Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample
Mansur R, Cunha G, Asevedo E, Zugman A, Rios A, Salum G, Pan P, Gadelha A, Levandowski M, Belangero S, Manfro G, Stertz L, Kauer-Sant’anna M, Miguel E, Bressan R, Mari J, Grassi-Oliveira R, Brietzke E. Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample. European Child & Adolescent Psychiatry 2016, 26: 521-529. PMID: 27785581, DOI: 10.1007/s00787-016-0914-6.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrazilChecklistChildChild Behavior DisordersCohort StudiesDevelopmental DisabilitiesFemaleHumansLipid PeroxidationLong Term Adverse EffectsMaleMalondialdehydeMental DisordersMental HealthOxidative StressPregnancyPsychopathologySocioeconomic FactorsThiobarbituric Acid Reactive SubstancesConceptsPerinatal complicationsMental health problemsCumulative exposureLipid peroxidationTBARS levelsChild Behavior ChecklistHealth problemsHigh Risk Cohort StudyMini-International Psychiatric InterviewYears of ageCBCL total problemsIndividual cumulative exposureEarly life environmentCohort studyCumulative risk indexSerum levelsPerinatal historyUnexposed groupExploratory mediation analysisPsychiatric interviewComplicationsPsychiatric disordersSocio-economic statusPediatric samplesOxidative stressAssociation of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantage
Mansur R, Cunha G, Asevedo E, Zugman A, Rizzo L, Grassi-Oliveira R, Levandowski M, Gadelha A, Pan P, Teixeira A, McIntyre R, Mari J, Rohde L, Miguel E, Bressan R, Brietzke E. Association of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantage. Psychoneuroendocrinology 2016, 71: 94-101. PMID: 27258821, DOI: 10.1016/j.psyneuen.2016.05.015.Peer-Reviewed Original ResearchConceptsParental mood disorderMental health problemsSerum interleukin-6Interleukin-6Perinatal complicationsEnvironmental risk factorsHealth problemsRisk factorsSerum levelsPsychiatric diagnosisParents' psychiatric diagnosisHigher serum levelsHigh Risk Cohort StudyMultiple risk factorsSocial disadvantageCohort studySystemic inflammationSocio-demographic characteristicsInflammatory activationMood disordersPsychiatric disordersDisorder pathogenesisComplicationsFamilial riskCumulative risk model