2023
Brain activation during fear extinction recall in unmedicated patients with obsessive-compulsive disorder
Diniz J, Bazán P, Pereira C, Saraiva E, Ramos P, de Oliveira A, Reimer A, Hoexter M, Miguel E, Shavitt R, Batistuzzo M. Brain activation during fear extinction recall in unmedicated patients with obsessive-compulsive disorder. Psychiatry Research Neuroimaging 2023, 336: 111733. PMID: 37913655, DOI: 10.1016/j.pscychresns.2023.111733.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderExtinction recallNeutral stimuliFear conditioningFear extinction recallBlood oxygenation level-dependent (BOLD) responseFear conditioning experimentSkin conductance reactivitySpecific brain activation patternsBrain activation patternsSkin conductance responsesLevel-dependent responsesEntire sampleDACC activationUnmedicated adult patientsFear responsesBrain activationAversive stimuliLingual gyrusUnmedicated samplesActivation patternsHealthy participantsRecallOpercular cortexInsular cortex
2017
Fear extinction in an obsessive-compulsive disorder animal model: Influence of sex and estrous cycle
Reimer A, de Oliveira A, Diniz J, Hoexter M, Miguel E, Milad M, Brandão M. Fear extinction in an obsessive-compulsive disorder animal model: Influence of sex and estrous cycle. Neuropharmacology 2017, 131: 104-115. PMID: 29225044, DOI: 10.1016/j.neuropharm.2017.12.015.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderFear extinctionOCD patientsTreatment of OCDFear extinction retentionExtinction retention deficitsFear extinction trainingOCD pathophysiologyOCD-like symptomsAnterior cingulate cortexFear inhibitionExtinction retentionAccount sex differencesEstrous cycleExtinction trainingRetention deficitsRepetitive behaviorsDistinct neurotransmitter systemsMedial prefrontalUntreated OCD patientsCingulate cortexAnimal modelsSelf-grooming behaviorBrain areasEstrous cycle phaseSpecific and social fears in children and adolescents: separating normative fears from problem indicators and phobias
Laporte P, Pan P, Hoffmann M, Wakschlag L, Rohde L, Miguel E, Pine D, Manfro G, Salum G. Specific and social fears in children and adolescents: separating normative fears from problem indicators and phobias. Brazilian Journal Of Psychiatry 2017, 39: 118-125. PMID: 28300935, PMCID: PMC7111439, DOI: 10.1590/1516-4446-2016-2064.Peer-Reviewed Original Research
2014
Musical obsessions: A comprehensive review of neglected clinical phenomena
Taylor S, McKay D, Miguel E, De Mathis M, Andrade C, Ahuja N, Sookman D, Kwon J, Huh M, Riemann B, Cottraux J, O’Connor K, Hale L, Abramowitz J, Fontenelle L, Storch E. Musical obsessions: A comprehensive review of neglected clinical phenomena. Journal Of Anxiety Disorders 2014, 28: 580-589. PMID: 24997394, DOI: 10.1016/j.janxdis.2014.06.003.Peer-Reviewed Original ResearchAdolescentAdultAgedAged, 80 and overAntipsychotic AgentsAvoidance LearningChildCognitive Behavioral TherapyDiagnosis, DifferentialFearFemaleHallucinationsHumansImaginationMaleMiddle AgedModels, PsychologicalMusicObsessive BehaviorObsessive-Compulsive DisorderSelective Serotonin Reuptake InhibitorsYoung Adult
2012
Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety
Diniz J, Miguel E, de Oliveira A, Reimer A, Brandão M, de Mathis M, Batistuzzo M, Costa D, Hoexter M. Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety. Brazilian Journal Of Psychiatry 2012, 34: 81-91. PMID: 22729451, DOI: 10.1590/s1516-44462012000500007.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAnxiety disordersExpression of fearTypes of obsessionsAnimal anxiety modelsFear conditioningCortico-striatal pathwaysFunctional neuroimagingNeurobiological studiesAnxiety modelsOCD patientsOCD onsetExtinction processAnxietyRelevant dimensionsMost interventionsFearDisordersDegree of overlapTreatment responsePsychopathologyComprehensionNeurocircuitryFunctioningFuture studies