2020
Social losses predict a faster onset and greater severity of obsessive-compulsive disorder
Destrée L, Albertella L, Torres A, Ferrão Y, Shavitt R, Miguel E, Fontenelle L. Social losses predict a faster onset and greater severity of obsessive-compulsive disorder. Journal Of Psychiatric Research 2020, 130: 187-193. PMID: 32828024, DOI: 10.1016/j.jpsychires.2020.07.027.Peer-Reviewed Original ResearchConceptsClinical obsessive-compulsive disorderObsessive-compulsive disorderStressful life eventsSpeed of progressionYale-Brown ObsessiveDSM-IV Axis I DisordersLife eventsCompulsive ScaleAxis I DisordersStructured Clinical InterviewSeverity of symptomsSymptom dimensionsBeck Depression InventorySubclinical obsessive-compulsive symptomsBeck Anxiety InventorySpecific obsessive-compulsive symptom dimensionsI disordersFaster onsetPsychiatric disordersHistory questionnaireBrown AssessmentClinical InterviewGreater severityDepression InventoryObsessive-compulsive symptomsCognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder
Bernardes E, Saraiva L, e Souza M, Hoexter M, Chacon P, Requena G, Miguel E, Shavitt R, Polanczyk G, Cappi C, Batistuzzo M. Cognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder. BMC Psychiatry 2020, 20: 380. PMID: 32690046, PMCID: PMC7370498, DOI: 10.1186/s12888-020-02751-5.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderObsessive-compulsive symptomsNeurocognitive domainsPediatric obsessive-compulsive disorderNon-verbal memoryProcessing speed domainCognitive domain analysisComprehensive neuropsychological batteryNon-clinical sampleYale-Brown ObsessiveSubdomain analysisVisuospatial memoryCognitive domainsExecutive functionVisuoconstructive abilitiesVisuoconstructive tasksCognitive performanceNeuropsychological variablesNeuropsychological batteryStructured Clinical InterviewProcessing speedNeurocognitive assessmentSpeed domainOCS severityCompulsive ScaleObsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD
Copetti M, Lopes A, Requena G, Johnson I, Greenberg B, Noren G, McLaughlin N, Shavitt R, Miguel E, Batistuzzo M, Hoexter M. Obsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD. Frontiers In Psychiatry 2020, 10: 936. PMID: 31998155, PMCID: PMC6962231, DOI: 10.3389/fpsyt.2019.00936.Peer-Reviewed Original ResearchGamma ventral capsulotomyPersonality disorder symptomsIntractable obsessive-compulsive disorderObsessive-compulsive disorderDisorder symptomsOCD patientsTreatment responseDisorder symptom changeSymptom changeStructured Clinical InterviewWorse treatment responseDSM-IV personality disordersWilcoxon signed-rank testPoorer ResponseClinical responseTreatment optionsInternal capsuleSigned-rank testTreatment attemptsAnterior limbClinical InterviewRadiosurgical proceduresPatientsSymptomsVentral part
2018
Dual diagnosis of obsessive compulsive and compulsive buying disorders: Demographic, clinical, and psychiatric correlates
Kim H, Hodgins D, Torres A, Fontenelle L, do Rosário M, de Mathis M, Ferrão Y, Miguel E, Tavares H. Dual diagnosis of obsessive compulsive and compulsive buying disorders: Demographic, clinical, and psychiatric correlates. Comprehensive Psychiatry 2018, 86: 67-73. PMID: 30081209, DOI: 10.1016/j.comppsych.2018.07.013.Peer-Reviewed Original ResearchConceptsCompulsive buying disorderObsessive-compulsive disorderBuying disorderComorbid obsessive-compulsive disorderDual diagnosisUnique clinical populationInternet use disordersDual diagnosis populationPsychiatric correlatesPsychiatric disordersPsychological mechanismsSocial phobiaOCD symptomsStructured Clinical InterviewClinical populationsSound measureLarge multi-centre studyClinical InterviewProtective factorsMulti-center studyUse disordersPresent researchTreatment utilityBinary logistic regressionCorrelates
2015
Comorbidity variation in patients with obsessive–compulsive disorder according to symptom dimensions: Results from a large multicentre clinical sample
Torres A, Fontenelle L, Shavitt R, Ferrão Y, do Rosário M, Storch E, Miguel E. Comorbidity variation in patients with obsessive–compulsive disorder according to symptom dimensions: Results from a large multicentre clinical sample. Journal Of Affective Disorders 2015, 190: 508-516. PMID: 26561941, DOI: 10.1016/j.jad.2015.10.051.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderObsessive-compulsive disorderAnxiety disordersTic disordersDimensional Yale-Brown Obsessive Compulsive ScaleSeparation anxiety disorderComorbid disordersSymptom dimensionsDifferent underlying pathogenic mechanismsTertiary mental health servicesDSM-IV Axis I DisordersSpecific phobiaMulticenter clinical studyPanic disorder/agoraphobiaAxis I DisordersStructured Clinical InterviewYale-Brown Obsessive Compulsive ScaleMental health servicesUnderlying pathogenic mechanismsImpulse control disordersBrazilian Research ConsortiumSocial phobiaBody dysmorphic disorderObsessive Compulsive ScaleCommon comorbidities
2013
Panic Disorder and Agoraphobia in OCD patients: Clinical profile and possible treatment implications
Torres A, Ferrão Y, Shavitt R, Diniz J, Costa D, do Rosário M, Miguel E, Fontenelle L. Panic Disorder and Agoraphobia in OCD patients: Clinical profile and possible treatment implications. Comprehensive Psychiatry 2013, 55: 588-597. PMID: 24374170, DOI: 10.1016/j.comppsych.2013.11.017.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPanic disorderClinical profileOCD patientsMajor depressionPrevalence of PDDSM-IV-TR Axis I DisordersCross-sectional studyAxis I DisordersStructured Clinical InterviewPD/agoraphobiaBrazilian Research ConsortiumLogistic regression modelsPosttraumatic stress disorderLarge clinical sampleYale-Brown ObsessiveComorbid conditionsPD comorbidityIndependent correlatesObsessive-compulsive spectrum disordersLifetime prevalenceTreatment strategiesI disordersStudy groupSeparation anxiety disorderClinical features of pure obsessive-compulsive disorder
Torres A, Shavitt R, Torresan R, Ferrão Y, Miguel E, Fontenelle L. Clinical features of pure obsessive-compulsive disorder. Comprehensive Psychiatry 2013, 54: 1042-1052. PMID: 23746710, DOI: 10.1016/j.comppsych.2013.04.013.Peer-Reviewed Original ResearchConceptsPure obsessive-compulsive disorderNon-comorbid patientsObsessive-compulsive disorderYale-Brown ObsessiveClinical characteristicsDSM-IV Axis I DisordersSuicidal thoughtsLogistic regressionCompulsive ScaleOCD patientsAnxious symptomsAxis I comorbidityCross-sectional studyAxis I DisordersStructured Clinical InterviewCo-occurring disordersPrevious suicidal thoughtsBrazilian Research ConsortiumLarge multicenter samplePure OCD patientsAdult patientsClinical featuresLifetime comorbidityPsychiatric comorbidityObsessive-compulsive spectrum disordersSymptom dimensions, clinical course and comorbidity in men and women with obsessive-compulsive disorder
Torresan R, Ramos-Cerqueira A, Shavitt R, do Rosário M, de Mathis M, Miguel E, Torres A. Symptom dimensions, clinical course and comorbidity in men and women with obsessive-compulsive disorder. Psychiatry Research 2013, 209: 186-195. PMID: 23298952, DOI: 10.1016/j.psychres.2012.12.006.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderClinical courseComorbid post-traumatic stress disorderDSM-IV Axis ICross-sectional studyStructured Clinical InterviewAlcohol use disorderSymptom dimensionsPost-traumatic stress disorderAdult OCD patientsBrazilian Research ConsortiumYale-Brown ObsessiveFemale patientsClinical presentationMean ageSymptom interferenceObsessive-compulsive spectrum disordersMajor depressionTic disordersFemale genderAxis IUse disordersClinical InterviewAnorexia nervosaSkin picking
2012
Social phobia in obsessive-compulsive disorder: Prevalence and correlates
Assunção M, da Conceição Costa D, de Mathis M, Shavitt R, Ferrão Y, do Rosário M, Miguel E, Torres A. Social phobia in obsessive-compulsive disorder: Prevalence and correlates. Journal Of Affective Disorders 2012, 143: 138-147. PMID: 22858214, DOI: 10.1016/j.jad.2012.05.044.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAnxiety DisordersBody Dysmorphic DisordersBrazilComorbidityCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPhobic DisordersPrevalenceRetrospective StudiesSex FactorsSocial ClassTourette SyndromeConceptsObsessive-compulsive disorderDSM-IV Axis I DisordersLogistic regressionSocial phobiaAnxiety disordersOCD patientsCross-sectional studyStructured Clinical InterviewAxis I DisordersLow socioeconomic statusBrazilian Research ConsortiumLarge multicenter sampleBroader treatment approachesGeneralized anxiety disorderBody dysmorphic disorderYale-Brown ObsessiveClinical factorsCross-sectional designSpecific comorbiditiesMale sexObsessive-compulsive spectrum disordersUnivariate analysisLifetime prevalenceI disordersTourette syndromeBODY DYSMORPHIC DISORDER IN PATIENTS WITH OBSESSIVE–COMPULSIVE DISORDER: PREVALENCE AND CLINICAL CORRELATES
Costa D, Assunção M, Ferrão Y, Conrado L, Gonzalez C, Fontenelle L, Fossaluza V, Miguel E, Torres A, Shavitt R. BODY DYSMORPHIC DISORDER IN PATIENTS WITH OBSESSIVE–COMPULSIVE DISORDER: PREVALENCE AND CLINICAL CORRELATES. Depression And Anxiety 2012, 29: 966-975. PMID: 22815241, DOI: 10.1002/da.21980.Peer-Reviewed Original ResearchConceptsBody dysmorphic disorderObsessive-compulsive disorderSkin pickingYale-Brown ObsessiveDSM-IV Axis I DisordersClinical Global Impression ScaleEarly onsetCompulsive ScaleOCD patientsDysmorphic disorderGroup of patientsSymptoms of BDDGlobal Impression ScaleAxis I DisordersStructured Clinical InterviewComorbid body dysmorphic disorderBrazilian Research ConsortiumYounger patientsUnemployed patientsClinical featuresObsessive-compulsive spectrum disordersClinical correlatesImpression ScaleChronic depressionClinical assessmentClinical features of tic-related obsessive-compulsive disorder: results from a large multicenter study
de Alvarenga P, de Mathis M, Alves A, do Rosário M, Fossaluza V, Hounie A, Miguel E, Torres A. Clinical features of tic-related obsessive-compulsive disorder: results from a large multicenter study. CNS Spectrums 2012, 17: 87-93. PMID: 22789066, DOI: 10.1017/s1092852912000491.Peer-Reviewed Original ResearchConceptsYale Global Tic Severity ScaleTic disordersComorbid tic disordersYale-Brown ObsessiveClinical featuresAnxiety disordersChronic vocal tic disorderDSM-IV Axis I DisordersTic-related obsessive-compulsive disorderChronic motor tic disorderCompulsive ScaleVocal tic disorderMotor tic disorderLarge multicenter studyCross-sectional studyStructured Clinical InterviewAxis I DisordersTic Severity ScaleObsessive-compulsive disorder patientsPost-traumatic stress disorderAttention deficit hyperactivity disorderSensory phenomenaSymptom onsetMulticenter studyMean age
2011
Skin picking and trichotillomania in adults with obsessive-compulsive disorder
Lovato L, Ferrão Y, Stein D, Shavitt R, Fontenelle L, Vivan A, Miguel E, Cordioli A. Skin picking and trichotillomania in adults with obsessive-compulsive disorder. Comprehensive Psychiatry 2011, 53: 562-568. PMID: 22014580, DOI: 10.1016/j.comppsych.2011.06.008.Peer-Reviewed Original ResearchConceptsPathologic skin pickingObsessive-compulsive disorderSkin pickingFourth Edition Axis IEdition Axis IStructured Clinical InterviewLogistic regression analysisComorbid body dysmorphic disorderBody dysmorphic disorderClinical characteristicsSuch comorbiditiesPrimary diagnosisAxis IClinical InterviewSpecific subgroupsMental disordersDysmorphic disorderStatistical ManualTrichotillomaniaDisordersCompulsive symptomsPatientsRegression analysisDiagnosisHigh levelsSuicidality in obsessive-compulsive disorder: prevalence and relation to symptom dimensions and comorbid conditions.
Torres A, Ramos-Cerqueira A, Ferrão Y, Fontenelle L, do Rosário M, Miguel E. Suicidality in obsessive-compulsive disorder: prevalence and relation to symptom dimensions and comorbid conditions. The Journal Of Clinical Psychiatry 2011, 72: 17-26; quiz 119-20. PMID: 21272513, DOI: 10.4088/jcp.09m05651blu.Peer-Reviewed Original ResearchMeSH KeywordsAdultComorbidityCross-Sectional StudiesDepressive Disorder, MajorDisruptive, Impulse Control, and Conduct DisordersFemaleHumansLongitudinal StudiesMaleObsessive-Compulsive DisorderPersonality InventoryPrevalenceReligion and PsychologyRisk FactorsSexual BehaviorStress Disorders, Post-TraumaticSuicideSuicide, AttemptedSurveys and QuestionnairesConceptsPosttraumatic stress disorderMajor depressive disorderObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleCurrent suicidal thoughtsSubstance use disordersImpulse control disordersSuicidal thoughtsObsessive Compulsive ScaleDepressive disorderUse disordersDSM-IV Axis I DisordersSuicidal behaviorComorbid substance use disorderCompulsive ScaleOCD patientsLifetime major depressive disorderCross-sectional studyStructured Clinical InterviewAxis I DisordersLogistic regression analysisPrimary obsessive-compulsive disorderSymptom dimensionsLifetime suicidal thoughtsBrazilian Research ConsortiumRisk factors for early treatment discontinuation in patients with obsessive-compulsive disorder
Diniz J, Malavazzi D, Fossaluza V, Belotto-Silva C, Borcato S, Pimentel I, Miguel E, Shavitt R. Risk factors for early treatment discontinuation in patients with obsessive-compulsive disorder. Clinics 2011, 66: 387-393. PMID: 21552660, PMCID: PMC3071996, DOI: 10.1590/s1807-59322011000300004.Peer-Reviewed Original ResearchConceptsEarly treatment discontinuationSelective serotonin reuptake inhibitorsTreatment discontinuationObsessive-compulsive disorder patientsObsessive-compulsive disorderDisorder patientsFirst-line treatmentGroup of patientsSerotonin reuptake inhibitorsStructured Clinical InterviewLogistic regression analysisLogistic regression modelsGeneralized anxiety disorderCognitive behavioral therapyMann-Whitney testClinical characteristicsCompliant patientsDiscontinuation ratesReuptake inhibitorsPsychiatric comorbidityClinical correlatesTreatment modalitiesRisk factorsSomatization disorderDiscontinuation
2010
Bipolar disorder and comorbid obsessive‐compulsive disorder is associated with higher rates of anxiety and impulse control disorders
Issler C, Monkul E, Amaral J, Tamada R, Shavitt R, Miguel E, Lafer B. Bipolar disorder and comorbid obsessive‐compulsive disorder is associated with higher rates of anxiety and impulse control disorders. Acta Neuropsychiatrica 2010, 22: 81-86. PMID: 25385033, DOI: 10.1111/j.1601-5215.2010.00457.x.Peer-Reviewed Original ResearchTreatment-emergent maniaObsessive-compulsive disorderFemale BD patientsComorbid obsessive-compulsive disorderBipolar disorderControl disordersResidual symptomsDepressive episodeBD patientsOCD patientsPrevious depressive episodesStructured Clinical InterviewHigh rateClinical characteristicsDisorder burdenChronic episodesFemale outpatientsTic disordersHigh riskComorbid disordersSevere formPatientsClinical InterviewSkin pickingDSM-IV
2009
Early Onset Obsessive-Compulsive Disorder With and Without Tics
de Mathis M, Diniz J, Shavitt R, Torres A, Ferrão Y, Fossaluza V, Pereira C, Miguel E, do Rosario M. Early Onset Obsessive-Compulsive Disorder With and Without Tics. CNS Spectrums 2009, 14: 362-370. PMID: 19773712, DOI: 10.1017/s1092852900023014.Peer-Reviewed Original ResearchConceptsOnset obsessive-compulsive disorderObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleYears of ageEarly-onset obsessive-compulsive disorderObsessive Compulsive ScaleObsessive-compulsive symptomsTic disordersDimensional Yale-Brown Obsessive Compulsive ScaleYale Global Tic Severity ScaleCompulsive ScaleHigher mean scoresFourth Edition criteriaStructured Clinical InterviewTic Severity ScaleVariable clinical manifestationsMean scoreObsessive-compulsive symptoms and disorder in patients with schizophrenia treated with clozapine or haloperidol
R. A, Hounie A, Sampaio A, Arrais J, Miguel E, Elkis H. Obsessive-compulsive symptoms and disorder in patients with schizophrenia treated with clozapine or haloperidol. Comprehensive Psychiatry 2009, 50: 437-442. PMID: 19683614, DOI: 10.1016/j.comppsych.2008.11.005.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive AgentsAntipsychotic AgentsClozapineComorbidityDiagnostic and Statistical Manual of Mental DisordersDrug Therapy, CombinationFemaleHaloperidolHumansInterview, PsychologicalMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesPsychometricsSchizophreniaYoung AdultConceptsObsessive-compulsive disorderObsessive-compulsive symptomsSchizophrenia patientsPrevalence of OCDSchizophrenia rating scalesPresence of OCSPrevalence of patientsUse of clozapineUse of antidepressantsClinical Global ImpressionPANSS total scoreCross-sectional studyStructured Clinical InterviewHigher severity scoresNegative Syndrome ScaleHigher severityYale-Brown ObsessiveGlobal ImpressionSeverity scorePatientsClozapineClinical InterviewHaloperidolSchizophrenia symptomsSyndrome Scale
2008
Alcohol use disorders in patients with obsessive–compulsive disorder: The importance of appropriate dual-diagnosis
Gentil A, de Mathis M, Torresan R, Diniz J, Alvarenga P, do Rosário M, Cordioli A, Torres A, Miguel E. Alcohol use disorders in patients with obsessive–compulsive disorder: The importance of appropriate dual-diagnosis. Drug And Alcohol Dependence 2008, 100: 173-177. PMID: 19004577, DOI: 10.1016/j.drugalcdep.2008.09.010.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderYale-Brown ObsessiveAUD comorbidityPsychiatric treatmentSuicidal thoughtsClinical Global Impression ScaleCompulsive ScaleOCD patientsDSM-IV Axis IDSM-IV OCD patientsSpecific clinical featuresGlobal Impression ScaleAlcohol use disorder comorbidityCross-sectional studyStructured Clinical InterviewPrevious psychiatric treatmentAlcohol use disorderLifetime suicidal thoughtsLarge clinical sampleMental health professionalsClinical featuresImpression ScalePast alcoholClinical questionnaireSomatization disorderSex differences in the phenotypic expression of obsessive-compulsive disorder: an exploratory study from Brazil
Torresan R, de Abreu Ramos-Cerqueira A, de Mathis M, Diniz J, Ferrão Y, Miguel E, Torres A. Sex differences in the phenotypic expression of obsessive-compulsive disorder: an exploratory study from Brazil. Comprehensive Psychiatry 2008, 50: 63-69. PMID: 19059516, DOI: 10.1016/j.comppsych.2008.05.005.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderObsessive-compulsive symptomsBeck DepressionYale Global Tic Severity ScaleComorbid simple phobiasFemale Brazilian patientsStructured Clinical InterviewPrivate practice clinicTic Severity ScaleAnxiety InventoryComorbid tic disordersEfficacious treatment approachGlobal symptom severityPosttraumatic stress disorderSex-related differencesYale-Brown ObsessiveClinical characteristicsClinical featuresMean agePsychiatric comorbiditySymptom interferencePractice clinicsTic disordersBrazilian patientsFamily historyObsessive–compulsive disorder: Influence of age at onset on comorbidity patterns
de Mathis M, do Rosario M, Diniz J, Torres A, Shavitt R, Ferrão Y, Fossaluza V, de Bragança Pereira C, Miguel E. Obsessive–compulsive disorder: Influence of age at onset on comorbidity patterns. European Psychiatry 2008, 23: 187-194. PMID: 18329252, DOI: 10.1016/j.eurpsy.2008.01.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAnxiety DisordersAttention Deficit Disorder with HyperactivityBrazilComorbidityCross-Sectional StudiesDisruptive, Impulse Control, and Conduct DisordersFeeding and Eating DisordersFemaleHumansMaleMental DisordersMiddle AgedObsessive-Compulsive DisorderPersonality AssessmentSex FactorsSomatoform DisordersTic DisordersConceptsImpulse control disordersInfluence of ageComorbidity patternsYale Global Tic Severity ScaleOCD patientsStructured Clinical InterviewTic Severity ScaleYale-Brown Obsessive Compulsive ScaleAttention-deficit/hyperactivity disorderObsessive Compulsive ScalePsychiatric comorbidityIllness durationTic disordersFemale genderSeverity ScaleClinical InterviewDSM-IVLower ageAnxiety disordersCompulsive ScaleHyperactivity disorderDisordersLower chanceAgeComorbidities