2023
The association between duration of breastfeeding and the trajectory of brain development from childhood to young adulthood: an 8-year longitudinal study
Grevet L, Teixeira D, Pan P, Jackowski A, Zugman A, Miguel E, Rohde L, Salum G. The association between duration of breastfeeding and the trajectory of brain development from childhood to young adulthood: an 8-year longitudinal study. European Child & Adolescent Psychiatry 2023, 33: 1863-1873. PMID: 37650992, DOI: 10.1007/s00787-023-02283-9.Peer-Reviewed Original ResearchOverall cortical thicknessDuration of breastfeedingTotal intracranial volumeCortical thicknessBrain developmentIntracranial volumeLong-term health benefitsHealth benefitsHigh-risk cohortTotal brain volumeGlobal cortical thicknessStructural brain developmentMental health benefitsMultiple confoundersCortical areasMRI scansBrain areasBrain volumeBreastfeedingMRI T1Time pointsBrain measuresEarly adulthoodYoung adulthoodLongitudinal studyLongitudinal invariance of psychotic experiences in children and adolescents: What do the data tell us?
Barbosa M, Machado V, Ziebold C, Moriyama T, Bressan R, Pan P, Rohde L, Miguel E, Fonseca L, Van Os J, Gadelha A. Longitudinal invariance of psychotic experiences in children and adolescents: What do the data tell us? Schizophrenia Research 2023, 255: 33-40. PMID: 36958268, DOI: 10.1016/j.schres.2023.03.003.Peer-Reviewed Original ResearchConceptsPsychotic experiencesTime pointsHigh-risk cohortPrevious systematic reviewDifferent age groupsDifferent time pointsBaseline evaluationLifetime psychotic experiencesPositive symptomsSystematic reviewAge groupsPerceptual abnormalitiesLongitudinal studyBrazilian High-Risk CohortPsychosis pronenessGood model fit indicesThree-factor solutionChildrenAlterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents
Honorato-Mauer J, Xavier G, Ota V, Chehimi S, Mafra F, Cuóco C, Ito L, Ormond R, Asprino P, Oliveira A, Bugiga A, Torrecilhas A, Bressan R, Manfro G, Miguel E, Rohde L, Pan P, Salum G, Pellegrino R, Belangero S, Santoro M. Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents. Translational Psychiatry 2023, 13: 47. PMID: 36746925, PMCID: PMC9902559, DOI: 10.1038/s41398-023-02326-4.Peer-Reviewed Original ResearchConceptsMental health disordersCross-sectional analysisMajor depressive disorderAttention-deficit/hyperactivity disorderHealth disordersAnxiety disordersExtracellular vesiclesLarge ongoing cohort studiesMiR-432-5pPeripheral extracellular vesiclesTime pointsOngoing cohort studyMiR-328-3pSerum extracellular vesiclesLongitudinal analysisWave 2Deficit/hyperactivity disorderAdolescent participantsTotal extracellular vesiclesAttention-deficit/hyperactivityMiRNA expressionCohort studyDepressive disorderMajor depressionMiR-584-5p
2018
Adaptive treatment strategies for children and adolescents with Obsessive-Compulsive Disorder: A sequential multiple assignment randomized trial
Fatori D, de Bragança Pereira CA, Asbahr FR, Requena G, Alvarenga PG, de Mathis MA, Rohde LA, Leckman JF, March JS, Polanczyk GV, Miguel EC, Shavitt RG. Adaptive treatment strategies for children and adolescents with Obsessive-Compulsive Disorder: A sequential multiple assignment randomized trial. Journal Of Anxiety Disorders 2018, 58: 42-50. PMID: 30025255, DOI: 10.1016/j.janxdis.2018.07.002.Peer-Reviewed Original ResearchConceptsGroup cognitive behavioral therapySequential multiple assignmentTreatment failureInitial treatmentBaseline Yale-Brown ObsessiveChildhood OCDEffective initial treatmentProvision of treatmentCompulsive Scale scoresCognitive behavioral therapyAdaptive treatment strategiesYale-Brown ObsessiveSame regimenObsessive-compulsive disorderTreatment strategiesSymptom reductionPrimary analysisScale scoreFluoxetineTime pointsWeeksTreatmentChildrenEffect sizeTrialsChildhood trauma and adolescent psychotic experiences in a community-based cohort: The potential role of positive attributes as a protective factor
Pan P, Gadelha A, Argolo F, Hoffmann M, Arcadepani F, Miguel E, Rohde L, McGuire P, Salum G, Bressan R. Childhood trauma and adolescent psychotic experiences in a community-based cohort: The potential role of positive attributes as a protective factor. Schizophrenia Research 2018, 205: 23-29. PMID: 30879477, DOI: 10.1016/j.schres.2018.06.044.Peer-Reviewed Original ResearchConceptsChildhood traumaPsychotic experiencesPositive attributesSelf-reported psychotic experiencesIndirect effectsBaseline psychotic experiencesHigh childhood traumaMediation modelAdolescent psychotic experiencesYear old childrenPersonality characteristicsProtective factorsPreventive interventionsBehavioral traitsHigh levelsIndirect pathwaysChildrenTraumaPsychologistsAdolescenceExperienceParentsRelationshipAttributesTime points