2019
Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis
Lisboa B, Oliveira K, Tahira A, Barbosa A, Feltrin A, Gouveia G, Lima L, Feio dos Santos A, Martins D, Puga R, Moretto A, De Bragança Pereira C, Lafer B, Leite R, Ferretti-Rebustini R, Farfel J, Grinberg L, Jacob-Filho W, Miguel E, Hoexter M, Brentani H. Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis. Scientific Reports 2019, 9: 3086. PMID: 30816141, PMCID: PMC6395771, DOI: 10.1038/s41598-019-38965-1.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSynaptic transmissionPathophysiology of OCDDifferent striatal subregionsPostmortem brain tissueChemical synaptic transmissionStriatal areasCortico-striatoNeurotransmitter levelsStriatum regionThalamic circuitryStriatal subregionsSubregion specificityPsychiatric disordersPresynaptic processesSynaptic plasticityBrain samplesOCD pathophysiologyBrain tissueCSTC modelControl casesPathophysiologyRare variantsDisordersCellular responses
2001
Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamento
Shavitt R, Ferrão Y, Bravo M, Belotto C, Lopes A, Miguel E. Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamento. Brazilian Journal Of Psychiatry 2001, 23: 52-57. DOI: 10.1590/s1516-44462001000600016.Peer-Reviewed Original ResearchSerotonin uptake inhibitorPredictive response factorsNon-pharmacological approachesTranscranial magnetic stimulationResistant casesAppropriate trialsPharmacological trialsMagnetic stimulationUptake inhibitorConventional treatmentBehavioral therapyPatientsOCD patientsBehavior therapyTherapyTrialsTreatmentAugmentation strategiesFurther researchMedicationsPathophysiologyPharmacogenetics
1999
Relationship between obsessive-compulsive disorders and diseases affecting primarily the basal ganglia
Maia A, Barbosa E, Menezes P, Filho E. Relationship between obsessive-compulsive disorders and diseases affecting primarily the basal ganglia. Clinics 1999, 54: 213-221. PMID: 10881070, DOI: 10.1590/s0041-87811999000600008.Peer-Reviewed Original Research
1995
Transtorno obsessivo-compulsivo e os gânglios da base
Filho E. Transtorno obsessivo-compulsivo e os gânglios da base. Arquivos De Neuro-Psiquiatria 1995, 53: 858-859. PMID: 8729788, DOI: 10.1590/s0004-282x1995000500036.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderBasal gangliaCaudate nucleusPathophysiology of OCDSmaller caudate nucleusPrimary lesionCingulate cortexBrain structuresMagnetic resonance imagesCortexMental functionsPatientsGangliaMotor controlResonance imagesNucleus functionRecent studiesAdaptative responseThalamusPathophysiology