2015
ORBITOFRONTAL THICKNESS AS A MEASURE FOR TREATMENT RESPONSE PREDICTION IN OBSESSIVE–COMPULSIVE DISORDER
Hoexter M, Diniz J, Lopes A, Batistuzzo M, Shavitt R, Dougherty D, Duran F, Bressan R, Busatto G, Miguel E, Sato J. ORBITOFRONTAL THICKNESS AS A MEASURE FOR TREATMENT RESPONSE PREDICTION IN OBSESSIVE–COMPULSIVE DISORDER. Depression And Anxiety 2015, 32: 900-908. PMID: 26032588, DOI: 10.1002/da.22380.Peer-Reviewed Original ResearchConceptsTreatment-naïve OCD patientsObsessive-compulsive disorderTreatment responseIndependent cohortOCD patientsOFC thicknessRefractory OCD patientsTreatment-naïve patientsOrbitofrontal cortex thicknessSecond independent cohortLogistic regression modelsBaseline thicknessClinical trialsTreatment outcomesInitial cohortClinical utilityOrbitofrontal thicknessIneffective treatmentPatientsCohortMedial OFCNeuroimaging techniquesMorphometric biomarkersBiomarkersCortex thickness
2012
Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive–compulsive disorder
Hoexter M, Dougherty D, Shavitt R, D'Alcante C, Duran F, Lopes A, Diniz J, Batistuzzo M, Evans K, Bressan R, Busatto G, Miguel E. Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive–compulsive disorder. European Neuropsychopharmacology 2012, 23: 569-580. PMID: 22841131, DOI: 10.1016/j.euroneuro.2012.06.014.Peer-Reviewed Original ResearchConceptsGray matter volumeMedial prefrontal cortexCognitive behavioral therapyObsessive-compulsive disorderTreatment responseTreatment-naïve OCD patientsTreatment groupsMagnetic resonance imagingMatter volumeOrbitofrontal cortexLateral orbitofrontal cortexSymptom improvementOCD patientsFluoxetine treatment groupTrial of fluoxetineSerotonin reuptake inhibitorsAdequate therapeutic approachStructural magnetic resonance imagingCBT treatment groupRight medial prefrontal cortexGroup-based cognitive behavioral therapyRegional gray matter volumeStructural MRI scansDistinct brain regionsYale-Brown ObsessiveNeuropsychological predictors of response to randomized treatment in obsessive–compulsive disorder
D'Alcante C, Diniz J, Fossaluza V, Batistuzzo M, Lopes A, Shavitt R, Deckersbach T, Malloy-Diniz L, Miguel E, Hoexter M. Neuropsychological predictors of response to randomized treatment in obsessive–compulsive disorder. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2012, 39: 310-317. PMID: 22789662, DOI: 10.1016/j.pnpbp.2012.07.002.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyObsessive-compulsive disorderCalifornia Verbal Learning TestVictoria Stroop TestVerbal Learning TestNeuropsychological measuresOCD patientsMental flexibilityVerbal memoryNeuropsychological predictorsLearning TestHigher verbal IQDifferent neuropsychological profilesUnderwent neuropsychological assessmentExecutive functioningExecutive abilitiesVerbal IQStroop testNeuropsychological profileNeuropsychological assessmentIntellectual functionHeuristic valueLarge sampleMemoryTreatment response
2006
Association of polymorphisms within the promoter region of the tumor necrosis factor-α with clinical outcomes of rheumatic fever
Ramasawmy R, Faé K, Spina G, Victora G, Tanaka A, Palácios S, Hounie A, Miguel E, Oshiro S, Goldberg A, Kalil J, Guilherme L. Association of polymorphisms within the promoter region of the tumor necrosis factor-α with clinical outcomes of rheumatic fever. Molecular Immunology 2006, 44: 1873-1878. PMID: 17079017, DOI: 10.1016/j.molimm.2006.10.001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAortic DiseasesAutoimmune DiseasesChildChoreaCohort StudiesFemaleGenetic Predisposition to DiseaseHumansMaleMyocarditisPolymorphism, Single NucleotidePredictive Value of TestsQuantitative Trait LociRheumatic Heart DiseaseStreptococcal InfectionsStreptococcus pyogenesTumor Necrosis Factor-alphaConceptsRheumatic feverRF patientsClinical outcomesHealthy controlsTNFA geneMinor alleleRF/RHDAortic valve lesionsRecognition of autoantigensStratification of patientsTumor necrosis factorAssociation of polymorphismsMild carditisValve lesionsAdaptive armsSydenham's choreaAutoimmune diseasesHeart diseaseInflammatory diseasesNecrosis factorBorderline associationG-308APatientsImmune systemClinical phenotype