2012
Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder
Cappi C, Muniz R, Sampaio A, Cordeiro Q, Brentani H, Palácios S, Marques A, Vallada H, Miguel E, Guilherme L, Hounie A. Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder. Arquivos De Neuro-Psiquiatria 2012, 70: 87-90. PMID: 22311210, PMCID: PMC4479271, DOI: 10.1590/s0004-282x2012000200003.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderImmune systemTumor necrosis factor alpha genePrevalent psychiatric disordersInflammatory cytokine genesNecrosis factor alpha geneTNF-alpha geneRs361525 polymorphismUnknown etiologyHealthy controlsPsychiatric disordersCytokine genesA alleleFunctional polymorphismsOCD patientsOCD subjectsDisordersPathogenesisPLINK softwarePresent studyPolymorphismAdditional evidenceAssociation studiesPatientsEtiology
2011
Association study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment
Miguita K, Cordeiro Q, Shavitt R, Miguel E, Vallada H. Association study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment. Arquivos De Neuro-Psiquiatria 2011, 69: 283-287. PMID: 21625751, DOI: 10.1590/s0004-282x2011000300003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive Agents, TricyclicClomipramineDopamine Plasma Membrane Transport ProteinsFemaleGene FrequencyGenotypeHumansMaleMutationNorepinephrine Plasma Membrane Transport ProteinsObsessive-Compulsive DisorderPolymorphism, GeneticReceptors, SerotoninSerotonin Plasma Membrane Transport ProteinsYoung Adult
2009
Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder
Cordeiro Q, Cappi C, Sampaio A, Palácios S, de Bragança Pereira C, Shavitt R, Miguel E, Guilherme L, Hounie A. Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder. Brazilian Journal Of Psychiatry 2009, 31: 131-135. PMID: 19578685, DOI: 10.1590/s1516-44462009000200009.Peer-Reviewed Original Research
2008
TNF-alpha polymorphisms are associated with obsessive-compulsive disorder
Hounie A, Cappi C, Cordeiro Q, Sampaio A, Moraes I, do Rosário M, Palácios S, Goldberg A, Vallada H, Machado-Lima A, Nakano E, Kalil J, Pauls D, Pereira C, Guilherme L, Miguel E. TNF-alpha polymorphisms are associated with obsessive-compulsive disorder. Neuroscience Letters 2008, 442: 86-90. PMID: 18639610, DOI: 10.1016/j.neulet.2008.07.022.Peer-Reviewed Original Research
2007
Association analysis between a VNTR intron 8 polymorphism of the dopamine transporter gene (SLC6A3) and obsessive- compulsive disorder in a Brazilian sample
Miguita K, Cordeiro Q, Siqueira-Roberto J, Shavitt R, Castillo J, Castillo A, Miguel E, Vallada H. Association analysis between a VNTR intron 8 polymorphism of the dopamine transporter gene (SLC6A3) and obsessive- compulsive disorder in a Brazilian sample. Arquivos De Neuro-Psiquiatria 2007, 65: 936-941. PMID: 18094849, DOI: 10.1590/s0004-282x2007000600002.Peer-Reviewed Original Research
2006
Association study between the 1287 A/G exonic polymorphism of the norepinephrine transporter (NET) gene and obsessive-compulsive disorder in a Brazilian sample
Miguita K, Cordeiro Q, Shavitt R, Miguel E, Vallada H. Association study between the 1287 A/G exonic polymorphism of the norepinephrine transporter (NET) gene and obsessive-compulsive disorder in a Brazilian sample. Brazilian Journal Of Psychiatry 2006, 28: 158-159. PMID: 16810402, DOI: 10.1590/s1516-44462006000200017.Peer-Reviewed Original Research
2003
Association analysis of the catechol‐o‐methyltransferase (COMT ), serotonin transporter (5‐HTT ) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive‐compulsive disorder
Meira‐Lima I, Shavitt R, Miguita K, Ikenaga E, Miguel E, Vallada H. Association analysis of the catechol‐o‐methyltransferase (COMT ), serotonin transporter (5‐HTT ) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive‐compulsive disorder. Genes Brain & Behavior 2003, 3: 75-79. PMID: 15005715, DOI: 10.1046/j.1601-1848.2003.0042.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmino Acid SubstitutionCarrier ProteinsCase-Control StudiesCatechol O-MethyltransferaseFemaleGene FrequencyHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsObsessive-Compulsive DisorderPolymorphism, GeneticReceptor, Serotonin, 5-HT2AReference ValuesRegulatory Sequences, Nucleic AcidSerotonin Plasma Membrane Transport ProteinsConceptsObsessive-compulsive disorderGene polymorphismsT variantOCD patientsSerotonin receptor type 2A geneSerotonin-2A receptor gene polymorphismCross-sectional studyReceptor gene polymorphismsStrong genetic factorGenetic risk factorsControl subjectsRisk factorsDopaminergic systemDisease pathogenesisControl groupSerotonin transporter genePharmacological studiesPatientsGenetic factorsGenotypic distributionPrecise mechanismSignificant differencesFurther studiesCOMT geneFrequency of alleles