2024
Childhood Anxiety Symptoms as a Predictor of Psychotic Experiences in Adolescence in a High-Risk Cohort for Psychiatric Disorders
Machado V, Fonseca L, Barbosa M, Bressan R, Pan P, Rohde L, Miguel E, Salum G, Ziebold C, Gadelha A. Childhood Anxiety Symptoms as a Predictor of Psychotic Experiences in Adolescence in a High-Risk Cohort for Psychiatric Disorders. Schizophrenia Bulletin Open 2024, 5: sgae003. PMID: 39144118, PMCID: PMC11207689, DOI: 10.1093/schizbullopen/sgae003.Peer-Reviewed Original ResearchBrazilian High-Risk CohortCross-lagged panel modelChildhood anxiety symptomsPsychotic experiencesAnxiety symptomsSubclinical psychotic symptomsContinuum of psychosisStandardized self-report questionnairesTime-lagged associationsCross-lagged effectsIncreased levels of anxietySelf-report questionnairesLevels of anxietyPsychosis pronenessPsychotic symptomsPsychiatric disordersSymptom domainsMental illnessAnxietyHigh-risk cohortAnxiety scoresPsychosisAdolescentsPE scoresPanel model
2022
Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways
Axelrud L, Hoffmann M, Vosberg D, Santoro M, Pan P, Gadelha A, Belangero S, Miguel E, Shin J, Thapar A, Smoller J, Pausova Z, Rohde L, Keller M, Paus T, Salum G. Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways. Journal Of Child Psychology And Psychiatry 2022, 64: 408-416. PMID: 36162806, DOI: 10.1111/jcpp.13708.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderPolygenic scoresOffspring cognitionIntergenerational transmissionMultiple mediation modelEducational attainmentBehavioral traitsCognitive measuresExecutive functionGeneral intelligenceHyperactivity disorderMediation modelMultiple mediationCognitive AssessmentCognitionPsychopathologyGenetic influencesParental educationPsychotic symptomsDirect associationParental geneticsAttainmentDiscovery sampleGenetic riskFathers
2021
Psychotic-like Experiences and Common Mental Disorders in Childhood and Adolescence: Bidirectional and Transdiagnostic Associations in a Longitudinal Community-based Study
Giocondo J, Salum G, Gadelha A, Argolo F, Simioni A, Mari J, Miguel E, Bressan R, Rohde L, Pan P. Psychotic-like Experiences and Common Mental Disorders in Childhood and Adolescence: Bidirectional and Transdiagnostic Associations in a Longitudinal Community-based Study. Schizophrenia Bulletin Open 2021, 2: sgab028. DOI: 10.1093/schizbullopen/sgab028.Peer-Reviewed Original ResearchCommon mental disordersComorbid psychiatric disordersRisk of PLEsCommunity-based studyMental disordersPsychiatric disordersPsychotic-like experiencesDepressive disorderLongitudinal community-based studyBidirectional associationsCommon psychiatric disordersSubthreshold psychotic symptomsNon-psychotic disordersSubsequent depressive disordersYear old subjectsPsychotic symptomsOlder subjectsCutoff valueComorbidity analysisClinician ratingsSubstance useDisordersBaseline ADHDDistinct phenotypesRisk
2019
Differences Between Self-Reported Psychotic Experiences, Clinically Relevant Psychotic Experiences, and Attenuated Psychotic Symptoms in the General Population
Moriyama T, van Os J, Gadelha A, Pan P, Salum G, Manfro G, de Jesus Mari J, Miguel E, Rohde L, Polanczyk G, McGuire P, Bressan R, Drukker M. Differences Between Self-Reported Psychotic Experiences, Clinically Relevant Psychotic Experiences, and Attenuated Psychotic Symptoms in the General Population. Frontiers In Psychiatry 2019, 10: 782. PMID: 31736802, PMCID: PMC6829673, DOI: 10.3389/fpsyt.2019.00782.Peer-Reviewed Original ResearchSelf-reported psychotic experiencesPsychotic symptomsPsychotic experiencesAffective flatteningHigh Risk Cohort StudyAttenuated Psychotic SymptomsChild mental healthCohort studyStrength of associationFemale sexClinical assessmentLevels of psychopathologyGeneral populationPsychiatric disordersClinical relevanceEarly interventionMental healthIndependent interviewerMost associationsParent informationSymptomsAssociationPresent studyPsychopathologyPsychologists' assessment