2022
Threat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents
Schäfer J, McLaughlin K, Manfro G, Pan P, Rohde L, Miguel E, Simioni A, Hoffmann M, Salum G. Threat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents. Developmental Science 2022, 26: e13267. PMID: 35417607, PMCID: PMC10028496, DOI: 10.1111/desc.13267.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild DevelopmentCognitionCross-Sectional StudiesEmotionsExecutive FunctionHumansConceptsChild Behavior ChecklistExecutive functionEmotional processingChildhood adversityBrazilian High-Risk CohortForms of adversityPoor developmental outcomesAttention biasAngry facesCognitive tasksCognitive developmentDevelopmental correlatesBehavior ChecklistChild developmentDevelopmental outcomesLongitudinal associationsGeneral psychopathologyPsychopathologyAdversityLatent constructsDifferential associationsWorse performanceDistinct aspectsCognitionMeaningful influence
2021
A randomized controlled trial testing the efficacy of a Nurse Home Visiting Program for Pregnant Adolescents
Fatori D, Fonseca Zuccolo P, Shephard E, Brentani H, Matijasevich A, Archanjo Ferraro A, Aparecida Fracolli L, Chiesa AM, Leckman J, Constantino Miguel E, V. Polanczyk G. A randomized controlled trial testing the efficacy of a Nurse Home Visiting Program for Pregnant Adolescents. Scientific Reports 2021, 11: 14432. PMID: 34257407, PMCID: PMC8277870, DOI: 10.1038/s41598-021-93938-7.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrazilChildChild DevelopmentChild, PreschoolFemaleHouse CallsHumansInfantMaleMothersParentingPregnancyConceptsWeeks of pregnancyAdolescent mothersNurse Home Visiting ProgramStandardized effect sizeChild's ageHome Visiting ProgramTrajectories of outcomesInfant Development-Third EditionEffect sizeLow-income adolescent mothersChildren's expressive language developmentAnthropometric indicesNurse homeDaily stimulationEndpoint assessmentBayley ScalesPregnant adolescentsVisiting ProgramExpressive language developmentPromising interventionChild developmentIntervention effectsPregnancyPoor urban areasAlpha frequency
2020
Effects of semantic categorization strategy training on episodic memory in children and adolescents
Miotto E, Balardin J, da Graça M. Martin M, Polanczyk G, Savage C, Miguel E, Batistuzzo M. Effects of semantic categorization strategy training on episodic memory in children and adolescents. PLOS ONE 2020, 15: e0228866. PMID: 32069310, PMCID: PMC7028277, DOI: 10.1371/journal.pone.0228866.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingEpisodic memoryPrefrontal cortexCognitive trainingStrategy trainingMiddle frontal gyrus activationDefault mode network areasVerbal episodic memoryImproved memory performanceRight frontal poleLateral orbital gyrusCategorization trainingSuccessful memoryExecutive processesNeural correlatesMemory performanceWord listsAnterior cingulateFrontal poleMemoryHigher activationBrain regionsAdolescentsOrbital gyrusBehavioral effects
2019
Effects of Maternal Psychopathology and Education Level on Neurocognitive Development in Infants of Adolescent Mothers Living in Poverty in Brazil
Shephard E, Fatori D, Mauro L, de Medeiros Filho M, Hoexter M, Chiesa A, Fracolli L, Brentani H, Ferraro A, Nelson C, Miguel E, Polanczyk G. Effects of Maternal Psychopathology and Education Level on Neurocognitive Development in Infants of Adolescent Mothers Living in Poverty in Brazil. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 4: 925-934. PMID: 31345780, PMCID: PMC6863387, DOI: 10.1016/j.bpsc.2019.05.009.Peer-Reviewed Original ResearchConceptsLow maternal educationMaternal psychopathologyAttention-deficit/hyperactivity disorderMaternal anxietyNeurocognitive developmentInfant neurodevelopmentAdolescent mothersMaternal educationHyperactivity disorderInfant neurocognitive developmentMonths of ageResting-state electroencephalographyCluster-based permutation testingEducation levelOscillatory powerEarly brain developmentMaternal symptomsRisk factorsConnectivity alterationsEarly neurocognitive developmentOscillatory connectivityRelative theta powerFunctional connectivityBrain developmentPilot study
2018
Socioeconomic diversities and infant development at 6 to 9 months in a poverty area of São Paulo, Brazil
Tella P, da Rosa Piccolo L, Rangel M, Rohde L, Polanczyk G, Miguel E, Grisi S, Fleitlich-Bilyk B, Ferraro A. Socioeconomic diversities and infant development at 6 to 9 months in a poverty area of São Paulo, Brazil. Trends In Psychiatry And Psychotherapy 2018, 40: 232-240. PMID: 30156646, DOI: 10.1590/2237-6089-2017-0008.Peer-Reviewed Original ResearchConceptsCognitive developmentInfant developmentInfant languageInfants' performanceMaternal educationCognitive scoresMotor skillsSocioeconomic statusIntervention effortsBayley ScalesHigh languageSES effectsParticipant familiesEarly childhoodMotor ScaleLanguageSocioeconomic backgroundHigher maternal educationPositive associationChildhoodSocioeconomic diversityInfancySkillsFirst yearChildren
2017
Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence
de Araujo C, Zugman A, Swardfager W, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, de Moura L, Del Aquilla M, Picon F, Amaro E, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence. Journal Of Psychiatric Research 2017, 98: 51-58. PMID: 29288952, DOI: 10.1016/j.jpsychires.2017.12.008.Peer-Reviewed Original ResearchConceptsPsychiatric disordersVal66Met polymorphismCortical thicknessBrain-derived neurotrophic factor (BDNF) Val66Met polymorphismRegional structural brain changesNeurotrophic factor Val66Met polymorphismPrefrontal cortexStructural brain changesLateral temporal cortexEffect of Val66MetBilateral prefrontal cortexVal66Met effectsWindow of vulnerabilityCortical maturationBrain changesOccipital lobeMet carriersAtypical neurodevelopmentMRI scansPsychiatric diagnosisTemporal cortexDiagnosis interactionVal66MetNeuropsychiatric disordersBrain morphologyAssociation between abnormal brain functional connectivity in children and psychopathology: A study based on graph theory and machine learning
Sato J, Biazoli C, Salum G, Gadelha A, Crossley N, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Amaro E, Anés M, Moura L, Del’Aquilla M, Mcguire P, Rohde L, Miguel E, Jackowski A, Bressan R. Association between abnormal brain functional connectivity in children and psychopathology: A study based on graph theory and machine learning. The World Journal Of Biological Psychiatry 2017, 19: 119-129. PMID: 28635541, DOI: 10.1080/15622975.2016.1274050.Peer-Reviewed Original ResearchConceptsBilateral posterior temporal corticesAbnormal brain functional connectivityMental health disordersBilateral posterior cingulateBrain networksBrain functional connectivityResting-state fMRI dataPosterior temporal cortexBrain network organizationLevels of psychopathologyTemporal cortexHealth disordersTemporal polePosterior cingulateMental disordersBrain developmentFunctional connectivityBrain connectivitySignificant decreaseDisordersGraph theory measuresIndividual brain networksBiological measuresPsychopathologySubjects
2014
Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study
Sato J, Salum G, Gadelha A, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Anés M, Moura L, Del’Aquilla M, Crossley N, Amaro E, Mcguire P, Lacerda A, Rohde L, Miguel E, Jackowski A, Bressan R. Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study. NeuroImage 2014, 104: 44-51. PMID: 25290886, DOI: 10.1016/j.neuroimage.2014.09.063.Peer-Reviewed Original ResearchConceptsAngular gyrusDevelopmental trajectoriesFunctional magnetic resonance imaging (fMRI) dataBrain developmental trajectoriesBrazilian community sampleBrain maturation processesFunctional connectivity studiesNetwork connectivity changesStructural imaging findingsInhibitory controlSensitive development periodCommunity sampleEmotional changesAbstract thoughtMagnetic resonance imaging dataComplex reasoningFMRI dataCerebellar regionsDevelopmental changesBrain regionsCortical regionsConnectivity changesConnectivity studiesSubcortical regionsAdolescenceAge effects on the default mode and control networks in typically developing children
Sato J, Salum G, Gadelha A, Picon F, Pan P, Vieira G, Zugman A, Hoexter M, Anés M, Moura L, Del'Aquilla M, Amaro E, McGuire P, Crossley N, Lacerda A, Rohde L, Miguel E, Bressan R, Jackowski A. Age effects on the default mode and control networks in typically developing children. Journal Of Psychiatric Research 2014, 58: 89-95. PMID: 25085608, DOI: 10.1016/j.jpsychires.2014.07.004.Peer-Reviewed Original ResearchConceptsDefault mode networkMode networkYears of ageCross-sectional community sampleRight anterior insulaDefault modePosterior temporal cortexDorsal anteriorAge effectsNeurodevelopment studiesHealthy subjectsTemporal cortexPosterior cingulateState fMRI dataAnterior insulaBrain developmentSame acquisition parametersLeft posterior temporal cortexNeuronal modulesState fMRILate childhoodDevelopmental formationBrain networksCommunity sampleField of neuroimaging
2010
Effects of childhood development on late-life mental disorders
Salum G, Polanczyk G, Miguel E, Rohde L. Effects of childhood development on late-life mental disorders. Current Opinion In Psychiatry 2010, 23: 498-503. PMID: 20733493, DOI: 10.1097/yco.0b013e32833ead33.Peer-Reviewed Original ResearchConceptsLate-life mental disordersMental disordersCentral nervous systemEnvironmental risk factorsChildhood developmentMental health trajectoriesPreventive intervention strategiesRisk factorsAtypical neurodevelopmentNervous systemPreventive interventionsHomotypic continuityHealth trajectoriesIntervention strategiesDisordersPsychiatric phenotypesCurrent findingsRecent findingsChildhoodAdulthoodUrgent needFindings documentNeurodevelopmentFindings