2020
Social losses predict a faster onset and greater severity of obsessive-compulsive disorder
Destrée L, Albertella L, Torres A, Ferrão Y, Shavitt R, Miguel E, Fontenelle L. Social losses predict a faster onset and greater severity of obsessive-compulsive disorder. Journal Of Psychiatric Research 2020, 130: 187-193. PMID: 32828024, DOI: 10.1016/j.jpsychires.2020.07.027.Peer-Reviewed Original ResearchMeSH KeywordsBrazilDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleObsessive-Compulsive DisorderPsychiatric Status Rating ScalesSeverity of Illness IndexSurveys and QuestionnairesConceptsClinical obsessive-compulsive disorderObsessive-compulsive disorderStressful life eventsSpeed of progressionYale-Brown ObsessiveDSM-IV Axis I DisordersLife eventsCompulsive ScaleAxis I DisordersStructured Clinical InterviewSeverity of symptomsSymptom dimensionsBeck Depression InventorySubclinical obsessive-compulsive symptomsBeck Anxiety InventorySpecific obsessive-compulsive symptom dimensionsI disordersFaster onsetPsychiatric disordersHistory questionnaireBrown AssessmentClinical InterviewGreater severityDepression InventoryObsessive-compulsive symptoms
2017
The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children
Saad LO, do Rosario MC, Cesar RC, Batistuzzo MC, Hoexter MQ, Manfro GG, Shavitt RG, Leckman JF, Miguel EC, Alvarenga PG. The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 342-348. PMID: 28151703, PMCID: PMC5439443, DOI: 10.1089/cap.2016.0125.Peer-Reviewed Original ResearchMeSH KeywordsAnxiety DisordersBrazilChecklistChildChild Behavior DisordersComorbidityDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleObsessive-Compulsive DisorderProblem BehaviorPsychiatric Status Rating ScalesConceptsObsessive-compulsive symptomsPsychiatric comorbidityPredictive valueBehavioral problemsDSM-IV psychiatric diagnosesPresence of OCSGroup of patientsHigh-risk cohortSignificant obsessive-compulsive symptomsNegative predictive valuePositive predictive valueHigh rateSeverity of OCSRisk cohortSchool-Aged ChildrenDepressive disorderFunctional impairmentPsychiatric diagnosisChild Behavior ChecklistComorbiditiesSevere psychopathologyBeing AssessmentScreening toolPediatric OCDAnxiety disorders
2016
Use of benzodiazepines in obsessive–compulsive disorder
Starcevic V, Berle D, do Rosário M, Brakoulias V, Ferrão Y, Viswasam K, Shavitt R, Miguel E, Fontenelle L. Use of benzodiazepines in obsessive–compulsive disorder. International Clinical Psychopharmacology 2016, 31: 27-33. PMID: 26426443, DOI: 10.1097/yic.0000000000000100.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Anxiety AgentsAnxietyBenzodiazepinesCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersDrug Therapy, CombinationFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesSelective Serotonin Reuptake InhibitorsSocioeconomic FactorsConceptsObsessive-compulsive disorderBDZ useOCD patientsUse of benzodiazepinesTreatment of OCDBrazilian Research ConsortiumAdditional medicationTreatment guidelinesMulticentre studyReuptake inhibitorsObsessive-compulsive spectrum disordersBenzodiazepine useMarked anxietyPatientsMedicationsBDZDisordersResearch ConsortiumCurrent age
2015
Comorbidity variation in patients with obsessive–compulsive disorder according to symptom dimensions: Results from a large multicentre clinical sample
Torres A, Fontenelle L, Shavitt R, Ferrão Y, do Rosário M, Storch E, Miguel E. Comorbidity variation in patients with obsessive–compulsive disorder according to symptom dimensions: Results from a large multicentre clinical sample. Journal Of Affective Disorders 2015, 190: 508-516. PMID: 26561941, DOI: 10.1016/j.jad.2015.10.051.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBrazilChildComorbidityCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMental DisordersMiddle AgedObsessive-Compulsive DisorderYoung AdultConceptsPosttraumatic stress disorderObsessive-compulsive disorderAnxiety disordersTic disordersDimensional Yale-Brown Obsessive Compulsive ScaleSeparation anxiety disorderComorbid disordersSymptom dimensionsDifferent underlying pathogenic mechanismsTertiary mental health servicesDSM-IV Axis I DisordersSpecific phobiaMulticenter clinical studyPanic disorder/agoraphobiaAxis I DisordersStructured Clinical InterviewYale-Brown Obsessive Compulsive ScaleMental health servicesUnderlying pathogenic mechanismsImpulse control disordersBrazilian Research ConsortiumSocial phobiaBody dysmorphic disorderObsessive Compulsive ScaleCommon comorbidities
2014
Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study
McGrath LM, Yu D, Marshall C, Davis LK, Thiruvahindrapuram B, Li B, Cappi C, Gerber G, Wolf A, Schroeder FA, Osiecki L, O'Dushlaine C, Kirby A, Illmann C, Haddad S, Gallagher P, Fagerness JA, Barr CL, Bellodi L, Benarroch F, Bienvenu OJ, Black DW, Bloch MH, Bruun RD, Budman CL, Camarena B, Cath DC, Cavallini MC, Chouinard S, Coric V, Cullen B, Delorme R, Denys D, Derks EM, Dion Y, Rosário MC, Eapen V, Evans P, Falkai P, Fernandez TV, Garrido H, Geller D, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Heiman GA, Hemmings SM, Herrera LD, Hounie AG, Jankovic J, Kennedy JL, King RA, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Lochner C, Lowe TL, Lyon GJ, Macciardi F, Maier W, McCracken JT, McMahon W, Murphy DL, Naarden AL, Neale BM, Nurmi E, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Reus VI, Richter MA, Riddle M, Robertson MM, Rosenberg D, Rouleau GA, Ruhrmann S, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Tischfield JA, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Wendland JR, Shugart YY, Miguel EC, Nicolini H, Oostra BA, Moessner R, Wagner M, Ruiz-Linares A, Heutink P, Nestadt G, Freimer N, Petryshen T, Posthuma D, Jenike MA, Cox NJ, Hanna GL, Brentani H, Scherer SW, Arnold PD, Stewart SE, Mathews CA, Knowles JA, Cook EH, Pauls DL, Wang K, Scharf JM. Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 2014, 53: 910-919. PMID: 25062598, PMCID: PMC4218748, DOI: 10.1016/j.jaac.2014.04.022.Peer-Reviewed Original ResearchAdolescentDiagnostic and Statistical Manual of Mental DisordersDNA Copy Number VariationsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleObsessive-Compulsive DisorderPolymorphism, Single NucleotideTourette Syndrome
2012
Social phobia in obsessive-compulsive disorder: Prevalence and correlates
Assunção M, da Conceição Costa D, de Mathis M, Shavitt R, Ferrão Y, do Rosário M, Miguel E, Torres A. Social phobia in obsessive-compulsive disorder: Prevalence and correlates. Journal Of Affective Disorders 2012, 143: 138-147. PMID: 22858214, DOI: 10.1016/j.jad.2012.05.044.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAnxiety DisordersBody Dysmorphic DisordersBrazilComorbidityCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPhobic DisordersPrevalenceRetrospective StudiesSex FactorsSocial ClassTourette SyndromeConceptsObsessive-compulsive disorderDSM-IV Axis I DisordersLogistic regressionSocial phobiaAnxiety disordersOCD patientsCross-sectional studyStructured Clinical InterviewAxis I DisordersLow socioeconomic statusBrazilian Research ConsortiumLarge multicenter sampleBroader treatment approachesGeneralized anxiety disorderBody dysmorphic disorderYale-Brown ObsessiveClinical factorsCross-sectional designSpecific comorbiditiesMale sexObsessive-compulsive spectrum disordersUnivariate analysisLifetime prevalenceI disordersTourette syndrome
2010
Obsessive–compulsive disorder: a review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM‐V
Leckman JF, Denys D, Simpson HB, Mataix‐Cols D, Hollander E, Saxena S, Miguel EC, Rauch SL, Goodman WK, Phillips KA, Stein DJ. Obsessive–compulsive disorder: a review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM‐V. Depression And Anxiety 2010, 27: 507-527. PMID: 20217853, PMCID: PMC3974619, DOI: 10.1002/da.20669.Peer-Reviewed Original ResearchMeSH KeywordsBrainDiagnostic and Statistical Manual of Mental DisordersHumansNeuropsychological TestsObsessive-Compulsive DisorderSelective Serotonin Reuptake Inhibitors
2009
Early Onset Obsessive-Compulsive Disorder With and Without Tics
de Mathis M, Diniz J, Shavitt R, Torres A, Ferrão Y, Fossaluza V, Pereira C, Miguel E, do Rosario M. Early Onset Obsessive-Compulsive Disorder With and Without Tics. CNS Spectrums 2009, 14: 362-370. PMID: 19773712, DOI: 10.1017/s1092852900023014.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetComorbidityDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleObsessive-Compulsive DisorderOutpatientsPersonality AssessmentSeverity of Illness IndexTicsConceptsOnset obsessive-compulsive disorderObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleYears of ageEarly-onset obsessive-compulsive disorderObsessive Compulsive ScaleObsessive-compulsive symptomsTic disordersDimensional Yale-Brown Obsessive Compulsive ScaleYale Global Tic Severity ScaleCompulsive ScaleHigher mean scoresFourth Edition criteriaStructured Clinical InterviewTic Severity ScaleVariable clinical manifestationsMean scoreThe impact of trauma and post-traumatic stress disorder on the treatment response of patients with obsessive-compulsive disorder
Shavitt R, Valério C, Fossaluza V, da Silva E, Cordeiro Q, Diniz J, Belotto-Silva C, Cordioli A, Mari J, Miguel E. The impact of trauma and post-traumatic stress disorder on the treatment response of patients with obsessive-compulsive disorder. European Archives Of Psychiatry And Clinical Neuroscience 2009, 260: 91-99. PMID: 20077119, DOI: 10.1007/s00406-009-0015-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAnxietyDepressionDiagnostic and Statistical Manual of Mental DisordersFemaleFollow-Up StudiesHumansMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesSelective Serotonin Reuptake InhibitorsStatistics, NonparametricStress Disorders, Post-TraumaticTreatment OutcomeConceptsHistory of traumaPost-traumatic stress disorderObsessive-compulsive disorderTreatment responseHT groupBeck Depression InventoryPTSD groupBeck Anxiety InventorySpecific OCD symptom dimensionsConventional treatmentOCD symptom dimensionsOCD patientsSelective serotonin reuptake inhibitorsStress disorderFull DSM-IV criteriaFirst-line treatmentSerotonin reuptake inhibitorsCase series studyPoor treatment responseResistant OCD patientsSymptom dimensionsGreater treatment responseDSM-IV criteriaGreater reductionGroup cognitive behavioral therapyObsessive-compulsive symptoms and disorder in patients with schizophrenia treated with clozapine or haloperidol
R. A, Hounie A, Sampaio A, Arrais J, Miguel E, Elkis H. Obsessive-compulsive symptoms and disorder in patients with schizophrenia treated with clozapine or haloperidol. Comprehensive Psychiatry 2009, 50: 437-442. PMID: 19683614, DOI: 10.1016/j.comppsych.2008.11.005.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive AgentsAntipsychotic AgentsClozapineComorbidityDiagnostic and Statistical Manual of Mental DisordersDrug Therapy, CombinationFemaleHaloperidolHumansInterview, PsychologicalMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesPsychometricsSchizophreniaYoung AdultConceptsObsessive-compulsive disorderObsessive-compulsive symptomsSchizophrenia patientsPrevalence of OCDSchizophrenia rating scalesPresence of OCSPrevalence of patientsUse of clozapineUse of antidepressantsClinical Global ImpressionPANSS total scoreCross-sectional studyStructured Clinical InterviewHigher severity scoresNegative Syndrome ScaleHigher severityYale-Brown ObsessiveGlobal ImpressionSeverity scorePatientsClozapineClinical InterviewHaloperidolSchizophrenia symptomsSyndrome Scale
2008
Sex differences in the phenotypic expression of obsessive-compulsive disorder: an exploratory study from Brazil
Torresan R, de Abreu Ramos-Cerqueira A, de Mathis M, Diniz J, Ferrão Y, Miguel E, Torres A. Sex differences in the phenotypic expression of obsessive-compulsive disorder: an exploratory study from Brazil. Comprehensive Psychiatry 2008, 50: 63-69. PMID: 19059516, DOI: 10.1016/j.comppsych.2008.05.005.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBrazilCatchment Area, HealthChildDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPhenotypeResearch DesignSex FactorsSurveys and QuestionnairesYoung AdultConceptsObsessive-compulsive disorderObsessive-compulsive symptomsBeck DepressionYale Global Tic Severity ScaleComorbid simple phobiasFemale Brazilian patientsStructured Clinical InterviewPrivate practice clinicTic Severity ScaleAnxiety InventoryComorbid tic disordersEfficacious treatment approachGlobal symptom severityPosttraumatic stress disorderSex-related differencesYale-Brown ObsessiveClinical characteristicsClinical featuresMean agePsychiatric comorbiditySymptom interferencePractice clinicsTic disordersBrazilian patientsFamily history
2007
Level of Insight and Clinical Features of Obsessive-Compulsive Disorder with and Without Body Dysmorphic Disorder
Nakata A, Diniz J, Torres A, de Mathis M, Fossaluza V, Bragancas C, Ferrão Y, Miguel E. Level of Insight and Clinical Features of Obsessive-Compulsive Disorder with and Without Body Dysmorphic Disorder. CNS Spectrums 2007, 12: 295-303. PMID: 17426667, DOI: 10.1017/s1092852900021052.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAwarenessBrazilComorbidityCultureDiagnosis, DifferentialDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMental DisordersMiddle AgedObsessive-Compulsive DisorderSomatoform DisordersConceptsBody dysmorphic disorderClinical featuresObsessive-compulsive symptomsOCD patientsObsessive-compulsive disorderLevel of insightDysmorphic disorderPsychiatric comorbid disordersFourth Edition criteriaStructured Clinical InterviewComorbid body dysmorphic disorderLow educational levelEducational levelYale-Brown ObsessiveHigh morbidityPsychiatric comorbidityPossible confoundersEdition criteriaStudy groupComorbid disordersBrown AssessmentClinical InterviewPatientsBeck DepressionMental disorders
2006
Association study between the 1287 A/G exonic polymorphism of the norepinephrine transporter (NET) gene and obsessive-compulsive disorder in a Brazilian sample
Miguita K, Cordeiro Q, Shavitt R, Miguel E, Vallada H. Association study between the 1287 A/G exonic polymorphism of the norepinephrine transporter (NET) gene and obsessive-compulsive disorder in a Brazilian sample. Brazilian Journal Of Psychiatry 2006, 28: 158-159. PMID: 16810402, DOI: 10.1590/s1516-44462006000200017.Peer-Reviewed Original ResearchAllelesCase-Control StudiesDiagnostic and Statistical Manual of Mental DisordersExonsGenetic MarkersGenetic Predisposition to DiseaseGenotypeHumansNorepinephrine Plasma Membrane Transport ProteinsObsessive-Compulsive DisorderPolymorphism, Genetic
2005
Chronic tics and Tourette syndrome in patients with obsessive–compulsive disorder
Diniz J, Rosario-Campos M, Hounie A, Curi M, Shavitt R, Lopes A, Miguel E. Chronic tics and Tourette syndrome in patients with obsessive–compulsive disorder. Journal Of Psychiatric Research 2005, 40: 487-493. PMID: 16289552, DOI: 10.1016/j.jpsychires.2005.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChi-Square DistributionChildDiagnosis, DifferentialDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMiddle AgedMultivariate AnalysisObsessive-Compulsive DisorderPersonality InventoryPsychiatric Status Rating ScalesPsychometricsRetrospective StudiesSeverity of Illness IndexTic DisordersTourette SyndromeConceptsObsessive-compulsive disorderTourette syndromeOCD patientsVocal ticsYale Global Tic Severity ScaleNumber of comorbiditiesStructured Clinical InterviewTic Severity ScaleYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleSymptom onsetChronic motorTic disordersCommon disorderSeverity ScalePatientsClinical InterviewChronic ticsDSM-IVBehaviors InterviewCompulsive ScaleSomatic obsessionsDisordersCompulsive disorderOCD phenotypeClinical expression of obsessive-compulsive disorder in women with bipolar disorder
Issler C, de Mello Siqueira Amaral J, Tamada R, Schwartzmann A, Shavitt R, Miguel E, Lafer B. Clinical expression of obsessive-compulsive disorder in women with bipolar disorder. Brazilian Journal Of Psychiatry 2005, 27: 139-142. PMID: 15962140, DOI: 10.1590/s1516-44462005000200013.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetBipolar DisorderBrazilChi-Square DistributionComorbidityDiagnostic and Statistical Manual of Mental DisordersFemaleHumansObsessive-Compulsive DisorderPsychiatric Status Rating ScalesRetrospective StudiesSeverity of Illness IndexSocioeconomic FactorsConceptsObsessive-compulsive disorderBipolar disorderRating ScaleObsessive-compulsive symptomsEarly onsetHamilton Depression Rating ScaleYoung Mania Rating ScaleNon-controlled designComorbid bipolar disorderSensory phenomenaDepression Rating ScaleStructured Clinical InterviewSeverity of symptomsMania Rating ScaleBipolar disorder ICompulsive Rating ScaleYale-Brown ObsessiveChronic motorManic episodesTic disordersVocal ticsClinical expressionClinical InterviewPsychopathological featuresDisorder I
2004
Obsessive-compulsive spectrum disorders in rheumatic fever with and without Sydenham's chorea.
Hounie A, Pauls D, Mercadante M, Rosário-Campos M, Shavitt R, de Mathis M, de Alvarenga P, Cúri M, Miguel E. Obsessive-compulsive spectrum disorders in rheumatic fever with and without Sydenham's chorea. The Journal Of Clinical Psychiatry 2004, 65: 994-9. PMID: 15291690, DOI: 10.4088/jcp.v65n0717.Peer-Reviewed Original Research