2017
Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample
Pan P, Sato J, Salum G, Rohde L, Gadelha A, Zugman A, Mari J, Jackowski A, Picon F, Miguel E, Pine D, Leibenluft E, Bressan R, Stringaris A. Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample. American Journal Of Psychiatry 2017, 174: 1112-1119. PMID: 28946760, PMCID: PMC10752293, DOI: 10.1176/appi.ajp.2017.17040430.Peer-Reviewed Original ResearchConceptsResting-state functional MRIIntrinsic functional connectivityDepressive disorderFunctional connectivityFunctional MRIReward networkFuture depressive disorderAdolescent depressive disordersLeft ventral striatumOnset of depressionBrain reward networksAberrant reward processingAttention deficit hyperactivity disorderDeficit hyperactivity disorderLongitudinal communityChildren 6Ventral striatumAdolescent depressionLogistic regressionHyperactivity disorderSubstance useYouth depressionDisordersDepressionFuture risk
2012
Clinical features of obsessive-compulsive disorder with hoarding symptoms: A multicenter study
Torres A, Fontenelle L, Ferrão Y, do Rosário M, Torresan R, Miguel E, Shavitt R. Clinical features of obsessive-compulsive disorder with hoarding symptoms: A multicenter study. Journal Of Psychiatric Research 2012, 46: 724-732. PMID: 22464941, DOI: 10.1016/j.jpsychires.2012.03.005.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderClinical featuresOCD patientsLogistic regressionDSM-IV OCD patientsCertain clinical featuresCross-sectional studyAttention-deficit/hyperactivity disorderStatistical univariate analysisBrazilian Research ConsortiumDeficit/hyperactivity disorderHigher anxiety scoresYale-Brown ObsessiveSymptom onsetInsidious onsetMulticenter studyObsessive-compulsive spectrum disordersSectional studyPossible confoundersUnivariate analysisTic disordersHoarding dimensionPatientsSymptomsPoor insight
2006
Obsessive-Compulsive Spectrum Disorders and Rheumatic Fever: A Family Study
Hounie A, Pauls D, do Rosario-Campos M, Mercadante M, Diniz J, De Mathis M, De Mathis M, Chacon P, Shavitt R, Curi M, Guilherme L, Miguel E. Obsessive-Compulsive Spectrum Disorders and Rheumatic Fever: A Family Study. Biological Psychiatry 2006, 61: 266-272. PMID: 16616727, DOI: 10.1016/j.biopsych.2006.02.021.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBacterial ProteinsCase-Control StudiesChildData Interpretation, StatisticalFamilyFemaleHumansInterview, PsychologicalLogistic ModelsMaleObserver VariationObsessive-Compulsive DisorderOdds RatioPsychiatric Status Rating ScalesRheumatic FeverRiskStreptococcal InfectionsStreptolysinsConceptsFirst-degree relativesRheumatic feverObsessive-compulsive spectrum disordersSydenham's choreaFDRs of controlsStructured psychiatric interviewUnderlying etiologic mechanismsCase-control family studyFamily studiesControl first-degree relativesBest-estimate diagnosesHigh rateRF patientsCompulsive spectrum disordersOdds ratioMorbid riskEtiologic mechanismsPsychiatric interviewSpectrum disorderLogistic regressionProbandsFeverPatientsChoreaDiagnosis
2005
A family study of early‐onset obsessive‐compulsive disorder
do Rosario‐Campos M, Leckman JF, Curi M, Quatrano S, Katsovitch L, Miguel EC, Pauls DL. A family study of early‐onset obsessive‐compulsive disorder. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2005, 136B: 92-97. PMID: 15892140, DOI: 10.1002/ajmg.b.30149.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRecurrence riskChronic ticsFirst-degree family membersChildhood-onset obsessive-compulsive disorderDiagnosis of OCDChronic tic disorderStandardized semi-structured interviewFirst-degree relativesEarly-onset casesOnset obsessive-compulsive disorderDSM-IV criteriaEarly-onset obsessive-compulsive disorderBest-estimate processRandom digit dialingHigh comorbid ratesAge of onsetFamily studiesHigh genetic loadingMean ageSpecialty clinicTic disordersComorbid ratesValid subgroupsCase relatives