2024
Increases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder
Echevarria M, Batistuzzo M, Silva R, Brunoni A, Sato J, Miguel E, Hoexter M, Shavitt R. Increases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder. Journal Of Affective Disorders 2024, 355: 175-183. PMID: 38548207, DOI: 10.1016/j.jad.2024.03.141.Peer-Reviewed Original ResearchTranscranial direct current stimulationObsessive-compulsive disorderDirect current stimulationCurrent stimulationActive transcranial direct current stimulationSensorimotor networkOCD symptom dimensionsTreatment-resistant obsessive-compulsive disorderNeurobiological mechanisms of actionObsessive-compulsive disorder pathophysiologyWhole-brain connectivity analysisDaily tDCS sessionsSymptom improvementResting-state functional MRITDCS sessionsNon-invasive neuromodulation interventionsBrain stimulation interventionsFunctional connectivity changesAssociated with connectivityLeft deltoidSymptom dimensionsNeurobiological mechanismsLeft precuneusMode networkPre/postcentral gyri
2021
Efficacy and safety of transcranial direct current stimulation as an add-on treatment for obsessive-compulsive disorder: a randomized, sham-controlled trial
Silva R, Brunoni A, Goerigk S, Batistuzzo M, Costa D, Diniz J, Padberg F, D’Urso G, Miguel E, Shavitt R. Efficacy and safety of transcranial direct current stimulation as an add-on treatment for obsessive-compulsive disorder: a randomized, sham-controlled trial. Neuropsychopharmacology 2021, 46: 1028-1034. PMID: 33452434, PMCID: PMC8115679, DOI: 10.1038/s41386-020-00928-w.Peer-Reviewed Original ResearchConceptsTreatment-resistant obsessive-compulsive disorderTranscranial direct current stimulationSupplementary motor areaBaseline Y-BOCS scoresActive transcranial direct current stimulationObsessive-compulsive disorderY-BOCS scoresDirect current stimulationAdverse eventsWeek 12Efficacy of tDCSCurrent stimulationCathodal transcranial direct current stimulationSham-controlled trialMild adverse eventsClinical Global ImpressionSham-controlled studyBetween-group differencesSymptoms of depressionSecondary outcomesPrimary outcomeImprovement subscaleGlobal ImpressionNeuromodulation therapiesTreatment resistance
2020
Efficacy and Safety of Transcranial Direct Current Stimulation as a Treatment for Obsessive-Compulsive Disorder: A Randomized, Sham-Controlled Trial
Silva R, Brunoni A, Goerigk S, Batistuzzo M, Costa D, Diniz J, Padberg F, D'Urso G, Miguel E, Shavitt R. Efficacy and Safety of Transcranial Direct Current Stimulation as a Treatment for Obsessive-Compulsive Disorder: A Randomized, Sham-Controlled Trial. Biological Psychiatry 2020, 87: s127. DOI: 10.1016/j.biopsych.2020.02.342.Peer-Reviewed Original ResearchTranscranial direct current stimulationDirect current stimulationCurrent stimulationCompulsive disorderSham
2019
Transcranial direct current stimulation for Obsessive-Compulsive Disorder: patient selection and perspectives
da Silva R, Brunoni A, Miguel E, Shavitt R. Transcranial direct current stimulation for Obsessive-Compulsive Disorder: patient selection and perspectives. Neuropsychiatric Disease And Treatment 2019, 15: 2663-2669. PMID: 31571882, PMCID: PMC6754675, DOI: 10.2147/ndt.s184839.Peer-Reviewed Original ResearchTranscranial direct current stimulationDirect current stimulationSevere obsessive-compulsive disorderObsessive-compulsive disorderCurrent stimulationPrevious conventional treatmentSafe tolerability profileFirst treatment optionImprovement of OCDModalities of treatmentNon-invasive neuromodulation techniqueAlternative treatment modalityPubMed/MEDLINETime of assessmentTolerability profileClinical characteristicsClinical presentationPatient selectionPsychiatric comorbidityPharmacological treatmentTreatment optionsTreatment modalitiesClinical severityNeuromodulation techniquesConventional treatmentTranscranial direct current stimulation in obsessive-compulsive disorder: an update in electric field modeling and investigations for optimal electrode montage
da Silva R, Batistuzzo M, Shavitt R, Miguel E, Stern E, Mezger E, Padberg F, D’Urso G, Brunoni A. Transcranial direct current stimulation in obsessive-compulsive disorder: an update in electric field modeling and investigations for optimal electrode montage. Expert Review Of Neurotherapeutics 2019, 19: 1025-1035. PMID: 31244347, DOI: 10.1080/14737175.2019.1637257.Peer-Reviewed Original Research
2016
Transcranial direct current stimulation for treatment-resistant obsessive-compulsive disorder: report on two cases and proposal for a randomized, sham-controlled trial
da Silva R, Brunoni A, Miguel E, Shavitt R. Transcranial direct current stimulation for treatment-resistant obsessive-compulsive disorder: report on two cases and proposal for a randomized, sham-controlled trial. Sao Paulo Medical Journal 2016, 134: 446-450. PMID: 27901245, PMCID: PMC10871858, DOI: 10.1590/1516-3180.2016.0155010716.Peer-Reviewed Original ResearchConceptsTreatment-resistant obsessive-compulsive disorderTranscranial direct current stimulationObsessive-compulsive disorderDirect current stimulationClinical trialsCurrent stimulationSham-controlled trialSerotonin reuptake inhibitorsSupplementary motor cortexPrimary obsessive-compulsive disorderCognitive behavioral therapySecondary outcomesPrimary outcomeReuptake inhibitorsSham interventionFirst patientCortical excitabilityMotor cortexUniversity HospitalWeek 4YBOCS scoresNeuromodulation techniquesNon-invasive techniqueBrain circuitsPatients
2015
Transcranial direct current stimulation in obsessive–compulsive disorder: emerging clinical evidence and considerations for optimal montage of electrodes
Senço N, Huang Y, D’Urso G, Parra L, Bikson M, Mantovani A, Shavitt R, Hoexter M, Miguel E, Brunoni A. Transcranial direct current stimulation in obsessive–compulsive disorder: emerging clinical evidence and considerations for optimal montage of electrodes. Expert Review Of Medical Devices 2015, 12: 381-391. PMID: 25982412, PMCID: PMC5777161, DOI: 10.1586/17434440.2015.1037832.Peer-Reviewed Original ResearchConceptsTranscranial direct current stimulationDirect current stimulationSystematic reviewCurrent stimulationPotential new treatmentPre-supplementary motor areaPubMed/MEDLINEObsessive-compulsive disorder (OCD) treatmentDeep brain stimulation trialsClinical evidenceObsessive-compulsive disorderStimulation trialsDBS trialsMotor areaRTMS targetsMagnetic stimulationEligibility criteriaNeuromodulation techniquesStimulation targetsDisorder treatmentNew treatmentsBrain circuitsDifferent electrode montagesTDCS montageTrials