2023
Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers
Damiano R, de Almeida Rocca C, de Pádua Serafim A, Loftis J, Talib L, Pan P, Cunha-Neto E, Kalil J, de Castro G, Seelaender M, Guedes B, Marie S, de Souza H, Nitrini R, Miguel E, Busatto G, Forlenza O, Group H, Utiyama E, Segurado A, Perondi B, Miethke-Morais A, Montal A, Harima L, Fusco S, Silva M, Rocha M, Marcilio I, Rios I, Kawano F, de Jesus M, Kallas É, Carmo C, Tanaka C, Marchini J, Carvalho C, Ferreira J, Levin A, Oliveira M, Guimarães T, dos Santos Lázari C, da Silva Duarte A, Sabino E, Magri M, Barros-Filho T, Francisco M. Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers. Frontiers In Immunology 2023, 14: 1174020. PMID: 37287969, PMCID: PMC10242059, DOI: 10.3389/fimmu.2023.1174020.Peer-Reviewed Original ResearchConceptsCognitive impairmentInflammatory markersSARS-CoV-2 infectionLong-term cognitive impairmentLong-term cognitive outcomesC-reactive proteinDisease severity markersCOVID-19 infectionCognitive performanceHospital dischargeInflammatory backgroundClinical statusD-dimerSeverity markersGeneral cognitionOverall cognitive performanceTNF-betaPhysical activityParticipants 6Severe formG-CSFPersistent dysregulationMultivariate analysisSociodemographic characteristicsCognitive deficits
2022
Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation – CORRIGENDUM
Busatto G, de Araujo A, Castaldelli-Maia J, Damiano R, Imamura M, Guedes B, Pinna F, Sawamura M, Mancini M, da Silva K, Garcia M, Sumita N, Brunoni A, da Silva Duarte A, Burdmann E, Kallas E, Cerri G, Nitrini R, Bento R, Rocha V, de Souza H, Miguel E, de Carvalho C, Forlenza O, Batistella L. Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation – CORRIGENDUM. Psychological Medicine 2022, 52: 2400-2400. PMID: 35757988, PMCID: PMC9981469, DOI: 10.1017/s0033291722001799.Peer-Reviewed Original ResearchChronic lung lesions in COVID-19 survivors: predictive clinical model
Carvalho C, Chate R, Sawamura M, Garcia M, Lamas C, Cardenas D, Lima D, Scudeller P, Salge J, Nomura C, Gutierrez M, Araújo A, Segurado A, Montal A, Miethke-Morais A, Levin A, Perondi B, Guedes B, Carmo C, Lázari C, Antonio C, Tanaka C, Leite C, Gomes C, Utiyama E, Burdmann E, Bonfá E, Kallas E, Sabino E, Miguel E, Pinna F, Kawano F, Busatto G, Cerri G, Fonseca G, Souza H, Marcilio I, Rios I, Hallak J, Krieger J, Ferreira J, Marchini J, Oliveira L, Harima L, Batisttella L, Yu L, Castro L, Rocha M, Magri M, Mancini M, de Jesus M, Corrêa M, Francisco M, Rossi M, Silva M, Imamura M, Oliveira M, Gouveia N, Forlenza O, Lotufo P, Bento R, Nitrini R, Damiano R, Chammas R, Francisco R, Fusco S, Barros-Filho T, Mauad T, Guimarães T, Avelino-Silva T, Filho W. Chronic lung lesions in COVID-19 survivors: predictive clinical model. BMJ Open 2022, 12: e059110. PMID: 35697456, PMCID: PMC9195157, DOI: 10.1136/bmjopen-2021-059110.Peer-Reviewed Original ResearchConceptsChest X-rayPredictive clinical modelCOVID-19 survivorsLung lesionsClinical modelLung lesion detectionMMRC scaleChest CTMedical Research Council dyspnoea scaleSARS-CoV-2-infected patientsSARS-CoV-2 infectionCOVID-19 sequelaeSignificant pulmonary abnormalitiesProspective cohort studyGround-glass opacitiesCOVID-19 infectionChronic lung lesionsLesion detectionDyspnoea scalePulmonary involvementTraction bronchiectasisCohort studyCXR findingsHospital dischargePulmonary functionAssociation between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study
Damiano R, Neto D, Oliveira J, Magalhães Santos J, Alves J, Guedes B, Nitrini R, de Araújo A, Oliveira M, Brunoni A, Voegels R, Bento R, Busatto G, Miguel E, Forlenza O, de Rezende Pinna F. Association between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study. European Archives Of Psychiatry And Clinical Neuroscience 2022, 273: 325-333. PMID: 35633395, PMCID: PMC9142732, DOI: 10.1007/s00406-022-01427-3.Peer-Reviewed Original ResearchConceptsCohort studyChemosensory impairmentPost-acute COVID-19 syndromeCOVID-19 syndromeCentral nervous systemCOVID-19SARS-CoV-2Word list memory taskEpisodic memory impairmentSmell functionAdult patientsChemosensory dysfunctionAcute phaseNeuropsychiatric symptomsNeuropsychiatric morbidityGustatory lossHospitalization dataNeuropsychiatric impairmentEligible individualsSevere formCognition dysfunctionNervous systemMemory impairmentMultivariate analysisNeuropsychiatric disordersPost-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation
Busatto G, de Araujo A, Castaldelli-Maia J, Damiano R, Imamura M, Guedes B, de Rezende Pinna F, Sawamura M, Mancini M, da Silva K, Garcia M, Sumita N, Brunoni A, da Silva Duarte A, Burdmann E, Kallas E, Cerri G, Nitrini R, Bento R, Rocha V, de Souza H, Miguel E, de Carvalho C, Forlenza O, Batistella L. Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation. Psychological Medicine 2022, 52: 2387-2398. PMID: 35521752, PMCID: PMC9151630, DOI: 10.1017/s0033291722001374.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionPost-acute sequelaeC-reactive proteinSystemic inflammationBlood levelsPhysical disabilityD-dimer blood levelsCentral nervous system manifestationsPersistent physical disabilityPersistent systemic inflammationNervous system manifestationsSevere COVID-19Cognitive manifestationsPoor physical performanceElevated blood levelsCoronavirus disease 2019Pattern of symptomsDifferent organ systemsExploratory factor analysisSame followSystem manifestationsD-dimerClinical manifestationsKidney dysfunctionPerson visitsPost-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study
Damiano R, Caruso M, Cincoto A, de Almeida Rocca C, de Pádua Serafim A, Bacchi P, Guedes B, Brunoni A, Pan P, Nitrini R, Beach S, Fricchione G, Busatto G, Miguel E, Forlenza O, Group H. Post-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study. General Hospital Psychiatry 2022, 75: 38-45. PMID: 35134702, PMCID: PMC8734055, DOI: 10.1016/j.genhosppsych.2022.01.002.Peer-Reviewed Original ResearchConceptsCognitive morbidityCognitive outcomesAnxiety disordersPost-traumatic stress disorderRelevant psychosocial variablesCognitive batteryMemory declineStructured psychiatric interviewStress disorderPsychosocial variablesStandardized measuresPsychosocial stressorsPsychometric testsCognitive impairmentPsychiatric interviewSevere formPreliminary findingsSARS-CoV-2 infectionCohort of survivorsLong-term outcomesAcute-phase diseaseBrazilian cohort studyCOVID-19DisordersDepression
2021
Mental health interventions following COVID-19 and other coronavirus infections: a systematic review of current recommendations and meta-analysis of randomized controlled trials
Damiano R, Di Santi T, Beach S, Pan P, Lucchetti A, Smith F, Forlenza O, Fricchione G, Miguel E, Lucchetti G. Mental health interventions following COVID-19 and other coronavirus infections: a systematic review of current recommendations and meta-analysis of randomized controlled trials. Brazilian Journal Of Psychiatry 2021, 43: 665-678. PMID: 33852690, PMCID: PMC8639008, DOI: 10.1590/1516-4446-2020-1582.Peer-Reviewed Original ResearchConceptsMental health interventionsSystematic reviewHealth interventionsCoronavirus disease 2019Non-RCT studiesCOVID-19Mental health strategiesMental health problemsMental health outcomesMental health issuesDisease 2019Psychiatric interventionCurrent recommendationsGeneral populationHealth strategiesHealth outcomesHealth problemsCoronavirus infectionHealth practitionersHealth issuesExpert recommendationsMore studiesInterventionTrialsReviewCOMVC-19: A Program to protect healthcare workers' mental health during the COVID-19 Pandemic. What we have learned
Fukuti P, Uchôa C, Mazzoco M, da Cruz I, Echegaray M, de Castro Humes E, Silveira J, Di Santi T, Miguel E, Corchs F, program C, Fatori D, Campello G, de Oliveira G, Argolo F, de M. Ferreira F, Machado G, Argeu A, de Oliveira G, de Pádua Serafim A, de Lima Siqueira L, de Rossi L, Rios I, de Oliveira T, Antoniazzi L, Gagliotti D, Abelama E, de Oliveira P, Correia A, Gonçalves L, Tortato L, Busato W, Guimarães-Fernandes F, Alves M, Leite O, de Campos Lindenberg Schoueri P, de Assis Roque M, Merlin S, Boer G, Sallet P, Malbergier A, Spedo M, Kamitsuji C, de Faria E, de Godoy Moreira M, Kaufman A, Abdo C, de Tubino Scanavino M, Lancman S, Tavares H, Polanczyk G, Brunoni A, Forlenza O, de Barros-Filho T. COMVC-19: A Program to protect healthcare workers' mental health during the COVID-19 Pandemic. What we have learned. Clinics 2021, 76: e2631. PMID: 34817044, PMCID: PMC8579850, DOI: 10.6061/clinics/2021/e2631.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyBrazilCOVID-19DepressionFemaleHealth PersonnelHumansMental HealthPandemicsSARS-CoV-2ConceptsNursing staffHospital das Clinicas da FaculdadeHealthcare workers' mental healthMedicina da Universidade de São PauloMental healthCOVID-19 patientsMental health impairmentMental health treatmentCOVID-19 pandemicMental health programsWorkers' mental healthCommon diagnosisPreventive actionsSleep disturbancesMood disordersPsychiatric evaluationMultimodal interventionHealth treatmentDepression symptomsHealth programsPublic hospitalsHealth impairmentSymptomsMobile phone appMost participantsMental Health Impact in Latin American Pediatric Rheumatologists During the COVID-19 Pandemic
Kozu K, Casella C, Strabelli C, Aikawa N, Campos L, Elias A, Miguel E, Polanczyk G, Silva C. Mental Health Impact in Latin American Pediatric Rheumatologists During the COVID-19 Pandemic. JCR Journal Of Clinical Rheumatology 2021, 28: e506-e510. PMID: 34371514, DOI: 10.1097/rhu.0000000000001782.Peer-Reviewed Original ResearchConceptsVisual analog scaleMental health impactVAS scoresPediatric rheumatologistsMental healthChildhood-onset systemic lupus erythematosusCOVID-19 pandemicPrevious mental health disordersMedian current ageIdiopathic arthritis patientsSystemic lupus erythematosusHealth promotion strategiesCross-sectional studyGAD-7 scoresMental health disordersCOVID-19Health impactsCOVID-19 frontlineArthritis patientsLupus erythematosusAnalog scaleSleep abnormalitiesSevere depressionHealth disordersResponse rateCOVID-19 specific phobia: A new psychiatric entity?
Damiano R, Oliva K, Albertoni F, Filho G, Miguel E, Forlenza O. COVID-19 specific phobia: A new psychiatric entity? Psychiatry Research 2021, 303: 114112. PMID: 34293644, PMCID: PMC8280369, DOI: 10.1016/j.psychres.2021.114112.Peer-Reviewed Original ResearchPost-acute sequelae of SARS-CoV-2 infection (PASC): a protocol for a multidisciplinary prospective observational evaluation of a cohort of patients surviving hospitalisation in Sao Paulo, Brazil
Busatto G, de Araújo A, da Silva Duarte A, Levin A, Guedes B, Kallas E, Pinna F, de Souza H, da Silva K, Sawamura M, Seelaender M, Imamura M, Garcia M, Forlenza O, Nitrini R, Damiano R, Rocha V, Batisttella L, de Carvalho C, Initiative O, da Costa Leite C, Gomes C, Burdmann E, Miguel E, Cerri G, Fonseca G, Hallak J, Krieger J, Yu L, Castro L, Corrêa M, Mancini M, Rossi M, Gouveia N, Lotufo P, Bento R, Chammas R, Francisco R, Mauad T, Avelino-Silva T, Filho W, Group H, Bonfá E, Utiyama E, Segurado A, Perondi B, Miethke-Morais A, Montal A, Harima L, Fusco S, Silva M, Rocha M, Marcilio I, Rios I, Kawano F, de Jesus M, Carmo C, Tanaka C, Marchini J, Ferreira J, Oliveira M, Guimarães T, dos Santos Lázari C, Sabino E, MC Magri M, Barros-Filho T, Francisco M. Post-acute sequelae of SARS-CoV-2 infection (PASC): a protocol for a multidisciplinary prospective observational evaluation of a cohort of patients surviving hospitalisation in Sao Paulo, Brazil. BMJ Open 2021, 11: e051706. PMID: 34193506, PMCID: PMC8249176, DOI: 10.1136/bmjopen-2021-051706.Peer-Reviewed Original ResearchConceptsMultidisciplinary assessmentLaboratory-confirmed COVID-19SARS-CoV-2 infectionProspective observational evaluationCohort of patientsCOVID-19 inpatientsPost-acute sequelaeProspective observational studyLarge academic health centerGreater disease severityCOVID-19Cardiopulmonary functioningMultiorgan symptomsEligible subjectsInflammatory markersPeer-reviewed journalsResearch Ethics CommitteeBlood testsClinical manifestationsMuscle ultrasoundOlfactory statusHealth centersObservational studyDisease featuresPathophysiological investigationsCognitive decline following acute viral infections: literature review and projections for post-COVID-19
Damiano R, Guedes B, de Rocca C, de Pádua Serafim A, Castro L, Munhoz C, Nitrini R, Filho G, Miguel E, Lucchetti G, Forlenza O. Cognitive decline following acute viral infections: literature review and projections for post-COVID-19. European Archives Of Psychiatry And Clinical Neuroscience 2021, 272: 139-154. PMID: 34173049, PMCID: PMC8231753, DOI: 10.1007/s00406-021-01286-4.Peer-Reviewed Original ResearchConceptsAcute viral infectionViral infectionCognitive declineHuman cognitionCoronavirus disease 2019Possible cognitive declineAsymptomatic individualsBrain dysfunctionDisease 2019Human dementiaNeuropsychiatric issuesCognitive sequelaeAlzheimer's diseaseNarrative reviewInfectionInfectious diseasesHealth leadersDiseaseCOVID-19COVID-19 pandemicIndirect pathwaysCognitionCurrent knowledgeRecent findingsLiterature reviewCOMVC-19, a Program to Protect Healthcare Workers' Mental Health During the COVID-19 Pandemic, and the Second Wave of the Pandemic: A New Moment and the Impact of Previous Experiences
Scarduelli F, Fukuti P, Corchs F, Miguel E, de Castro Humes E. COMVC-19, a Program to Protect Healthcare Workers' Mental Health During the COVID-19 Pandemic, and the Second Wave of the Pandemic: A New Moment and the Impact of Previous Experiences. Clinics 2021, 76: e3574. PMID: 34878035, PMCID: PMC8610216, DOI: 10.6061/clinics/2021/e3574.Peer-Reviewed Original Research
2020
The impact of coronavirus (COVID‐19) in the diagnosis and treatment of obsessive‐compulsive disorder
Fontenelle L, Miguel E. The impact of coronavirus (COVID‐19) in the diagnosis and treatment of obsessive‐compulsive disorder. Depression And Anxiety 2020, 37: 510-511. PMID: 32383802, PMCID: PMC7267460, DOI: 10.1002/da.23037.Peer-Reviewed Original ResearchHow Institutions Can Protect the Mental Health and Psychosocial Well-Being of Their Healthcare Workers in the Current COVID-19 Pandemic
Fukuti P, Uchôa C, Mazzoco M, Corchs F, Kamitsuji C, De Rossi L, Rios I, Lancman S, Bonfa E, de Barros-Filho T, Miguel E. How Institutions Can Protect the Mental Health and Psychosocial Well-Being of Their Healthcare Workers in the Current COVID-19 Pandemic. Clinics 2020, 75: e1963. PMID: 32520224, PMCID: PMC7247736, DOI: 10.6061/clinics/2020/e1963.Peer-Reviewed Original Research