2024
Association Between Juvenile Psychotic Experiences and Problematic Gaming
Fernandes A, Biokino R, Miguel A, Machado V, Koga G, Fonseca L, Pan P, Roza T, Salum G, Passos I, Rohde L, Miguel E, Ziebold C, Gadelha A. Association Between Juvenile Psychotic Experiences and Problematic Gaming. Schizophrenia Bulletin Open 2024, 5: sgae021. PMID: 39296676, PMCID: PMC11408271, DOI: 10.1093/schizbullopen/sgae021.Peer-Reviewed Original ResearchPsychotic experiencesProblematic gamingGame addictionDSM-IVBrazilian community sampleDSM-IV diagnosisMental health conditionsCommunity samplePsychiatric disordersCross-sectional subsamplePsychiatric conditionsAssociated with significant adverse outcomesReport PEBehavioral pathwaysLevels of PESignificant adverse outcomesAssociated with PEPE scoresSociodemographic variablesAdverse outcomesBrazilian cohortDisordersParticipantsHealth conditionsLinear regression analysisGPT-based normative models of brain sMRI correlate with dimensional psychopathology
Mendes S, Pinaya W, Pan P, Gadelha A, Belangero S, Jackowski A, Rohde L, Miguel E, Sato J. GPT-based normative models of brain sMRI correlate with dimensional psychopathology. Imaging Neuroscience 2024, 2: 1-15. DOI: 10.1162/imag_a_00204.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderChild Behavior ChecklistDeficit hyperactivity disorderAutism spectrum disorderPsychiatric disordersBrain regionsStructural MRIDimensional psychopathologyHyperactivity disorderBrazilian High-Risk Cohort StudyAttention deficit hyperactivity disorder scoresAutism Brain Imaging Data Exchange IIAdolescent Brain Cognitive DevelopmentChild Behavior Checklist scalesHigh Risk Cohort StudyDetect psychiatric symptomsEmergent psychiatric disordersBrain structural MRINeurobiological substratesNeuroimaging studiesLanguage tasksPsychiatric symptomsBehavior ChecklistPsychiatric conditionsSpectrum disorderIs waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample
Bado P, Salum G, Rohde L, Gadelha A, Pan P, Miguel E, Tripp G, Furukawa E. Is waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample. JCPP Advances 2024, 4: e12231. PMID: 38827985, PMCID: PMC11143955, DOI: 10.1002/jcv2.12231.Peer-Reviewed Original ResearchDelayed rewardsPsychiatric conditionsPresence of psychiatric disordersLife outcomesBaseline task performanceImpulsive choicePositive long-term outcomesImmediate rewardsPsychiatric disordersTask performanceADHDResults ChildrenRewardChildren's preferencesStronger preferenceSchool-based cohortDisordersLongitudinal outcomesCohort sampleFunctional outcomesChildrenCohort of Brazilian childrenBrazilian childrenPsychopathologyDiverse populationsPerinatal and neonatal factors and mental disorders in children and adolescents: looking for the contributions of the early environment to common and dissociable aspects of psychopathology
Leusin F, Damiano R, Mendes L, Hoffmann M, Manfro A, Pan P, Gadelha A, de Jesus Mari J, Manfro G, Miguel E, Rohde L, Bressan R, Salum G. Perinatal and neonatal factors and mental disorders in children and adolescents: looking for the contributions of the early environment to common and dissociable aspects of psychopathology. European Child & Adolescent Psychiatry 2024, 1-11. PMID: 38519607, DOI: 10.1007/s00787-024-02402-0.Peer-Reviewed Original ResearchMental disordersPsychiatric disordersCo-occurrence of mental disordersPresence of mental disordersDomains of psychopathologyYears of age childrenModel psychiatric disordersPsychiatric disorder diagnosisOverall psychopathologyBifactor modelDisorder diagnosisPsychopathologyBehavioral assessmentP-factorEarly environmentLow level of maternal educationLevel of maternal educationLow socioeconomic statusDisordersNeonatal factorsPrimary caregiversAge childrenAssociated with male sexSocioeconomic statusMaternal educationChapter 21 Gamma Knife for psychiatric indications
Lopes A, de Arruda I, Batistuzzo M, Gorgulho A, de Salles A, Miguel E. Chapter 21 Gamma Knife for psychiatric indications. 2024, 495-517. DOI: 10.1016/b978-0-443-18496-3.00021-5.Peer-Reviewed Original ResearchAnorexia nervosaObsessive-compulsive disorder patientsTreatment of psychiatric disordersAnterior limb of internal capsuleObsessive-compulsive disorderVentral anterior limbGamma KnifeGK radiosurgeryMajor depressionDisorder patientsPsychiatric disordersPsychiatric indicationsNervosaDepressionInternal capsuleSurgical modalitiesAdverse eventsDisordersAnorexiaRadiosurgeryWeight gainManiaPsychiatryBrain cystsComplicationsChildhood Anxiety Symptoms as a Predictor of Psychotic Experiences in Adolescence in a High-Risk Cohort for Psychiatric Disorders
Machado V, Fonseca L, Barbosa M, Bressan R, Pan P, Rohde L, Miguel E, Salum G, Ziebold C, Gadelha A. Childhood Anxiety Symptoms as a Predictor of Psychotic Experiences in Adolescence in a High-Risk Cohort for Psychiatric Disorders. Schizophrenia Bulletin Open 2024, 5: sgae003. PMID: 39144118, PMCID: PMC11207689, DOI: 10.1093/schizbullopen/sgae003.Peer-Reviewed Original ResearchBrazilian High-Risk CohortCross-lagged panel modelChildhood anxiety symptomsPsychotic experiencesAnxiety symptomsSubclinical psychotic symptomsContinuum of psychosisStandardized self-report questionnairesTime-lagged associationsCross-lagged effectsIncreased levels of anxietySelf-report questionnairesLevels of anxietyPsychosis pronenessPsychotic symptomsPsychiatric disordersSymptom domainsMental illnessAnxietyHigh-risk cohortAnxiety scoresPsychosisAdolescentsPE scoresPanel model
2023
W27. POLYGENIC RISK SCORE AND HOUSEHOLD DEPRIVATION ARE RELATED TO INTERNALIZING SYMPTOMS IN YOUTH
Belangero S, De Oliveira A, Carvalho C, Ota V, Bugiga A, Pan P, Mauer J, Mari J, Santoro M, Miguel E, Hoffmann M, Salum G. W27. POLYGENIC RISK SCORE AND HOUSEHOLD DEPRIVATION ARE RELATED TO INTERNALIZING SYMPTOMS IN YOUTH. European Neuropsychopharmacology 2023, 75: s118-s119. DOI: 10.1016/j.euroneuro.2023.08.217.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsLinear mixed modelsMental disordersHigh Risk Cohort StudyInternalizing symptomsWell-Being AssessmentPotential biological markersParent reportGenome-wide association studiesSelf-report measuresTraumatic eventsCohort studyHigh prevalenceRisk scoreGene-environment interactionsPsychiatric disordersInternalizing psychopathologySignificant associationSymptomsBiological markersUnderlying causeHousehold deprivationScore studyInternalizing problemsEarly lifeAssessing atypical brain functional connectivity development: An approach based on generative adversarial networks
Dos Santos P, Mendes S, Biazoli C, Gadelha A, Salum G, Miguel E, Rohde L, Sato J. Assessing atypical brain functional connectivity development: An approach based on generative adversarial networks. Frontiers In Neuroscience 2023, 16: 1025492. PMID: 36699518, PMCID: PMC9868740, DOI: 10.3389/fnins.2022.1025492.Peer-Reviewed Original ResearchResting-state functional magnetic resonance imaging (fMRI) dataCommunity-based cohortFunctional connectivity patternsFunctional connectivity developmentFunctional connectivity measuresMagnetic resonance imaging dataPrognostic biomarkerPsychiatric disordersPotential biomarkersFunctional connectivityNeurodevelopmental processesUnrelated patterns
2022
Utilisation and costs of mental health-related service use among adolescents
Ziebold C, Silva-Ribeiro W, King D, McDaid D, Hoffmann M, Romeo R, Pan P, Miguel E, Bressan R, Rohde L, Salum G, de Jesus Mari J, Evans-Lacko S. Utilisation and costs of mental health-related service use among adolescents. PLOS ONE 2022, 17: e0273628. PMID: 36084089, PMCID: PMC9462733, DOI: 10.1371/journal.pone.0273628.Peer-Reviewed Original ResearchConceptsService useMental illnessParental stigmaSocial care service useTrajectories of psychopathologyCare service useProspective community cohortMental health conditionsMental health problemsMiddle-income countriesAverage annual costService utilisationCommunity cohortHigher oddsPsychiatric disordersCare needsWhite ethnicityMental health-related service useHealth problemsStigmatising attitudesPsychiatric conditionsMental disordersLogistic regressionHealth conditionsMental healthObsessive-Compulsive Disorder Treatment Based on Neurocircuits
Shephard E, Stern E, Miguel E. Obsessive-Compulsive Disorder Treatment Based on Neurocircuits. Psychiatric Annals 2022, 52: 152-156. DOI: 10.3928/00485713-20220317-01.Peer-Reviewed Original ResearchObsessive-compulsive disorderNew treatment approachesObsessive-compulsive disorder (OCD) treatmentClinical profileIndividual patientsGlobal burdenNeurocognitive alterationsPsychiatric disordersPsychiatric treatmentTreatment approachesDisorder treatmentPsychiatric conditionsClinical useSpecific neurocircuitsUnderlying neurobiological basisModels of OCDNeurobiological basisTreatmentNeurocircuitsDisordersPatients
2021
Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action
Terra T, Schafer J, Pan P, Costa A, Caye A, Gadelha A, Miguel E, Bressan R, Rohde L, Salum G. Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action. Journal Of Affective Disorders 2021, 298: 190-193. PMID: 34715179, DOI: 10.1016/j.jad.2021.10.108.Peer-Reviewed Original ResearchConceptsAsexual youthMental disordersWell-Being Behavior AssessmentHigh-risk cohortMental health conditionsPost-traumatic stress disorderAttention deficit hyperactivity disorderMental health problemsDeficit hyperactivity disorderMental health disparitiesStressful life eventsDepressive disorderPsychiatric disordersPrevalence estimatesHealth problemsConfidential questionnaireHealth disparitiesLogistic regressionStress disorderAnxiety disordersHealth conditionsConduct disorderGroup comparisonsHyperactivity disorderDisordersPredictors of gaming disorder in children and adolescents: a school-based study
Ferreira F, Bambini B, Tonsig G, Fonseca L, Picon F, Pan P, Salum G, Jackowski A, Miguel E, Rohde L, Bressan R, Gadelha A. Predictors of gaming disorder in children and adolescents: a school-based study. Brazilian Journal Of Psychiatry 2021, 43: 289-292. PMID: 32756806, PMCID: PMC8136393, DOI: 10.1590/1516-4446-2020-0964.Peer-Reviewed Original ResearchConceptsMental disordersWell-Being Behavior AssessmentHigh-risk cohortLogistic regression modelsSchool-based studyGaming disorderPsychiatric disordersUnhealthy patternsDisorder ratesSchool-based sampleDisordersSignificant predictorsFurther riskBrazilian High-Risk CohortCommunity sampleHigh rateBehavior changeMore hoursRegression modelsChildrenPredictorsAdolescentsHoursBehavior assessmentPattern variablesPsychotic-like Experiences and Common Mental Disorders in Childhood and Adolescence: Bidirectional and Transdiagnostic Associations in a Longitudinal Community-based Study
Giocondo J, Salum G, Gadelha A, Argolo F, Simioni A, Mari J, Miguel E, Bressan R, Rohde L, Pan P. Psychotic-like Experiences and Common Mental Disorders in Childhood and Adolescence: Bidirectional and Transdiagnostic Associations in a Longitudinal Community-based Study. Schizophrenia Bulletin Open 2021, 2: sgab028. DOI: 10.1093/schizbullopen/sgab028.Peer-Reviewed Original ResearchCommon mental disordersComorbid psychiatric disordersRisk of PLEsCommunity-based studyMental disordersPsychiatric disordersPsychotic-like experiencesDepressive disorderLongitudinal community-based studyBidirectional associationsCommon psychiatric disordersSubthreshold psychotic symptomsNon-psychotic disordersSubsequent depressive disordersYear old subjectsPsychotic symptomsOlder subjectsCutoff valueComorbidity analysisClinician ratingsSubstance useDisordersBaseline ADHDDistinct phenotypesRiskDisability in children and adolescents: the extent of the impact on psychiatric disorders and educational deficits.
Zaqueu L, Teixeira M, Lowenthal R, Mari J, Miguel E, Rohde L, Paula C. Disability in children and adolescents: the extent of the impact on psychiatric disorders and educational deficits. Trends In Psychiatry And Psychotherapy 2021, 43: 235-239. PMID: 34860479, PMCID: PMC8638709, DOI: 10.47626/2237-6089-2020-0059.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderChildren/adolescentsAcademic performanceTypical developmentSchool failureType of disabilityPsychiatric disordersDeficit hyperactivity disorderEducational deficitsPoor academic performanceWorse academic performanceBrazilian children/adolescentsPresence of disabilityMental health problemsSchool-aged childrenMiddle-income countriesHyperactivity disorderSixth gradersMulticenter cross-sectional studyAdolescentsTen Questions QuestionnaireCross-sectional studyIntellectual disabilityLogistic regression modelsSpecific interventions
2020
Stressful Life Events and the Clinical Expression of Obsessive–Compulsive Disorder (OCD): An Exploratory Study
Imthon A, Caldart C, do Rosário M, Fontenelle L, Miguel E, Ferrão Y. Stressful Life Events and the Clinical Expression of Obsessive–Compulsive Disorder (OCD): An Exploratory Study. Journal Of Clinical Medicine 2020, 9: 3371. PMID: 33096706, PMCID: PMC7590000, DOI: 10.3390/jcm9103371.Peer-Reviewed Original ResearchStressful life eventsObsessive-compulsive disorderPost-traumatic stress disorderOCD patientsOccurrence of SLEsNonwhite skin colorLife eventsLogistic regression variablesCross-sectional studySensory phenomenaYale-Brown ObsessiveClinical characteristicsClinical expressionPsychiatric disordersHistory questionnairePatientsObsessive-compulsive symptomsStress disorderCompulsive ScaleDimensional Yale-Brown ObsessiveStatistical significanceDisordersPositive associationOCD symptomsSymptomsSocial losses predict a faster onset and greater severity of obsessive-compulsive disorder
Destrée L, Albertella L, Torres A, Ferrão Y, Shavitt R, Miguel E, Fontenelle L. Social losses predict a faster onset and greater severity of obsessive-compulsive disorder. Journal Of Psychiatric Research 2020, 130: 187-193. PMID: 32828024, DOI: 10.1016/j.jpsychires.2020.07.027.Peer-Reviewed Original ResearchConceptsClinical obsessive-compulsive disorderObsessive-compulsive disorderStressful life eventsSpeed of progressionYale-Brown ObsessiveDSM-IV Axis I DisordersLife eventsCompulsive ScaleAxis I DisordersStructured Clinical InterviewSeverity of symptomsSymptom dimensionsBeck Depression InventorySubclinical obsessive-compulsive symptomsBeck Anxiety InventorySpecific obsessive-compulsive symptom dimensionsI disordersFaster onsetPsychiatric disordersHistory questionnaireBrown AssessmentClinical InterviewGreater severityDepression InventoryObsessive-compulsive symptomsPopulation neuroscience: challenges and opportunities for psychiatric research in low- and middle-income countries
Cirillo A, Diniz E, Gadelha A, Asevedo E, Axelrud L, Miguel E, Rohde L, Bressan R, Pan P, de J. Mari J. Population neuroscience: challenges and opportunities for psychiatric research in low- and middle-income countries. Brazilian Journal Of Psychiatry 2020, 42: 442-448. PMID: 32267341, PMCID: PMC7430393, DOI: 10.1590/1516-4446-2019-0761.Peer-Reviewed Original ResearchConceptsMiddle-income countriesHigh-income countriesPopulation neuroscienceLongitudinal cohort studyCohort studyCohort designPsychiatric disordersElectronic searchMEDLINE databaseSystematic reviewBrain functioningCohortPsychiatric researchLMICsPsychiatry researchSearch criteriaKey studiesEMBASEEpidemiologyStudy
2019
Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence?
de Araujo C, Swardfager W, Zugman A, Cogo-Moreira H, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, Mansur R, Hoexter M, Picon F, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence? CNS Spectrums 2019, 25: 790-796. PMID: 31845634, DOI: 10.1017/s1092852919001688.Peer-Reviewed Original ResearchConceptsSerum BDNF concentrationsBrain-derived neurotrophic factorBDNF concentrationsBDNF genotypeCortical thicknessPsychiatric disordersSerum brain-derived neurotrophic factor (BDNF) concentrationsBrain-derived neurotrophic factor concentrationSubcortical volumesMental disordersWell-Being Behavior AssessmentBrain structuresBDNF serum concentrationsNeurotrophic factor concentrationsPeripheral blood concentrationsHigh Risk Cohort StudyLate childhoodAdult psychiatric disordersLarge independent samplesCohort studyNeurotrophic factorCortical maturationSerum concentrationsBlood concentrationsMet carriersDifferences Between Self-Reported Psychotic Experiences, Clinically Relevant Psychotic Experiences, and Attenuated Psychotic Symptoms in the General Population
Moriyama T, van Os J, Gadelha A, Pan P, Salum G, Manfro G, de Jesus Mari J, Miguel E, Rohde L, Polanczyk G, McGuire P, Bressan R, Drukker M. Differences Between Self-Reported Psychotic Experiences, Clinically Relevant Psychotic Experiences, and Attenuated Psychotic Symptoms in the General Population. Frontiers In Psychiatry 2019, 10: 782. PMID: 31736802, PMCID: PMC6829673, DOI: 10.3389/fpsyt.2019.00782.Peer-Reviewed Original ResearchSelf-reported psychotic experiencesPsychotic symptomsPsychotic experiencesAffective flatteningHigh Risk Cohort StudyAttenuated Psychotic SymptomsChild mental healthCohort studyStrength of associationFemale sexClinical assessmentLevels of psychopathologyGeneral populationPsychiatric disordersClinical relevanceEarly interventionMental healthIndependent interviewerMost associationsParent informationSymptomsAssociationPresent studyPsychopathologyPsychologists' assessmentIs there any relationship between Neuroscience and Psychiatry
Farhat L, Hoexter M, Miguel E. Is there any relationship between Neuroscience and Psychiatry. Revista De Medicina 2019, 98: i-ii. DOI: 10.11606/issn.1679-9836.v98i4pi-ii.Peer-Reviewed Original Research