2019
Effects of the interaction between genetic factors and maltreatment on child and adolescent psychiatric disorders
Carvalho C, Pan P, Ota V, Spindola L, Xavier G, Santoro M, Mazzotti D, Pellegrino R, Hakonarson H, Rohde L, Miguel E, Gadelha A, Bressan R, Belangero S. Effects of the interaction between genetic factors and maltreatment on child and adolescent psychiatric disorders. Psychiatry Research 2019, 273: 575-577. PMID: 30716596, DOI: 10.1016/j.psychres.2019.01.078.Peer-Reviewed Original ResearchConceptsMental disordersSingle nucleotide polymorphismsSchool-based prospective studyAdolescent psychiatric disordersBonferroni multiple comparison correctionChild maltreatmentProspective studyPsychiatric disordersMultiple comparison correctionSignificant associationGenetic factorsDisordersNucleotide polymorphismsPsychopathologyLogistic modelMaltreatment
2009
Treatment of Resistant Obsessive-Compulsive Disorder With Ventral CapsularVentral Striatal Gamma Capsulotomy: A Pilot Prospective Study
Lopes A, Greenberg B, Norén G, Canteras M, Busatto G, de Mathis M, Taub A, D'Alcante C, Hoexter M, Gouvea F, Cecconi J, Gentil A, Ferrão Y, Fuentes D, de Castro C, Leite C, Salvajoli J, Duran F, Rasmussen S, Miguel E. Treatment of Resistant Obsessive-Compulsive Disorder With Ventral CapsularVentral Striatal Gamma Capsulotomy: A Pilot Prospective Study. Journal Of Neuropsychiatry 2009, 21: 381-392. PMID: 19996246, DOI: 10.1176/jnp.2009.21.4.381.Peer-Reviewed Original ResearchConceptsResistant obsessive-compulsive disorderRefractory OCD patientsAdverse effectsPilot prospective studyObsessive-compulsive disorder patientsAdverse eventsProspective studyObsessive-compulsive disorderStereotactic radiosurgeryDepressive symptomsDisorder patientsSide effectsConventional treatmentCapsulotomyTherapeutic promisePatientsOCD patientsTreatmentSurgeryRadiosurgerySymptomsMonths
2008
Gamma ventral capsulotomy for treatment of resistant obsessive-compulsive disorder: A structural MRI pilot prospective study
Cecconi J, Lopes A, de Souza Duran F, Santos L, Hoexter M, Gentil A, Canteras M, de Castro C, Norén G, Greenberg B, Rauch S, Busatto G, Miguel E. Gamma ventral capsulotomy for treatment of resistant obsessive-compulsive disorder: A structural MRI pilot prospective study. Neuroscience Letters 2008, 447: 138-142. PMID: 18835422, DOI: 10.1016/j.neulet.2008.09.061.Peer-Reviewed Original ResearchConceptsGamma ventral capsulotomyObsessive-compulsive disorderRefractory obsessive-compulsive disorderResistant obsessive-compulsive disorderRefractory OCD patientsYear of radiosurgeryPilot prospective studyVoxel-based morphometry methodRegional structural abnormalitiesGray matter volumeRight inferior frontal gyrusInferior orbitofrontal cortexPostoperative increaseProspective studyInferior frontal gyrusMagnetic resonance imaging dataMatter volumeMRI scansNeurobiological changesStructural abnormalitiesOrbitofrontal cortexCapsulotomyPatientsOCD patientsFrontal gyrus
1990
Psychic changes in systemic lupus erythematosus: a multidisciplinary prospective study.
Miguel Filho E, Pereira R, Busatto Filho G, Shavitt R, Hirsch R, de Sá L, de Arruda P. Psychic changes in systemic lupus erythematosus: a multidisciplinary prospective study. Revista Da Associação Médica Brasileira 1990, 36: 83-90. PMID: 1965671.Peer-Reviewed Original ResearchConceptsProspective studyAnti-Ro/SSNervous system involvementCerebrospinal fluid analysisOrganic mental syndromeSystemic lupus erythematosusMultidisciplinary approachAnti-U1 RNPMultidisciplinary prospective studyAdequate control groupsAnti-nDNALupus patientsNeurologic findingsLupus erythematosusLaboratory findingsMental syndromesSystem involvementHigh prevalenceOphthalmologic alterationsPsychic alterationsElevated proteinPrimary manifestationCognitive symptomsControl groupPsychic symptoms