2023
Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers
Damiano R, de Almeida Rocca C, de Pádua Serafim A, Loftis J, Talib L, Pan P, Cunha-Neto E, Kalil J, de Castro G, Seelaender M, Guedes B, Marie S, de Souza H, Nitrini R, Miguel E, Busatto G, Forlenza O, Group H, Utiyama E, Segurado A, Perondi B, Miethke-Morais A, Montal A, Harima L, Fusco S, Silva M, Rocha M, Marcilio I, Rios I, Kawano F, de Jesus M, Kallas É, Carmo C, Tanaka C, Marchini J, Carvalho C, Ferreira J, Levin A, Oliveira M, Guimarães T, dos Santos Lázari C, da Silva Duarte A, Sabino E, Magri M, Barros-Filho T, Francisco M. Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers. Frontiers In Immunology 2023, 14: 1174020. PMID: 37287969, PMCID: PMC10242059, DOI: 10.3389/fimmu.2023.1174020.Peer-Reviewed Original ResearchConceptsCognitive impairmentInflammatory markersSARS-CoV-2 infectionLong-term cognitive impairmentLong-term cognitive outcomesC-reactive proteinDisease severity markersCOVID-19 infectionCognitive performanceHospital dischargeInflammatory backgroundClinical statusD-dimerSeverity markersGeneral cognitionOverall cognitive performanceTNF-betaPhysical activityParticipants 6Severe formG-CSFPersistent dysregulationMultivariate analysisSociodemographic characteristicsCognitive deficits
2022
Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium
Ivanov I, Boedhoe PSW, Abe Y, Alonso P, Ameis SH, Arnold PD, Balachander S, Baker JT, Banaj N, Bargalló N, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Brem S, Brennan BP, Buitelaar J, Calvo R, Cheng Y, Cho KIK, Dallaspezia S, Denys D, Diniz JB, Ely BA, Feusner JD, Ferreira S, Fitzgerald KD, Fontaine M, Gruner P, Hanna GL, Hirano Y, Hoexter MQ, Huyser C, Ikari K, James A, Jaspers-Fayer F, Jiang H, Kathmann N, Kaufmann C, Kim M, Koch K, Kwon JS, Lázaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Morer A, Morgado P, Nakagawa A, Nakamae T, Nakao T, Narayanaswamy JC, Nurmi EL, Oh S, Perriello C, Piacentini JC, Picó-Pérez M, Piras F, Piras F, Reddy YCJ, Manrique DR, Sakai Y, Shimizu E, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Tolin DF, van Rooij D, Veltman DJ, van der Werf YD, van Wingen GA, Venkatasubramanian G, Walitza S, Wang Z, Watanabe A, Wolters LH, Xu X, Yun JY, Zarei M, Zhang F, Zhao Q, Jahanshad N, Thomopoulos SI, Thompson PM, Stein DJ, van den Heuvel OA, O'Neill J, Group T, Poletti S, Fridgeirsson E, Ikuta T, de Wit S, Vriend C, Kasprzak S, Kuno M, Takahashi J, Miguel E, Shavitt R, Hough M, Pariente J, Ortiz A, Bertolín S, Real E, Segalàs C, Moreira P, Sousa N, Narumoto J, Yamada K, Tang J, Fouche J, Kim T, Choi S, Ha M, Park S. Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium. Journal Of Affective Disorders 2022, 318: 204-216. PMID: 36041582, DOI: 10.1016/j.jad.2022.08.084.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderUnmedicated patientsOlder adultsAssociation of medicationVolumes of putamenSubcortical brain structuresReuptake inhibitorsVentricular hypertrophyHippocampal atrophyMedicated patientsPsychotropic medicationsTherapeutic responseHippocampal volumeStriatal volumeSubcortical nucleiPatientsPsychotic disordersAntipsychoticsSubcortical morphologyStructural MRINormal agingBrain structuresBenzodiazepinesOCD patientsENIGMA consortiumPost-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation
Busatto G, de Araujo A, Castaldelli-Maia J, Damiano R, Imamura M, Guedes B, de Rezende Pinna F, Sawamura M, Mancini M, da Silva K, Garcia M, Sumita N, Brunoni A, da Silva Duarte A, Burdmann E, Kallas E, Cerri G, Nitrini R, Bento R, Rocha V, de Souza H, Miguel E, de Carvalho C, Forlenza O, Batistella L. Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation. Psychological Medicine 2022, 52: 2387-2398. PMID: 35521752, PMCID: PMC9151630, DOI: 10.1017/s0033291722001374.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionPost-acute sequelaeC-reactive proteinSystemic inflammationBlood levelsPhysical disabilityD-dimer blood levelsCentral nervous system manifestationsPersistent physical disabilityPersistent systemic inflammationNervous system manifestationsSevere COVID-19Cognitive manifestationsPoor physical performanceElevated blood levelsCoronavirus disease 2019Pattern of symptomsDifferent organ systemsExploratory factor analysisSame followSystem manifestationsD-dimerClinical manifestationsKidney dysfunctionPerson visits
2021
Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation
de Oliveira K, Camilo C, Gastaldi V, Sant’Anna Feltrin A, Lisboa B, de Jesus Rodrigues de Paula V, Moretto A, Lafer B, Hoexter M, Miguel E, Maschietto M, Brentani H. Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation. BMC Genomic Data 2021, 22: 45. PMID: 34717534, PMCID: PMC8557022, DOI: 10.1186/s12863-021-00993-0.Peer-Reviewed Original ResearchConceptsGene modulesMethylation changesBrain areasCpG sitesProtein-protein interaction networkDNA methylation modulationCommon transcriptional factorsDNA methylation changesSpecific signaling pathwaysGene expression dataOCD patientsPost-mortem brain tissueEpigenetic mechanismsInteraction networksMethylation modulationHypomethylation patternTranscriptional factorsEnvironmental risk factorsGene expressionBiological processesBackgroundObsessive–compulsive disorderSignaling pathwaysExpression dataG proteinsRisk factorsMental Health Impact in Latin American Pediatric Rheumatologists During the COVID-19 Pandemic
Kozu K, Casella C, Strabelli C, Aikawa N, Campos L, Elias A, Miguel E, Polanczyk G, Silva C. Mental Health Impact in Latin American Pediatric Rheumatologists During the COVID-19 Pandemic. JCR Journal Of Clinical Rheumatology 2021, 28: e506-e510. PMID: 34371514, DOI: 10.1097/rhu.0000000000001782.Peer-Reviewed Original ResearchConceptsVisual analog scaleMental health impactVAS scoresPediatric rheumatologistsMental healthChildhood-onset systemic lupus erythematosusCOVID-19 pandemicPrevious mental health disordersMedian current ageIdiopathic arthritis patientsSystemic lupus erythematosusHealth promotion strategiesCross-sectional studyGAD-7 scoresMental health disordersCOVID-19Health impactsCOVID-19 frontlineArthritis patientsLupus erythematosusAnalog scaleSleep abnormalitiesSevere depressionHealth disordersResponse rate
2020
A transdiagnostic perspective of constructs underlying obsessive-compulsive and related disorders: An international Delphi consensus study
Fontenelle L, Oldenhof E, Moreira-de-Oliveira M, Abramowitz J, Antony M, Cath D, Carter A, Dougherty D, Ferrão Y, Figee M, Harrison B, Hoexter M, Kwon J, Küelz A, Lazaro L, Lochner C, Marazziti D, Mataix-Cols D, McKay D, Miguel E, Morein-Zamir S, Moritz S, Nestadt G, O’Connor K, Pallanti S, Purdon C, Rauch S, Richter P, Rotge J, Shavitt R, Soriano-Mas C, Starcevic V, Stein D, Steketee G, Storch E, Taylor S, van den Heuvel O, Veale D, Woods D, Verdejo-Garcia A, Yücel M. A transdiagnostic perspective of constructs underlying obsessive-compulsive and related disorders: An international Delphi consensus study. Australian & New Zealand Journal Of Psychiatry 2020, 54: 719-731. PMID: 32364439, DOI: 10.1177/0004867420912327.Peer-Reviewed Original Research
2019
The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects
Blanco‐Vieira T, Santos M, Ferrão YA, Torres AR, Miguel EC, Bloch MH, Leckman JF, do Rosario MC. The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects. Depression And Anxiety 2019, 36: 533-542. PMID: 30990937, DOI: 10.1002/da.22898.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAdult OCD patientsObsessive-compulsive disorderDeficit hyperactivity disorderOCD patientsClinical characteristicsExact testFeatures of ADHDHyperactivity disorderSubgroup of patientsAdult obsessive-compulsive disorderComorbid attention deficit hyperactivity disorderSpecific clinical featuresCross-sectional studyObsessive-compulsive disorder (OCD) subjectsLogistic regression analysisFisher's exact testBrazilian Research ConsortiumMann-Whitney testAdult patientsRheumatic feverDevelopment of interventionsClinical featuresObsessive-compulsive spectrum disordersLifetime prevalenceInitial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis
Lisboa B, Oliveira K, Tahira A, Barbosa A, Feltrin A, Gouveia G, Lima L, Feio dos Santos A, Martins D, Puga R, Moretto A, De Bragança Pereira C, Lafer B, Leite R, Ferretti-Rebustini R, Farfel J, Grinberg L, Jacob-Filho W, Miguel E, Hoexter M, Brentani H. Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis. Scientific Reports 2019, 9: 3086. PMID: 30816141, PMCID: PMC6395771, DOI: 10.1038/s41598-019-38965-1.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSynaptic transmissionPathophysiology of OCDDifferent striatal subregionsPostmortem brain tissueChemical synaptic transmissionStriatal areasCortico-striatoNeurotransmitter levelsStriatum regionThalamic circuitryStriatal subregionsSubregion specificityPsychiatric disordersPresynaptic processesSynaptic plasticityBrain samplesOCD pathophysiologyBrain tissueCSTC modelControl casesPathophysiologyRare variantsDisordersCellular responses
2018
Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive–compulsive disorder
de Oliveira K, Grinberg L, Hoexter M, Brentani H, Suemoto C, Nery F, Lima L, Alho A, Farfel J, Ferretti-Rebustini R, Leite R, Moretto A, da Silva A, Lafer B, Miguel E, Nitrini R, Jacob-Filho W, Heinsen H, Pasqualucci C. Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive–compulsive disorder. Brain Structure And Function 2018, 224: 191-203. PMID: 30298291, DOI: 10.1007/s00429-018-1752-8.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMedial orbitofrontalOrbitofrontal cortexNeuronal densityOCD casesLower neuron densityCortical-subcortical circuitryOFC abnormalitiesEfferent targetsNeuron densityClinical evaluationAnterolateral areaControl groupCognitive impairmentAutopsy serviceOrbitofrontal regionsAnteromedialOlder adultsControl casesOFC areasCortexConsistent evidenceDisordersCellular levelTotal
2017
Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder.
Costa DLC, Diniz JB, Requena G, Joaquim MA, Pittenger C, Bloch MH, Miguel EC, Shavitt RG. Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder. The Journal Of Clinical Psychiatry 2017, 78: e766-e773. PMID: 28617566, DOI: 10.4088/jcp.16m11101.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAdolescentAdultAgedAnxiety DisordersComorbidityDepressive DisorderDouble-Blind MethodDrug ResistanceDrug Therapy, CombinationFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesPsychometricsSelective Serotonin Reuptake InhibitorsYoung AdultConceptsTreatment-resistant obsessive-compulsive disorderObsessive-compulsive disorderY-BOCS scoresN-acetylcysteineNAC groupYale-Brown Obsessive Compulsive Scale scoresTreatment-resistant OCD patientsBaseline Y-BOCS scoresTreatment-Resistant ObsessivePrimary outcome measureAnxiety symptomsDSM-IV criteriaSymptom dimensionsCompulsive Scale scoresSpecific OCD symptom dimensionsOCD symptom dimensionsAntioxidant medicationsAbdominal painPlacebo groupGlutamate modulatorsSecondary outcomesTertiary hospitalOutpatient clinicSeverity scoreWeek 16
2015
Comorbidity variation in patients with obsessive–compulsive disorder according to symptom dimensions: Results from a large multicentre clinical sample
Torres A, Fontenelle L, Shavitt R, Ferrão Y, do Rosário M, Storch E, Miguel E. Comorbidity variation in patients with obsessive–compulsive disorder according to symptom dimensions: Results from a large multicentre clinical sample. Journal Of Affective Disorders 2015, 190: 508-516. PMID: 26561941, DOI: 10.1016/j.jad.2015.10.051.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderObsessive-compulsive disorderAnxiety disordersTic disordersDimensional Yale-Brown Obsessive Compulsive ScaleSeparation anxiety disorderComorbid disordersSymptom dimensionsDifferent underlying pathogenic mechanismsTertiary mental health servicesDSM-IV Axis I DisordersSpecific phobiaMulticenter clinical studyPanic disorder/agoraphobiaAxis I DisordersStructured Clinical InterviewYale-Brown Obsessive Compulsive ScaleMental health servicesUnderlying pathogenic mechanismsImpulse control disordersBrazilian Research ConsortiumSocial phobiaBody dysmorphic disorderObsessive Compulsive ScaleCommon comorbiditiesDefining clinical severity in adults with obsessive–compulsive disorder
Storch E, De Nadai A, do Rosário M, Shavitt R, Torres A, Ferrão Y, Miguel E, Lewin A, Fontenelle L. Defining clinical severity in adults with obsessive–compulsive disorder. Comprehensive Psychiatry 2015, 63: 30-35. PMID: 26555489, PMCID: PMC4643407, DOI: 10.1016/j.comppsych.2015.08.007.Peer-Reviewed Original Research
2014
Phenomenology of OCD: Lessons from a large multicenter study and implications for ICD-11
Shavitt R, de Mathis M, Oki F, Ferrao Y, Fontenelle L, Torres A, Diniz J, Costa D, do Rosário M, Hoexter M, Miguel E, Simpson H. Phenomenology of OCD: Lessons from a large multicenter study and implications for ICD-11. Journal Of Psychiatric Research 2014, 57: 141-148. PMID: 25012187, PMCID: PMC7326117, DOI: 10.1016/j.jpsychires.2014.06.010.Peer-Reviewed Original ResearchMusical obsessions: A comprehensive review of neglected clinical phenomena
Taylor S, McKay D, Miguel E, De Mathis M, Andrade C, Ahuja N, Sookman D, Kwon J, Huh M, Riemann B, Cottraux J, O’Connor K, Hale L, Abramowitz J, Fontenelle L, Storch E. Musical obsessions: A comprehensive review of neglected clinical phenomena. Journal Of Anxiety Disorders 2014, 28: 580-589. PMID: 24997394, DOI: 10.1016/j.janxdis.2014.06.003.Peer-Reviewed Original ResearchAdolescentAdultAgedAged, 80 and overAntipsychotic AgentsAvoidance LearningChildCognitive Behavioral TherapyDiagnosis, DifferentialFearFemaleHallucinationsHumansImaginationMaleMiddle AgedModels, PsychologicalMusicObsessive BehaviorObsessive-Compulsive DisorderSelective Serotonin Reuptake InhibitorsYoung AdultHoarding symptoms and prediction of poor response to limbic system surgery for treatment-refractory obsessive-compulsive disorder.
Gentil AF, Lopes AC, Dougherty DD, Rück C, Mataix-Cols D, Lukacs TL, Canteras MM, Eskandar EN, Larsson KJ, Hoexter MQ, Batistuzzo MC, Greenberg BD, Miguel EC. Hoarding symptoms and prediction of poor response to limbic system surgery for treatment-refractory obsessive-compulsive disorder. Journal Of Neurosurgery 2014, 121: 123-30. PMID: 24702323, DOI: 10.3171/2014.2.jns131423.Peer-Reviewed Original ResearchConceptsLimbic system surgeryClinical outcomesWorse responseMean Y-BOCS scoreTreatment-refractory obsessive-compulsive disorderSymptom dimensionsPreoperative symptom severityWorse clinical outcomesTreatment-refractory patientsYale-Brown Obsessive Compulsive ScaleY-BOCS scoresSymptom Checklist scoresHoarding dimensionObsessive Compulsive ScaleSurgery needObsessive-compulsive disorderSurgical modalitiesAblative surgeryPoor responseWorse outcomesTreatment outcomesDimensional Yale-Brown Obsessive Compulsive ScaleYBOCS scoresPatientsSurgeryMulticenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder
de Wit S, Alonso P, Schweren L, Mataix-Cols D, Lochner C, Menchón J, Stein D, Fouche J, Soriano-Mas C, Sato J, Hoexter M, Denys D, Nakamae T, Nishida S, Kwon J, Jang J, Busatto G, Cardoner N, Cath D, Fukui K, Jung W, Kim S, Miguel E, Narumoto J, Phillips M, Pujol J, Remijnse P, Sakai Y, Shin N, Yamada K, Veltman D, van den Heuvel O. Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder. American Journal Of Psychiatry 2014, 171: 340-349. PMID: 24220667, DOI: 10.1176/appi.ajp.2013.13040574.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsObsessive-compulsive disorderOCD patientsHealthy subjectsComparison subjectsGreater cerebellar gray matter volumeMatter volumeStructural T1-weighted MRI scansWhite matter brain volumesWhite matter volume differencesT1-weighted MRI scansWhite matter volumePrevious smaller studiesStructural brain scansGray matter volumeVoxel-based morphometryAdult OCD patientsCerebellar gray matter volumeAnterior cingulate cortexAltered neuroplasticityClinical variablesInferior frontal gyrusCognitive dysfunctionDorsomedial prefrontal cortexTemporal cortex
2013
Can early improvement be an indicator of treatment response in obsessive-compulsive disorder? Implications for early-treatment decision-making
da Conceição Costa D, Shavitt R, Cesar R, Joaquim M, Borcato S, Valério C, Miguel E, Diniz J. Can early improvement be an indicator of treatment response in obsessive-compulsive disorder? Implications for early-treatment decision-making. Journal Of Psychiatric Research 2013, 47: 1700-1707. PMID: 23948637, DOI: 10.1016/j.jpsychires.2013.07.006.Peer-Reviewed Original ResearchConceptsBaseline Y-BOCS scoresSerotonin reuptake inhibitorsEarly improvementTreatment responseY-BOCS scoresBaseline Yale-Brown ObsessiveLogistic regressionAdequate pharmacological treatmentPotential predictive factorsWeeks of treatmentGreater reductionObsessive-compulsive disorder patientsStepwise logistic regressionWarrants further investigationYale-Brown ObsessiveClinical featuresReuptake inhibitorsObsessive-compulsive disorderPharmacological treatmentPredictive factorsMajor depressionDisorder patientsOCD treatment responseCompulsive ScaleWeeksSymptom dimensions, clinical course and comorbidity in men and women with obsessive-compulsive disorder
Torresan R, Ramos-Cerqueira A, Shavitt R, do Rosário M, de Mathis M, Miguel E, Torres A. Symptom dimensions, clinical course and comorbidity in men and women with obsessive-compulsive disorder. Psychiatry Research 2013, 209: 186-195. PMID: 23298952, DOI: 10.1016/j.psychres.2012.12.006.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderClinical courseComorbid post-traumatic stress disorderDSM-IV Axis ICross-sectional studyStructured Clinical InterviewAlcohol use disorderSymptom dimensionsPost-traumatic stress disorderAdult OCD patientsBrazilian Research ConsortiumYale-Brown ObsessiveFemale patientsClinical presentationMean ageSymptom interferenceObsessive-compulsive spectrum disordersMajor depressionTic disordersFemale genderAxis IUse disordersClinical InterviewAnorexia nervosaSkin picking
2012
Clinical correlates of social adjustment in patients with obsessive-compulsive disorder
Rosa A, Diniz J, Fossaluza V, Torres A, Fontenelle L, De Mathis A, da Conceição Rosário M, Miguel E, Shavitt R. Clinical correlates of social adjustment in patients with obsessive-compulsive disorder. Journal Of Psychiatric Research 2012, 46: 1286-1292. PMID: 22800713, DOI: 10.1016/j.jpsychires.2012.05.019.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPoor social adjustmentSocial adjustmentSocial functioningOverall social functioningYale-Brown ObsessiveOCD severityReligious obsessionsCompulsive ScaleCurrent post-traumatic stress disorderSpecific OCD symptomsPost-traumatic stress disorderPrimary DSM-IV diagnosisOCD symptom onsetPoor social functioningSocial adjustment measuresObsessive-compulsive spectrum disordersGreater OCD severitySocial Adjustment ScaleBrazilian Research ConsortiumPoorer overall social functioningDimensional Yale-Brown ObsessivePsychiatric comorbidityCurrent psychiatric comorbidityCurrent major depressive disorderNeuropsychological predictors of response to randomized treatment in obsessive–compulsive disorder
D'Alcante C, Diniz J, Fossaluza V, Batistuzzo M, Lopes A, Shavitt R, Deckersbach T, Malloy-Diniz L, Miguel E, Hoexter M. Neuropsychological predictors of response to randomized treatment in obsessive–compulsive disorder. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2012, 39: 310-317. PMID: 22789662, DOI: 10.1016/j.pnpbp.2012.07.002.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyObsessive-compulsive disorderCalifornia Verbal Learning TestVictoria Stroop TestVerbal Learning TestNeuropsychological measuresOCD patientsMental flexibilityVerbal memoryNeuropsychological predictorsLearning TestHigher verbal IQDifferent neuropsychological profilesUnderwent neuropsychological assessmentExecutive functioningExecutive abilitiesVerbal IQStroop testNeuropsychological profileNeuropsychological assessmentIntellectual functionHeuristic valueLarge sampleMemoryTreatment response