2022
Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother–infant pairs
Wiley K, Camilo C, Gouveia G, Euclydes V, Panter‐Brick C, Matijasevich A, Ferraro A, Fracolli L, Chiesa A, Miguel E, Polanczyk G, Brentani H. Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother–infant pairs. Developmental Psychobiology 2022, 65: e22352. PMID: 36567654, PMCID: PMC9792831, DOI: 10.1002/dev.22352.Peer-Reviewed Original ResearchConceptsPrenatal psychological distressLate pregnancyMaternal prenatal psychosocial stressMaternal hair cortisolMaternal prenatal psychological distressPrenatal psychosocial stressPsychological distressAdrenal axis functionInfants of mothersEvening salivary cortisolMother-infant pairsInfant DNA methylationMultivariable linear regressionHair cortisol concentrationsElevated anxiety symptomsAxis functionFetal programingEvening cortisolPregnant adolescentsMaternal distressPsychosocial stressCortisol concentrationsPregnancyHair cortisolSalivary cortisolDNA methylation mediates a randomized controlled trial home-visiting intervention during pregnancy and the Bayley infant’s cognitive scores at 12 months of age
Euclydes V, Gastaldi V, Feltrin A, Hoffman D, Gouveia G, Cogo H, Felipe-Silva A, Vieira R, Miguel E, Polanczyk G, Chiesa A, Fracolli L, Matijasevich A, Ferraro A, Argeu A, Maschietto M, Brentani H. DNA methylation mediates a randomized controlled trial home-visiting intervention during pregnancy and the Bayley infant’s cognitive scores at 12 months of age. Journal Of Developmental Origins Of Health And Disease 2022, 13: 556-565. PMID: 35256034, DOI: 10.1017/s2040174421000738.Peer-Reviewed Original Research
2021
Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation
de Oliveira K, Camilo C, Gastaldi V, Sant’Anna Feltrin A, Lisboa B, de Jesus Rodrigues de Paula V, Moretto A, Lafer B, Hoexter M, Miguel E, Maschietto M, Brentani H. Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation. BMC Genomic Data 2021, 22: 45. PMID: 34717534, PMCID: PMC8557022, DOI: 10.1186/s12863-021-00993-0.Peer-Reviewed Original ResearchConceptsGene modulesMethylation changesBrain areasCpG sitesProtein-protein interaction networkDNA methylation modulationCommon transcriptional factorsDNA methylation changesSpecific signaling pathwaysGene expression dataOCD patientsPost-mortem brain tissueEpigenetic mechanismsInteraction networksMethylation modulationHypomethylation patternTranscriptional factorsEnvironmental risk factorsGene expressionBiological processesBackgroundObsessive–compulsive disorderSignaling pathwaysExpression dataG proteinsRisk factors
2019
Detecting multiple differentially methylated CpG sites and regions related to dimensional psychopathology in youths
Spindola L, Santoro M, Pan P, Ota V, Xavier G, Carvalho C, Talarico F, Sleiman P, March M, Pellegrino R, Brietzke E, Grassi-Oliveira R, Mari J, Gadelha A, Miguel E, Rohde L, Bressan R, Mazzotti D, Sato J, Salum G, Hakonarson H, Belangero S. Detecting multiple differentially methylated CpG sites and regions related to dimensional psychopathology in youths. Clinical Epigenetics 2019, 11: 146. PMID: 31639064, PMCID: PMC6805541, DOI: 10.1186/s13148-019-0740-z.Peer-Reviewed Original Research
2017
Sex differences in DNA methylation of the cord blood are related to sex-bias psychiatric diseases
Maschietto M, Bastos L, Tahira A, Bastos E, Euclydes V, Brentani A, Fink G, de Baumont A, Felipe-Silva A, Francisco R, Gouveia G, Grisi S, Escobar A, Moreira-Filho C, Polanczyk G, Miguel E, Brentani H. Sex differences in DNA methylation of the cord blood are related to sex-bias psychiatric diseases. Scientific Reports 2017, 7: 44547. PMID: 28303968, PMCID: PMC5355991, DOI: 10.1038/srep44547.Peer-Reviewed Original ResearchConceptsDNA methylationCpG sitesSex-specific DNA methylationCord bloodIllumina HumanMethylation450 BeadChipPsychiatric outcomesMethylation profilesSex differencesHumanMethylation450 BeadChipBrains of boysMethylationXY probesPsychiatric disordersPsychiatric diseasesBrain tissueEnvironmental factorsBrain developmentNeurodevelopmental disordersPrimary driverGestationBloodPotential connectionBeadChipDisordersGenes
2016
Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive–compulsive disorder
Cappi C, Diniz J, Requena G, Lourenço T, Lisboa B, Batistuzzo M, Marques A, Hoexter M, Pereira C, Miguel E, Brentani H. Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive–compulsive disorder. BMC Neuroscience 2016, 17: 79. PMID: 27903255, PMCID: PMC5131547, DOI: 10.1186/s12868-016-0313-4.Peer-Reviewed Original Research