Detecting multiple differentially methylated CpG sites and regions related to dimensional psychopathology in youths
Spindola L, Santoro M, Pan P, Ota V, Xavier G, Carvalho C, Talarico F, Sleiman P, March M, Pellegrino R, Brietzke E, Grassi-Oliveira R, Mari J, Gadelha A, Miguel E, Rohde L, Bressan R, Mazzotti D, Sato J, Salum G, Hakonarson H, Belangero S. Detecting multiple differentially methylated CpG sites and regions related to dimensional psychopathology in youths. Clinical Epigenetics 2019, 11: 146. PMID: 31639064, PMCID: PMC6805541, DOI: 10.1186/s13148-019-0740-z.Peer-Reviewed Original ResearchInitial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis
Lisboa B, Oliveira K, Tahira A, Barbosa A, Feltrin A, Gouveia G, Lima L, Feio dos Santos A, Martins D, Puga R, Moretto A, De Bragança Pereira C, Lafer B, Leite R, Ferretti-Rebustini R, Farfel J, Grinberg L, Jacob-Filho W, Miguel E, Hoexter M, Brentani H. Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis. Scientific Reports 2019, 9: 3086. PMID: 30816141, PMCID: PMC6395771, DOI: 10.1038/s41598-019-38965-1.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSynaptic transmissionPathophysiology of OCDDifferent striatal subregionsPostmortem brain tissueChemical synaptic transmissionStriatal areasCortico-striatoNeurotransmitter levelsStriatum regionThalamic circuitryStriatal subregionsSubregion specificityPsychiatric disordersPresynaptic processesSynaptic plasticityBrain samplesOCD pathophysiologyBrain tissueCSTC modelControl casesPathophysiologyRare variantsDisordersCellular responses