorderClinical effectivenessClinical trialsMajor depressionCGI ratingsInclusion criteriaComorbiditiesWorse response
2009
The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description
Hoexter M, Shavitt R, D'Alcante C, Cecconi J, Diniz J, Belotto-Silva C, Hounie A, Borcato S, Moraes I, Joaquim M, Cappi C, Sampaio A, de Mathis M, Batistuzzo M, Lopes A, Rosa A, Muniz R, Marques A, Santos L, Taub A, de Souza Duran F, Dougherty D, Busatto G, Bressan R, Miguel E. The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description. Brazilian Journal Of Psychiatry 2009, 31: 349-353. PMID: 20098825, DOI: 10.1590/s1516-44462009000400011.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorder patientsObsessive-compulsive disorderNeuropsychological evaluationClinical trialsGroup cognitive behavioral therapyDisorder patientsTRODAT-1 single photon emissionIntegrative neurobiological modelCognitive behavioral therapySelective serotonin reuptake inhibitorsAdult obsessive-compulsive disorder (OCD) patientsMagnetic resonance imagesDrug-naïve OCD patientsDrug-naïve patientsSerotonin reuptake inhibitorsSame research procedureNeurobiological modelsSingle photon emissionResonance imagesTreatment response studiesOCD patientsReuptake inhibitorsHealthy controlsBlood samplesPatients