2022
The Phenomenology of Obsessive–Compulsive Symptoms in Tourette Syndrome
Ferrão Y, de Alvarenga P, Hounie A, de Mathis M, Farhat L, do Rosário M, Miguel E. The Phenomenology of Obsessive–Compulsive Symptoms in Tourette Syndrome. 2022, 45-64. DOI: 10.1093/med/9780197543214.003.0004.Peer-Reviewed Original ResearchTourette syndromeObsessive-compulsive disorderObsessive-compulsive symptomsComorbid obsessive-compulsive disorderPost-traumatic stress disorderAttention-deficit/hyperactivity disorderPsychiatric comorbidityBasal gangliaBehavioral comorbiditiesSeparation anxiety disorderTreatment approachesClinical practiceComorbid diagnosesSymptom presentationComorbiditiesSimple phobiaStress disorderAnxiety disordersHyperactivity disorderSymptomsDisordersGenetic vulnerabilityBehavioral problemsSyndrome
2013
The Phenomenology of Obsessive-Compulsive Symptoms in Tourette Syndrome
FerrãO Y, De Alvarenga P, Hounie A, De Mathis M, De RosáRio M, Miguel E. The Phenomenology of Obsessive-Compulsive Symptoms in Tourette Syndrome. 2013, 50-73. DOI: 10.1093/med/9780199796267.003.0003.Peer-Reviewed Original ResearchObsessive-compulsive disorderTourette syndromeObsessive-compulsive symptomsComorbid obsessive-compulsive disorderAttention-deficit/hyperactivity disorderPosttraumatic stress disorderPsychiatric comorbidityBehavioral comorbiditiesSeparation anxiety disorderClinical practiceComorbid diagnosesComorbiditiesSymptomsSimple phobiaStress disorderAnxiety disordersHyperactivity disorderDisordersSyndromeBehavioral problems
2012
Social phobia in obsessive-compulsive disorder: Prevalence and correlates
Assunção M, da Conceição Costa D, de Mathis M, Shavitt R, Ferrão Y, do Rosário M, Miguel E, Torres A. Social phobia in obsessive-compulsive disorder: Prevalence and correlates. Journal Of Affective Disorders 2012, 143: 138-147. PMID: 22858214, DOI: 10.1016/j.jad.2012.05.044.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAnxiety DisordersBody Dysmorphic DisordersBrazilComorbidityCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPhobic DisordersPrevalenceRetrospective StudiesSex FactorsSocial ClassTourette SyndromeConceptsObsessive-compulsive disorderDSM-IV Axis I DisordersLogistic regressionSocial phobiaAnxiety disordersOCD patientsCross-sectional studyStructured Clinical InterviewAxis I DisordersLow socioeconomic statusBrazilian Research ConsortiumLarge multicenter sampleBroader treatment approachesGeneralized anxiety disorderBody dysmorphic disorderYale-Brown ObsessiveClinical factorsCross-sectional designSpecific comorbiditiesMale sexObsessive-compulsive spectrum disordersUnivariate analysisLifetime prevalenceI disordersTourette syndromeSensory phenomena associated with repetitive behaviors in obsessive-compulsive disorder: An exploratory study of 1001 patients
Ferrão Y, Shavitt R, Prado H, Fontenelle L, Malavazzi D, de Mathis M, Hounie A, Miguel E, do Rosário M. Sensory phenomena associated with repetitive behaviors in obsessive-compulsive disorder: An exploratory study of 1001 patients. Psychiatry Research 2012, 197: 253-258. PMID: 22361443, DOI: 10.1016/j.psychres.2011.09.017.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSensory phenomenaOCD patientsConsecutive OCD patientsPresence/severityLogistic regression analysisFrequency/severityClinical characteristicsTic disordersFamily historyRepetitive behaviorsPatientsTourette syndromeGreater severityPsychopathological aspectsLevel of insightSeverityDisordersSymptom dimensionsRegression analysisFurther investigationSubstantial numberOC symptomsSymmetry/
2006
Tourette's Syndrome
Shavitt R, Hounie A, Campos M, Miguel E. Tourette's Syndrome. Psychiatric Clinics Of North America 2006, 29: 471-486. PMID: 16650718, DOI: 10.1016/j.psc.2006.02.005.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitorsReuptake inhibitorsLong-term side effect profileFirst-choice treatmentFirst-line optionSide effect profileCurrent treatment strategiesDorsolateral caudate nucleusPathophysiology of OCDExpression of TSTypical antipsychoticsAtypical antipsychoticsClinical manifestationsSomato-sensoryGenetic epidemiologic studiesGlobus pallidusTreatment strategiesEpidemiologic studiesCaudate nucleusTourette syndromePatient associationsRelated disordersBehavioral therapyPresence of TsSegregation analysis studiesTourette syndrome: treatment
Hounie A, Rosário-Campos M, Quarantini L, Sampaio A, Alvarenga P, Diniz J, Lopes A, Seixas A, Pinto A, Chacon P, Prado H, Belotto C, Motta M, De Mathis M, De Mathis M, Borcatto S, Carvalho M, Miguel E. Tourette syndrome: treatment. 2006, 156-205. DOI: 10.1201/b14454-9.Peer-Reviewed Original ResearchTourette syndromeGilles deSimilar medical historyMultiple motor ticsGilles de la TouretteCase seriesMedical historyMotor ticsParticular physicianPatientsSymptomsTouretteDiseaseTreatmentEventual appearanceStrange diseaseDifferent treatmentsLa TouretteChoreaSyndromeCase historiesPsychologicPhysiciansHistory
2005
Chronic tics and Tourette syndrome in patients with obsessive–compulsive disorder
Diniz J, Rosario-Campos M, Hounie A, Curi M, Shavitt R, Lopes A, Miguel E. Chronic tics and Tourette syndrome in patients with obsessive–compulsive disorder. Journal Of Psychiatric Research 2005, 40: 487-493. PMID: 16289552, DOI: 10.1016/j.jpsychires.2005.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildChi-Square DistributionDiagnosis, DifferentialDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMiddle AgedMultivariate AnalysisObsessive-Compulsive DisorderPersonality InventoryPsychiatric Status Rating ScalesPsychometricsRetrospective StudiesSeverity of Illness IndexTic DisordersTourette SyndromeConceptsObsessive-compulsive disorderTourette syndromeOCD patientsVocal ticsYale Global Tic Severity ScaleNumber of comorbiditiesStructured Clinical InterviewTic Severity ScaleYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleSymptom onsetChronic motorTic disordersCommon disorderSeverity ScalePatientsClinical InterviewChronic ticsDSM-IVBehaviors InterviewCompulsive ScaleSomatic obsessionsDisordersCompulsive disorderOCD phenotype
2003
How to treat OCD in patients with Tourette syndrome
Miguel E, Shavitt RG, Ferrão YA, Brotto SA, Diniz JB. How to treat OCD in patients with Tourette syndrome. Journal Of Psychosomatic Research 2003, 55: 49-57. PMID: 12842231, DOI: 10.1016/s0022-3999(02)00583-4.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsObsessive-compulsive disorderTourette syndromeCognitive behavior therapyOCD patientsCircuit-based therapiesGonadal hormone systemsWorse treatment responsePresence of ticsRefractory patientsAutoimmune processReuptake inhibitorsSuch patientsCombined therapyResistant casesTreatment responseDrug treatmentPharmacological approachesNew therapiesPatientsEffective psychological interventionsTherapyHormone systemPsychological interventions
2001
Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders
Morshed S, Parveen S, Leckman J, Mercadante M, Kiss M, Miguel E, Arman A, Yazgan Y, Fujii T, Paul S, Peterson B, Zhang H, King R, Scahill L, Lombroso P. Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders. Biological Psychiatry 2001, 50: 566-577. PMID: 11690591, DOI: 10.1016/s0006-3223(01)01096-4.Peer-Reviewed Original ResearchConceptsTotal antinuclear antibodiesAntinuclear antibodiesAutoimmune disordersTourette syndromeAnticytoskeletal antibodiesAntineural antibodiesStreptococcal infectionT patientsTS patientsBeta-hemolytic streptococcal infectionPrior streptococcal infectionHemolytic streptococcal infectionAntistreptolysin O titerIndirect immunofluorescent assayLevels of immunoreactivityWestern blot techniqueMean rankClinical characteristicsSydenham's choreaO titerPatient groupSC patientsIgG antibodiesIgG classNormal controlsSíndrome de Gilles de la Tourette: estudo clínico de 58 casos
Chien H, Barbosa E, Miguel E. Síndrome de Gilles de la Tourette: estudo clínico de 58 casos. Arquivos De Neuro-Psiquiatria 2001, 59: 729-732. PMID: 11593274, DOI: 10.1590/s0004-282x2001000500015.Peer-Reviewed Original ResearchConceptsGilles de la Tourette's syndromeGilles de la TouretteLa Tourette's syndromeAge of onsetObsessive-compulsive disorderFemale ratioInitial symptomsMotor ticsVocal ticsChildhood onsetAssociated manifestationsComplex ticsTourette syndromePatientsNeuropsychiatric disordersHyperactivity disorderAge rangeAttention deficitsDisordersSyndromeSensory phenomenaOnsetYearsCopropraxiaLa Tourette
1999
Relationship between obsessive-compulsive disorders and diseases affecting primarily the basal ganglia
Maia A, Barbosa E, Menezes P, Filho E. Relationship between obsessive-compulsive disorders and diseases affecting primarily the basal ganglia. Clinics 1999, 54: 213-221. PMID: 10881070, DOI: 10.1590/s0041-87811999000600008.Peer-Reviewed Original Research
1998
Trichotillomania, Obsessive-Compulsive Disorder, and Tourette Syndrome: Comorbid Relationships and Risks for Expression
O'Sullivan R, Miguel E, Coffey B, Rauch S, Savage C, Keuthen N, Baer L, Jenike M. Trichotillomania, Obsessive-Compulsive Disorder, and Tourette Syndrome: Comorbid Relationships and Risks for Expression. CNS Spectrums 1998, 3: 49-51. DOI: 10.1017/s1092852900006659.Peer-Reviewed Original ResearchObsessive-compulsive disorderTourette syndromeComorbid relationshipConsiderable psychological distressUnderdiagnosed syndromePotential treatment implicationsTic disordersDopamine antagonistsTreatment responseClinical phenomenologyPhysical disfigurementSyndromePsychological distressTreatment implicationsDisordersStructured interviews
1997
Obsessive-compulsive disorder and Tourette Syndrome: is there a relationship?
do Rosário M, Filho E. Obsessive-compulsive disorder and Tourette Syndrome: is there a relationship? Sao Paulo Medical Journal 1997, 115: 1410-1411. PMID: 9460303, DOI: 10.1590/s1516-31801997000200008.Peer-Reviewed Original ResearchPhenomenological differences appearing with repetitive behaviours in obsessive-compulsive disorder and Gilles de la Tourette's syndrome
Miguel E, Baer L, Coffey B, Rauch S, Savage C, O'Sullivan R, Phillips K, Moretti C, Leckman J, Jenike M. Phenomenological differences appearing with repetitive behaviours in obsessive-compulsive disorder and Gilles de la Tourette's syndrome. The British Journal Of Psychiatry 1997, 170: 140-145. PMID: 9093502, DOI: 10.1192/bjp.170.2.140.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRepetitive behaviorsSensory phenomenaAutonomic anxietyMore cognitionsOCD groupGilles de la Tourette's syndromeOCD subtypesSubjective experienceGTS groupSemi-structured interviewsCognitionTourette syndromeValid predictorPhenomenological differencesAnxietyLa Tourette's syndromeAdult outpatientsPhenomenological studyDisordersBehaviorTreatment responsePredictorsInterviewsExperience
1996
Obsessive compulsive disorder and Tourette syndrome in patients with rheumatic fever with or without Sydenham's chorea: phenomenological and laboratorial aspects.
Mercadante M, Miguel Filho E. Obsessive compulsive disorder and Tourette syndrome in patients with rheumatic fever with or without Sydenham's chorea: phenomenological and laboratorial aspects. Revista Da Associação Médica Brasileira 1996, 42: 61-2. PMID: 8935679.Peer-Reviewed Original Research