2020
Higher volumes of hippocampal subfields in pediatric obsessive-compulsive disorder
Vattimo E, Dos Santos A, Hoexter M, Frudit P, Miguel E, Shavitt R, Batistuzzo M. Higher volumes of hippocampal subfields in pediatric obsessive-compulsive disorder. Psychiatry Research Neuroimaging 2020, 307: 111200. PMID: 33059948, DOI: 10.1016/j.pscychresns.2020.111200.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderHippocampal volumeTotal gray matter volumeRight whole hippocampusBilateral hippocampal headsLarger hippocampal volumesGray matter volumePediatric obsessive-compulsive disorderRight parasubiculumAdult patientsPediatric patientsHippocampal bodyAnatomic subregionsHippocampal headLimbic structuresHealthy controlsFreeSurfer softwareHippocampus volumeHippocampal subfieldsWhole hippocampusHippocampal cytoarchitectureEarly markerMatter volumePatientsSignificant larger volumesCognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder
Bernardes E, Saraiva L, e Souza M, Hoexter M, Chacon P, Requena G, Miguel E, Shavitt R, Polanczyk G, Cappi C, Batistuzzo M. Cognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder. BMC Psychiatry 2020, 20: 380. PMID: 32690046, PMCID: PMC7370498, DOI: 10.1186/s12888-020-02751-5.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderObsessive-compulsive symptomsNeurocognitive domainsPediatric obsessive-compulsive disorderNon-verbal memoryProcessing speed domainCognitive domain analysisComprehensive neuropsychological batteryNon-clinical sampleYale-Brown ObsessiveSubdomain analysisVisuospatial memoryCognitive domainsExecutive functionVisuoconstructive abilitiesVisuoconstructive tasksCognitive performanceNeuropsychological variablesNeuropsychological batteryStructured Clinical InterviewProcessing speedNeurocognitive assessmentSpeed domainOCS severityCompulsive Scale
2019
Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium
Kong XZ, Boedhoe PSW, Abe Y, Alonso P, Ameis SH, Arnold PD, Assogna F, Baker JT, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Brennan BP, Buitelaar J, Calvo R, Cheng Y, Cho KIK, Dallaspezia S, Denys D, Ely BA, Feusner J, Fitzgerald KD, Fouche JP, Fridgeirsson EA, Glahn DC, Gruner P, Gürsel DA, Hauser TU, Hirano Y, Hoexter MQ, Hu H, Huyser C, James A, Jaspers-Fayer F, Kathmann N, Kaufmann C, Koch K, Kuno M, Kvale G, Kwon JS, Lazaro L, Liu Y, Lochner C, Marques P, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Medland SE, Menchón JM, Minuzzi L, Moreira PS, Morer A, Morgado P, Nakagawa A, Nakamae T, Nakao T, Narayanaswamy JC, Nurmi EL, O'Neill J, Pariente JC, Perriello C, Piacentini J, Piras F, Piras F, Pittenger C, Reddy YCJ, Rus-Oswald OG, Sakai Y, Sato JR, Schmaal L, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Tolin DF, Tsuchiyagaito A, van Rooij D, van Wingen GA, Venkatasubramanian G, Wang Z, Yun JY, Group E, Kong X, Boedhoe P, Abe Y, Alonso P, Ameis S, Anticevic A, Arnold P, Assogna F, Baker J, Banaj N, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Bollettini I, Bose A, Brandeis D, Brem S, Brennan B, Buitelaar J, Busatto G, Calvo A, Calvo R, Cheng Y, Cho K, Ciullo V, Dallaspezia S, Denys D, de Vries F, de Wit S, Dickie E, Drechsler R, Ely B, Esteves M, Falini A, Fang Y, Feusner J, Figee M, Fitzgerald K, Fontaine M, Fouche J, Fridgeirsson E, Gruner P, Gürsel D, Hall G, Hamatani S, Hanna G, Hansen B, Hauser T, Hirano Y, Hoexter M, Hu H, Huyser C, Ikari K, Jahanshad N, James A, Jaspers-Fayer F, Kathmann N, Kaufmann C, Koch K, Kuno M, Kvale G, Kwon J, Lazaro L, Liu Y, Lochner C, Magalhães R, Marques P, Marsh R, Martínez-Zalacaín I, Masuda Y, Mataix-Cols D, Matsumoto K, McCracken J, Menchón J, Miguel E, Minuzzi L, Moreira P, Morer A, Morgado P, Nakagawa A, Nakamae T, Nakao T, Narayanaswamy J, Narumoto J, Nishida S, Nurmi E, O'Neill J, Pariente J, Perriello C, Piacentini J, Piras F, Piras F, Pittenger C, Poletti S, Reddy Y, Reess T, Rus-Oswald O, Sakai Y, Sato J, Schmaal L, Shimizu E, Simpson H, Soreni N, Soriano-Mas C, Sousa N, Spalletta G, Stern E, Stevens M, Stewart S, Szeszko P, Takahashi J, Tang J, Thorsen A, Tolin D, Tsuchiyagaito A, van Rooij D, van Wingen G, van der Werf Y, Veltman D, Vecchio D, Venkatasubramanian G, Walitza S, Wang Z, Watanabe A, Xu J, Xu X, Yamada K, Yoshida T, Yun J, Zarei M, Zhao Q, Zhou C, Thompson P, Stein D, van den Heuvel O, Francks C, Thompson P, Stein D, van den Heuvel O, Francks C. Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium. Biological Psychiatry 2019, 87: 1022-1034. PMID: 31178097, PMCID: PMC7094802, DOI: 10.1016/j.biopsych.2019.04.022.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCase-control differencesBrain structural asymmetryMedication statusSubcortical structuresENIGMA consortiumSignificant case-control differencesRegional cortical thicknessPediatric obsessive-compulsive disorderPediatric datasetSubcortical asymmetriesDepression comorbidityCortical thicknessPotential associationLarger studyNeurodevelopmental processesVolume asymmetryBrain asymmetryAbnormal patternsDisordersPossible alterationsPutative linkOCD severityAsymmetry patternsMagnetic resonanceCaudate volume differences among treatment responders, non-responders and controls in children with obsessive–compulsive disorder
Vattimo E, Barros V, Requena G, Sato J, Fatori D, Miguel E, Shavitt R, Hoexter M, Batistuzzo M. Caudate volume differences among treatment responders, non-responders and controls in children with obsessive–compulsive disorder. European Child & Adolescent Psychiatry 2019, 28: 1607-1617. PMID: 30972581, DOI: 10.1007/s00787-019-01320-w.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderGroup cognitive behavioral therapyPediatric obsessive-compulsive disorderRight caudateTreatment responseCognitive behavioral therapyCaudate nucleusPossible neural substrateTreatment respondersGM volumeStructural magnetic resonance imagingNeural substratesPrevious evidenceNeurobiological underpinningsOrbitofrontal cortexAge-matched controlsTotal GM volumeMagnetic resonance imagingBrain structuresResonance imagingChildrenRespondersBonferroni correctionCaudatePatients
2016
Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis
Boedhoe PS, Schmaal L, Abe Y, Ameis SH, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Cheng Y, Cho KI, Dallaspezia S, Denys D, Fitzgerald KD, Fouche JP, Giménez M, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Nakamae T, Nakao T, Narayanaswamy JC, Piras F, Piras F, Pittenger C, Reddy YC, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, Venkatasubramanian G, Walitza S, Wang Z, van Wingen GA, Xu J, Xu X, Yun JY, Zhao Q, Thompson P, Stein D, van den Heuvel O, Abe Y, Alonso P, Ameis S, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Boedhoe P, Bollettini I, Bose A, Brem S, Busatto G, Calvo A, Calvo R, Cath D, Cheng Y, Cho K, Dallaspezia S, de Vries F, de Wit S, Denys D, Fang Y, Fitzgerald K, Fontaine M, Fouche J, Giménez M, Gruner P, Hanna G, Hibar D, Hoexter M, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón J, Miguel E, Minuzzii L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Piras F, Piras F, Pittenger C, Reddy Y, Sato J, Simpson H, Schmaal L, Soreni N, Soriano-Mas C, Spalletta G, Stein D, Stevens M, Szeszko P, Thompson P, Tolin D, Veltman D, Venkatasubramanian G, van den Heuvel O, van der Werf Y, van Wingen G, Walitza S, Wang Z, Xu J, Xu X, Yun J, Zhao Q. Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis. American Journal Of Psychiatry 2016, 174: 60-69. PMID: 27609241, PMCID: PMC5344782, DOI: 10.1176/appi.ajp.2016.16020201.Peer-Reviewed Original ResearchConceptsAdult obsessive-compulsive disorderObsessive-compulsive disorderOCD patientsLarger thalamic volumesSubcortical volume alterationsSmaller hippocampal volumesAdult OCD patientsPediatric obsessive-compulsive disorderPotential modulating effectSubcortical brain volumesLimited statistical powerPallidum volumeClinical characteristicsAdult patientsPediatric patientsMean ageThalamic volumeControl subjectsPediatric controlsSubcortical abnormalitiesIllness profileHippocampal volumeHealthy subjectsNeurodevelopmental alterationsPatients