2018
Obsessive-compulsive symptoms in children with first degree relatives diagnosed with obsessive-compulsive disorder
Chacon P, Bernardes E, Faggian L, Batistuzzo M, Moriyama T, Miguel E, Polanczyk G. Obsessive-compulsive symptoms in children with first degree relatives diagnosed with obsessive-compulsive disorder. Brazilian Journal Of Psychiatry 2018, 40: 388-393. PMID: 29898190, PMCID: PMC6899383, DOI: 10.1590/1516-4446-2017-2321.Peer-Reviewed Original ResearchConceptsPresence of OCSObsessive-compulsive disorderFirst-degree relativesObsessive-compulsive symptomsSocioeconomic statusImportant risk factorLow socioeconomic statusFuture longitudinal studiesClinical correlatesAssessed childrenRisk factorsDegree relativesFamily historySymptomsContamination/Longitudinal studyOCD diagnosisDisordersChildrenHigh rateFamily membersChildhoodCorrelatesStatus
2016
Whole-exome sequencing in obsessive-compulsive disorder identifies rare mutations in immunological and neurodevelopmental pathways
Cappi C, Brentani H, Lima L, Sanders SJ, Zai G, Diniz BJ, Reis VN, Hounie AG, Conceição do Rosário M, Mariani D, Requena GL, Puga R, Souza-Duran FL, Shavitt RG, Pauls DL, Miguel EC, Fernandez TV. Whole-exome sequencing in obsessive-compulsive disorder identifies rare mutations in immunological and neurodevelopmental pathways. Translational Psychiatry 2016, 6: e764-e764. PMID: 27023170, PMCID: PMC4872454, DOI: 10.1038/tp.2016.30.Peer-Reviewed Original ResearchConceptsSingle nucleotide variantsPPI networkPathway analysisProtein-protein interaction networkGenome-wide association studiesNovo single nucleotide variantsParticular biological pathwaysRare genetic variationDisease gene prioritizationDirect molecular interactionWhole-exome sequencing studiesGene discoveryNetwork genesSpecific risk genesNetwork enrichmentGenetic variationInteraction networksGene prioritizationCandidate genesAssociation studiesBiological pathwaysSequencing platformsSequencing studiesWhole-exome sequencingGenes
2015
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study
Sampaio A, Hounie A, Petribú K, Cappi C, Morais I, Vallada H, do Rosário M, Stewart S, Fargeness J, Mathews C, Arnold P, Hanna G, Richter M, Kennedy J, Fontenelle L, de Bragança Pereira C, Pauls D, Miguel E. COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study. PLOS ONE 2015, 10: e0119592. PMID: 25793616, PMCID: PMC4368617, DOI: 10.1371/journal.pone.0119592.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesCatechol O-MethyltransferaseChildEpistasis, GeneticFamilyFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHaplotypesHumansLinkage DisequilibriumMaleMonoamine OxidaseObsessive-Compulsive DisorderPhenotypePolymorphism, Single NucleotideYoung AdultConceptsAssociation studiesBroad spectrum phenotypesTransmission disequilibrium analysisSingle geneSingle nucleotide polymorphismsGenetic association studiesGene-gene interactionsGenesClassical case-control designDisequilibrium analysisGenetic componentAssociation investigationsEpistatic influencesPhenotypePolymorphismSpectrum phenotypeEpistasisOCD susceptibilityAlternative strategyRoleNarrow phenotype
2014
High risk cohort study for psychiatric disorders in childhood: rationale, design, methods and preliminary results
Salum G, Gadelha A, Pan P, Moriyama T, Graeff‐Martins A, Tamanaha A, Alvarenga P, Krieger F, Fleitlich‐Bilyk B, Jackowski A, Sato J, Brietzke E, Polanczyk G, Brentani H, de Jesus Mari J, Do Rosário M, Manfro G, Bressan R, Mercadante M, Miguel E, Rohde L. High risk cohort study for psychiatric disorders in childhood: rationale, design, methods and preliminary results. International Journal Of Methods In Psychiatric Research 2014, 24: 58-73. PMID: 25469819, PMCID: PMC6878239, DOI: 10.1002/mpr.1459.Peer-Reviewed Original ResearchConceptsHigh Risk Cohort StudyMental disordersCohort studyPsychiatric disordersHigh-risk stratumChild mental disordersChildhood psychiatric disordersUseful clinical informationDiagnostic instrumentHigh riskClinical informationScreening instrumentFamily psychopathologyDisordersBaseline phaseScreening procedureChild psychiatryChildrenParticipation ratesPreliminary resultsPrevalenceStudyFamily rates
2009
Performance of patients with refractory obsessive–compulsive disorder in the Frontal Systems Behavior Scale
Batistuzzo M, Taub A, Nakano E, D'Alcante C, de Mathis M, Hoexter M, Miguel E, Lopes A. Performance of patients with refractory obsessive–compulsive disorder in the Frontal Systems Behavior Scale. Neurocase 2009, 15: 157-162. PMID: 19274575, DOI: 10.1080/13554790802709047.Peer-Reviewed Original Research
2008
Anxiety Disorders and Rheumatic Fever: Is There an Association?
Seixas A, Hounie A, Fossaluza V, Curi M, Alvarenga P, De Mathis M, De Mathis M, Vallada H, Pauls D, de Bragança Pereira C, Miguel E. Anxiety Disorders and Rheumatic Fever: Is There an Association? CNS Spectrums 2008, 13: 1039-1046. PMID: 19179939, DOI: 10.1017/s1092852900017090.Peer-Reviewed Original ResearchConceptsFirst-degree relativesRheumatic feverObsessive-compulsive spectrum disordersObsessive-compulsive disorderAnxiety disordersFamily membersCase-control family studyRates of disorderRelatives of individualsPoisson regression modelsRF patientsSydenham's choreaSeparation anxiety disorderPsychiatric interviewPossible familial relationshipControl probandsRelated disordersDisordersFamilial aggregationFurther studiesPatientsChoreaFeverOCD spectrumFamily studies
2006
Obsessive-Compulsive Spectrum Disorders and Rheumatic Fever: A Family Study
Hounie A, Pauls D, do Rosario-Campos M, Mercadante M, Diniz J, De Mathis M, De Mathis M, Chacon P, Shavitt R, Curi M, Guilherme L, Miguel E. Obsessive-Compulsive Spectrum Disorders and Rheumatic Fever: A Family Study. Biological Psychiatry 2006, 61: 266-272. PMID: 16616727, DOI: 10.1016/j.biopsych.2006.02.021.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBacterial ProteinsCase-Control StudiesChildData Interpretation, StatisticalFamilyFemaleHumansInterview, PsychologicalLogistic ModelsMaleObserver VariationObsessive-Compulsive DisorderOdds RatioPsychiatric Status Rating ScalesRheumatic FeverRiskStreptococcal InfectionsStreptolysinsConceptsFirst-degree relativesRheumatic feverObsessive-compulsive spectrum disordersSydenham's choreaFDRs of controlsStructured psychiatric interviewUnderlying etiologic mechanismsCase-control family studyFamily studiesControl first-degree relativesBest-estimate diagnosesHigh rateRF patientsCompulsive spectrum disordersOdds ratioMorbid riskEtiologic mechanismsPsychiatric interviewSpectrum disorderLogistic regressionProbandsFeverPatientsChoreaDiagnosis