2019
The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects
Blanco‐Vieira T, Santos M, Ferrão YA, Torres AR, Miguel EC, Bloch MH, Leckman JF, do Rosario MC. The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects. Depression And Anxiety 2019, 36: 533-542. PMID: 30990937, DOI: 10.1002/da.22898.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAdult OCD patientsObsessive-compulsive disorderDeficit hyperactivity disorderOCD patientsClinical characteristicsExact testFeatures of ADHDHyperactivity disorderSubgroup of patientsAdult obsessive-compulsive disorderComorbid attention deficit hyperactivity disorderSpecific clinical featuresCross-sectional studyObsessive-compulsive disorder (OCD) subjectsLogistic regression analysisFisher's exact testBrazilian Research ConsortiumMann-Whitney testAdult patientsRheumatic feverDevelopment of interventionsClinical featuresObsessive-compulsive spectrum disordersLifetime prevalence
2014
Searching for the Immune Basis of Obsessive-Compulsive Disorder
Teixeira AL, Rodrigues DH, Marques AH, Miguel EC, Fontenelle LF. Searching for the Immune Basis of Obsessive-Compulsive Disorder. NeuroImmunoModulation 2014, 21: 152-158. PMID: 24557049, DOI: 10.1159/000356554.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderImmune parametersAnti-basal ganglia antibodiesParticular immune profileRheumatic feverImmune profileComorbid conditionsImmune basisAutoimmune diseasesImmune cellsPsychotropic drugsClinical observationsObsessive-compulsive symptomsPatientsUnequivocal changesOCD patientsElevated frequencyDisordersFeverEtiopathogenesisCytokinesSymptomsDiseaseAntibodies
2009
Higher prevalence of obsessive–compulsive spectrum disorders in rheumatic fever
de Alvarenga P, Floresi A, Torres A, Hounie A, Fossaluza V, Gentil A, Pereira C, Miguel E. Higher prevalence of obsessive–compulsive spectrum disorders in rheumatic fever. General Hospital Psychiatry 2009, 31: 178-180. PMID: 19269540, DOI: 10.1016/j.genhosppsych.2008.11.003.Peer-Reviewed Original ResearchConceptsRheumatic feverObsessive-compulsive spectrum disordersHigh prevalencePrevious historyPsychiatric outpatientsAnalytical cross-sectional studyConsecutive psychiatric outpatientsCross-sectional studySubclinical obsessive-compulsive disorderObsessive-compulsive disorderPositive historySpectrum disorderPsychiatric diagnosisMental disordersRelated disordersSenior psychiatristsObsessive-compulsive symptomsStatistical ManualDisordersPrevalencePrivate practiceFeverOutpatientsFourth EditionSuch history
2008
Anxiety Disorders and Rheumatic Fever: Is There an Association?
Seixas A, Hounie A, Fossaluza V, Curi M, Alvarenga P, De Mathis M, De Mathis M, Vallada H, Pauls D, de Bragança Pereira C, Miguel E. Anxiety Disorders and Rheumatic Fever: Is There an Association? CNS Spectrums 2008, 13: 1039-1046. PMID: 19179939, DOI: 10.1017/s1092852900017090.Peer-Reviewed Original ResearchConceptsFirst-degree relativesRheumatic feverObsessive-compulsive spectrum disordersObsessive-compulsive disorderAnxiety disordersFamily membersCase-control family studyRates of disorderRelatives of individualsPoisson regression modelsRF patientsSydenham's choreaSeparation anxiety disorderPsychiatric interviewPossible familial relationshipControl probandsRelated disordersDisordersFamilial aggregationFurther studiesPatientsChoreaFeverOCD spectrumFamily studiesTNF-alpha polymorphisms are associated with obsessive-compulsive disorder
Hounie A, Cappi C, Cordeiro Q, Sampaio A, Moraes I, do Rosário M, Palácios S, Goldberg A, Vallada H, Machado-Lima A, Nakano E, Kalil J, Pauls D, Pereira C, Guilherme L, Miguel E. TNF-alpha polymorphisms are associated with obsessive-compulsive disorder. Neuroscience Letters 2008, 442: 86-90. PMID: 18639610, DOI: 10.1016/j.neulet.2008.07.022.Peer-Reviewed Original Research
2006
Association of polymorphisms within the promoter region of the tumor necrosis factor-α with clinical outcomes of rheumatic fever
Ramasawmy R, Faé K, Spina G, Victora G, Tanaka A, Palácios S, Hounie A, Miguel E, Oshiro S, Goldberg A, Kalil J, Guilherme L. Association of polymorphisms within the promoter region of the tumor necrosis factor-α with clinical outcomes of rheumatic fever. Molecular Immunology 2006, 44: 1873-1878. PMID: 17079017, DOI: 10.1016/j.molimm.2006.10.001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAortic DiseasesAutoimmune DiseasesChildChoreaCohort StudiesFemaleGenetic Predisposition to DiseaseHumansMaleMyocarditisPolymorphism, Single NucleotidePredictive Value of TestsQuantitative Trait LociRheumatic Heart DiseaseStreptococcal InfectionsStreptococcus pyogenesTumor Necrosis Factor-alphaConceptsRheumatic feverRF patientsClinical outcomesHealthy controlsTNFA geneMinor alleleRF/RHDAortic valve lesionsRecognition of autoantigensStratification of patientsTumor necrosis factorAssociation of polymorphismsMild carditisValve lesionsAdaptive armsSydenham's choreaAutoimmune diseasesHeart diseaseInflammatory diseasesNecrosis factorBorderline associationG-308APatientsImmune systemClinical phenotypeObsessive-Compulsive Symptoms in Heart Disease Patients With and Without History of Rheumatic Fever
Alvarenga P, Hounie A, Mercadante M, Diniz J, Salem M, Spina G, Miguel E. Obsessive-Compulsive Symptoms in Heart Disease Patients With and Without History of Rheumatic Fever. Journal Of Neuropsychiatry 2006, 18: 405-408. PMID: 16963592, DOI: 10.1176/jnp.2006.18.3.405.Peer-Reviewed Original ResearchObsessive-Compulsive Spectrum Disorders and Rheumatic Fever: A Family Study
Hounie A, Pauls D, do Rosario-Campos M, Mercadante M, Diniz J, De Mathis M, De Mathis M, Chacon P, Shavitt R, Curi M, Guilherme L, Miguel E. Obsessive-Compulsive Spectrum Disorders and Rheumatic Fever: A Family Study. Biological Psychiatry 2006, 61: 266-272. PMID: 16616727, DOI: 10.1016/j.biopsych.2006.02.021.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBacterial ProteinsCase-Control StudiesChildData Interpretation, StatisticalFamilyFemaleHumansInterview, PsychologicalLogistic ModelsMaleObserver VariationObsessive-Compulsive DisorderOdds RatioPsychiatric Status Rating ScalesRheumatic FeverRiskStreptococcal InfectionsStreptolysinsConceptsFirst-degree relativesRheumatic feverObsessive-compulsive spectrum disordersSydenham's choreaFDRs of controlsStructured psychiatric interviewUnderlying etiologic mechanismsCase-control family studyFamily studiesControl first-degree relativesBest-estimate diagnosesHigh rateRF patientsCompulsive spectrum disordersOdds ratioMorbid riskEtiologic mechanismsPsychiatric interviewSpectrum disorderLogistic regressionProbandsFeverPatientsChoreaDiagnosis
2001
Transtorno obsessivo-compulsivo: possíveis subtipos
Hounie A, de A Brotto S, Diniz J, Chacon P, Miguel E. Transtorno obsessivo-compulsivo: possíveis subtipos. Brazilian Journal Of Psychiatry 2001, 23: 13-16. DOI: 10.1590/s1516-44462001000600005.Peer-Reviewed Original ResearchPutative subtypesUnderlying pathophysiological substrateEarly age onsetMore specific treatmentsGenetic family studiesExistence of subtypesRheumatic feverDisease coursePathophysiological substrateClinical featuresTreatment responseSpecific treatmentAge onsetPoor insightHeterogeneous disorderSubtypesPossible subgroupsFamily studiesSubgroupsOCDPhenotypic characterizationFeverGroup
2000
The Psychiatric Symptoms of Rheumatic Fever
Mercadante MT, Busatto GF, Lombroso PJ, Prado L, Rosário-Campos MC, do Valle R, Marques-Dias MJ, Kiss MH, Leckman JF, Miguel EC. The Psychiatric Symptoms of Rheumatic Fever. American Journal Of Psychiatry 2000, 157: 2036-2038. PMID: 11097972, DOI: 10.1176/appi.ajp.157.12.2036.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderRheumatic feverSydenham's choreaTic disordersHigh riskComparison groupFever groupMajor depressive disorderDeficit hyperactivity disorderObsessive-compulsive disorderDepressive disorderRisk factorsPsychiatric symptomsPsychiatric disordersChoreaFeverNeuropsychiatric disordersObsessive-compulsive symptomsRating ScaleHyperactivity disorderSymptomsDisordersADHD symptomsChildrenSemistructured interviewsMarcador D8-17: implicações para a neuropsiquiatria
DINIZ J, DE ALVARENGA P, HOUNIE A, MIGUEL E. Marcador D8-17: implicações para a neuropsiquiatria. Arquivos De Neuro-Psiquiatria 2000, 58: 366-370. PMID: 10849643, DOI: 10.1590/s0004-282x2000000200028.Peer-Reviewed Original Research
1996
Obsessive compulsive disorder and Tourette syndrome in patients with rheumatic fever with or without Sydenham's chorea: phenomenological and laboratorial aspects.
Mercadante M, Miguel Filho E. Obsessive compulsive disorder and Tourette syndrome in patients with rheumatic fever with or without Sydenham's chorea: phenomenological and laboratorial aspects. Revista Da Associação Médica Brasileira 1996, 42: 61-2. PMID: 8935679.Peer-Reviewed Original Research