2023
Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers
Damiano R, de Almeida Rocca C, de Pádua Serafim A, Loftis J, Talib L, Pan P, Cunha-Neto E, Kalil J, de Castro G, Seelaender M, Guedes B, Marie S, de Souza H, Nitrini R, Miguel E, Busatto G, Forlenza O, Group H, Utiyama E, Segurado A, Perondi B, Miethke-Morais A, Montal A, Harima L, Fusco S, Silva M, Rocha M, Marcilio I, Rios I, Kawano F, de Jesus M, Kallas É, Carmo C, Tanaka C, Marchini J, Carvalho C, Ferreira J, Levin A, Oliveira M, Guimarães T, dos Santos Lázari C, da Silva Duarte A, Sabino E, Magri M, Barros-Filho T, Francisco M. Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers. Frontiers In Immunology 2023, 14: 1174020. PMID: 37287969, PMCID: PMC10242059, DOI: 10.3389/fimmu.2023.1174020.Peer-Reviewed Original ResearchConceptsCognitive impairmentInflammatory markersSARS-CoV-2 infectionLong-term cognitive impairmentLong-term cognitive outcomesC-reactive proteinDisease severity markersCOVID-19 infectionCognitive performanceHospital dischargeInflammatory backgroundClinical statusD-dimerSeverity markersGeneral cognitionOverall cognitive performanceTNF-betaPhysical activityParticipants 6Severe formG-CSFPersistent dysregulationMultivariate analysisSociodemographic characteristicsCognitive deficits
2022
Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation – CORRIGENDUM
Busatto G, de Araujo A, Castaldelli-Maia J, Damiano R, Imamura M, Guedes B, Pinna F, Sawamura M, Mancini M, da Silva K, Garcia M, Sumita N, Brunoni A, da Silva Duarte A, Burdmann E, Kallas E, Cerri G, Nitrini R, Bento R, Rocha V, de Souza H, Miguel E, de Carvalho C, Forlenza O, Batistella L. Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation – CORRIGENDUM. Psychological Medicine 2022, 52: 2400-2400. PMID: 35757988, PMCID: PMC9981469, DOI: 10.1017/s0033291722001799.Peer-Reviewed Original ResearchChronic lung lesions in COVID-19 survivors: predictive clinical model
Carvalho C, Chate R, Sawamura M, Garcia M, Lamas C, Cardenas D, Lima D, Scudeller P, Salge J, Nomura C, Gutierrez M, Araújo A, Segurado A, Montal A, Miethke-Morais A, Levin A, Perondi B, Guedes B, Carmo C, Lázari C, Antonio C, Tanaka C, Leite C, Gomes C, Utiyama E, Burdmann E, Bonfá E, Kallas E, Sabino E, Miguel E, Pinna F, Kawano F, Busatto G, Cerri G, Fonseca G, Souza H, Marcilio I, Rios I, Hallak J, Krieger J, Ferreira J, Marchini J, Oliveira L, Harima L, Batisttella L, Yu L, Castro L, Rocha M, Magri M, Mancini M, de Jesus M, Corrêa M, Francisco M, Rossi M, Silva M, Imamura M, Oliveira M, Gouveia N, Forlenza O, Lotufo P, Bento R, Nitrini R, Damiano R, Chammas R, Francisco R, Fusco S, Barros-Filho T, Mauad T, Guimarães T, Avelino-Silva T, Filho W. Chronic lung lesions in COVID-19 survivors: predictive clinical model. BMJ Open 2022, 12: e059110. PMID: 35697456, PMCID: PMC9195157, DOI: 10.1136/bmjopen-2021-059110.Peer-Reviewed Original ResearchConceptsChest X-rayPredictive clinical modelCOVID-19 survivorsLung lesionsClinical modelLung lesion detectionMMRC scaleChest CTMedical Research Council dyspnoea scaleSARS-CoV-2-infected patientsSARS-CoV-2 infectionCOVID-19 sequelaeSignificant pulmonary abnormalitiesProspective cohort studyGround-glass opacitiesCOVID-19 infectionChronic lung lesionsLesion detectionDyspnoea scalePulmonary involvementTraction bronchiectasisCohort studyCXR findingsHospital dischargePulmonary functionPost-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation
Busatto G, de Araujo A, Castaldelli-Maia J, Damiano R, Imamura M, Guedes B, de Rezende Pinna F, Sawamura M, Mancini M, da Silva K, Garcia M, Sumita N, Brunoni A, da Silva Duarte A, Burdmann E, Kallas E, Cerri G, Nitrini R, Bento R, Rocha V, de Souza H, Miguel E, de Carvalho C, Forlenza O, Batistella L. Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation. Psychological Medicine 2022, 52: 2387-2398. PMID: 35521752, PMCID: PMC9151630, DOI: 10.1017/s0033291722001374.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionPost-acute sequelaeC-reactive proteinSystemic inflammationBlood levelsPhysical disabilityD-dimer blood levelsCentral nervous system manifestationsPersistent physical disabilityPersistent systemic inflammationNervous system manifestationsSevere COVID-19Cognitive manifestationsPoor physical performanceElevated blood levelsCoronavirus disease 2019Pattern of symptomsDifferent organ systemsExploratory factor analysisSame followSystem manifestationsD-dimerClinical manifestationsKidney dysfunctionPerson visitsPost-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study
Damiano R, Caruso M, Cincoto A, de Almeida Rocca C, de Pádua Serafim A, Bacchi P, Guedes B, Brunoni A, Pan P, Nitrini R, Beach S, Fricchione G, Busatto G, Miguel E, Forlenza O, Group H. Post-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study. General Hospital Psychiatry 2022, 75: 38-45. PMID: 35134702, PMCID: PMC8734055, DOI: 10.1016/j.genhosppsych.2022.01.002.Peer-Reviewed Original ResearchConceptsCognitive morbidityCognitive outcomesAnxiety disordersPost-traumatic stress disorderRelevant psychosocial variablesCognitive batteryMemory declineStructured psychiatric interviewStress disorderPsychosocial variablesStandardized measuresPsychosocial stressorsPsychometric testsCognitive impairmentPsychiatric interviewSevere formPreliminary findingsSARS-CoV-2 infectionCohort of survivorsLong-term outcomesAcute-phase diseaseBrazilian cohort studyCOVID-19DisordersDepression
2021
Post-acute sequelae of SARS-CoV-2 infection (PASC): a protocol for a multidisciplinary prospective observational evaluation of a cohort of patients surviving hospitalisation in Sao Paulo, Brazil
Busatto G, de Araújo A, da Silva Duarte A, Levin A, Guedes B, Kallas E, Pinna F, de Souza H, da Silva K, Sawamura M, Seelaender M, Imamura M, Garcia M, Forlenza O, Nitrini R, Damiano R, Rocha V, Batisttella L, de Carvalho C, Initiative O, da Costa Leite C, Gomes C, Burdmann E, Miguel E, Cerri G, Fonseca G, Hallak J, Krieger J, Yu L, Castro L, Corrêa M, Mancini M, Rossi M, Gouveia N, Lotufo P, Bento R, Chammas R, Francisco R, Mauad T, Avelino-Silva T, Filho W, Group H, Bonfá E, Utiyama E, Segurado A, Perondi B, Miethke-Morais A, Montal A, Harima L, Fusco S, Silva M, Rocha M, Marcilio I, Rios I, Kawano F, de Jesus M, Carmo C, Tanaka C, Marchini J, Ferreira J, Oliveira M, Guimarães T, dos Santos Lázari C, Sabino E, MC Magri M, Barros-Filho T, Francisco M. Post-acute sequelae of SARS-CoV-2 infection (PASC): a protocol for a multidisciplinary prospective observational evaluation of a cohort of patients surviving hospitalisation in Sao Paulo, Brazil. BMJ Open 2021, 11: e051706. PMID: 34193506, PMCID: PMC8249176, DOI: 10.1136/bmjopen-2021-051706.Peer-Reviewed Original ResearchConceptsMultidisciplinary assessmentLaboratory-confirmed COVID-19SARS-CoV-2 infectionProspective observational evaluationCohort of patientsCOVID-19 inpatientsPost-acute sequelaeProspective observational studyLarge academic health centerGreater disease severityCOVID-19Cardiopulmonary functioningMultiorgan symptomsEligible subjectsInflammatory markersPeer-reviewed journalsResearch Ethics CommitteeBlood testsClinical manifestationsMuscle ultrasoundOlfactory statusHealth centersObservational studyDisease featuresPathophysiological investigations