2022
Latency to treatment seeking in patients with obsessive-compulsive disorder: Results from a large multicenter clinical sample
Costa D, de Campos A, Pereira C, Torres A, Dos Santos A, Requena G, Ferrão Y, do Rosário M, Miguel E, Simpson H, Shavitt R, Diniz J. Latency to treatment seeking in patients with obsessive-compulsive disorder: Results from a large multicenter clinical sample. Psychiatry Research 2022, 312: 114567. PMID: 35490573, DOI: 10.1016/j.psychres.2022.114567.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEarly onsetOne-thirdCross-sectional studyInterval-censored survival modelClinical characteristicsOlder patientsSymptom awarenessPatientsNeuropsychiatric disordersSymptomsOlder ageOCD patientsContamination/Clinical samplesDisordersAggression symptomsOCD symptomsMore yearsTreatmentSurvival modelsOnsetYearsFull-time employmentComorbiditiesObsessive-Compulsive Disorder Treatment Based on Neurocircuits
Shephard E, Stern E, Miguel E. Obsessive-Compulsive Disorder Treatment Based on Neurocircuits. Psychiatric Annals 2022, 52: 152-156. DOI: 10.3928/00485713-20220317-01.Peer-Reviewed Original ResearchObsessive-compulsive disorderNew treatment approachesObsessive-compulsive disorder (OCD) treatmentClinical profileIndividual patientsGlobal burdenNeurocognitive alterationsPsychiatric disordersPsychiatric treatmentTreatment approachesDisorder treatmentPsychiatric conditionsClinical useSpecific neurocircuitsUnderlying neurobiological basisModels of OCDNeurobiological basisTreatmentNeurocircuitsDisordersPatients
2021
Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder
Shephard E, Stern E, van den Heuvel O, Costa D, Batistuzzo M, Godoy P, Lopes A, Brunoni A, Hoexter M, Shavitt R, Reddy Y, Lochner C, Stein D, Simpson H, Miguel E. Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder. Molecular Psychiatry 2021, 26: 4583-4604. PMID: 33414496, PMCID: PMC8260628, DOI: 10.1038/s41380-020-01007-8.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCognitive neuroscienceNeurobiological alterationsMental health researchClinical profileFuture researchCase vignettesPsychiatric symptomsNeuromodulatory treatmentDifferent clinical profilesNeuroscienceEffective treatmentDisordersResearchBehavioralVignettesFindingsHealth researchTreatmentDysfunctionSymptomsPhenotypic expressionImportant limitationsTaxonomyPatients
2019
Use of Mental Health Services by Children With Mental Disorders in Two Major Cities in Brazil
Fatori D, Salum G, Rohde L, Pan P, Bressan R, Evans-Lacko S, Polanczyk G, Miguel E, Graeff-Martins A. Use of Mental Health Services by Children With Mental Disorders in Two Major Cities in Brazil. Psychiatric Services 2019, 70: 337-341. PMID: 30651056, DOI: 10.1176/appi.ps.201800389.Peer-Reviewed Original ResearchConceptsMental health servicesMental disordersUnmet needHealth servicesHigh Risk Cohort StudyCombination of psychotherapyMental health treatmentChildren ages 6Cohort studyHealth treatmentCommunity studyAge 6DisordersHealth careLifetime useWhite childrenChildrenHigh rateTreatmentCurrent studyPorto AlegreSao PauloMedicationsPsychotherapyDiagnosis
2018
Adaptive treatment strategies for children and adolescents with Obsessive-Compulsive Disorder: A sequential multiple assignment randomized trial
Fatori D, de Bragança Pereira CA, Asbahr FR, Requena G, Alvarenga PG, de Mathis MA, Rohde LA, Leckman JF, March JS, Polanczyk GV, Miguel EC, Shavitt RG. Adaptive treatment strategies for children and adolescents with Obsessive-Compulsive Disorder: A sequential multiple assignment randomized trial. Journal Of Anxiety Disorders 2018, 58: 42-50. PMID: 30025255, DOI: 10.1016/j.janxdis.2018.07.002.Peer-Reviewed Original ResearchConceptsGroup cognitive behavioral therapySequential multiple assignmentTreatment failureInitial treatmentBaseline Yale-Brown ObsessiveChildhood OCDEffective initial treatmentProvision of treatmentCompulsive Scale scoresCognitive behavioral therapyAdaptive treatment strategiesYale-Brown ObsessiveSame regimenObsessive-compulsive disorderTreatment strategiesSymptom reductionPrimary analysisScale scoreFluoxetineTime pointsWeeksTreatmentChildrenEffect sizeTrials
2014
An updated review of antidepressants with marked serotonergic effects in obsessive–compulsive disorder
Pizarro M, Fontenelle L, Paravidino D, Yücel M, Miguel E, de Menezes G. An updated review of antidepressants with marked serotonergic effects in obsessive–compulsive disorder. Expert Opinion On Pharmacotherapy 2014, 15: 1391-1401. PMID: 24766145, DOI: 10.1517/14656566.2014.914493.Peer-Reviewed Original ResearchConceptsDouble-blind studyObsessive-compulsive disorderPathophysiology of OCDEfficacy of desvenlafaxineEfficacy of antidepressantsShort-term treatmentOlder antidepressantsSerotonergic effectsClinical trialsSerotonergic systemNew agentsAntidepressantsSystematic reviewReliable efficacyEfficacyUpdated reviewClomipramineOCD symptomsDisordersTreatmentCurrent studyReviewSSRIsDuloxetineMirtazapine
2009
Treatment of Resistant Obsessive-Compulsive Disorder With Ventral CapsularVentral Striatal Gamma Capsulotomy: A Pilot Prospective Study
Lopes A, Greenberg B, Norén G, Canteras M, Busatto G, de Mathis M, Taub A, D'Alcante C, Hoexter M, Gouvea F, Cecconi J, Gentil A, Ferrão Y, Fuentes D, de Castro C, Leite C, Salvajoli J, Duran F, Rasmussen S, Miguel E. Treatment of Resistant Obsessive-Compulsive Disorder With Ventral CapsularVentral Striatal Gamma Capsulotomy: A Pilot Prospective Study. Journal Of Neuropsychiatry 2009, 21: 381-392. PMID: 19996246, DOI: 10.1176/jnp.2009.21.4.381.Peer-Reviewed Original ResearchConceptsResistant obsessive-compulsive disorderRefractory OCD patientsAdverse effectsPilot prospective studyObsessive-compulsive disorder patientsAdverse eventsProspective studyObsessive-compulsive disorderStereotactic radiosurgeryDepressive symptomsDisorder patientsSide effectsConventional treatmentCapsulotomyTherapeutic promisePatientsOCD patientsTreatmentSurgeryRadiosurgerySymptomsMonths
2007
Resistência e refratariedade no transtorno obsessivo-compulsivo
Ferrão Y, Diniz J, Lopes A, Shavitt R, Greenberg B, Miguel E. Resistência e refratariedade no transtorno obsessivo-compulsivo. Brazilian Journal Of Psychiatry 2007, 29: s66-s76. PMID: 18172943, DOI: 10.1590/s1516-44462006005000059.Peer-Reviewed Original ResearchMeSH KeywordsAntidepressive AgentsAntipsychotic AgentsBehavior TherapyClinical Trials as TopicCombined Modality TherapyDrug ResistanceDrug ToleranceFamily RelationsHumansMeta-Analysis as TopicObsessive-Compulsive DisorderPsychiatric Status Rating ScalesPsychotherapySelective Serotonin Reuptake InhibitorsConceptsObsessive-compulsive disorder patientsObsessive-compulsive disorderTherapeutic alternativeDisorder patientsConventional treatmentEffective therapeutic alternativeCompulsive disorder patientsAvailable treatmentsTreatment responseClinical challengeTreatment resistanceSymptom remissionAdequate treatmentPatient sufferingPatientsCurrent conceptsRemissionMore studiesTreatmentDisordersSignificant numberLiterature reviewUnanswered questionsExtrinsic factors
2006
Tourette syndrome: treatment
Hounie A, Rosário-Campos M, Quarantini L, Sampaio A, Alvarenga P, Diniz J, Lopes A, Seixas A, Pinto A, Chacon P, Prado H, Belotto C, Motta M, De Mathis M, De Mathis M, Borcatto S, Carvalho M, Miguel E. Tourette syndrome: treatment. 2006, 156-205. DOI: 10.1201/b14454-9.Peer-Reviewed Original ResearchTourette syndromeGilles deSimilar medical historyMultiple motor ticsGilles de la TouretteCase seriesMedical historyMotor ticsParticular physicianPatientsSymptomsTouretteDiseaseTreatmentEventual appearanceStrange diseaseDifferent treatmentsLa TouretteChoreaSyndromeCase historiesPsychologicPhysiciansHistory
2004
Transtorno de déficit de atenção/hiperatividade na infância e na adolescência: considerações clínicas e terapêuticas
Rohde L, Filho E, Benetti L, Gallois C, Kieling C. Transtorno de déficit de atenção/hiperatividade na infância e na adolescência: considerações clínicas e terapêuticas. Archives Of Clinical Psychiatry 2004, 31: 124-131. DOI: 10.1590/s0101-60832004000300002.Peer-Reviewed Original ResearchBipolar disorderAttention-deficit/hyperactivity disorderNon-systematic reviewPharmacological managementTherapeutic dilemmaDifferential diagnosisPrevalent disorderComorbid disordersClinical relevancePrecise diagnosisClinical tipsHyperactivity disorderDisordersClinical psychiatristsImpairment criteriaDiagnosisImportant impairmentComorbiditiesTreatmentAdequate useMedicationsReviewImpairment
2001
Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamento
Shavitt R, Ferrão Y, Bravo M, Belotto C, Lopes A, Miguel E. Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamento. Brazilian Journal Of Psychiatry 2001, 23: 52-57. DOI: 10.1590/s1516-44462001000600016.Peer-Reviewed Original ResearchSerotonin uptake inhibitorPredictive response factorsNon-pharmacological approachesTranscranial magnetic stimulationResistant casesAppropriate trialsPharmacological trialsMagnetic stimulationUptake inhibitorConventional treatmentBehavioral therapyPatientsOCD patientsBehavior therapyTherapyTrialsTreatmentAugmentation strategiesFurther researchMedicationsPathophysiologyPharmacogenetics
1994
Tourette's Disorder and Related Problems: A Review and Update
Coffey B, Miguel E, Savage C, Rauch S. Tourette's Disorder and Related Problems: A Review and Update. Harvard Review Of Psychiatry 1994, 2: 121-132. PMID: 9384893, DOI: 10.3109/10673229409017128.Peer-Reviewed Original ResearchConceptsTourette's disorderSerotonin reuptake inhibitorsNonmedication approachesNeuroleptic treatmentObsessive-compulsive disorderPsychiatric comorbidityVariety of agentsBasal gangliaModerate symptomsTricyclic antidepressantsCorticothalamic circuitVocal ticsLongitudinal followSevere symptomsStudy of childrenPsychiatric symptomatologyNeurological originMultifaceted conditionClinical settingObsessive-compulsive symptomsSymptomsDisordersNeuropsychological studiesFurther investigationTreatment